TB Profiler
This tool processes raw sequence data to infer strain type and identify known drug resistance markers.
A stand alone version of this tool is now available and can now be run on linux or mac. Installation instructions can be found on GitHub and on the bioconda page.



This tool is for Research Use Only. Data and information provided through use of this tool are not intended for medical purpose or objective and should not be used for clinical diagnosis, patient management, or human clinical trials.
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Single nucleotide polymorphisms (SNPs) in coding regions are annotated using the reference amino acid, codon number and alternative amino acid (e.g. Ser315Thr in katG). SNPs in non-coding regions (i.e. RNA genes and intergenic regions) are annotated using the reference nucleotide, gene coordinate and alternative nucleotide (e.g. A1401G in rrs or C-37A in eis promoter). Indels are annotated using the reference VCF allele, gene coordinate and alternative VCF allele (e.g. T902TA insertion in katG).
Name: 5d739657527f5
Sample: 5d739657527f5

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Summary
ID: 5d739657527f5
Date: Sat Sep 7 12:40:15 2019
Strain: lineage4.3;lineage4.1.1;lineage4.1.2
Drug-resistance: Drug-resistant

Drug1ResistanceSupporting Mutations (frequency)
IsoniazidRkasA p.Met77Ile (1.00), kasA p.Arg121Lys (1.00)
Rifampicin
EthambutolRembB p.Asp311Gly (0.98)
Pyrazinamide
Streptomycin
Ethionamide
Fluoroquinolones
Amikacin
Capreomycin
Kanamycin

Lineage2FamilyMain SpoligotypeRDS
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.2Euro-American (X-type)T;HNone

Mutations in candidate genes:
GeneChromosome PositionMutationEstimated fraction
gyrB5296c.57T>C1.000
gyrB5299c.60C>G1.000
gyrB5305c.66G>C1.000
gyrB5323c.84A>G1.000
gyrB5326c.87T>C1.000
gyrB5341c.102T>C1.000
gyrB5347c.108G>C1.000
gyrB5353c.114T>C1.000
gyrB5362c.123T>G1.000
gyrB5363c.124T>C1.000
gyrB5371c.132T>C1.000
gyrB5374c.135C>G1.000
gyrB5375p.Ile46Val1.000
gyrB5386c.147G>C1.000
gyrB5398c.159G>C0.867
gyrB5605c.366C>G1.000
gyrB5611c.372C>G1.000
gyrB5623c.384T>C1.000
gyrB5632c.393A>G1.000
gyrB5641c.402G>C1.000
gyrB5644c.405C>G1.000
gyrB5647c.408A>G1.000
gyrB5770c.531C>G1.000
gyrB5772p.Ala178Asp1.000
gyrB5776c.537T>C1.000
gyrB5782c.543A>G1.000
gyrB5788c.549G>C1.000
gyrB5791c.552A>G1.000
gyrB5803c.564A>G1.000
gyrB5810p.Ala191Ser1.000
gyrB5824c.585A>G1.000
gyrB5848c.609G>C1.000
gyrB5853p.Thr205Ile1.000
gyrB5859p.Asn207Thr1.000
gyrB5863c.624G>C1.000
gyrB5902c.663A>G1.000
gyrB5905c.666G>C1.000
gyrB5914c.675C>T1.000
gyrB6109c.870G>C1.000
gyrB6115c.876A>G1.000
gyrB6123p.Ala295Asp1.000
gyrB6127c.888G>C1.000
gyrB6130c.891T>C1.000
gyrB6133c.894G>C1.000
gyrB6136c.897G>A1.000
gyrB6148c.909C>G1.000
gyrB6160c.921C>G1.000
gyrB6170p.His311Ala1.000
gyrB6175c.936G>A1.000
gyrB6196c.957C>A1.000
gyrB6203c.964A>T1.000
gyrB6280c.1041T>C1.000
gyrB6283c.1044C>T1.000
gyrB6286c.1047T>C1.000
gyrB6292c.1053G>T1.000
gyrB6295c.1056A>G1.000
gyrB6298c.1059C>G1.000
gyrB6301c.1062G>C1.000
gyrB6307c.1068T>G0.988
gyrB6319c.1080G>C1.000
gyrB6343c.1104G>A1.000
gyrB6361c.1122G>A1.000
gyrB6362c.1123T>C1.000
gyrB6379c.1140C>G1.000
gyrB6382c.1143A>G1.000
gyrB6388c.1149T>C1.000
gyrB6403c.1164T>C1.000
gyrB6415c.1176G>C1.000
gyrB6556c.1317C>G1.000
gyrB6571c.1332T>C1.000
gyrB6610c.1371C>G0.981
gyrB6613c.1374A>G0.981
gyrB6622c.1383C>T0.983
gyrB6634c.1395T>C0.982
gyrB6637c.1398T>C0.982
gyrB6640c.1401A>C0.982
gyrB6643c.1404A>G0.982
gyrB6649c.1410T>G0.983
gyrB6652c.1413C>T0.983
gyrB6655c.1416T>C0.984
gyrB6673c.1434A>C0.986
gyrB6676c.1437T>G0.987
gyrB6700c.1461T>C0.975
gyrB6703c.1464G>C0.988
gyrB6709c.1470A>G0.986
gyrB6712c.1473G>A0.987
gyrB6730c.1491A>G0.989
gyrB6742c.1503A>G0.988
gyrB6745c.1506T>C0.988
gyrB6751c.1512G>C0.989
gyrB6760c.1521G>C1.000
gyrB6775c.1536G>C1.000
gyrB6793c.1554T>C1.000
gyrB6798p.Gly520Ala1.000
gyrB6808c.1569C>G1.000
gyrB6841c.1602T>C1.000
gyrB6844c.1605T>C1.000
gyrB6853c.1614A>G1.000
gyrB6856c.1617T>C1.000
gyrB6859c.1620T>C1.000
gyrB6860p.Ser541Ala1.000
gyrB6865c.1626G>C1.000
gyrB6869c.1630T>C1.000
gyrB6878c.1639T>C1.000
gyrB6881c.1642T>C1.000
gyrB6898c.1659G>A1.000
gyrB6904c.1665C>G1.000
gyrB6916c.1677G>C1.000
gyrB6919c.1680T>C1.000
gyrB6922c.1683G>C1.000
gyrB6931c.1692A>C1.000
gyrB6934c.1695A>G1.000
gyrB6937c.1698G>C1.000
gyrB6949c.1710A>G0.957
gyrB6952c.1713C>G0.944
gyrB6955c.1716G>A0.944
gyrB6976c.1737A>G0.923
gyrB6982c.1743A>C0.926
gyrB6994c.1755C>G0.929
gyrB6997c.1758G>A0.929
gyrB7012c.1773G>C0.913
gyrB7014p.Glu592Ala0.913
gyrB7021c.1782G>C0.913
gyrB7024c.1785G>C0.913
gyrB7025p.Lys596Glu0.913
gyrB7033c.1794G>C0.950
gyrB7048c.1809G>A0.951
gyrB7051p.Glu604Asp0.951
gyrB7060c.1821T>C0.951
gyrB7078c.1839A>C0.923
gyrB7081c.1842T>G0.920
gyrB7084c.1845A>G0.923
gyrB7093c.1854T>C0.923
gyrB7099c.1860G>A0.941
gyrB7100c.1861T>C0.941
gyrB7168c.1929C>G1.000
gyrB7178c.1939T>C1.000
gyrB7186c.1947C>G1.000
gyrB7192c.1953G>C1.000
gyrB7210p.Asp657Glu1.000
gyrB7222c.1983C>T1.000
gyrB7225c.1986T>C1.000
gyrB7243c.2004G>A1.000
gyrB7246c.2007T>C1.000
gyrB7252c.2013G>C1.000
gyrA7343c.42G>C1.000
gyrA7355c.54T>C1.000
gyrA7362p.Glu21Gln1.000
gyrA7394c.93T>C1.000
gyrA7406c.105G>C1.000
gyrA7415c.114C>A1.000
gyrA7418c.117C>T1.000
gyrA7421c.120G>C1.000
gyrA7427c.126G>C1.000
gyrA7442c.141G>C1.000
gyrA7448c.147G>A1.000
gyrA7451c.150C>G1.000
gyrA7457c.156T>C1.000
gyrA7463c.162G>C1.000
gyrA7472c.171T>C1.000
gyrA7475c.174A>C1.000
gyrA7480p.Phe60Tyr1.000
gyrA7484c.183T>C1.000
gyrA7487c.186C>G1.000
gyrA7490c.189C>G1.000
gyrA7496c.195C>T1.000
gyrA7499c.198G>C1.000
gyrA7506p.Ser69Gly1.000
gyrA7517c.216G>A1.000
gyrA7523c.222C>G1.000
gyrA7532c.231T>C1.000
gyrA7569p.Ala90Ser1.000
gyrA7585p.Ser95Thr1.000
gyrA7587c.286C>T1.000
gyrA7601c.300C>G1.000
gyrA7605p.Pro102Ser1.000
gyrA7614p.Leu105Met1.000
gyrA7631c.330G>C1.000
gyrA7637c.336C>T1.000
gyrA7652c.351C>G1.000
gyrA7658c.357A>G1.000
gyrA7661c.360C>T1.000
gyrA7664c.363T>C1.000
gyrA7670c.369A>G1.000
gyrA7671p.Pro124Ala1.000
gyrA7679c.378G>C1.000
gyrA7683c.382A>C0.960
gyrA7694c.393A>G1.000
gyrA7697c.396C>A1.000
gyrA7700c.399G>C0.972
gyrA7706c.405C>G1.000
gyrA7710c.409T>C1.000
gyrA7728c.427A>C1.000
gyrA7748c.447A>C1.000
gyrA7763c.462T>C1.000
gyrA7781c.480G>C1.000
gyrA7790c.489G>C1.000
gyrA7797c.496C>T1.000
gyrA7821c.520C>T1.000
gyrA7832c.531G>C1.000
gyrA7835c.534A>C1.000
gyrA7847c.546G>C1.000
gyrA7853c.552C>T1.000
gyrA7859c.558A>C1.000
gyrA7865c.564T>C1.000
gyrA7871c.570G>C1.000
gyrA7883c.582G>C0.933
gyrA7884p.Arg195Asn0.933
gyrA7889c.588G>A0.935
gyrA7892c.591G>C0.946
gyrA7898p.Asp199Glu0.963
gyrA7906p.Phe202Tyr1.000
gyrA7919p.Glu206Asp1.000
gyrA7922c.621T>C1.000
gyrA7937c.636A>G1.000
gyrA7941p.Glu214Thr0.965
gyrA7958c.657C>G0.986
gyrA7963p.Gly221Glu0.986
gyrA7970c.669T>C0.986
gyrA7979c.678G>C0.986
gyrA7988c.687G>C0.988
gyrA7997c.696A>G0.976
gyrA8121c.820T>C0.968
gyrA8126c.825G>C0.980
gyrA8156c.855T>C0.955
gyrA8168c.867A>G0.972
gyrA8177c.876A>C0.968
gyrA8186c.885G>A0.960
gyrA8189c.888G>C0.960
gyrA8190p.Ala297Ser0.960
gyrA8198c.897T>C0.947
gyrA8202p.Asn301His0.947
gyrA8207c.906T>C0.944
gyrA8217c.916T>A0.900
gyrA8225p.Asp308Glu0.900
gyrA8234c.933T>C0.900
gyrA8235c.934T>C0.900
gyrA8252p.Glu317Asp0.934
gyrA8258c.957G>A0.931
gyrA8261c.960C>T0.925
gyrA8264c.963T>C0.924
gyrA8270c.969G>C0.899
gyrA8283p.Ile328Leu0.879
gyrA8288c.987T>C0.932
gyrA8294c.993T>C0.934
gyrA8309c.1008G>A0.964
gyrA8321c.1020C>T0.964
gyrA8324c.1023T>C0.964
gyrA8327c.1026C>G0.964
gyrA8339c.1038A>G0.962
gyrA8340p.Ala347Ser0.962
gyrA8354c.1053G>C0.771
gyrA8366c.1065G>C0.765
gyrA8372c.1071G>C0.769
gyrA8382p.Leu361Met0.978
gyrA8390c.1089C>G0.947
gyrA8391p.Tyr364Leu0.947
gyrA8399c.1098T>C0.947
gyrA8402p.Asp367Glu0.947
gyrA8417c.1116C>G1.000
gyrA8420c.1119T>C1.000
gyrA8426c.1125G>C1.000
gyrA8433p.Thr378Arg0.971
gyrA8450c.1149G>A1.000
gyrA8453c.1152A>C1.000
gyrA8462c.1161A>G1.000
gyrA8471c.1170T>C1.000
gyrA8480c.1179C>G1.000
gyrA8486c.1185T>C1.000
gyrA8489c.1188A>G1.000
gyrA8492c.1191G>C1.000
gyrA8501c.1200G>C1.000
gyrA8504c.1203G>C1.000
gyrA8513c.1212C>G1.000
gyrA8516c.1215T>C1.000
gyrA8519c.1218A>G1.000
gyrA8520c.1219C>T1.000
gyrA8529p.Ala410Ser1.000
gyrA8535p.Glu412Gln1.000
gyrA8546c.1245T>C1.000
gyrA8547p.Ile416Asp1.000
gyrA8555c.1254G>C1.000
gyrA8556p.Ala419Thr1.000
gyrA8561c.1260A>C1.000
gyrA8603c.1302A>C1.000
gyrA8609c.1308G>C1.000
gyrA8619c.1318T>C1.000
gyrA8636c.1335A>G1.000
gyrA8642c.1341A>G1.000
gyrA8645c.1344C>G1.000
gyrA8649p.Arg450Lys1.000
gyrA8655p.Ile452Val1.000
gyrA8663c.1362C>T1.000
gyrA8672c.1371A>G1.000
gyrA8693c.1392T>C1.000
gyrA8696c.1395G>C1.000
gyrA8699c.1398A>G1.000
gyrA8711c.1410A>C1.000
gyrA8717c.1416C>G1.000
gyrA8723c.1422G>C1.000
gyrA8780p.Asp493Glu1.000
gyrA8786c.1485T>C1.000
gyrA8787p.Thr496Ser1.000
gyrA8799p.Ala500Pro1.000
gyrA8810c.1509A>C1.000
gyrA8828c.1527T>C1.000
gyrA8829c.1528T>C1.000
gyrA8849c.1548C>G1.000
gyrA8852c.1551T>G1.000
gyrA8858c.1557T>C1.000
gyrA8867c.1566A>G1.000
gyrA8870c.1569G>C1.000
gyrA8882c.1581G>A1.000
gyrA8889p.Lys530Arg1.000
gyrA8897c.1596T>C1.000
gyrA8903c.1602T>C1.000
gyrA8930c.1629C>G1.000
gyrA8939c.1638T>C1.000
gyrA8945c.1644G>T1.000
gyrA8946c.1645T>C1.000
gyrA8951c.1650G>A1.000
gyrA8967p.Ala556Lys1.000
gyrA8981c.1680G>C1.000
gyrA8996c.1695T>C1.000
gyrA8998p.Leu566Trp1.000
gyrA9023c.1722A>C1.000
gyrA9029c.1728T>G1.000
gyrA9032c.1731T>C1.000
gyrA9035c.1734G>C1.000
gyrA9051c.1750T>C1.000
gyrA9056c.1755C>G1.000
gyrA9068c.1767G>C1.000
gyrA9071c.1770G>C1.000
gyrA9074c.1773G>C1.000
gyrA9080c.1779G>C1.000
gyrA9099c.1798T>C1.000
gyrA9119c.1818A>G1.000
gyrA9143c.1842T>C0.969
gyrA9144p.Arg615Lys0.967
gyrA9153p.Thr618Glu0.967
gyrA9164c.1863G>C0.979
gyrA9174c.1873C>T0.980
gyrA9179c.1878C>A0.980
gyrA9182c.1881T>C0.980
gyrA9191c.1890G>C0.982
gyrA9197c.1896G>C0.982
gyrA9200c.1899A>G0.982
gyrA9212c.1911G>C0.981
gyrA9230c.1929T>C0.981
gyrA9236c.1935G>C0.980
gyrA9242c.1941A>C0.979
gyrA9252p.Val651Ile0.980
gyrA9263c.1962C>T0.974
gyrA9267p.Asn656Gly0.974
gyrA9275c.1974G>A0.979
gyrA9284c.1983T>C1.000
gyrA9293c.1992G>C1.000
gyrA9296c.1995T>C1.000
gyrA9299c.1998G>C0.875
gyrA9304p.Gly668Asp0.882
gyrA9318c.2017C>T1.000
gyrA9323c.2022C>G1.000
gyrA9335c.2034G>T1.000
gyrA9341c.2040C>G1.000
gyrA9345c.2044A>C1.000
gyrA9356c.2055G>C1.000
gyrA9368c.2067G>A1.000
gyrA9377c.2076A>G1.000
gyrA9383c.2082T>C1.000
gyrA9386c.2085T>G1.000
gyrA9395c.2094G>C1.000
gyrA9503c.2202T>C0.933
gyrA9704c.2403T>G1.000
gyrA9716c.2415T>C1.000
gyrA9717c.2416C>T1.000
gyrA9722c.2421C>T1.000
gyrA9740c.2439G>A1.000
gyrA9743c.2442C>G1.000
gyrA9749c.2448G>T1.000
rpoB759788c.-19A>G1.000
rpoB759801c.-6T>C1.000
rpoB759814p.Asp3Val1.000
rpoB759884c.78A>G1.000
rpoB759890c.84A>C1.000
rpoB759896c.90A>C1.000
rpoB759914c.108T>G1.000
rpoB760070c.264T>G1.000
rpoB760091c.285G>C1.000
rpoB760092p.Ser96Thr1.000
rpoB760101c.295T>C1.000
rpoB760112c.306T>C1.000
rpoB760115c.309C>T1.000
rpoB760118c.312T>G1.000
rpoB760127c.321C>T1.000
rpoB760130c.324T>C1.000
rpoB760139c.333A>G1.000
rpoB760144p.Val113Glu1.000
rpoB760148p.Asp114Glu1.000
rpoB760155p.Lys117Arg1.000
rpoB760172c.366G>C1.000
rpoB760174p.Tyr123Phe1.000
rpoB760181c.375T>C1.000
rpoB760184c.378A>G1.000
rpoB760235c.429T>C1.000
rpoB760265p.Met153Ile0.981
rpoB760283c.477G>C0.980
rpoB760298c.492G>C0.979
rpoB760310c.504G>C0.980
rpoB760316c.510C>G0.980
rpoB760328c.522G>C0.980
rpoB760331c.525G>C0.979
rpoB760337c.531C>G0.978
rpoB760357p.Thr184Ser0.977
rpoB760361c.555T>C0.976
rpoB760376p.Asp190Glu0.857
rpoB760383c.577C>T0.761
rpoB760389c.583A>T0.703
rpoB760394c.588C>G0.711
rpoB760406c.600G>C0.980
rpoB760412c.606C>G0.962
rpoB760418c.612G>C0.982
rpoB760424c.618C>G0.983
rpoB760430c.624T>C0.983
rpoB760434p.Val210Ile0.984
rpoB760457c.651C>T0.985
rpoB760475c.669A>G1.000
rpoB760481c.675G>T1.000
rpoB760484c.678A>G1.000
rpoB760511c.705G>C1.000
rpoB760522p.Ser239Asn1.000
rpoB760532c.726T>C1.000
rpoB760533p.Val243Arg1.000
rpoB760538c.732G>A1.000
rpoB760541c.735G>C1.000
rpoB760563p.Arg253Met1.000
rpoB760591p.Val262Ala1.000
rpoB760596p.Thr264Pro1.000
rpoB760611c.805T>C1.000
rpoB760634c.828T>C1.000
rpoB760643c.837G>A1.000
rpoB760646c.840C>G1.000
rpoB760649c.843G>C1.000
rpoB760655c.849A>G1.000
rpoB760661c.855A>G1.000
rpoB760670c.864G>C1.000
rpoB760674c.868T>C1.000
rpoB760679c.873A>G1.000
rpoB760683c.877T>C1.000
rpoB760697p.Glu297Asp1.000
rpoB760703c.897C>T0.982
rpoB760718c.912C>G1.000
rpoB760721c.915C>G1.000
rpoB760724c.918T>G1.000
rpoB760730c.924T>C1.000
rpoB760733c.927G>A1.000
rpoB760734p.Val310Ile1.000
rpoB760796c.990A>G1.000
rpoB760805c.999G>C1.000
rpoB760817c.1011A>G1.000
rpoB760820c.1014T>C1.000
rpoB760826c.1020C>G1.000
rpoB760829c.1023C>G1.000
rpoB760830c.1024T>C1.000
rpoB760838p.Glu344Asp1.000
rpoB760841c.1035T>C1.000
rpoB760848p.Thr348Glu1.000
rpoB760856c.1050C>G1.000
rpoB760859c.1053T>G1.000
rpoB760862c.1056G>C1.000
rpoB760868c.1062C>G0.941
rpoB760877c.1071G>C0.943
rpoB760886c.1080A>G1.000
rpoB760910c.1104C>T1.000
rpoB760916c.1110C>G1.000
rpoB760925c.1119T>C1.000
rpoB760928c.1122G>C1.000
rpoB760946c.1140A>G1.000
rpoB760964c.1158C>G1.000
rpoB760965p.Met387Leu1.000
rpoB760970c.1164G>C0.984
rpoB760982c.1176G>C1.000
rpoB760991c.1185G>C1.000
rpoB761015c.1209G>C1.000
rpoB761027c.1221A>G1.000
rpoB761036c.1230G>C1.000
rpoB761037c.1231T>C1.000
rpoB761051c.1245G>C1.000
rpoB761097c.1291A>T1.000
rpoB761102c.1296A>G1.000
rpoB761150c.1344A>T1.000
rpoB761171c.1365C>T1.000
rpoB761180c.1374A>G1.000
rpoB761183c.1377T>G1.000
rpoB761189c.1383T>G1.000
rpoB761220c.1414T>A1.000
rpoB761249c.1443A>G1.000
rpoB761255c.1449T>G1.000
rpoB761258c.1452G>A1.000
rpoB761261c.1455G>C1.000
rpoB761282c.1476C>G1.000
rpoB761306c.1500C>G1.000
rpoB761327c.1521A>G1.000
rpoB761381c.1575G>C1.000
rpoB761390c.1584C>T1.000
rpoB761396c.1590G>A1.000
rpoB761403p.His533Tyr1.000
rpoB761414c.1608A>G1.000
rpoB761462c.1656C>T1.000
rpoB761471c.1665C>G1.000
rpoB761482p.Ala559Gly1.000
rpoB761492c.1686G>C1.000
rpoB761502p.Pro566Ser0.966
rpoB761507c.1701G>C0.964
rpoB761508p.Ser568Ala0.966
rpoB761519p.Asp571Glu0.974
rpoB761537c.1731C>G0.971
rpoB761549c.1743G>C0.971
rpoB761570c.1764T>C0.977
rpoB761573c.1767C>G0.978
rpoB761579c.1773G>C1.000
rpoB761606c.1800C>G1.000
rpoB761612c.1806G>C1.000
rpoB761615c.1809A>G1.000
rpoB761627c.1821C>T1.000
rpoB761636c.1830G>C1.000
rpoB761645c.1839C>G0.977
rpoB761648c.1842T>C0.976
rpoB761666c.1860G>C0.974
rpoB761675c.1869G>C0.976
rpoB761682c.1876C>T0.974
rpoB761687c.1881C>T0.974
rpoB761690c.1884G>C0.974
rpoB761693c.1887G>C0.974
rpoB761705c.1899C>T0.889
rpoB761723c.1917A>G0.304
rpoB761724p.Glu640Lys0.304
rpoB761727p.Ser641Ala0.957
rpoB761732c.1926C>G0.958
rpoB761735c.1929C>G0.960
rpoB761747c.1941G>C0.974
rpoB761750c.1944G>C0.974
rpoB761765c.1959T>G0.979
rpoB761772p.His656Ala1.000
rpoB761778p.Asn658Asp1.000
rpoB761789c.1983G>C1.000
rpoB761790c.1984C>A1.000
rpoB761813c.2007T>C1.000
rpoB761814p.Ala670Asn1.000
rpoB761834c.2028T>C1.000
rpoB761847p.Cys681Arg1.000
rpoB761852c.2046C>G1.000
rpoB761858c.2052G>C1.000
rpoB761864c.2058G>C1.000
rpoB761867c.2061C>G1.000
rpoB761868p.Asp688Gln1.000
rpoB761873c.2067A>G1.000
rpoB761876c.2070C>G1.000
rpoB761885c.2079T>C1.000
rpoB761891c.2085G>C1.000
rpoB761892p.Ile696Val1.000
rpoB761909c.2103T>C1.000
rpoB761912c.2106T>C1.000
rpoB761915p.Asp703Glu1.000
rpoB761933c.2127G>C1.000
rpoB761936c.2130C>G1.000
rpoB761945c.2139G>T1.000
rpoB761948c.2142G>C1.000
rpoB761954c.2148C>G1.000
rpoB761955p.Ile717Val1.000
rpoB761972c.2166C>G1.000
rpoB761984c.2178G>A1.000
rpoB761990c.2184G>C0.981
rpoB761997c.2191C>T0.982
rpoB762008c.2202C>G0.982
rpoB762011c.2205G>C0.983
rpoB762020p.Glu738Asp0.969
rpoB762053c.2247T>C0.986
rpoB762062c.2256T>C0.986
rpoB762065c.2259T>C0.986
rpoB762078c.2272C>T0.974
rpoB762083c.2277T>C0.987
rpoB762086c.2280G>C0.987
rpoB762110c.2304G>C0.975
rpoB762134c.2328C>T0.867
rpoB762140c.2334G>C1.000
rpoB762143c.2337T>C1.000
rpoB762149c.2343G>C1.000
rpoB762170c.2364C>G0.987
rpoB762176c.2370T>C0.987
rpoB762185c.2379G>C0.987
rpoB762218c.2412T>G0.985
rpoB762233c.2427G>C0.984
rpoB762236c.2430G>C0.983
rpoB762246c.2440C>T0.984
rpoB762254c.2448T>C0.982
rpoB762257c.2451C>G0.962
rpoB762266c.2460T>G0.963
rpoB762284c.2478G>C0.960
rpoB762293c.2487T>C0.979
rpoB762296c.2490G>C0.980
rpoB762314c.2508C>G0.979
rpoB762329c.2523G>C0.979
rpoB762335c.2529C>A0.976
rpoB762338c.2532T>C0.976
rpoB762347c.2541T>C0.977
rpoB762362p.Glu852Asp0.980
rpoB762369c.2563T>C0.980
rpoB762380c.2574T>G0.980
rpoB762395c.2589G>C0.953
rpoB762398c.2592T>G0.953
rpoB762401c.2595G>C0.953
rpoB762404c.2598T>C0.953
rpoB762407c.2601G>C0.953
rpoB762410c.2604T>G0.977
rpoB762416c.2610A>G0.982
rpoB762467c.2661C>T0.984
rpoB762486p.Pro894Ala0.982
rpoB762489p.Val895Gln0.981
rpoB762509c.2703T>G0.952
rpoB762510p.Ala902Pro0.953
rpoB762518c.2712C>A0.985
rpoB762527c.2721G>C1.000
rpoB762533c.2727T>C1.000
rpoB762536c.2730T>C1.000
rpoB762551c.2745C>T1.000
rpoB762581c.2775T>C1.000
rpoB762582c.2776T>C1.000
rpoB762716c.2910G>C1.000
rpoB762736p.Ala977Glu1.000
rpoB762782c.2976T>C0.412
rpoB762783p.Asp993Asn0.353
rpoB762788c.2982G>C0.412
rpoB762790p.Leu995Gln0.412
rpoB762795p.Asp997Asn0.412
rpoB762836c.3030C>G0.900
rpoB762857c.3051C>G0.984
rpoB762860c.3054G>C0.984
rpoB762863c.3057T>C0.985
rpoB762983c.3177C>T1.000
rpoB762989c.3183G>C1.000
rpoB762995c.3189G>T1.000
rpoB763013c.3207C>G0.979
rpoB763031c.3225T>G1.000
rpoB763040c.3234C>G1.000
rpoB763049c.3243G>A1.000
rpoB763058c.3252C>G1.000
rpoB763064c.3258G>A1.000
rpoB763070c.3264T>C1.000
rpoB763082c.3276C>G1.000
rpoB763085c.3279C>G1.000
rpoB763094c.3288G>C1.000
rpoB763115c.3309T>C1.000
rpoB763127c.3321G>C1.000
rpoB763136c.3330C>G1.000
rpoB763139c.3333C>T1.000
rpoB763169c.3363A>G0.987
rpoB763202c.3396A>G0.986
rpoB763206c.3400A>T0.986
rpoB763220c.3414G>C0.988
rpoB763226c.3420A>G0.987
rpoB763227c.3421C>T0.987
rpoB763238c.3432T>C0.988
rpoB763247p.Glu1147Asp0.988
rpoB763259c.3453G>C1.000
rpoB763268c.3462C>G1.000
rpoB763274c.3468G>C1.000
rpoB763277c.3471A>G1.000
rpoB763283c.3477T>C1.000
rpoB763289c.3483C>G1.000
rpoB763298c.3492A>G1.000
rpoC763402c.33C>A0.989
rpoC763411c.42T>G0.989
rpoC763414c.45T>C0.989
rpoC763420c.51G>C0.989
rpoC763429c.60C>T1.000
rpoC763430c.61A>C1.000
rpoC763444c.75T>C1.000
rpoC763453c.84C>G1.000
rpoC763456c.87A>G1.000
rpoC763468c.99G>C1.000
rpoC763483c.114G>C1.000
rpoC763486c.117T>C1.000
rpoC763528c.159G>A1.000
rpoC763546c.177A>G1.000
rpoC763573c.204G>C1.000
rpoC763594c.225C>T1.000
rpoC763609c.240C>G1.000
rpoC763615c.246G>C1.000
rpoC763633c.264T>C1.000
rpoC763642c.273G>C1.000
rpoC763658c.289C>T1.000
rpoC763666c.297G>C1.000
rpoC763669c.300C>G1.000
rpoC763702c.333C>G1.000
rpoC763703c.334T>A1.000
rpoC763711c.342G>C1.000
rpoC763714c.345G>T1.000
rpoC763717c.348T>C1.000
rpoC763732c.363C>G1.000
rpoC763741c.372C>T1.000
rpoC763747c.378G>A1.000
rpoC763765c.396T>C1.000
rpoC763781p.Ser138Ala1.000
rpoC763792p.Glu141Asp1.000
rpoC763801c.432C>G1.000
rpoC763807c.438T>C1.000
rpoC763813c.444C>G1.000
rpoC763816c.447C>G1.000
rpoC763819c.450G>C1.000
rpoC763825c.456G>A1.000
rpoC763831c.462A>G1.000
rpoC763836p.Ala156Gly1.000
rpoC763858c.489A>G1.000
rpoC763867c.498C>T1.000
rpoC763872p.Gly168Ala1.000
rpoC763876p.Glu169Asp1.000
rpoC763879c.510A>G0.984
rpoC763894c.525A>G1.000
rpoC763900c.531G>C1.000
rpoC763903c.534G>A1.000
rpoC763912c.543G>C1.000
rpoC763933c.564C>A1.000
rpoC763945c.576T>C1.000
rpoC763960c.591T>G1.000
rpoC763963c.594C>T1.000
rpoC763972c.603C>T1.000
rpoC763987c.618C>T1.000
rpoC763991p.Ile208Leu1.000
rpoC764002c.633C>T1.000
rpoC764005c.636G>C1.000
rpoC764011c.642T>C1.000
rpoC764014c.645G>A1.000
rpoC764024c.655T>C1.000
rpoC764032p.Asp221Glu1.000
rpoC764040p.Ser224Thr1.000
rpoC764044c.675T>G1.000
rpoC764059c.690G>C1.000
rpoC764071c.702G>C1.000
rpoC764075p.Val236Ile1.000
rpoC764083c.714A>G1.000
rpoC764085p.Asn239Ser1.000
rpoC764087p.Leu240Ile1.000
rpoC764098c.729A>G1.000
rpoC764113c.744C>T1.000
rpoC764131c.762T>C1.000
rpoC764134c.765C>G1.000
rpoC764188c.819A>G0.878
rpoC764191c.822C>G0.875
rpoC764203c.834G>C1.000
rpoC764206c.837T>C1.000
rpoC764213p.Arg282Lys1.000
rpoC764227c.858G>C1.000
rpoC764239c.870T>G1.000
rpoC764242c.873C>G1.000
rpoC764245c.876C>G1.000
rpoC764254c.885G>T1.000
rpoC764257c.888G>C1.000
rpoC764260c.891G>A1.000
rpoC764278c.909A>G1.000
rpoC764317c.948C>G0.967
rpoC764320c.951C>T1.000
rpoC764347c.978G>C1.000
rpoC764365c.996C>T1.000
rpoC764380c.1011G>C1.000
rpoC764387c.1018T>C1.000
rpoC764405c.1036A>C1.000
rpoC764431c.1062G>C1.000
rpoC764434c.1065A>G1.000
rpoC764435c.1066A>C1.000
rpoC764443p.Ile358Met1.000
rpoC764446c.1077T>C1.000
rpoC764449c.1080G>C1.000
rpoC764452c.1083T>C1.000
rpoC764458c.1089G>C1.000
rpoC764461c.1092A>G1.000
rpoC764497c.1128A>G1.000
rpoC764503c.1134G>C1.000
rpoC764509c.1140G>C1.000
rpoC764510c.1141C>T1.000
rpoC764521c.1152T>C1.000
rpoC764524c.1155C>T0.953
rpoC764527c.1158C>T0.969
rpoC764539c.1170C>G0.972
rpoC764548c.1179G>C1.000
rpoC764560c.1191T>C1.000
rpoC764566c.1197C>G1.000
rpoC764575c.1206T>C1.000
rpoC764602c.1233C>A1.000
rpoC764605c.1236G>C1.000
rpoC764611c.1242G>T1.000
rpoC764626c.1257C>T1.000
rpoC764650c.1281G>C1.000
rpoC764662c.1293G>C1.000
rpoC764701c.1332C>G1.000
rpoC764713c.1344G>A1.000
rpoC764716c.1347G>C0.990
rpoC764752c.1383G>C1.000
rpoC764764c.1395T>C1.000
rpoC764791c.1422C>G1.000
rpoC764815c.1446A>G1.000
rpoC764824c.1455T>C1.000
rpoC764827c.1458G>C1.000
rpoC764858c.1489T>C1.000
rpoC764863c.1494G>C1.000
rpoC764869c.1500C>T1.000
rpoC764872c.1503A>G1.000
rpoC764887c.1518G>T1.000
rpoC764888c.1519T>C1.000
rpoC764911c.1542A>G1.000
rpoC764912p.Met515Gln1.000
rpoC764923c.1554A>G1.000
rpoC764932c.1563C>G1.000
rpoC764948c.1579T>C1.000
rpoC764968c.1599T>C1.000
rpoC764995c.1626C>G1.000
rpoC765007c.1638T>G1.000
rpoC765008c.1639T>C1.000
rpoC765011c.1642A>T1.000
rpoC765019c.1650A>G1.000
rpoC765034c.1665T>C1.000
rpoC765040c.1671T>C1.000
rpoC765041c.1672T>C1.000
rpoC765052c.1683C>G1.000
rpoC765053c.1684T>A1.000
rpoC765076c.1707A>G1.000
rpoC765079c.1710T>G1.000
rpoC765082c.1713G>C1.000
rpoC765085c.1716T>G1.000
rpoC765089c.1720T>C1.000
rpoC765103c.1734G>T1.000
rpoC765122c.1753C>T0.963
rpoC765127c.1758C>T0.964
rpoC765202c.1833C>G1.000
rpoC765208c.1839T>C1.000
rpoC765220c.1851A>G1.000
rpoC765232c.1863G>C1.000
rpoC765376c.2007C>G1.000
rpoC765383p.Met672Leu1.000
rpoC765404p.Leu679Val1.000
rpoC765409c.2040T>G1.000
rpoC765412c.2043T>C1.000
rpoC765439c.2070G>A1.000
rpoC765454c.2085C>G1.000
rpoC765466c.2097C>T1.000
rpoC765469c.2100G>C1.000
rpoC765478c.2109T>C1.000
rpoC765493c.2124G>C0.931
rpoC765520c.2151G>A1.000
rpoC765529c.2160C>G1.000
rpoC765550c.2181C>T1.000
rpoC765553c.2184C>T1.000
rpoC765556c.2187G>C1.000
rpoC765559c.2190G>C1.000
rpoC765562c.2193G>C1.000
rpoC765565c.2196G>C1.000
rpoC765580c.2211G>C0.975
rpoC765611p.His748Ala0.986
rpoC765625c.2256C>G1.000
rpoC765628c.2259G>C1.000
rpoC765658c.2289C>G0.984
rpoC765661c.2292T>G0.984
rpoC765662c.2293T>C1.000
rpoC765669p.His767Arg1.000
rpoC765681p.Asn771Thr1.000
rpoC765700c.2331T>C1.000
rpoC765712c.2343C>G1.000
rpoC765718p.Asp783Glu1.000
rpoC765728p.Gln787Asn1.000
rpoC765734c.2365T>C1.000
rpoC765751c.2382C>G0.971
rpoC765752p.Asp795Ser0.971
rpoC765772c.2403C>G1.000
rpoC765778c.2409C>G1.000
rpoC765781p.Asp804Glu1.000
rpoC765796c.2427C>T0.989
rpoC765811c.2442T>C0.989
rpoC765814c.2445A>C0.989
rpoC765817c.2448G>C0.989
rpoC765826c.2457T>G0.991
rpoC765835c.2466C>T0.991
rpoC765850c.2481G>C0.991
rpoC765875p.Val836Ile0.992
rpoC765884c.2515T>A0.992
rpoC765892c.2523T>C1.000
rpoC765934c.2565C>T1.000
rpoC765937c.2568T>C1.000
rpoC765940c.2571A>T1.000
rpoC765946c.2577C>T1.000
rpoC765947c.2578T>C1.000
rpoC765952c.2583G>C1.000
rpoC765962c.2593T>C1.000
rpoC765982c.2613C>T1.000
rpoC765994c.2625A>T1.000
rpoC766003c.2634G>C1.000
rpoC766012c.2643C>G1.000
rpoC766042c.2673C>T1.000
rpoC766043p.Gln892Gly1.000
rpoC766061p.Val898Thr1.000
rpoC766072c.2703G>C1.000
rpoC766081c.2712T>C1.000
rpoC766082p.Ala905Gln1.000
rpoC766105c.2736C>G1.000
rpoC766113p.Tyr915Phe1.000
rpoC766120c.2751A>G1.000
rpoC766129c.2760C>G1.000
rpoC766135c.2766G>A1.000
rpoC766270c.2901G>C1.000
rpoC766273c.2904T>C1.000
rpoC766280p.Ser971Gly1.000
rpoC766288c.2919C>G1.000
rpoC766298p.Thr977Leu1.000
rpoC766309c.2940G>C1.000
rpoC766312c.2943T>C1.000
rpoC766315c.2946C>G1.000
rpoC766345c.2976T>C1.000
rpoC766348c.2979A>G1.000
rpoC766363c.2994G>C1.000
rpoC766381c.3012C>T0.990
rpoC766384c.3015A>G1.000
rpoC766387c.3018C>G1.000
rpoC766393c.3024C>G1.000
rpoC766426c.3057C>T1.000
rpoC766456c.3087C>G1.000
rpoC766459c.3090G>C1.000
rpoC766486c.3117A>G1.000
rpoC766492c.3123T>C1.000
rpoC766516c.3148 3151del0.554
rpoC766517r.3148a>g1.000
rpoC767287c.3918G>C1.000
rpoC767306c.3937A>T1.000
rpsL781571c.12C>T1.000
rpsL781589c.30G>A1.000
rpsL781592c.33T>G1.000
rpsL781595c.36T>C1.000
rpsL781598c.39G>C1.000
rpsL781604c.45G>A1.000
rpsL781605p.Ile16Pro1.000
rpsL781608p.Ser17Ala1.000
rpsL781628c.69T>C1.000
rpsL781631c.72G>C1.000
rpsL781649c.90T>C1.000
rpsL781652c.93T>C1.000
rpsL781655c.96T>G0.908
rpsL781658c.99A>G0.975
rpsL781682c.123T>A0.983
rpsL781709c.150G>C0.982
rpsL781715c.156T>G0.971
rpsL781718c.159C>G0.971
rpsL781721c.162C>T0.971
rpsL781728c.169T>C0.971
rpsL781742c.183C>G0.972
rpsL781751c.192G>C0.982
rpsL781754c.195G>C0.982
rpsL781760c.201T>C0.983
rpsL781832c.273T>C1.000
rpsL781859c.300T>C1.000
rpsL781868c.309T>C1.000
rpsL781871c.312G>C1.000
rpsL781880c.321C>G1.000
rpsL781898c.339A>C1.000
rpsL781916c.357T>C1.000
rpsL781929p.Gly124Ser1.000
rplC800838c.30G>A1.000
rplC800844c.36T>C1.000
rplC800856c.48A>G1.000
rplC800865c.57A>G1.000
rplC800867p.Ser20Asn1.000
rplC800872c.64A>C1.000
rplC800877c.69A>C1.000
rplC800880c.72A>C1.000
rplC800886c.78G>C1.000
rplC800904c.96G>T0.979
rplC800907c.99C>G0.979
rplC800910c.102C>T0.979
rplC800916c.108A>G0.982
rplC800931c.123G>C0.980
rplC800937c.129A>G0.979
rplC800946c.138T>C0.976
rplC800949c.141T>C0.976
rplC800950c.142A>T0.976
rplC800970c.162T>C0.955
rplC800973c.165C>A0.953
rplC800985c.177A>C0.955
rplC801004p.Leu66Val0.933
rplC801009c.201A>C0.933
rplC801012c.204T>C0.931
rplC801019p.Thr71Ala0.933
rplC801117c.309G>C1.000
rplC801128p.Ala107Val1.000
rplC801132c.324T>C0.984
rplC801147c.339T>C1.000
rplC801150c.342G>C1.000
rplC801153c.345G>C1.000
rplC801156c.348T>C1.000
rplC801171c.363A>G0.987
rplC801183c.375C>G0.987
rplC801205p.Arg133Ala0.988
rplC801210c.402T>A0.988
rplC801222c.414T>C0.989
rplC801228c.420T>C0.988
rplC801229p.Ala141Thr0.988
rplC801246c.438C>T0.988
rplC801249c.441T>C0.988
rplC801252c.444G>C0.987
rplC801264c.456C>T0.982
rplC801267c.459A>C0.982
rplC801270c.462T>C0.982
rplC801276c.468G>C0.982
rplC801279c.471G>C0.915
rplC801281p.Ala158Gly0.915
rplC801312c.504G>C1.000
rplC801324c.516T>C1.000
rplC801337p.Val177Thr1.000
rplC801341p.Leu178Gln1.000
rplC801348c.540T>G1.000
rplC801349c.541T>C1.000
rplC801357c.549T>C1.000
rplC801372c.564G>A1.000
rplC801396c.588T>C1.000
rplC801402c.594T>C1.000
rplC801405c.597T>C1.000
rplC801412p.Thr202Ala1.000
rplC801420c.612A>G1.000
rplC801437p.Ser210Thr1.000
rrs1471923r.78t>c1.000
rrs1471925r.80t>c1.000
rrs1471932r.87a>g1.000
rrs1471934r.89a>g1.000
rrs1471936r.91a>g1.000
rrs1471985r.140t>c0.987
rrs1471986r.141c>t0.995
rrs1472028r.183a>g0.980
rrs1472031r.186g>c0.990
rrs1472032r.187g>a0.990
rrs1472033r.188a>t0.990
rrs1472034r.189t>c1.000
rrs1472040r.195t>g1.000
rrs1472041r.196c>t1.000
rrs1472042r.197t>g1.000
rrs1472053r.208agc>a1.000
rrs1472061r.216a>t1.000
rrs1472075r.230a>g1.000
rrs1472106r.261g>t1.000
rrs1472108r.263c>t1.000
rrs1472225r.380c>g1.000
rrs1472251r.406g>a1.000
rrs1472286r.441c>g1.000
rrs1472288r.443a>c1.000
rrs1472297r.452ggtccgggttctct>g1.000
rrs1472300r.455ccgggttctctcg>c1.000
rrs1472313r.468g>a1.000
rrs1472315r.470t>g1.000
rrs1472326r.481t>g1.000
rrs1472328r.483g>c1.000
rrs1472435r.590t>c1.000
rrs1472438r.593t>c1.000
rrs1472448r.603t>c1.000
rrs1472451r.606c>t1.000
rrs1472464r.619a>g1.000
rrs1472489r.644a>t1.000
rrs1472846r.1001c>a0.987
rrs1472847r.1002g>c0.987
rrs1472849r.1004c>g0.987
rrs1472850r.1005t>c0.974
rrs1472857r.1012a>g0.987
rrs1472858r.1013g>t0.987
rrs1472860r.1015c>g0.987
rrs1472861r.1016g>t0.974
rrs1472873r.1028c>t0.993
rrs1472880r.1035g>a1.000
rrs1472955r.1110c>t1.000
rrs1472956r.1111t>c0.996
rrs1472969r.1124a>g1.000
rrs1472973r.1128a>t0.428
rrs1472978r.1133t>c1.000
rrs1472987r.1142g>a1.000
rrs1472990r.1145a>g1.000
rrs1473104r.1259c>t1.000
rrs1473110r.1265t>g1.000
rrs1473111r.1266a>g1.000
rrs1473120r.1275c>ct0.914
rrs1473123r.1278a>c1.000
rrs1473288r.1443c>ct0.808
rrs1473290r.1445c>t0.992
rrs1473294r.1449a>g1.000
rrl1473569c.-89A>T0.963
rrl1473570c.-88A>T0.963
rrl1473571c.-87C>G0.967
rrl1473667r.10t>a0.985
rrl1473668r.11c>a0.985
rrl1473670r.13a>c0.985
rrl1473697r.40c>t0.978
rrl1473699r.42a>g0.977
rrl1473722r.65g>a0.978
rrl1473743r.86c>t0.979
rrl1473754r.97g>a0.965
rrl1473757r.100t>a0.964
rrl1473758r.101g>a0.964
rrl1473768r.111a>g0.968
rrl1473770r.113t>g0.969
rrl1473806r.149c>t0.952
rrl1473811r.154c>t0.932
rrl1473814r.157a>c0.930
rrl1473815r.158t>g0.930
rrl1473816r.159c>g0.930
rrl1473833r.176g>a0.946
rrl1473836r.179a>g0.934
rrl1473876r.219g>a0.986
rrl1473888r.231t>a0.985
rrl1473898r.241c>t0.993
rrl1473899r.242a>t0.986
rrl1473922r.265a>g0.991
rrl1473923r.266c>g0.991
rrl1473935r.278c>t1.000
rrl1473937r.280c>t1.000
rrl1473942r.285g>c0.545
rrl1473944r.287g>a1.000
rrl1473946r.289a>g1.000
rrl1473983r.326a>t1.000
rrl1473985r.328a>g1.000
rrl1473992r.335a>g1.000
rrl1473994r.337c>g1.000
rrl1473995r.338g>t1.000
rrl1474003r.346g>c1.000
rrl1474007r.350a>g0.950
rrl1474008r.351g>a0.950
rrl1474008r.351ga>g1.000
rrl1474009r.352a>g1.000
rrl1474016r.359c>g1.000
rrl1474026r.369c>t1.000
rrl1474083r.426c>t1.000
rrl1474093r.436g>a1.000
rrl1474103r.446a>t1.000
rrl1474106r.449a>g0.990
rrl1474140r.483c>t1.000
rrl1474151r.494c>t1.000
rrl1474174r.517a>g1.000
rrl1474181r.524c>t1.000
rrl1474183r.526t>c1.000
rrl1474201r.544t>c0.994
rrl1474202r.545t>g0.994
rrl1474263r.606g>a0.994
rrl1474266r.609t>c0.994
rrl1474287r.630t>ttc0.648
rrl1474306r.649a>t0.989
rrl1474310r.653t>tgg0.941
rrl1474362r.705a>g1.000
rrl1474387r.730c>t1.000
rrl1474424r.767c>t1.000
rrl1474427r.770a>c1.000
rrl1474431r.774g>t1.000
rrl1474432r.775c>g1.000
rrl1474495r.838g>a1.000
rrl1474496r.839c>g1.000
rrl1474497r.840g>c1.000
rrl1474498r.841g>a1.000
rrl1474505r.848c>t1.000
rrl1474506r.849c>g1.000
rrl1474507r.850g>c1.000
rrl1474508r.851c>t1.000
rrl1474632r.975g>c1.000
rrl1474709r.1052g>ggca0.831
rrl1474710r.1053t>c0.980
rrl1474712r.1055g>t0.980
rrl1474753r.1096a>g0.991
rrl1474760r.1103a>g0.986
rrl1474794r.1137c>t0.987
rrl1474812r.1155g>a0.991
rrl1474830r.1173a>g0.995
rrl1475061r.1404c>t0.995
rrl1475202r.1545g>a1.000
rrl1475209r.1552g>c1.000
rrl1475217r.1560t>a1.000
rrl1475243r.1586g>c1.000
rrl1475250r.1593c>a1.000
rrl1475273r.1616t>a1.000
rrl1475275r.1618c>g1.000
rrl1475276r.1619t>c1.000
rrl1475291r.1634a>c1.000
rrl1475315r.1658a>t1.000
rrl1475355r.1698c>t1.000
rrl1475369r.1712g>c1.000
rrl1475375r.1718g>a1.000
rrl1475395r.1738t>g1.000
rrl1475396r.1739c>g1.000
rrl1475397r.1740g>t1.000
rrl1475403r.1746t>a1.000
rrl1475404r.1747a>t1.000
rrl1475407r.1750c>t0.962
rrl1475409r.1752t>c1.000
rrl1475429r.1772g>a1.000
rrl1475452r.1795c>a1.000
rrl1475460r.1803a>g1.000
rrl1475477r.1820a>at0.971
rrl1475505r.1848g>a1.000
rrl1475526r.1869c>a1.000
rrl1475544r.1887a>t1.000
rrl1475545r.1888t>g1.000
rrl1475586r.1929c>a1.000
rrl1475606r.1949t>c1.000
rrl1475608r.1951t>c1.000
rrl1475612r.1955g>c1.000
rrl1475621r.1964t>c1.000
rrl1475629r.1972g>ga0.972
rrl1475659r.2002g>a1.000
rrl1475753r.2096c>g1.000
rrl1475757r.2100a>agtgg0.981
rrl1475767r.2110g>c1.000
rrl1475769r.2112t>c1.000
rrl1475775r.2118g>t1.000
rrl1475995r.2338g>a0.994
rrl1475997r.2340a>g0.994
rrl1476025r.2368g>a0.512
rrl1476033r.2376t>c1.000
rrl1476034r.2377c>g0.993
rrl1476035r.2378g>c0.993
rrl1476044r.2387t>g1.000
rrl1476045r.2388g>t1.000
rrl1476085r.2428g>a1.000
rrl1476086r.2429g>a1.000
rrl1476088r.2431a>c1.000
rrl1476099r.2442a>g1.000
rrl1476103r.2446c>g1.000
rrl1476105r.2448g>c1.000
rrl1476106r.2449a>t1.000
rrl1476110r.2453g>c1.000
rrl1476114r.2457t>c1.000
rrl1476115r.2458t>c1.000
rrl1476119r.2462g>a1.000
rrl1476131r.2474c>t1.000
rrl1476165r.2508t>a1.000
rrl1476214r.2557g>t1.000
rrl1476215r.2558c>t1.000
rrl1476224r.2567a>g1.000
rrl1476252r.2595t>g1.000
rrl1476256r.2599a>c1.000
rrl1476281r.2624t>c1.000
rrl1476583r.2926g>a1.000
rrl1476597r.2940g>a0.994
rrl1476628r.2971t>a1.000
rrl1476674r.3017t>c1.000
rrl1476690r.3033c>t1.000
rrl1476691r.3034t>c1.000
rrl1476692r.3035t>a1.000
rrl1476693r.3036g>a1.000
rrl1476723r.3066t>a1.000
rrl1476726r.3069a>g1.000
rrl1476770r.3113t>c1.000
rrl1476771r.3114g>a1.000
rrl1476791r.3134ca>c1.000
fabG11673568c.129C>G1.000
fabG11673571c.132C>G1.000
fabG11673580c.141T>C1.000
fabG11673786p.Ala116Val1.000
fabG11673799c.360T>C1.000
fabG11673800p.Gln121Lys1.000
fabG11673808c.369A>C1.000
fabG11673988c.549G>C1.000
fabG11673991c.552C>G1.000
fabG11673993p.Tyr185Phe1.000
fabG11674006c.567T>C1.000
fabG11674090c.651C>G1.000
fabG11674100p.Val221Ile1.000
fabG11674114c.675T>C1.000
fabG11674118p.Glu227Pro1.000
fabG11674123c.684T>C1.000
fabG11674126c.687G>C1.000
fabG11674127p.Ser230Gly1.000
fabG11674132c.693T>C1.000
fabG11674141c.702T>G1.000
fabG11674153c.714G>C1.000
fabG11674166p.Met243Leu1.000
fabG11674171c.732T>C1.000
inhA1674258c.57G>C1.000
inhA1674279c.78A>C1.000
inhA1674282c.81G>C1.000
inhA1674285c.84A>C1.000
inhA1674295p.Gln32Ala1.000
inhA1674300c.99C>T1.000
inhA1674303c.102C>G1.000
inhA1674306c.105G>A1.000
inhA1674321c.120G>C1.000
inhA1674331p.Leu44Met1.000
inhA1674342c.141T>C1.000
inhA1674352p.Thr51Val1.000
inhA1674455p.Gly85Asp1.000
inhA1674462c.261G>A1.000
inhA1674480c.279T>C1.000
inhA1674483c.282G>C1.000
inhA1674486c.285T>C1.000
inhA1674489c.288G>C1.000
inhA1674503p.Thr101Ser1.000
inhA1674507c.306G>C1.000
inhA1674513c.312C>G1.000
inhA1674514p.Ile105Val1.000
inhA1674534c.333G>C1.000
inhA1674542p.Ala114Glu1.000
inhA1674546c.345T>C1.000
inhA1674549c.348G>C1.000
inhA1674550p.Ser117Ala1.000
inhA1674570c.369G>C1.000
inhA1674573c.372G>C1.000
inhA1674576c.375T>C1.000
inhA1674585c.384T>G1.000
inhA1674589p.Met130Leu1.000
inhA1674601p.Leu134Val1.000
inhA1674624c.423A>C1.000
inhA1674630c.429C>G1.000
inhA1674636c.435C>G1.000
inhA1674656p.Ser152Thr1.000
inhA1674687c.486G>C1.000
inhA1674690c.489C>G1.000
inhA1674696c.495G>A1.000
inhA1674702c.501G>C1.000
inhA1674703c.502T>C1.000
inhA1674714c.513C>G1.000
inhA1674718c.517A>C1.000
inhA1674729c.528G>C0.970
inhA1674786c.585G>C1.000
inhA1674789c.588G>C0.923
inhA1674816c.615T>C1.000
inhA1674819c.618G>C1.000
inhA1674828p.Glu209Asp1.000
inhA1674837c.636C>T1.000
inhA1674838p.Ala213Gln1.000
inhA1674846p.Ile215Met1.000
inhA1674847p.Gln216Lys1.000
inhA1674858c.657G>A1.000
inhA1674870c.669T>C1.000
inhA1674879c.678T>C1.000
inhA1674883p.Ile228Val1.000
inhA1674892p.Asn231Asp1.000
inhA1674900c.699G>A1.000
inhA1674903c.702T>C1.000
inhA1674904p.Ala235Pro1.000
inhA1674909c.708G>C1.000
inhA1674915c.714C>G1.000
inhA1674927c.726G>C1.000
inhA1674930c.729C>T1.000
inhA1674934c.733C>T1.000
inhA1674942c.741T>G1.000
inhA1674949c.748C>T1.000
inhA1674957c.756G>C1.000
rpsA1833539c.-3A>C1.000
rpsA1833541c.-1T>C1.000
rpsA1833547c.6G>A1.000
rpsA1833554p.Thr5Ser1.000
rpsA1833589c.48A>C1.000
rpsA1833595c.54T>G1.000
rpsA1833596p.Ser19Ala1.000
rpsA1833604c.63C>T0.986
rpsA1833607c.66T>C1.000
rpsA1833610c.69C>T1.000
rpsA1833616c.75A>C1.000
rpsA1833619c.78A>C1.000
rpsA1833658c.117C>G1.000
rpsA1833664c.123C>G1.000
rpsA1833676c.135A>G1.000
rpsA1833679c.138G>T1.000
rpsA1833685c.144G>C1.000
rpsA1833691c.150G>A1.000
rpsA1833694c.153G>C1.000
rpsA1833697c.156C>G1.000
rpsA1833709c.168C>G0.988
rpsA1833724c.183C>G0.987
rpsA1833727c.186G>C0.987
rpsA1833733c.192C>G0.974
rpsA1833734p.Ala65Ser0.974
rpsA1833748c.207C>G0.990
rpsA1833754c.213G>A0.990
rpsA1833770p.Asn77His0.991
rpsA1833778c.237C>T0.989
rpsA1833781c.240T>C0.989
rpsA1833782p.Ser81Ala0.989
rpsA1833790c.249T>C0.989
rpsA1833793c.252C>T0.989
rpsA1833796p.Glu85Asp0.989
rpsA1833808c.267G>C0.992
rpsA1833811c.270G>C0.992
rpsA1833832c.291G>A1.000
rpsA1833838c.297G>A1.000
rpsA1833841c.300C>G1.000
rpsA1833847c.306C>G1.000
rpsA1833856c.315A>G1.000
rpsA1833862c.321G>C1.000
rpsA1833874c.333T>C1.000
rpsA1833892c.351G>A1.000
rpsA1833894p.Ala118Glu0.990
rpsA1833928c.387G>C1.000
rpsA1833955c.414G>C0.978
rpsA1833971c.430C>T1.000
rpsA1833979c.438T>C0.990
rpsA1833988c.447C>G0.990
rpsA1834000c.459G>C0.990
rpsA1834012c.471G>C0.980
rpsA1834039c.498C>T0.975
rpsA1834040p.Lys167Arg0.974
rpsA1834051c.510G>A0.978
rpsA1834054c.513C>G0.978
rpsA1834102c.561T>G0.967
rpsA1834144c.603G>A0.980
rpsA1834150c.609G>C0.971
rpsA1834153c.612T>C0.985
rpsA1834154p.Asn205His0.985
rpsA1834157c.616T>C0.985
rpsA1834162c.621A>G0.986
rpsA1834165c.624A>G0.986
rpsA1834169p.Thr210Ala0.986
rpsA1834177c.636A>C0.990
rpsA1834189c.648G>C0.990
rpsA1834222c.681T>C0.991
rpsA1834231c.690T>G1.000
rpsA1834240c.699T>C1.000
rpsA1834249c.708T>C1.000
rpsA1834261c.720A>G1.000
rpsA1834264c.723G>C1.000
rpsA1834288c.747C>G1.000
rpsA1834294c.753G>C1.000
rpsA1834298p.Gln253Ala1.000
rpsA1834303c.762T>C1.000
rpsA1834306c.765T>C1.000
rpsA1834336c.795C>G1.000
rpsA1834348c.807T>C1.000
rpsA1834366c.825A>G1.000
rpsA1834375c.834G>C1.000
rpsA1834378c.837T>C1.000
rpsA1834411c.870T>C1.000
rpsA1834417c.876G>C1.000
rpsA1834423c.882G>C1.000
rpsA1834435c.894G>C1.000
rpsA1834451c.910T>C1.000
rpsA1834456c.915T>G1.000
rpsA1834465c.924T>G1.000
rpsA1834468c.927A>G1.000
rpsA1834477c.936C>T1.000
rpsA1834489c.948T>C1.000
rpsA1834519c.978G>C1.000
rpsA1834520p.Ala327Ser1.000
rpsA1834527p.Arg329Gln1.000
rpsA1834531c.990C>T1.000
rpsA1834546c.1005T>C1.000
rpsA1834555c.1014T>C1.000
rpsA1834558c.1017C>G1.000
rpsA1834603p.Glu354Asp1.000
rpsA1834609c.1068T>C1.000
rpsA1834619c.1078T>C1.000
rpsA1834633c.1092A>G1.000
rpsA1834639c.1098T>C1.000
rpsA1834666c.1125G>C1.000
rpsA1834667p.Ala376Ser1.000
rpsA1834690c.1149T>C1.000
rpsA1834699p.Glu386Asp1.000
rpsA1834720c.1179C>G1.000
rpsA1834732c.1191T>C1.000
rpsA1834738p.Glu399Asp1.000
rpsA1834747c.1206A>G1.000
rpsA1834751c.1210C>T1.000
rpsA1834759c.1218A>C1.000
rpsA1834765c.1224A>G1.000
rpsA1834767p.Lys409Thr0.980
rpsA1834780c.1239A>G1.000
rpsA1834786c.1245A>G1.000
rpsA1834789c.1248T>C1.000
rpsA1834792c.1251G>T1.000
rpsA1834804c.1263C>G1.000
rpsA1834844p.Phe435Val1.000
rpsA1834852c.1311C>G1.000
rpsA1834944p.Ala468Glu0.875
rpsA1834957c.1416C>G1.000
rpsA1834966c.1425A>G1.000
tlyA1918417c.478T>C1.000
tlyA1918422c.483T>C1.000
tlyA1918425c.486C>G1.000
tlyA1918429c.490T>C1.000
tlyA1918604p.Ser222Thr1.000
tlyA1918616p.Lys226Thr1.000
tlyA1918620c.681C>G1.000
tlyA1918632c.693G>A1.000
tlyA1918638c.699A>G1.000
tlyA1918653c.714G>A1.000
tlyA1918656c.717C>T1.000
tlyA1918666c.727T>C1.000
kasA2518336c.222A>G1.000
kasA2518337c.223C>T1.000
kasA2518351c.237C>G1.000
kasA2518360c.246C>T1.000
kasA2518462c.348A>C1.000
kasA2518465c.351T>C1.000
kasA2518468c.354A>C1.000
kasA2518470p.Ala119Gly1.000
kasA2518480c.366T>C1.000
kasA2518488p.Ser125Thr1.000
kasA2518504c.390T>C1.000
kasA2518506p.Ala131Glu1.000
kasA2518516c.402C>G1.000
kasA2518519c.405G>C1.000
kasA2518528c.414C>G1.000
kasA2518540c.426T>G1.000
kasA2518561c.447T>C0.975
kasA2518573c.459G>C0.967
kasA2518574p.Ile154Ala0.967
kasA2518579c.465T>G0.967
kasA2518585c.471G>A1.000
kasA2518588c.474T>C1.000
kasA2518591c.477G>C1.000
kasA2518606c.492G>C1.000
kasA2518609p.Met165Ile1.000
kasA2518612c.498C>A1.000
kasA2518630c.516G>C1.000
kasA2518636c.522C>T1.000
kasA2518639c.525G>C1.000
kasA2518642c.528A>G1.000
kasA2518663c.549T>C1.000
kasA2518672c.558G>C1.000
kasA2518678c.564C>T1.000
kasA2518684c.570C>G1.000
kasA2518688p.Val192Met1.000
kasA2518692p.Ala193Val1.000
kasA2518702c.588C>T1.000
kasA2518705c.591T>C1.000
kasA2518714c.600A>C1.000
kasA2518715p.Pro201Gly1.000
kasA2518726c.612G>A1.000
kasA2518727c.613C>T1.000
kasA2518732c.618C>G1.000
kasA2518747c.633C>G1.000
kasA2518756c.642G>C1.000
kasA2518759c.645C>G1.000
kasA2518768c.654C>G0.985
kasA2518783c.669T>C0.983
kasA2518787p.Arg225Lys0.982
kasA2518792c.678C>T0.982
kasA2518795c.681C>G0.951
kasA2518825c.711T>C0.938
kasA2518843c.729T>C0.956
kasA2518847p.Leu245Met0.955
kasA2518853p.Leu247Ile0.949
kasA2518864c.750G>C0.954
kasA2518879c.765A>G0.950
kasA2518885c.771T>C0.948
kasA2518898c.784T>C0.689
kasA2518903c.789C>T0.689
kasA2518906c.792A>G0.886
kasA2518910p.Leu266Met0.882
kasA2518921c.807T>A0.903
kasA2518930c.816G>C0.880
kasA2518939c.825T>C0.870
kasA2518942c.828T>C0.870
kasA2519036p.Val308Ile0.923
kasA2519272c.1158C>G0.364
kasA2519332c.1218C>G1.000
ahpC2726348c.156T>C0.966
ahpC2726357c.165A>G0.926
ahpC2726366c.174G>C0.913
ahpC2726372c.180G>C0.938
ahpC2726375c.183C>T0.938
ahpC2726378c.186T>G0.938
ahpC2726381c.189C>G0.938
ahpC2726390c.198G>C0.938
ahpC2726397p.Ser69Gly0.933
ahpC2726408c.216T>C0.929
ahpC2726570c.378C>T0.636
ahpC2726579c.387T>G0.636
ahpC2726593p.Val134Ala1.000
ahpC2726600c.408T>C1.000
ahpC2726612c.420C>G1.000
ahpC2726638p.Ala149Val1.000
ahpC2726654c.462G>C1.000
ahpC2726657c.465A>C1.000
ahpC2726669c.477T>C1.000
ahpC2726675c.483A>G1.000
ahpC2726678c.486G>C1.000
ahpC2726681c.489A>C1.000
ahpC2726684c.492G>T1.000
ahpC2726693c.501C>G1.000
ahpC2726696c.504C>G1.000
ahpC2726699c.507G>A1.000
ahpC2726708c.516G>A1.000
ahpC2726717c.525A>C1.000
ahpC2726727p.Arg179Lys1.000
ahpC2726735c.543C>T1.000
folC2746819c.780A>G1.000
folC2746825c.774C>G1.000
folC2746948c.651C>G1.000
folC2746958p.Gly214Ala1.000
folC2746974p.Ile209Leu1.000
folC2746975p.Asp208Glu1.000
folC2746980p.Ala207Pro1.000
folC2746981c.618A>G1.000
folC2746987c.612A>G1.000
folC2746999c.600A>G1.000
folC2747002c.597A>G1.000
folC2747007p.Ser198Gly1.000
folC2747047c.552G>C1.000
folC2747059c.540A>G1.000
folC2747062c.537T>C1.000
folC2747065c.534G>A0.968
folC2747074c.525C>G1.000
folC2747083c.516C>G1.000
folC2747086c.513T>G1.000
folC2747092p.Asp169Glu1.000
folC2747101c.498C>G1.000
folC2747107c.492C>G1.000
folC2747110c.489A>G1.000
folC2747113c.486G>C1.000
folC2747116c.483C>G1.000
folC2747131c.468G>C0.980
folC2747299c.300G>A0.909
folC2747302c.297T>C0.909
folC2747313p.Thr96Phe0.917
folC2747314c.285T>C0.917
folC2747343p.Val86Leu0.979
folC2747350c.249G>A0.979
folC2747359c.240G>C0.957
folC2747365c.234C>G0.977
folC2747374c.225C>T0.974
folC2747390p.Ala70Gly0.943
folC2747395c.204A>G0.943
folC2747407c.192A>G0.818
folC2747411p.Ser63Thr0.800
folC2747467p.Asp44Glu0.842
folC2747474p.Arg42Gln0.769
folC2747484p.Pro39Gly0.714
folC2747488c.111G>A0.769
folC2747491c.108T>C0.769
folC2747500c.99T>C0.833
folC2747509c.90A>C0.833
thyX3067325c.621T>C0.900
thyX3067330p.Val206Leu0.909
thyX3067339p.His203Asn1.000
thyX3067343c.603G>A1.000
thyX3067347p.Ala200Gly1.000
thyX3067355c.591T>G1.000
thyX3067360p.Ile196Val1.000
thyX3067364c.582G>A1.000
thyX3067385c.561G>T1.000
thyX3067389p.Thr186Ser1.000
thyX3067391c.555C>G1.000
thyX3067399p.Ile183Leu1.000
thyX3067400c.546G>C1.000
thyX3067412c.534G>C1.000
thyX3067423c.523G>A1.000
thyX3067430c.516G>C1.000
thyX3067439c.507T>C1.000
thyX3067451c.495C>T1.000
thyA3073692c.780T>G1.000
thyA3073695c.777A>G1.000
thyA3073710c.762A>G1.000
thyA3073716c.756A>G1.000
thyA3073839c.633A>G1.000
thyA3073844p.Asp210Asn1.000
thyA3073860c.612G>C1.000
thyA3073863c.609A>G0.980
thyA3073874p.Ile200Val1.000
thyA3073881c.591G>C1.000
thyA3073889p.Ser195Ala1.000
thyA3073892c.580A>G1.000
thyA3073894p.Gly193Asp1.000
thyA3073902c.570G>C1.000
thyA3073905c.567G>C1.000
thyA3073920c.552G>C1.000
thyA3073925c.547A>G1.000
thyA3073929c.543A>G1.000
thyA3073958c.514G>A1.000
thyA3073959c.513A>G1.000
thyA3073977c.495T>C1.000
thyA3073989c.483A>G1.000
thyA3073995c.477C>G1.000
thyA3074000c.472G>T1.000
thyA3074004c.468A>G1.000
thyA3074013c.459G>A1.000
thyA3074076c.396G>C1.000
thyA3074082c.390C>G1.000
thyA3074100c.372A>G1.000
thyA3074103c.369G>C1.000
thyA3074106c.366A>G1.000
thyA3074403c.69G>A0.909
thyA3074417p.Ser19Ala1.000
fbiA3640320c.-223G>C0.969
fbiA3640339c.-204C>G0.966
fbiA3640341c.-202A>G0.966
fbiA3640348c.-195A>T0.966
fbiA3640349c.-194A>T0.966
fbiA3640350c.-193C>T0.966
fbiA3640355c.-188C>T0.967
fbiA3640584c.42C>A0.812
fbiA3640599c.57C>G0.750
fbiA3640605p.Gln21His0.733
fbiA3640701p.Ile53Met0.986
fbiA3640713c.171T>C0.982
fbiA3640714p.Val58Ile0.982
fbiA3640722c.180G>C0.982
fbiA3640725c.183T>C0.982
fbiA3640743c.201T>C0.982
fbiA3640751p.Gly70Ala1.000
fbiA3640755c.213C>T1.000
fbiA3640757p.Gly72Val1.000
fbiA3640761c.219G>A1.000
fbiA3640765p.Pro75Thr1.000
fbiA3640768p.Gln76Glu1.000
fbiA3640785p.Gln81His1.000
fbiA3640788c.246T>C1.000
fbiA3640794c.252A>G1.000
fbiA3640797c.255T>C1.000
fbiA3640801p.His87Asn1.000
fbiA3640808p.Met89Lys1.000
fbiA3640810p.Gln90Glu1.000
fbiA3640850p.Glu103Ala1.000
fbiA3640857c.315G>C0.933
fbiA3640866c.324T>C0.941
fbiA3640871p.Ala110Gly0.941
fbiA3640889p.Thr116Ser0.938
fbiA3640901p.Gln120Arg0.933
fbiA3641220c.678C>A0.429
fbiA3641227p.Ile229Val0.333
fbiA3641235c.693G>C0.333
alr3840382p.Met347Val1.000
alr3840470c.951G>A1.000
alr3840476c.945T>G1.000
alr3840482c.939A>C1.000
alr3840504p.Asn306Thr1.000
alr3841129c.292T>C1.000
alr3841151c.270G>C1.000
alr3841234p.Ala63Thr1.000
alr3841240p.Leu61Val1.000
panD4044006c.276C>G1.000
panD4044009c.273C>G1.000
panD4044015c.267C>G0.952
panD4044018c.264A>G1.000
panD4044024c.258A>G1.000
panD4044027c.255C>G1.000
panD4044033c.249A>G1.000
panD4044042c.240A>G1.000
panD4044050c.232A>G1.000
panD4044051c.231G>A1.000
panD4044075c.207A>G1.000
panD4044081c.201A>C1.000
panD4044084c.198A>G1.000
panD4044090c.192G>C0.969
panD4044093c.189T>C1.000
panD4044096c.186G>C1.000
panD4044105c.177C>G1.000
panD4044120c.162T>G1.000
panD4044123c.159A>C1.000
panD4044126c.156A>G1.000
panD4044138c.144A>G1.000
panD4044147c.135G>C1.000
panD4044150c.132T>C1.000
panD4044156c.126T>C1.000
panD4044162c.120T>C1.000
panD4044171c.111G>A1.000
panD4044188c.94C>G1.000
panD4044195c.87A>G1.000
panD4044201c.81G>C1.000
panD4044210c.72G>C1.000
panD4044233p.Cys17Gln1.000
panD4044237c.45C>G1.000
panD4044240c.42C>G1.000
panD4044246c.36G>A1.000
panD4044261c.21C>T1.000
panD4044266c.16G>A1.000
panD4044270c.12C>T1.000
panD4044273c.9C>G1.000
embC4240020p.Asn53Thr1.000
embC4240056p.Gly65Asp0.385
embC4240058p.Thr66Val0.385
embC4240069c.207T>C0.652
embC4240075p.Glu71Asp1.000
embC4240078c.216A>C1.000
embC4240087c.225T>C1.000
embC4240096c.234G>C1.000
embC4240256p.Leu132Val1.000
embC4240405c.543T>G1.000
embC4240410p.Pro183Arg1.000
embC4240420c.558T>G1.000
embC4240435c.573C>T1.000
embC4240462c.600G>C0.902
embC4240610p.Ile250Arg1.000
embC4240615c.753G>C1.000
embC4240619p.Thr253Ala1.000
embC4240622p.Ala254Thr1.000
embC4240642c.780G>C1.000
embC4240648c.786C>T1.000
embC4240654c.792C>G1.000
embC4240655p.Ala265Pro1.000
embC4240726c.864G>C1.000
embC4240756c.894G>C1.000
embC4240771c.909G>C1.000
embC4240777c.915G>A1.000
embC4240780c.918T>C1.000
embC4240783c.921G>C1.000
embC4240789c.927T>C1.000
embC4240819c.957A>C1.000
embC4240822c.960C>G0.972
embC4240828c.966G>C1.000
embC4240831c.969T>G1.000
embC4240897c.1035C>G1.000
embC4240900c.1038A>G1.000
embC4240911p.Ala350Val1.000
embC4240921c.1059C>G1.000
embC4240922p.Thr354Ala1.000
embC4240936c.1074A>G1.000
embC4240945c.1083T>G1.000
embC4241039p.Asp393Asn1.000
embC4241047c.1185C>G1.000
embC4241050c.1188T>G1.000
embC4241053c.1191G>C1.000
embC4241059c.1197G>A1.000
embC4241107c.1245G>C1.000
embC4241140c.1278A>G1.000
embC4241141p.Ile427Val1.000
embC4241158c.1296T>C1.000
embC4241161c.1299C>G1.000
embC4241162c.1300T>C1.000
embC4241167c.1305C>G1.000
embC4241185c.1323G>C0.957
embC4241188c.1326C>G1.000
embC4241189p.Ile443Val1.000
embC4241203c.1341T>G1.000
embC4241215c.1353C>G1.000
embC4241407c.1545A>G1.000
embC4241443c.1581C>G1.000
embC4241567p.Ile569Val1.000
embC4241572c.1710C>G1.000
embC4241584c.1722T>C1.000
embC4241587c.1725C>G1.000
embC4241591p.Leu577Ile1.000
embC4241604p.Phe581Ser1.000
embC4241611c.1749G>C1.000
embC4241614c.1752A>C1.000
embC4241617c.1755G>A1.000
embC4241626c.1764T>C1.000
embC4241644c.1782G>C1.000
embC4241648c.1786T>C1.000
embC4241656c.1794G>C1.000
embC4241662c.1800G>C1.000
embC4241665c.1803G>C1.000
embC4241671c.1809T>C1.000
embC4241686c.1824G>C0.917
embC4241688p.Thr609Ser0.917
embC4241691p.Gly610Ala0.917
embC4241695c.1833T>G0.917
embC4241697p.Ala612Val0.917
embC4241699p.Met613Leu0.917
embC4241713c.1851G>C0.923
embC4241719c.1857G>C0.923
embC4241725c.1863G>C0.923
embC4241734c.1872C>G0.923
embC4241770c.1908T>C0.984
embC4241791c.1929G>C0.983
embC4241803c.1941T>G0.981
embC4241809c.1947A>G0.980
embC4241887c.2025A>G1.000
embC4241893c.2031A>C1.000
embC4242025c.2163A>G1.000
embC4242035p.Gln725Ala1.000
embC4242046c.2184T>C1.000
embC4242047p.Ser729Gly1.000
embC4242065p.Ser735Thr1.000
embC4242070c.2208T>G1.000
embC4242076c.2214G>C0.923
embC4242079c.2217T>C0.923
embC4242085c.2223A>G0.923
embC4242086p.Gln742Glu0.923
embC4242091c.2229T>A0.923
embC4242092c.2230T>C0.923
embC4242095p.Ala745Thr0.923
embC4242109c.2247C>T0.962
embC4242121p.Glu753Asp0.957
embC4242232c.2370T>C0.860
embC4242245p.Thr795Ser0.867
embC4242427c.2565A>C0.969
embC4242433c.2571C>G0.968
embC4242625c.2763T>C1.000
embC4242630p.Ala923Glu1.000
embA4243580c.348G>C1.000
embA4244228c.996A>G1.000
embA4244312c.1080T>G1.000
embA4244316p.Phe362Leu1.000
embA4244324c.1092T>C1.000
embA4244327c.1095T>G1.000
embA4244329p.Ala366Val1.000
embA4244337c.1105C>T1.000
embA4244340p.Ser370Ala1.000
embA4244345c.1113C>G1.000
embA4244366c.1134C>G0.980
embA4244372c.1140T>C0.979
embA4244378c.1146G>A0.979
embA4244666c.1434G>C0.986
embA4244669c.1437G>C0.987
embA4244675c.1443A>G0.987
embA4244681c.1449A>G0.987
embA4244684c.1452C>G0.976
embA4244690c.1458G>A0.989
embA4244694p.Lys488Glu0.989
embA4244712p.Ala494Ser0.990
embA4244720c.1488C>T0.989
embA4244726p.Asp498Glu0.990
embA4244747c.1515T>C0.979
embA4244761p.Asn510Thr0.917
embA4244765c.1533T>G0.917
embA4244768p.Glu512Asp0.917
embA4244778p.Ser516Thr0.917
embA4244783c.1551C>A0.917
embA4244786c.1554G>C0.917
embA4244843c.1611G>C0.972
embA4244853p.Val541Leu0.972
embA4244856p.Ala542Pro0.972
embA4244919c.1687C>T0.909
embA4244930c.1698G>C0.963
embA4244933c.1701A>C0.889
embA4244945c.1713C>G0.938
embA4244957c.1725C>G0.938
embA4244960c.1728A>G0.938
embA4244978c.1746G>T0.880
embA4244980p.Val583Ala0.880
embA4244982c.1750T>C0.917
embA4244987c.1755T>C0.917
embA4245041c.1809C>G0.818
embA4245042p.Thr604Ser0.833
embA4245053c.1821G>C0.982
embA4245060c.1828T>C0.984
embA4245069p.Val613Leu0.986
embA4245083c.1851A>C0.987
embA4245092c.1860C>G0.988
embA4245101c.1869G>C0.988
embA4245136p.Tyr635Phe0.875
embA4245142p.Ile637Lys0.846
embA4245149c.1917C>G0.786
embA4245152c.1920C>G0.786
embA4245153p.Ile641Leu0.786
embA4245170c.1938G>C0.850
embA4245173c.1941G>C0.850
embA4245174p.Ser648Thr0.850
embA4245183c.1951C>T0.850
embA4245186p.Thr652Val0.850
embA4245192p.Ser654Ala0.850
embA4245206c.1974A>G0.882
embA4245207c.1975T>C0.882
embA4245215c.1983A>C0.882
embA4245216p.Ala662Thr0.882
embA4245222p.Tyr664Gln0.882
embA4245234p.Met668Leu0.892
embA4245241p.Tyr670Phe0.892
embA4245402p.Thr724Ala0.982
embA4245412p.Ser727Thr0.979
embA4245414p.Thr728Ser0.979
embA4245423p.Ser731Ala0.941
embA4245428c.2196C>T0.971
embA4245431c.2199T>C0.971
embA4245445p.Asp738Ala0.980
embA4245452c.2220G>C0.979
embA4245860c.2628C>G1.000
embA4245873p.Lys881Asp1.000
embA4245885p.Asp885Thr1.000
embA4245892p.Ile887Thr1.000
embA4245905c.2673C>G1.000
embA4245915p.Gln895Glu1.000
embA4246013c.2781T>C0.976
embA4246028c.2796G>A0.979
embA4246048p.Ala939Val0.977
embA4246055c.2823T>C0.977
embA4246062p.Tyr944Asp0.974
embA4246076c.2844G>C0.963
embA4246080p.Pro950Ser0.923
embA4246085p.Glu951Asp0.960
embA4246088c.2856A>G0.960
embA4246097c.2865C>G1.000
embA4246109c.2877C>G1.000
embA4246115c.2883T>G1.000
embA4246184c.2952A>C1.000
embA4246187c.2955C>G1.000
embA4246196c.2964C>G1.000
embA4246205c.2973A>G1.000
embA4246250c.3018G>C1.000
embA4246259c.3027G>C1.000
embA4246274c.3042G>C1.000
embA4246278p.Ala1016Ser1.000
embA4246292c.3060A>G1.000
embA42462991023SSST>1023APEA1.000
embA4246309p.Thr1026Asn1.000
embA4246316c.3084T>G1.000
embA4246385c.3153T>C1.000
embA4246401p.Val1057Leu1.000
embA4246408p.Gln1059Arg1.000
embB4246642c.129G>C1.000
embB4246645c.132G>C1.000
embB4246657c.144C>G1.000
embB4246660c.147C>G1.000
embB4247068c.555T>C1.000
embB4247095c.582G>C1.000
embB4247101c.588G>C1.000
embB4247105p.Pro198Ala1.000
embB4247110c.597G>C1.000
embB4247115p.Ala201Glu1.000
embB4247117p.Val202Phe1.000
embB4247122c.609G>C0.912
embB4247125c.612G>C0.912
embB4247144p.Ser211Thr1.000
embB4247390p.Ile293Leu0.957
embB4247398c.885G>C0.957
embB4247401c.888T>C0.978
embB4247404c.891G>C0.978
embB4247407c.894G>C0.979
embB4247437c.924A>T0.983
embB4247455c.942C>G0.982
embB4247462c.949T>A0.980
embB4247470c.957T>C0.980
embB4247476c.963C>G0.980
embB4247491c.978G>C0.979
embB4247497c.984T>C0.955
embB4247500c.987C>G1.000
embB4247512c.999T>C1.000
embB4247527c.1014G>C1.000
embB4247528p.Leu339Trp1.000
embB4247539c.1026T>C1.000
embB4247741p.Leu410Val1.000
embB4247749c.1236G>C1.000
embB4247753p.Val414Ile1.000
embB4247767c.1254G>C1.000
embB4247851c.1338C>G1.000
embB4247890c.1377C>T1.000
embB4247893c.1380C>T1.000
embB4247897p.Met462Leu1.000
embB4247909c.1396T>C1.000
embB4247920c.1407T>C0.900
embB4248064c.1551G>C1.000
embB4248070c.1557T>C1.000
embB4248085c.1572T>C1.000
embB4248097c.1584C>G1.000
embB4248106c.1593C>G1.000
embB4248118c.1605T>G1.000
embB4248133c.1620C>G1.000
embB4248139c.1626C>G1.000
embB4248142c.1629T>C1.000
embB4248157c.1644A>G1.000
embB4248173p.Val554Met1.000
embB4248179p.Ile556Leu1.000
embB4248185c.1672T>C1.000
embB4248194p.Lys561Gly1.000
embB4248199c.1686A>G1.000
embB4248200p.Ile563Val1.000
embB4248206p.Ser565Gly1.000
embB4248214c.1701C>G1.000
embB4248220c.1707A>G1.000
embB4248223c.1710G>T1.000
embB4248232c.1719G>A1.000
embB4248256c.1743C>G1.000
embB4248277c.1764G>C1.000
embB4248304c.1791G>C1.000
embB4248316c.1803C>G1.000
embB4248319c.1806A>G1.000
embB4248322c.1809G>T1.000
embB4248334c.1821C>G1.000
embB4248337c.1824G>A1.000
embB4248341p.Thr610Ala1.000
embB4248355c.1842A>C1.000
embB4248358c.1845C>G1.000
embB4248360p.Pro616Arg1.000
embB4248364c.1851G>A1.000
embB4248375p.Trp621Ser1.000
embB4248377p.Ser622Ala1.000
embB4248397c.1884C>T1.000
embB4248448c.1935C>A1.000
embB4248457c.1944T>C1.000
embB4248472c.1959T>G1.000
embB4248486p.Ser658Asn0.963
embB4248757c.2244A>G1.000
embB4248767p.Asp752Tyr1.000
embB4248772c.2259A>G1.000
embB4248940c.2427C>G0.976
embB4249138c.2625C>G0.880
embB4249158p.Lys882Thr1.000
embB4249168c.2655C>G1.000
embB4249169p.Asn886Tyr1.000
embB4249469p.Leu986Met1.000
embB4249486c.2973T>G1.000
embB4249487p.Leu992Met1.000
embB4249492c.2979C>G1.000
embB4249498c.2985G>C1.000
embB4249510c.2997G>C1.000
ethA4326610c.864G>C1.000
ethA4326620p.His285Arg1.000
ethA4326847c.627G>C1.000
ethA4326868c.606G>C1.000
ethA4326871c.603G>A1.000
ethA4326876p.Lys200Gly1.000
ethA4326877c.597G>C1.000
ethA4326883c.591C>G1.000
ethA4326888p.Asp196Asn1.000
ethA4326903p.Val191Ile0.950
ethA4326904c.570G>C0.905
ethA4326916c.558C>G0.909
ethA4326919c.555T>C0.909
ethA4326925c.549A>G0.913
ethA4326939p.Val179Ile0.857
ethA4326943p.Asn177Lys0.905
ethA4326950p.Ala175Gly0.900
ethA4326953p.Asp174Val0.900
ethA4326970c.504G>C0.931
ethA4326985c.489A>G0.812
ethA4326990p.Ile162Val0.800
ethA4326996p.Pro160Thr0.800
ethA4326997c.477C>G0.800
ethA4327002p.Val158Thr0.800
ethA4327006c.468A>G0.812
ethA4327014p.Ser154Ala0.800
ethA4327020p.Ala152Pro0.850
ethA4327025p.Arg150Thr0.850
ethA4327033c.441G>A0.941
ethA4327036c.438G>C0.946
ethA4327396c.78A>T1.000
ethA4327399p.Asp25Glu1.000
ethA4327408c.66G>A1.000
ethA4327417c.57C>G1.000
ethA4327425p.Val17Ile1.000
ethA4327426c.48A>G1.000
ethA4327435c.39T>G1.000
ethA4327438c.36A>G1.000
ethA4327446p.Val10Ile1.000
ethA4327460p.Leu5His1.000
ethA4327465c.9C>T1.000
ethR4327713c.165T>G0.923
ethR4327719c.171G>C0.923
ethR4327720c.172A>C0.929
ethR4327744p.Pro66Lys0.941
ethR4327755p.Glu69Asp0.933
ethR4328181c.633T>C1.000

Analysis pipeline specifications

TBProfiler Version: 2.1.1

AnalysisProgram
Mappingbwa
Variant CallingBCFtools


Log

Drug Details
The estimated accuracy of drug resistance predictions is:

Drug1Sensitivity (%)Specificity (%)
Isoniazid 92.8 (89.9-95.7)100 (100-100)
Rifampicin 96.2 (93.9-98.5)98.1 (96.8-99.4)
Ethambutal 88.7 (83.6-93.8)81.7 (77.6-85.8)
Pyrazinamide70.9 (62.4-79.4)93.9 (90.6-97.2)
Streptomycin87.1 (82.7-91.5)89.7 (86.0-93.4)
Ethionamide 73.6 (66.7-80.5)93.3 (89.6-97.0)
Moxifloxacin60.0 (29.6-90.4)68.7 (52.6-84.8)
Ofloxacin 85.5 (79.1-91.9)94.9 (91.8-98.0)
Amikacin 82.9 (74.4-91.4)98.3 (96.0-100)
Capreomycin 60.7 (50.6-70.8)90.7 (87.2-94.2)
Kanamycin 87.3 (81.3-93.3)93.4 (89.9-96.9)
Para-aminosalisylic acidNot determinedNot determined
Linezolid Not determinedNot determined
Clofazimine Not determinedNot determined
Bedaquiline Not determinedNot determined
Multi drug resistance91.2 (87.8-94.6)98.4 (97.2-99.6)
Extremely drug resistance75.9 (64.5-87.3)98.4 (97.3-99.5)

Lineages
Lineage2LocationStrainRD type
lineage1Indo-OceanicEAIRD239
lineage1.1Indo-OceanicEAI3;EAI4;EAI5;EAI6RD239
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineage1.1.1.1Indo-OceanicEAI4;ZERORD239
lineage1.1.2Indo-OceanicEAI3;EAI5RD239
lineage1.1.3Indo-OceanicEAI6RD239
lineage1.2Indo-OceanicEAI1;EAI2RD239
lineage1.2.1Indo-OceanicEAI2RD239
lineage1.2.2Indo-OceanicEAI1RD239
lineage2East-AsianBeijingRD105
lineage2.1East-Asian (non-Beijing)NoneNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.2East-Asian (Beijing)Beijing-RD105/RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181
lineage2.2.1.2East-Asian (Beijing)Beijing-RD142RD105;RD207;RD181;RD142
lineage2.2.1.1East-Asian (Beijing)Beijing-RD150RD105;RD207;RD181;RD150
lineage3East-African-IndianCASRD750
lineage3.1East-African-IndianNon-CAS1-DelhiRD750
lineage3.1.1East-African-IndianCAS1-KiliRD750
lineage3.1.2East-African-IndianCAS;CAS2RD750
lineage3.1.2.1East-African-IndianCAS2RD750
lineage3.1.2.2East-African-IndianCASRD750
lineage4Euro-AmericanLAM;T;S;X;HNone
lineage4.1Euro-AmericanT;X;HNone
lineage4.1.2Euro-American (X-type)T;HNone
lineage4.1.2.1Euro-American (X-type)T1;H1RD182
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.2Euro-American (X-type)X1None
lineage4.1.1.1Euro-American (X-type)X2RD183
lineage4.1.1.3Euro-American (Haarlem)X1;X3RD193
lineage4.2Euro-AmericanH;T;LAMNone
lineage4.2.2Euro-American (Ural)T;LAM7-TURNone
lineage4.2.2.1Euro-AmericanLAM7-TURNone
lineage4.2.1Euro-American (TUR)H3;H4None
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.3.1Euro-American (LAM)LAM9None
lineage4.3.3Euro-American (LAM)LAM;TRD115
lineage4.3.4Euro-American (LAM)LAMRD174
lineage4.3.4.1Euro-American (LAM)LAM1;LAM2RD174
lineage4.3.4.2Euro-American (LAM)LAM1;LAM4;LAM11RD174
lineage4.3.4.2.1Euro-American (LAM)LAM11RD174
lineage4.3.2Euro-American (LAM)LAM3None
lineage4.3.2.1Euro-American (LAM)LAM3RD761
lineage4.4Euro-AmericanS;TNone
lineage4.4.2Euro-AmericanT1;T2None
lineage4.4.1Euro-American (S-type)S;TNone
lineage4.4.1.2Euro-AmericanT1None
lineage4.4.1.1Euro-AmericanS;OrphansNone
lineage4.5Euro-AmericanH;TRD122
lineage4.6Euro-AmericanT;LAMNone
lineage4.6.1Euro-American (Uganda)T2RD724
lineage4.6.1.1Euro-American T2-UgandaRD724
lineage4.6.1.2Euro-AmericanT2RD724
lineage4.6.2Euro-AmericanT;LAMRD726
lineage4.6.2.1Euro-AmericanT3RD726
lineage4.6.2.2Euro-American (Cameroon)LAM10-CAMRD726
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.8Euro-American (mainly T)T1;T2;T3;T5RD219
lineage4.9Euro-American (H37Rv-like)T1None
lineage5West-Africa 1AFRI_2;AFRI_3RD711
lineage6West-Africa 2AFRI_1RD702
lineage7Lineage 7NoneNone
lineageBOVM. bovisBOV_1;BOV_2None

Citations
1. Coll F, et al. Rapid determination of anti-tuberculosis drug resistance from whole genome sequences. Genome Medicine (in press)
2. Coll F, et al. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications 2014.

Disclaimer
This tool is for Research Use Only and is offered free for use. The London School of Hygiene and Tropical Medicine shall have no liability for any loss or damages of any kind, however sustained relating to the use of this tool.
© 2019 London School of Hygiene and Tropical Medicine;