| Drug1 | Resistance | Supporting Mutations (frequency) |
| Isoniazid | ||
| Rifampicin | ||
| Ethambutol | R | embB p.Tyr384Asn (1.00), embB p.Asn399Asp (1.00) |
| Pyrazinamide | ||
| Streptomycin | R | rrs r.462c>t (1.00) |
| Ethionamide | ||
| Fluoroquinolones | ||
| Amikacin | ||
| Capreomycin | ||
| Kanamycin |
| Lineage2 | Family | Main Spoligotype | RDS |
| lineage4.6 | Euro-American | T;LAM | None |
| lineage4.7 | Euro-American (mainly T) | T1;T5 | None |
| lineage4.6.2.2 | Euro-American (Cameroon) | LAM10-CAM | RD726 |
| Gene | Chromosome Position | Mutation | Estimated fraction |
| gyrB | 6193 | c.954G>A | 0.917 |
| gyrB | 6196 | c.957C>G | 1.000 |
| gyrB | 6208 | c.969G>A | 1.000 |
| gyrB | 6214 | c.975G>A | 1.000 |
| gyrB | 6898 | c.1659G>C | 1.000 |
| gyrA | 7361 | c.60C>T | 1.000 |
| gyrA | 7362 | p.Glu21Gln | 1.000 |
| gyrA | 7370 | c.69G>A | 1.000 |
| gyrA | 7391 | c.90C>T | 1.000 |
| gyrA | 7394 | c.93T>C | 1.000 |
| gyrA | 7415 | c.114C>G | 1.000 |
| gyrA | 7427 | c.126G>T | 1.000 |
| gyrA | 7430 | c.129G>A | 1.000 |
| gyrA | 7451 | c.150C>G | 1.000 |
| gyrA | 7457 | c.156T>C | 1.000 |
| gyrA | 7469 | c.168C>G | 1.000 |
| gyrA | 7475 | c.174A>C | 1.000 |
| gyrA | 7480 | p.Phe60Tyr | 1.000 |
| gyrA | 7484 | c.183T>C | 1.000 |
| gyrA | 7490 | c.189C>G | 1.000 |
| gyrA | 8090 | c.789C>G | 1.000 |
| gyrA | 8096 | c.795T>C | 1.000 |
| gyrA | 8099 | c.798T>C | 1.000 |
| gyrA | 8121 | c.820T>C | 1.000 |
| gyrA | 8138 | c.837C>T | 1.000 |
| gyrA | 8156 | c.855T>C | 1.000 |
| gyrA | 8162 | c.861C>T | 1.000 |
| gyrA | 8168 | c.867A>G | 1.000 |
| gyrA | 8174 | c.873C>T | 1.000 |
| gyrA | 8177 | c.876A>C | 1.000 |
| gyrA | 8207 | c.906T>C | 1.000 |
| gyrA | 8213 | c.912C>T | 1.000 |
| gyrA | 8219 | c.918T>C | 1.000 |
| gyrA | 8225 | c.924T>C | 1.000 |
| gyrA | 8228 | c.927G>A | 1.000 |
| gyrA | 8234 | c.933T>C | 1.000 |
| gyrA | 8237 | c.936A>G | 1.000 |
| gyrA | 8711 | c.1410A>C | 1.000 |
| gyrA | 8717 | c.1416C>G | 1.000 |
| gyrA | 8723 | c.1422G>C | 1.000 |
| gyrA | 8729 | c.1428T>A | 1.000 |
| gyrA | 8730 | p.Gly477Lys | 1.000 |
| gyrA | 8756 | c.1455A>G | 1.000 |
| gyrA | 8762 | c.1461G>C | 1.000 |
| gyrA | 8765 | p.Asp488Glu | 1.000 |
| gyrA | 8767 | p.Arg489Lys | 1.000 |
| gyrA | 8783 | c.1482G>T | 1.000 |
| gyrA | 8810 | c.1509A>C | 1.000 |
| gyrA | 8813 | c.1512C>T | 1.000 |
| gyrA | 8819 | c.1518C>T | 1.000 |
| gyrA | 9197 | c.1896G>C | 1.000 |
| gyrA | 9200 | c.1899A>G | 1.000 |
| gyrA | 9230 | c.1929T>C | 1.000 |
| gyrA | 9248 | c.1947G>C | 1.000 |
| gyrA | 9252 | p.Val651Ile | 1.000 |
| gyrA | 9265 | p.Asp655Gly | 1.000 |
| gyrA | 9267 | p.Asn656Glu | 1.000 |
| gyrA | 9281 | c.1980C>G | 1.000 |
| gyrA | 9284 | c.1983T>C | 1.000 |
| gyrA | 9317 | c.2016G>A | 1.000 |
| gyrA | 9332 | c.2031C>T | 1.000 |
| gyrA | 9365 | p.Glu688Asp | 0.900 |
| rpoB | 760223 | c.417T>C | 1.000 |
| rpoB | 760235 | c.429T>C | 1.000 |
| rpoB | 760253 | c.447T>C | 1.000 |
| rpoB | 760343 | c.537G>C | 1.000 |
| rpoB | 760361 | c.555T>C | 1.000 |
| rpoB | 760376 | p.Asp190Glu | 1.000 |
| rpoB | 760381 | p.Thr192Met | 1.000 |
| rpoB | 760424 | c.618C>G | 1.000 |
| rpoB | 760430 | c.624T>C | 1.000 |
| rpoB | 760454 | c.648C>T | 1.000 |
| rpoB | 760457 | c.651C>T | 1.000 |
| rpoB | 760463 | c.657C>T | 1.000 |
| rpoB | 760938 | c.1132C>T | 1.000 |
| rpoB | 760943 | c.1137C>T | 1.000 |
| rpoB | 760946 | c.1140A>G | 1.000 |
| rpoB | 760970 | c.1164G>C | 1.000 |
| rpoB | 760982 | c.1176G>C | 1.000 |
| rpoB | 760985 | c.1179G>C | 1.000 |
| rpoB | 760988 | c.1182C>G | 1.000 |
| rpoB | 760991 | c.1185G>C | 1.000 |
| rpoB | 761015 | c.1209G>C | 1.000 |
| rpoB | 761027 | c.1221A>G | 1.000 |
| rpoB | 761036 | c.1230G>C | 1.000 |
| rpoB | 761037 | c.1231T>C | 1.000 |
| rpoB | 761054 | c.1248G>T | 1.000 |
| rpoB | 761057 | c.1251G>C | 1.000 |
| rpoB | 761168 | c.1362C>G | 1.000 |
| rpoB | 761180 | c.1374A>C | 1.000 |
| rpoB | 761189 | c.1383T>G | 1.000 |
| rpoB | 761207 | c.1401C>T | 1.000 |
| rpoB | 761249 | c.1443A>G | 1.000 |
| rpoB | 761255 | c.1449T>G | 1.000 |
| rpoB | 761261 | c.1455G>T | 1.000 |
| rpoB | 761264 | c.1458C>G | 1.000 |
| rpoB | 761267 | c.1461C>T | 1.000 |
| rpoB | 761270 | c.1464C>T | 1.000 |
| rpoB | 761282 | c.1476C>G | 1.000 |
| rpoB | 761300 | c.1494G>A | 1.000 |
| rpoB | 761327 | c.1521A>G | 1.000 |
| rpoB | 761531 | c.1725C>G | 1.000 |
| rpoB | 761537 | c.1731C>G | 1.000 |
| rpoB | 761573 | c.1767C>G | 1.000 |
| rpoB | 761579 | c.1773G>C | 1.000 |
| rpoB | 761669 | c.1863C>T | 0.900 |
| rpoB | 761675 | c.1869G>T | 0.900 |
| rpoB | 761682 | c.1876C>T | 0.900 |
| rpoB | 761768 | c.1962G>C | 1.000 |
| rpoB | 761778 | p.Asn658Ala | 1.000 |
| rpoB | 761792 | c.1986T>C | 1.000 |
| rpoB | 761813 | c.2007T>C | 1.000 |
| rpoB | 761885 | c.2079T>C | 1.000 |
| rpoB | 761969 | c.2163G>A | 1.000 |
| rpoB | 761990 | c.2184G>C | 1.000 |
| rpoB | 761999 | c.2193G>C | 1.000 |
| rpoB | 762008 | c.2202C>G | 1.000 |
| rpoB | 762014 | c.2208C>T | 1.000 |
| rpoB | 762047 | c.2241G>A | 1.000 |
| rpoB | 762062 | c.2256T>C | 1.000 |
| rpoB | 762065 | c.2259T>C | 1.000 |
| rpoB | 762233 | c.2427G>C | 1.000 |
| rpoB | 762246 | c.2440C>T | 1.000 |
| rpoB | 762284 | c.2478G>C | 1.000 |
| rpoB | 762293 | c.2487T>C | 1.000 |
| rpoB | 762296 | c.2490G>A | 1.000 |
| rpoB | 762314 | c.2508C>T | 1.000 |
| rpoB | 762341 | c.2535G>C | 1.000 |
| rpoB | 762347 | c.2541T>C | 1.000 |
| rpoB | 762362 | p.Glu852Asp | 1.000 |
| rpoB | 762368 | c.2562G>A | 1.000 |
| rpoB | 762369 | c.2563T>C | 1.000 |
| rpoB | 762374 | c.2568G>T | 1.000 |
| rpoB | 762380 | c.2574T>C | 1.000 |
| rpoB | 762395 | c.2589G>C | 1.000 |
| rpoB | 762398 | c.2592T>C | 1.000 |
| rpoB | 762401 | c.2595G>C | 1.000 |
| rpoB | 762404 | c.2598T>C | 1.000 |
| rpoB | 762410 | c.2604T>C | 1.000 |
| rpoB | 762416 | c.2610A>G | 1.000 |
| rpoB | 762458 | c.2652C>T | 1.000 |
| rpoB | 762470 | c.2664G>T | 1.000 |
| rpoB | 762483 | c.2677C>T | 1.000 |
| rpoB | 762857 | c.3051C>G | 0.900 |
| rpoB | 762917 | c.3111C>T | 1.000 |
| rpoB | 762923 | c.3117C>G | 1.000 |
| rpoB | 762929 | c.3123G>T | 1.000 |
| rpoB | 762957 | c.3151C>T | 1.000 |
| rpoB | 762962 | c.3156C>T | 1.000 |
| rpoB | 762971 | c.3165G>C | 1.000 |
| rpoB | 762995 | c.3189G>T | 0.947 |
| rpoB | 762998 | c.3192G>A | 1.000 |
| rpoB | 763028 | c.3222T>C | 1.000 |
| rpoB | 763031 | c.3225T>C | 1.000 |
| rpoB | 763034 | c.3228C>G | 1.000 |
| rpoB | 763040 | c.3234C>G | 1.000 |
| rpoB | 763053 | c.3247T>C | 1.000 |
| rpoB | 763070 | c.3264T>C | 1.000 |
| rpoB | 763085 | c.3279C>G | 1.000 |
| rpoB | 763094 | c.3288G>C | 1.000 |
| rpoB | 763115 | c.3309T>C | 1.000 |
| rpoB | 763139 | c.3333C>T | 1.000 |
| rpoB | 763142 | c.3336C>G | 1.000 |
| rpoB | 763166 | c.3360A>G | 1.000 |
| rpoB | 763169 | c.3363A>G | 1.000 |
| rpoB | 763175 | c.3369G>A | 1.000 |
| rpoC | 763375 | c.6C>A | 1.000 |
| rpoC | 763402 | c.33C>T | 1.000 |
| rpoC | 763417 | c.48C>T | 1.000 |
| rpoC | 763444 | c.75T>C | 1.000 |
| rpoC | 763456 | c.87A>G | 1.000 |
| rpoC | 763468 | c.99G>C | 1.000 |
| rpoC | 763486 | c.117T>C | 1.000 |
| rpoC | 763492 | c.123G>A | 1.000 |
| rpoC | 763528 | c.159G>A | 1.000 |
| rpoC | 763531 | c.162G>T | 1.000 |
| rpoC | 763546 | c.177A>G | 1.000 |
| rpoC | 763573 | c.204G>T | 1.000 |
| rpoC | 763576 | c.207C>T | 1.000 |
| rpoC | 763594 | c.225C>T | 1.000 |
| rpoC | 763603 | c.234C>T | 1.000 |
| rpoC | 763660 | c.291T>G | 1.000 |
| rpoC | 763666 | c.297G>A | 1.000 |
| rpoC | 763669 | c.300C>G | 1.000 |
| rpoC | 763702 | c.333C>G | 1.000 |
| rpoC | 763714 | c.345G>A | 1.000 |
| rpoC | 763723 | c.354G>C | 1.000 |
| rpoC | 763732 | c.363C>G | 1.000 |
| rpoC | 763735 | c.366G>C | 1.000 |
| rpoC | 763747 | c.378G>A | 1.000 |
| rpoC | 764040 | p.Ser224Thr | 1.000 |
| rpoC | 764044 | c.675T>C | 1.000 |
| rpoC | 764077 | c.708C>G | 1.000 |
| rpoC | 764083 | c.714A>G | 1.000 |
| rpoC | 764131 | c.762T>C | 1.000 |
| rpoC | 764134 | c.765C>A | 1.000 |
| rpoC | 764140 | c.771C>T | 1.000 |
| rpoC | 764152 | c.783C>T | 1.000 |
| rpoC | 764623 | c.1254C>A | 1.000 |
| rpoC | 764626 | c.1257C>T | 1.000 |
| rpoC | 764632 | c.1263T>C | 1.000 |
| rpoC | 764650 | c.1281G>T | 1.000 |
| rpoC | 764752 | c.1383G>T | 1.000 |
| rpoC | 764764 | c.1395T>C | 1.000 |
| rpoC | 764791 | c.1422C>G | 1.000 |
| rpoC | 764803 | c.1434C>T | 1.000 |
| rpoC | 764809 | c.1440C>T | 1.000 |
| rpoC | 764812 | c.1443C>G | 1.000 |
| rpoC | 764815 | c.1446A>G | 1.000 |
| rpoC | 764824 | c.1455T>C | 1.000 |
| rpoC | 764833 | c.1464A>G | 1.000 |
| rpoC | 764858 | c.1489T>C | 1.000 |
| rpoC | 764869 | c.1500C>G | 1.000 |
| rpoC | 764888 | c.1519T>C | 1.000 |
| rpoC | 764893 | c.1524T>C | 1.000 |
| rpoC | 764902 | c.1533C>T | 1.000 |
| rpoC | 764932 | c.1563C>A | 1.000 |
| rpoC | 764968 | c.1599T>C | 1.000 |
| rpoC | 764995 | c.1626C>T | 1.000 |
| rpoC | 765007 | c.1638T>G | 0.900 |
| rpoC | 765008 | c.1639T>C | 1.000 |
| rpoC | 765011 | c.1642A>T | 0.900 |
| rpoC | 765019 | c.1650A>G | 1.000 |
| rpoC | 765040 | c.1671T>C | 1.000 |
| rpoC | 765047 | c.1678T>C | 1.000 |
| rpoC | 765052 | c.1683C>G | 1.000 |
| rpoC | 765055 | c.1686C>T | 1.000 |
| rpoC | 765079 | c.1710T>C | 1.000 |
| rpoC | 765082 | c.1713G>C | 1.000 |
| rpoC | 765085 | c.1716T>G | 1.000 |
| rpoC | 765089 | c.1720T>C | 1.000 |
| rpoC | 765100 | c.1731G>C | 1.000 |
| rpoC | 765103 | c.1734G>A | 1.000 |
| rpoC | 765129 | p.Tyr587Phe | 1.000 |
| rpoC | 765352 | c.1983G>C | 1.000 |
| rpoC | 765356 | p.Met663Val | 1.000 |
| rpoC | 765383 | p.Met672Leu | 1.000 |
| rpoC | 765409 | c.2040T>C | 1.000 |
| rpoC | 765421 | c.2052C>G | 1.000 |
| rpoC | 765454 | c.2085C>G | 1.000 |
| rpoC | 765478 | c.2109T>C | 1.000 |
| rpoC | 765493 | c.2124G>C | 1.000 |
| rpoC | 765499 | c.2130C>A | 1.000 |
| rpoC | 765589 | c.2220G>T | 1.000 |
| rpoC | 765592 | c.2223C>T | 1.000 |
| rpoC | 765625 | c.2256C>G | 1.000 |
| rpoC | 765628 | c.2259G>C | 1.000 |
| rpoC | 765640 | c.2271A>G | 1.000 |
| rpoC | 765670 | c.2301C>T | 1.000 |
| rpoC | 765688 | c.2319G>A | 1.000 |
| rpoC | 765700 | c.2331T>C | 1.000 |
| rpoC | 765734 | c.2365T>C | 1.000 |
| rpoC | 765850 | c.2481G>C | 1.000 |
| rpoC | 765934 | c.2565C>T | 1.000 |
| rpoC | 765937 | c.2568T>A | 1.000 |
| rpoC | 765958 | c.2589C>G | 1.000 |
| rpoC | 765961 | c.2592G>A | 1.000 |
| rpoC | 765967 | c.2598C>T | 1.000 |
| rpoC | 765973 | c.2604C>A | 1.000 |
| rpoC | 765979 | c.2610C>G | 1.000 |
| rpoC | 765994 | c.2625A>T | 1.000 |
| rpoC | 766082 | p.Ala905Gln | 1.000 |
| rpoC | 766087 | c.2718C>G | 1.000 |
| rpoC | 766096 | c.2727G>T | 1.000 |
| rpoC | 766129 | c.2760C>G | 1.000 |
| rpoC | 766135 | c.2766G>A | 1.000 |
| rpoC | 766280 | p.Ser971Gly | 1.000 |
| rpoC | 766291 | c.2922G>C | 1.000 |
| rpoC | 766312 | c.2943T>G | 1.000 |
| rpoC | 766315 | c.2946C>G | 1.000 |
| rpoC | 766345 | c.2976T>C | 1.000 |
| rpoC | 766348 | c.2979A>G | 1.000 |
| rpoC | 766363 | c.2994G>C | 1.000 |
| rpoC | 766366 | c.2997C>A | 1.000 |
| rpoC | 766657 | c.3288A>G | 1.000 |
| rpoC | 766660 | c.3291G>A | 1.000 |
| rpoC | 766666 | c.3297C>G | 1.000 |
| rpoC | 766693 | c.3324C>T | 1.000 |
| rpoC | 766741 | c.3372G>C | 1.000 |
| rpoC | 766769 | c.3400C>T | 1.000 |
| rpoC | 766774 | c.3405T>C | 1.000 |
| rpoC | 766798 | c.3429C>G | 1.000 |
| rpoC | 766801 | c.3432C>T | 1.000 |
| rpoC | 766804 | c.3435A>G | 1.000 |
| rpoC | 766843 | c.3474T>G | 1.000 |
| rpoC | 766861 | c.3492G>C | 1.000 |
| rpoC | 766864 | c.3495G>C | 1.000 |
| rpoC | 766882 | c.3513C>T | 1.000 |
| rpoC | 766996 | c.3627C>T | 1.000 |
| rpoC | 767002 | c.3633G>C | 1.000 |
| rpoC | 767098 | c.3729T>C | 1.000 |
| rpoC | 767119 | c.3750A>G | 1.000 |
| rpoC | 767167 | c.3798C>T | 1.000 |
| rpoC | 767180 | p.Ala1271Gln | 1.000 |
| rpoC | 767185 | c.3816G>T | 1.000 |
| rpoC | 767209 | c.3840T>C | 1.000 |
| rpoC | 767221 | c.3852C>G | 1.000 |
| rpoC | 767230 | c.3861G>C | 1.000 |
| rpoC | 767233 | c.3864T>C | 1.000 |
| rpsL | 781571 | c.12C>T | 1.000 |
| rpsL | 781608 | p.Ser17Gly | 1.000 |
| rpsL | 781631 | c.72G>T | 1.000 |
| rpsL | 781649 | c.90T>C | 1.000 |
| rpsL | 781655 | c.96T>C | 1.000 |
| rpsL | 781682 | c.123T>C | 1.000 |
| rpsL | 781694 | c.135G>C | 1.000 |
| rpsL | 781715 | c.156T>C | 1.000 |
| rpsL | 781718 | c.159C>T | 1.000 |
| rpsL | 781721 | c.162C>T | 1.000 |
| rpsL | 781728 | c.169T>C | 1.000 |
| rpsL | 781742 | c.183C>T | 1.000 |
| rpsL | 781751 | c.192G>C | 1.000 |
| rpsL | 781754 | c.195G>C | 1.000 |
| rpsL | 781760 | c.201T>C | 1.000 |
| rpsL | 781763 | c.204C>G | 1.000 |
| rpsL | 781766 | c.207C>T | 1.000 |
| rpsL | 781787 | c.228G>A | 1.000 |
| rpsL | 781808 | c.249C>T | 1.000 |
| rpsL | 781811 | c.252C>T | 1.000 |
| rpsL | 781827 | c.268C>T | 1.000 |
| rpsL | 781832 | c.273T>C | 1.000 |
| rpsL | 781865 | c.306G>C | 1.000 |
| rpsL | 781868 | c.309T>C | 1.000 |
| rpsL | 781871 | c.312G>C | 1.000 |
| rpsL | 781880 | c.321C>G | 1.000 |
| rplC | 801222 | c.414T>C | 1.000 |
| rplC | 801255 | c.447C>T | 1.000 |
| rplC | 801258 | c.450C>G | 1.000 |
| rplC | 801267 | c.459A>C | 1.000 |
| rplC | 801270 | c.462T>C | 1.000 |
| rplC | 801276 | c.468G>T | 1.000 |
| rplC | 801282 | c.474G>C | 1.000 |
| rplC | 801307 | p.Ala167Ser | 1.000 |
| rplC | 801312 | c.504G>C | 1.000 |
| rplC | 801324 | c.516T>C | 1.000 |
| rrs | 1471923 | r.78t>c | 1.000 |
| rrs | 1471925 | r.80t>c | 1.000 |
| rrs | 1471932 | r.87a>g | 1.000 |
| rrs | 1471934 | r.89a>g | 1.000 |
| rrs | 1471970 | r.125g>a | 1.000 |
| rrs | 1472028 | r.183a>c | 1.000 |
| rrs | 1472031 | r.186g>a | 1.000 |
| rrs | 1472033 | r.188a>g | 1.000 |
| rrs | 1472034 | r.189t>c | 1.000 |
| rrs | 1472040 | r.195t>c | 1.000 |
| rrs | 1472045 | r.200t>g | 1.000 |
| rrs | 1472053 | r.208agc>a | 1.000 |
| rrs | 1472061 | r.216a>t | 1.000 |
| rrs | 1472075 | r.230a>g | 1.000 |
| rrs | 1472489 | r.644a>g | 1.000 |
| rrs | 1472969 | r.1124a>g | 1.000 |
| rrs | 1472970 | r.1125c>g | 1.000 |
| rrs | 1472977 | r.1132g>c | 1.000 |
| rrs | 1472978 | r.1133t>c | 1.000 |
| rrs | 1473120 | r.1275c>ct | 0.923 |
| rrs | 1473123 | r.1278a>t | 1.000 |
| rrs | 1473290 | r.1445c>t | 1.000 |
| rrl | 1473571 | c.-87C>T | 1.000 |
| rrl | 1473594 | c.-64A>AT | 0.800 |
| rrl | 1473600 | c.-58A>G | 1.000 |
| rrl | 1473612 | c.-46A>C | 1.000 |
| rrl | 1473614 | c.-44C>T | 1.000 |
| rrl | 1473797 | r.140g>c | 1.000 |
| rrl | 1473806 | r.149c>t | 1.000 |
| rrl | 1473813 | r.156c>t | 1.000 |
| rrl | 1473876 | r.219g>a | 1.000 |
| rrl | 1473877 | r.220g>a | 1.000 |
| rrl | 1473887 | r.230t>a | 1.000 |
| rrl | 1473888 | r.231t>a | 1.000 |
| rrl | 1473899 | r.242a>t | 1.000 |
| rrl | 1473923 | r.266c>t | 1.000 |
| rrl | 1473924 | r.267a>at | 1.000 |
| rrl | 1473938 | r.281g>a | 1.000 |
| rrl | 1473943 | r.286g>t | 1.000 |
| rrl | 1473974 | r.317t>c | 1.000 |
| rrl | 1473986 | r.329t>c | 1.000 |
| rrl | 1473987 | r.330g>a | 1.000 |
| rrl | 1473995 | r.338g>t | 1.000 |
| rrl | 1474001 | r.344c>t | 1.000 |
| rrl | 1474009 | r.352a>g | 1.000 |
| rrl | 1474018 | r.361g>a | 1.000 |
| rrl | 1474056 | r.399t>c | 1.000 |
| rrl | 1474083 | r.426c>t | 1.000 |
| rrl | 1474084 | r.427g>t | 1.000 |
| rrl | 1474093 | r.436g>t | 1.000 |
| rrl | 1474103 | r.446a>t | 1.000 |
| rrl | 1474127 | r.470g>a | 1.000 |
| rrl | 1474139 | r.482c>t | 1.000 |
| rrl | 1474140 | r.483c>t | 1.000 |
| rrl | 1474151 | r.494c>t | 1.000 |
| rrl | 1474181 | r.524c>t | 1.000 |
| rrl | 1474289 | r.632cttttcctctccggag>c | 0.810 |
| rrl | 1474291 | r.634tttcctctccggagga>t | 1.000 |
| rrl | 1474308 | r.651g>t | 1.000 |
| rrl | 1474310 | r.653t>g | 1.000 |
| rrl | 1474447 | r.790g>a | 1.000 |
| rrl | 1474627 | r.970g>a | 1.000 |
| rrl | 1474632 | r.975g>t | 1.000 |
| rrl | 1474639 | r.982g>a | 1.000 |
| rrl | 1474717 | r.1060a>t | 1.000 |
| rrl | 1474794 | r.1137c>a | 1.000 |
| rrl | 1474831 | r.1174a>g | 1.000 |
| rrl | 1474950 | r.1293g>a | 1.000 |
| rrl | 1474961 | r.1304t>g | 1.000 |
| rrl | 1474962 | r.1305t>c | 1.000 |
| rrl | 1474963 | r.1306g>a | 1.000 |
| rrl | 1474964 | r.1307t>a | 1.000 |
| rrl | 1475007 | r.1350c>t | 1.000 |
| rrl | 1475013 | r.1356g>a | 1.000 |
| rrl | 1475061 | r.1404c>t | 1.000 |
| rrl | 1475315 | r.1658a>t | 1.000 |
| rrl | 1475333 | r.1676t>c | 1.000 |
| rrl | 1475355 | r.1698c>t | 1.000 |
| rrl | 1475369 | r.1712g>c | 1.000 |
| rrl | 1475402 | r.1745c>t | 1.000 |
| rrl | 1475429 | r.1772g>a | 1.000 |
| rrl | 1475479 | r.1822c>t | 1.000 |
| rrl | 1475480 | r.1823a>t | 1.000 |
| rrl | 1475505 | r.1848g>a | 1.000 |
| rrl | 1475526 | r.1869c>a | 1.000 |
| rrl | 1475604 | r.1947a>c | 1.000 |
| rrl | 1475607 | r.1950a>g | 1.000 |
| rrl | 1475608 | r.1951t>c | 1.000 |
| rrl | 1475619 | r.1962c>t | 1.000 |
| rrl | 1475622 | r.1965g>t | 1.000 |
| rrl | 1475635 | r.1978g>a | 1.000 |
| rrl | 1475637 | r.1980t>a | 1.000 |
| rrl | 1475659 | r.2002g>a | 1.000 |
| rrl | 1475760 | r.2103c>t | 1.000 |
| rrl | 1475763 | r.2106c>t | 1.000 |
| rrl | 1475975 | r.2318c>t | 1.000 |
| rrl | 1475977 | r.2320a>g | 1.000 |
| rrl | 1475988 | r.2331a>t | 1.000 |
| rrl | 1476032 | r.2375c>t | 1.000 |
| rrl | 1476033 | r.2376t>c | 1.000 |
| rrl | 1476035 | r.2378g>a | 1.000 |
| rrl | 1476040 | r.2383c>t | 1.000 |
| rrl | 1476086 | r.2429g>a | 1.000 |
| rrl | 1476089 | r.2432t>c | 1.000 |
| rrl | 1476095 | r.2438c>g | 1.000 |
| rrl | 1476131 | r.2474c>t | 1.000 |
| rrl | 1476214 | r.2557g>t | 1.000 |
| rrl | 1476215 | r.2558c>t | 1.000 |
| rrl | 1476529 | r.2872a>g | 1.000 |
| rrl | 1476580 | r.2923g>a | 1.000 |
| rrl | 1476594 | r.2937c>t | 1.000 |
| rrl | 1476597 | r.2940g>a | 1.000 |
| rrl | 1476603 | r.2946g>a | 1.000 |
| rrl | 1476608 | r.2951c>t | 1.000 |
| rrl | 1476619 | r.2962c>t | 1.000 |
| rrl | 1476628 | r.2971t>a | 1.000 |
| fabG1 | 1673916 | c.477A>T | 1.000 |
| fabG1 | 1673922 | c.483T>C | 1.000 |
| inhA | 1674703 | c.502T>C | 1.000 |
| rpsA | 1833568 | c.27G>C | 1.000 |
| rpsA | 1833595 | c.54T>C | 1.000 |
| rpsA | 1833709 | c.168C>T | 1.000 |
| rpsA | 1833724 | c.183C>G | 1.000 |
| rpsA | 1833727 | c.186G>C | 1.000 |
| rpsA | 1833742 | c.201A>G | 1.000 |
| rpsA | 1833745 | c.204G>C | 1.000 |
| rpsA | 1833748 | c.207C>G | 1.000 |
| rpsA | 1833754 | c.213G>A | 1.000 |
| rpsA | 1833772 | c.231C>T | 1.000 |
| rpsA | 1833790 | c.249T>C | 1.000 |
| rpsA | 1833802 | c.261A>G | 1.000 |
| rpsA | 1833808 | c.267G>C | 1.000 |
| rpsA | 1833811 | c.270G>C | 1.000 |
| rpsA | 1833856 | c.315A>G | 1.000 |
| rpsA | 1833874 | c.333T>C | 1.000 |
| rpsA | 1833877 | c.336C>G | 1.000 |
| rpsA | 1833916 | c.375C>A | 1.000 |
| rpsA | 1833940 | c.399C>G | 1.000 |
| rpsA | 1833970 | c.429G>C | 1.000 |
| rpsA | 1833979 | c.438T>C | 1.000 |
| rpsA | 1834000 | c.459G>C | 1.000 |
| rpsA | 1834021 | c.480C>T | 1.000 |
| rpsA | 1834030 | c.489C>G | 1.000 |
| rpsA | 1834099 | c.558C>G | 1.000 |
| rpsA | 1834102 | c.561T>G | 1.000 |
| rpsA | 1834144 | c.603G>A | 1.000 |
| rpsA | 1834177 | c.636A>C | 1.000 |
| rpsA | 1834186 | c.645C>G | 1.000 |
| rpsA | 1834189 | c.648G>C | 1.000 |
| rpsA | 1834213 | c.672G>A | 1.000 |
| rpsA | 1834231 | c.690T>G | 1.000 |
| rpsA | 1834249 | c.708T>C | 1.000 |
| rpsA | 1834252 | c.711C>G | 1.000 |
| rpsA | 1834261 | c.720A>G | 1.000 |
| rpsA | 1834264 | c.723G>C | 1.000 |
| rpsA | 1834297 | c.756C>T | 1.000 |
| rpsA | 1834303 | c.762T>G | 1.000 |
| rpsA | 1834306 | c.765T>C | 1.000 |
| rpsA | 1834330 | c.789C>T | 1.000 |
| rpsA | 1834348 | c.807T>C | 1.000 |
| rpsA | 1834366 | c.825A>G | 1.000 |
| rpsA | 1834369 | c.828C>G | 1.000 |
| rpsA | 1834396 | c.855G>T | 1.000 |
| rpsA | 1834411 | c.870T>C | 1.000 |
| rpsA | 1834417 | c.876G>C | 1.000 |
| rpsA | 1834423 | c.882G>C | 1.000 |
| rpsA | 1834435 | c.894G>C | 1.000 |
| rpsA | 1834438 | c.897C>A | 1.000 |
| rpsA | 1834451 | c.910T>C | 1.000 |
| rpsA | 1834546 | c.1005T>C | 1.000 |
| rpsA | 1834609 | c.1068T>C | 1.000 |
| rpsA | 1834612 | c.1071G>A | 1.000 |
| rpsA | 1834624 | c.1083G>A | 1.000 |
| rpsA | 1834633 | c.1092A>G | 1.000 |
| rpsA | 1834639 | c.1098T>C | 1.000 |
| rpsA | 1834657 | c.1116G>A | 1.000 |
| rpsA | 1834690 | c.1149T>C | 1.000 |
| folC | 2747065 | c.534G>A | 1.000 |
| thyX | 3067718 | c.228G>T | 1.000 |
| thyX | 3067721 | c.225A>G | 1.000 |
| thyX | 3067727 | c.219T>C | 1.000 |
| fbiA | 3640260 | c.-283TC>T | 1.000 |
| fbiA | 3640262 | c.-281G>T | 1.000 |
| fbiA | 3640268 | c.-275T>G | 1.000 |
| fbiA | 3640303 | c.-240TA>T | 1.000 |
| fbiA | 3640308 | c.-235C>A | 1.000 |
| fbiA | 3640347 | c.-196A>G | 1.000 |
| fbiA | 3640365 | c.-178C>G | 1.000 |
| fbiA | 3640377 | c.-166G>C | 1.000 |
| embC | 4241050 | c.1188T>G | 1.000 |
| embC | 4241053 | c.1191G>C | 1.000 |
| embC | 4241059 | c.1197G>A | 1.000 |
| embC | 4241077 | c.1215C>A | 1.000 |
| embC | 4242877 | c.3015G>A | 1.000 |
| embC | 4242880 | c.3018A>C | 1.000 |
| embC | 4242883 | c.3021C>G | 1.000 |
| embC | 4242892 | c.3030G>C | 1.000 |
| embC | 4242901 | c.3039G>A | 1.000 |
| embC | 4242919 | c.3057A>G | 1.000 |
| embA | 4245077 | c.1845G>C | 1.000 |
| embA | 4245083 | c.1851A>C | 1.000 |
| embA | 4245092 | c.1860C>G | 1.000 |
| embA | 4245125 | c.1893G>C | 1.000 |
| embA | 4245149 | c.1917C>G | 1.000 |
| embA | 4245173 | c.1941G>C | 1.000 |
| embA | 4245182 | c.1950T>C | 1.000 |
| embA | 4245187 | p.Thr652Met | 1.000 |
| embA | 4245198 | p.Leu656Val | 1.000 |
| embA | 4245224 | c.1992T>C | 1.000 |
| embB | 4247434 | c.921C>G | 1.000 |
| embB | 4247437 | c.924A>C | 1.000 |
| embB | 4247440 | c.927C>A | 1.000 |
| embB | 4247452 | c.939C>G | 1.000 |
| embB | 4247491 | c.978G>C | 1.000 |
| embB | 4247494 | c.981G>A | 1.000 |
| embB | 4247497 | c.984T>C | 1.000 |
| embB | 4247500 | c.987C>G | 1.000 |
| embB | 4247512 | c.999T>C | 1.000 |
| embB | 4247683 | c.1170C>G | 1.000 |
| embB | 4247684 | c.1171T>C | 1.000 |
| embB | 4247716 | c.1203C>G | 1.000 |
| embB | 4247722 | c.1209G>C | 1.000 |
| embB | 4247755 | c.1242C>G | 1.000 |
| embB | 4247761 | c.1248T>C | 1.000 |
| embB | 4248025 | c.1512A>G | 1.000 |
| embB | 4248041 | p.Ala510Ser | 1.000 |
| embB | 4248046 | c.1533A>G | 1.000 |
| embB | 4248055 | c.1542G>C | 1.000 |
| embB | 4248064 | c.1551G>C | 1.000 |
| embB | 4248070 | c.1557T>C | 1.000 |
| embB | 4248085 | c.1572T>C | 1.000 |
| embB | 4248106 | c.1593C>G | 1.000 |
| embB | 4248118 | c.1605T>C | 1.000 |
| embB | 4248124 | c.1611G>C | 1.000 |
| embB | 4248130 | c.1617G>C | 1.000 |
| embB | 4248133 | c.1620C>G | 1.000 |
| embB | 4248142 | c.1629T>C | 1.000 |
| embB | 4248143 | c.1630T>C | 1.000 |
| embB | 4248157 | c.1644A>G | 1.000 |
| embB | 4248172 | c.1659G>C | 1.000 |
| embB | 4248175 | c.1662G>C | 1.000 |
| embB | 4248266 | c.1753C>T | 1.000 |
| embB | 4248277 | c.1764G>C | 1.000 |
| embB | 4248316 | c.1803C>A | 1.000 |
| embB | 4248319 | c.1806A>G | 1.000 |
| embB | 4248325 | c.1812G>C | 1.000 |
| embB | 4248349 | c.1836G>A | 1.000 |
| embB | 4248358 | c.1845C>G | 1.000 |
| embB | 4248397 | c.1884C>T | 1.000 |
| embB | 4248398 | c.1885C>T | 1.000 |
| embB | 4248407 | p.Leu632Val | 1.000 |
| embB | 4248416 | p.Leu635Met | 1.000 |
| embB | 4248432 | p.Trp640Phe | 1.000 |
| embB | 4248472 | c.1959T>C | 1.000 |
| embB | 4248478 | c.1965G>C | 1.000 |
| embB | 4249381 | c.2868A>G | 1.000 |
| ethA | 4326469 | c.1005A>G | 1.000 |
| ethA | 4326481 | c.993G>C | 1.000 |
| ethA | 4326484 | c.990A>C | 1.000 |
| ethA | 4326487 | c.987T>C | 1.000 |
| ethA | 4326511 | c.963G>C | 1.000 |
| ethA | 4326520 | p.Glu318Asp | 1.000 |
| ethA | 4326523 | c.951A>G | 1.000 |
| ethA | 4326532 | c.942G>A | 1.000 |
| ethA | 4326535 | c.939C>G | 1.000 |
TBProfiler Version: 2.1.1
| Analysis | Program |
| Mapping | bwa |
| Variant Calling | BCFtools |
| Drug1 | Sensitivity (%) | Specificity (%) |
| Isoniazid | 92.8 (89.9-95.7) | 100 (100-100) |
| Rifampicin | 96.2 (93.9-98.5) | 98.1 (96.8-99.4) |
| Ethambutal | 88.7 (83.6-93.8) | 81.7 (77.6-85.8) |
| Pyrazinamide | 70.9 (62.4-79.4) | 93.9 (90.6-97.2) |
| Streptomycin | 87.1 (82.7-91.5) | 89.7 (86.0-93.4) |
| Ethionamide | 73.6 (66.7-80.5) | 93.3 (89.6-97.0) |
| Moxifloxacin | 60.0 (29.6-90.4) | 68.7 (52.6-84.8) |
| Ofloxacin | 85.5 (79.1-91.9) | 94.9 (91.8-98.0) |
| Amikacin | 82.9 (74.4-91.4) | 98.3 (96.0-100) |
| Capreomycin | 60.7 (50.6-70.8) | 90.7 (87.2-94.2) |
| Kanamycin | 87.3 (81.3-93.3) | 93.4 (89.9-96.9) |
| Para-aminosalisylic acid | Not determined | Not determined |
| Linezolid | Not determined | Not determined |
| Clofazimine | Not determined | Not determined |
| Bedaquiline | Not determined | Not determined |
| Multi drug resistance | 91.2 (87.8-94.6) | 98.4 (97.2-99.6) |
| Extremely drug resistance | 75.9 (64.5-87.3) | 98.4 (97.3-99.5) |
| Lineage2 | Location | Strain | RD type |
| lineage1 | Indo-Oceanic | EAI | RD239 |
| lineage1.1 | Indo-Oceanic | EAI3;EAI4;EAI5;EAI6 | RD239 |
| lineage1.1.1 | Indo-Oceanic | EAI4;EAI5 | RD239 |
| lineage1.1.1.1 | Indo-Oceanic | EAI4;ZERO | RD239 |
| lineage1.1.2 | Indo-Oceanic | EAI3;EAI5 | RD239 |
| lineage1.1.3 | Indo-Oceanic | EAI6 | RD239 |
| lineage1.2 | Indo-Oceanic | EAI1;EAI2 | RD239 |
| lineage1.2.1 | Indo-Oceanic | EAI2 | RD239 |
| lineage1.2.2 | Indo-Oceanic | EAI1 | RD239 |
| lineage2 | East-Asian | Beijing | RD105 |
| lineage2.1 | East-Asian (non-Beijing) | None | None |
| lineage2.2 | East-Asian (Beijing) | Beijing-RD207 | RD105;RD207 |
| lineage2.2.2 | East-Asian (Beijing) | Beijing-RD105/RD207 | RD105;RD207 |
| lineage2.2.1 | East-Asian (Beijing) | Beijing-RD181 | RD105;RD207;RD181 |
| lineage2.2.1.2 | East-Asian (Beijing) | Beijing-RD142 | RD105;RD207;RD181;RD142 |
| lineage2.2.1.1 | East-Asian (Beijing) | Beijing-RD150 | RD105;RD207;RD181;RD150 |
| lineage3 | East-African-Indian | CAS | RD750 |
| lineage3.1 | East-African-Indian | Non-CAS1-Delhi | RD750 |
| lineage3.1.1 | East-African-Indian | CAS1-Kili | RD750 |
| lineage3.1.2 | East-African-Indian | CAS;CAS2 | RD750 |
| lineage3.1.2.1 | East-African-Indian | CAS2 | RD750 |
| lineage3.1.2.2 | East-African-Indian | CAS | RD750 |
| lineage4 | Euro-American | LAM;T;S;X;H | None |
| lineage4.1 | Euro-American | T;X;H | None |
| lineage4.1.2 | Euro-American (X-type) | T;H | None |
| lineage4.1.2.1 | Euro-American (X-type) | T1;H1 | RD182 |
| lineage4.1.1 | Euro-American (X-type) | X1;X2;X3 | None |
| lineage4.1.1.2 | Euro-American (X-type) | X1 | None |
| lineage4.1.1.1 | Euro-American (X-type) | X2 | RD183 |
| lineage4.1.1.3 | Euro-American (Haarlem) | X1;X3 | RD193 |
| lineage4.2 | Euro-American | H;T;LAM | None |
| lineage4.2.2 | Euro-American (Ural) | T;LAM7-TUR | None |
| lineage4.2.2.1 | Euro-American | LAM7-TUR | None |
| lineage4.2.1 | Euro-American (TUR) | H3;H4 | None |
| lineage4.3 | Euro-American (LAM) | mainly-LAM | None |
| lineage4.3.1 | Euro-American (LAM) | LAM9 | None |
| lineage4.3.3 | Euro-American (LAM) | LAM;T | RD115 |
| lineage4.3.4 | Euro-American (LAM) | LAM | RD174 |
| lineage4.3.4.1 | Euro-American (LAM) | LAM1;LAM2 | RD174 |
| lineage4.3.4.2 | Euro-American (LAM) | LAM1;LAM4;LAM11 | RD174 |
| lineage4.3.4.2.1 | Euro-American (LAM) | LAM11 | RD174 |
| lineage4.3.2 | Euro-American (LAM) | LAM3 | None |
| lineage4.3.2.1 | Euro-American (LAM) | LAM3 | RD761 |
| lineage4.4 | Euro-American | S;T | None |
| lineage4.4.2 | Euro-American | T1;T2 | None |
| lineage4.4.1 | Euro-American (S-type) | S;T | None |
| lineage4.4.1.2 | Euro-American | T1 | None |
| lineage4.4.1.1 | Euro-American | S;Orphans | None |
| lineage4.5 | Euro-American | H;T | RD122 |
| lineage4.6 | Euro-American | T;LAM | None |
| lineage4.6.1 | Euro-American (Uganda) | T2 | RD724 |
| lineage4.6.1.1 | Euro-American | T2-Uganda | RD724 |
| lineage4.6.1.2 | Euro-American | T2 | RD724 |
| lineage4.6.2 | Euro-American | T;LAM | RD726 |
| lineage4.6.2.1 | Euro-American | T3 | RD726 |
| lineage4.6.2.2 | Euro-American (Cameroon) | LAM10-CAM | RD726 |
| lineage4.7 | Euro-American (mainly T) | T1;T5 | None |
| lineage4.8 | Euro-American (mainly T) | T1;T2;T3;T5 | RD219 |
| lineage4.9 | Euro-American (H37Rv-like) | T1 | None |
| lineage5 | West-Africa 1 | AFRI_2;AFRI_3 | RD711 |
| lineage6 | West-Africa 2 | AFRI_1 | RD702 |
| lineage7 | Lineage 7 | None | None |
| lineageBOV | M. bovis | BOV_1;BOV_2 | None |
