Drug1 | Resistance | Supporting Mutations (frequency) |
Isoniazid | R | katG p.Ile317Val (0.36), katG p.Ser315Thr (1.00) |
Rifampicin | R | rpoB p.Asp435Val (0.80), rpoB p.Ser450Leu (0.29) |
Ethambutol | R | embB p.Met306Val (0.18), embB p.Gln497Arg (0.75) |
Pyrazinamide | R | pncA c.194 195insA (0.33) |
Streptomycin | ||
Ethionamide | ||
Fluoroquinolones | ||
Amikacin | ||
Capreomycin | ||
Kanamycin |
Lineage2 | Family | Main Spoligotype | RDS |
lineage4 | Euro-American | LAM;T;S;X;H | None |
lineage3.1 | East-African-Indian | Non-CAS1-Delhi | RD750 |
lineage4.2 | Euro-American | H;T;LAM | None |
lineage4.2.2 | Euro-American (Ural) | T;LAM7-TUR | None |
Gene | Chromosome Position | Mutation | Estimated fraction |
gyrB | 7033 | c.1794G>A | 0.182 |
gyrA | 7362 | p.Glu21Gln | 1.000 |
gyrA | 7585 | p.Ser95Thr | 1.000 |
gyrA | 8414 | c.1113C>T | 0.143 |
gyrA | 8688 | p.Ala463Ser | 0.706 |
gyrA | 8869 | p.Thr523Met | 0.400 |
gyrA | 9304 | p.Gly668Asp | 1.000 |
rpoB | 761489 | c.1683G>A | 0.625 |
rpoC | 763537 | c.168C>G | 0.133 |
rpoC | 763546 | c.177A>G | 0.138 |
rpoC | 763570 | c.201G>C | 0.138 |
rpoC | 763573 | c.204G>C | 0.138 |
rpoC | 763594 | c.225C>T | 0.154 |
rpoC | 763622 | p.Ala85Ser | 0.148 |
rpoC | 764018 | p.Asp217His | 0.188 |
rpoC | 765588 | p.Pro740Gln | 0.200 |
rpoC | 766490 | p.Arg1041Cys | 0.160 |
rpoC | 766957 | p.Glu1196Asp | 0.200 |
rpsL | 781395 | c.-165T>C | 1.000 |
rpsL | 781436 | c.-124C>G | 0.222 |
embR | 1416222 | p.Phe376Leu | 0.185 |
embR | 1416234 | p.Cys372Gly | 0.207 |
rrs | 1472085 | r.240c>t | 0.364 |
rrs | 1473053 | r.1208t>a | 0.200 |
rrl | 1474156 | r.499g>t | 0.400 |
rrl | 1474823 | r.1166c>g | 0.308 |
rrl | 1474827 | r.1170c>t | 0.308 |
rrl | 1474830 | r.1173a>g | 0.308 |
rrl | 1474831 | r.1174a>t | 0.308 |
rrl | 1474853 | r.1196a>g | 0.286 |
rrl | 1474864 | r.1207c>t | 0.286 |
rrl | 1475704 | r.2047c>t | 0.200 |
rrl | 1475803 | r.2146t>c | 0.231 |
rrl | 1475804 | r.2147g>c | 0.231 |
rrl | 1475816 | r.2159c>g | 0.143 |
rrl | 1475817 | r.2160a>g | 0.143 |
rrl | 1476356 | r.2699c>a | 0.200 |
rrl | 1476357 | r.2700t>c | 0.200 |
rrl | 1476425 | r.2768g>a | 0.250 |
rrl | 1476463 | r.2806c>t | 0.214 |
rrl | 1476466 | r.2809c>t | 0.214 |
rrl | 1476481 | r.2824t>c | 0.167 |
rrl | 1476506 | r.2849t>c | 0.158 |
tlyA | 1917972 | c.33A>G | 1.000 |
katG | 2154724 | p.Arg463Leu | 0.174 |
katG | 2155166 | p.Gly316Cys | 0.250 |
katG | 2155182 | p.Lys310Asn | 0.182 |
katG | 2155488 | p.Glu208Asp | 0.160 |
katG | 2155742 | p.Gly124Cys | 0.200 |
ahpC | 2726105 | c.-88G>A | 0.200 |
ahpC | 2726251 | p.Gly20Val | 0.133 |
ald | 3086788 | c.-32T>C | 1.000 |
alr | 3840619 | p.Asp268Tyr | 0.211 |
embC | 4240172 | p.Val104Met | 0.250 |
embC | 4241077 | c.1215C>A | 0.200 |
embC | 4242075 | p.Arg738Gln | 0.407 |
embC | 4242643 | c.2781C>T | 1.000 |
embB | 4247610 | p.Ser366Leu | 0.138 |
ethA | 4327085 | p.Thr130Ile | 0.200 |
gid | 4408100 | c.102 102del | 0.882 |
TBProfiler Version: 2.1.1
Analysis | Program |
Mapping | bwa |
Variant Calling | BCFtools |
Drug1 | Sensitivity (%) | Specificity (%) |
Isoniazid | 92.8 (89.9-95.7) | 100 (100-100) |
Rifampicin | 96.2 (93.9-98.5) | 98.1 (96.8-99.4) |
Ethambutal | 88.7 (83.6-93.8) | 81.7 (77.6-85.8) |
Pyrazinamide | 70.9 (62.4-79.4) | 93.9 (90.6-97.2) |
Streptomycin | 87.1 (82.7-91.5) | 89.7 (86.0-93.4) |
Ethionamide | 73.6 (66.7-80.5) | 93.3 (89.6-97.0) |
Moxifloxacin | 60.0 (29.6-90.4) | 68.7 (52.6-84.8) |
Ofloxacin | 85.5 (79.1-91.9) | 94.9 (91.8-98.0) |
Amikacin | 82.9 (74.4-91.4) | 98.3 (96.0-100) |
Capreomycin | 60.7 (50.6-70.8) | 90.7 (87.2-94.2) |
Kanamycin | 87.3 (81.3-93.3) | 93.4 (89.9-96.9) |
Para-aminosalisylic acid | Not determined | Not determined |
Linezolid | Not determined | Not determined |
Clofazimine | Not determined | Not determined |
Bedaquiline | Not determined | Not determined |
Multi drug resistance | 91.2 (87.8-94.6) | 98.4 (97.2-99.6) |
Extremely drug resistance | 75.9 (64.5-87.3) | 98.4 (97.3-99.5) |
Lineage2 | Location | Strain | RD type |
lineage1 | Indo-Oceanic | EAI | RD239 |
lineage1.1 | Indo-Oceanic | EAI3;EAI4;EAI5;EAI6 | RD239 |
lineage1.1.1 | Indo-Oceanic | EAI4;EAI5 | RD239 |
lineage1.1.1.1 | Indo-Oceanic | EAI4;ZERO | RD239 |
lineage1.1.2 | Indo-Oceanic | EAI3;EAI5 | RD239 |
lineage1.1.3 | Indo-Oceanic | EAI6 | RD239 |
lineage1.2 | Indo-Oceanic | EAI1;EAI2 | RD239 |
lineage1.2.1 | Indo-Oceanic | EAI2 | RD239 |
lineage1.2.2 | Indo-Oceanic | EAI1 | RD239 |
lineage2 | East-Asian | Beijing | RD105 |
lineage2.1 | East-Asian (non-Beijing) | None | None |
lineage2.2 | East-Asian (Beijing) | Beijing-RD207 | RD105;RD207 |
lineage2.2.2 | East-Asian (Beijing) | Beijing-RD105/RD207 | RD105;RD207 |
lineage2.2.1 | East-Asian (Beijing) | Beijing-RD181 | RD105;RD207;RD181 |
lineage2.2.1.2 | East-Asian (Beijing) | Beijing-RD142 | RD105;RD207;RD181;RD142 |
lineage2.2.1.1 | East-Asian (Beijing) | Beijing-RD150 | RD105;RD207;RD181;RD150 |
lineage3 | East-African-Indian | CAS | RD750 |
lineage3.1 | East-African-Indian | Non-CAS1-Delhi | RD750 |
lineage3.1.1 | East-African-Indian | CAS1-Kili | RD750 |
lineage3.1.2 | East-African-Indian | CAS;CAS2 | RD750 |
lineage3.1.2.1 | East-African-Indian | CAS2 | RD750 |
lineage3.1.2.2 | East-African-Indian | CAS | RD750 |
lineage4 | Euro-American | LAM;T;S;X;H | None |
lineage4.1 | Euro-American | T;X;H | None |
lineage4.1.2 | Euro-American (X-type) | T;H | None |
lineage4.1.2.1 | Euro-American (X-type) | T1;H1 | RD182 |
lineage4.1.1 | Euro-American (X-type) | X1;X2;X3 | None |
lineage4.1.1.2 | Euro-American (X-type) | X1 | None |
lineage4.1.1.1 | Euro-American (X-type) | X2 | RD183 |
lineage4.1.1.3 | Euro-American (Haarlem) | X1;X3 | RD193 |
lineage4.2 | Euro-American | H;T;LAM | None |
lineage4.2.2 | Euro-American (Ural) | T;LAM7-TUR | None |
lineage4.2.2.1 | Euro-American | LAM7-TUR | None |
lineage4.2.1 | Euro-American (TUR) | H3;H4 | None |
lineage4.3 | Euro-American (LAM) | mainly-LAM | None |
lineage4.3.1 | Euro-American (LAM) | LAM9 | None |
lineage4.3.3 | Euro-American (LAM) | LAM;T | RD115 |
lineage4.3.4 | Euro-American (LAM) | LAM | RD174 |
lineage4.3.4.1 | Euro-American (LAM) | LAM1;LAM2 | RD174 |
lineage4.3.4.2 | Euro-American (LAM) | LAM1;LAM4;LAM11 | RD174 |
lineage4.3.4.2.1 | Euro-American (LAM) | LAM11 | RD174 |
lineage4.3.2 | Euro-American (LAM) | LAM3 | None |
lineage4.3.2.1 | Euro-American (LAM) | LAM3 | RD761 |
lineage4.4 | Euro-American | S;T | None |
lineage4.4.2 | Euro-American | T1;T2 | None |
lineage4.4.1 | Euro-American (S-type) | S;T | None |
lineage4.4.1.2 | Euro-American | T1 | None |
lineage4.4.1.1 | Euro-American | S;Orphans | None |
lineage4.5 | Euro-American | H;T | RD122 |
lineage4.6 | Euro-American | T;LAM | None |
lineage4.6.1 | Euro-American (Uganda) | T2 | RD724 |
lineage4.6.1.1 | Euro-American | T2-Uganda | RD724 |
lineage4.6.1.2 | Euro-American | T2 | RD724 |
lineage4.6.2 | Euro-American | T;LAM | RD726 |
lineage4.6.2.1 | Euro-American | T3 | RD726 |
lineage4.6.2.2 | Euro-American (Cameroon) | LAM10-CAM | RD726 |
lineage4.7 | Euro-American (mainly T) | T1;T5 | None |
lineage4.8 | Euro-American (mainly T) | T1;T2;T3;T5 | RD219 |
lineage4.9 | Euro-American (H37Rv-like) | T1 | None |
lineage5 | West-Africa 1 | AFRI_2;AFRI_3 | RD711 |
lineage6 | West-Africa 2 | AFRI_1 | RD702 |
lineage7 | Lineage 7 | None | None |
lineageBOV | M. bovis | BOV_1;BOV_2 | None |