TB Profiler
This tool processes raw sequence data to infer strain type and identify known drug resistance markers.
A stand alone version of this tool is now available and can now be run on linux or mac. Installation instructions can be found on GitHub and on the bioconda page.



This tool is for Research Use Only. Data and information provided through use of this tool are not intended for medical purpose or objective and should not be used for clinical diagnosis, patient management, or human clinical trials.
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Single nucleotide polymorphisms (SNPs) in coding regions are annotated using the reference amino acid, codon number and alternative amino acid (e.g. Ser315Thr in katG). SNPs in non-coding regions (i.e. RNA genes and intergenic regions) are annotated using the reference nucleotide, gene coordinate and alternative nucleotide (e.g. A1401G in rrs or C-37A in eis promoter). Indels are annotated using the reference VCF allele, gene coordinate and alternative VCF allele (e.g. T902TA insertion in katG).
Name: 5d77257e64a94
Sample: 5d77257e64a94

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Summary
ID: 5d77257e64a94
Date: Tue Sep 10 05:25:56 2019
Strain: lineageBOV;lineage4.7;lineage4.2.1;lineage1.2.1;lineage4.1.1;lineage4.1.1.1
Drug-resistance: Drug-resistant

Drug1ResistanceSupporting Mutations (frequency)
Isoniazid
Rifampicin
EthambutolRembB p.Tyr384Asn (1.00), embB p.Thr437Ala (1.00)
Pyrazinamide
Streptomycin
Ethionamide
Fluoroquinolones
Amikacin
Capreomycin
Kanamycin

Lineage2FamilyMain SpoligotypeRDS
lineageBOVM. bovisBOV 1;BOV 2None
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.2.1Euro-American (TUR)H3;H4None
lineage1.2.1Indo-OceanicEAI2RD239
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.1Euro-American (X-type)X2RD183

Mutations in candidate genes:
GeneChromosome PositionMutationEstimated fraction
gyrB5238c.-2T>C1.000
gyrB5254c.15A>G1.000
gyrB5284c.45G>A1.000
gyrB5287c.48T>C1.000
gyrB5293c.54C>G1.000
gyrB5302c.63A>G1.000
gyrB5305c.66G>A1.000
gyrB5308c.69G>A1.000
gyrB5326c.87T>C1.000
gyrB5341c.102T>C1.000
gyrB5362c.123T>C1.000
gyrB5363c.124T>C1.000
gyrB5404c.165C>T1.000
gyrB5410c.171G>A1.000
gyrB5422c.183T>C1.000
gyrB5425c.186A>G1.000
gyrB5426p.Thr63Ala1.000
gyrB5431c.192A>C1.000
gyrB5434c.195G>C1.000
gyrB5436p.Asn66Thr1.000
gyrB5440c.201A>G1.000
gyrB5449c.210T>C1.000
gyrB5819c.580C>T1.000
gyrB5824c.585A>G1.000
gyrB5836c.597C>T1.000
gyrB5851c.612G>C1.000
gyrB5869c.630C>T1.000
gyrB5870p.Glu211Gln1.000
gyrB5873c.634A>C1.000
gyrB5878c.639G>C1.000
gyrB5880p.Thr214Ser1.000
gyrB5902c.663A>G1.000
gyrB5926c.687G>C1.000
gyrB6013c.774G>T1.000
gyrB6016c.777C>T1.000
gyrB6022c.783G>C1.000
gyrB6025c.786A>G1.000
gyrB6046c.807C>T1.000
gyrB6049c.810G>C1.000
gyrB6052c.813T>C1.000
gyrB6067c.828G>C1.000
gyrB6073c.834T>C1.000
gyrB6079c.840C>T1.000
gyrB6086p.Thr283Pro1.000
gyrB6091c.852G>C1.000
gyrB6115c.876A>G1.000
gyrB6121c.882C>T1.000
gyrB6130c.891T>C1.000
gyrB6139c.900G>A1.000
gyrB6172c.933C>T1.000
gyrB6178c.939C>T1.000
gyrB6181c.942C>G1.000
gyrB6184c.945C>T1.000
gyrB6196c.957C>G1.000
gyrB6214c.975G>C1.000
gyrB6217c.978G>C1.000
gyrB6247c.1008G>A1.000
gyrB6253c.1014G>C1.000
gyrB6280c.1041T>C1.000
gyrB6286c.1047T>C1.000
gyrB6298c.1059C>G1.000
gyrB6299c.1060C>T1.000
gyrB6307c.1068T>G1.000
gyrB6313c.1074C>T1.000
gyrB6322c.1083G>A1.000
gyrB6331c.1092A>G1.000
gyrB6343c.1104G>A1.000
gyrB6346c.1107C>T1.000
gyrB6676c.1437T>G1.000
gyrB6680c.1441C>T1.000
gyrB6700c.1461T>C1.000
gyrB6703c.1464G>C1.000
gyrB6709c.1470A>G1.000
gyrB6712c.1473G>C1.000
gyrB6728c.1489C>T1.000
gyrB6745c.1506T>C1.000
gyrB6760c.1521G>C1.000
gyrB6769c.1530C>T1.000
gyrB6775c.1536G>A1.000
gyrB6787c.1548G>A1.000
gyrB6808c.1569C>T1.000
gyrB6820c.1581C>T1.000
gyrA7496c.195C>T1.000
gyrA7502c.201C>T1.000
gyrA7523c.222C>A1.000
gyrA7532c.231T>C1.000
gyrA7541c.240C>G1.000
gyrA7556c.255C>T1.000
gyrA7585p.Ser95Thr1.000
gyrA7595c.294C>G1.000
gyrA7601c.300C>G1.000
gyrA7619c.318C>T1.000
gyrA7622c.321C>T1.000
gyrA7631c.330G>C1.000
gyrA7683c.382A>C1.000
gyrA7694c.393A>G1.000
gyrA7710c.409T>C1.000
gyrA7715c.414G>C1.000
gyrA7728c.427A>C1.000
gyrA7763c.462T>C1.000
gyrA7784c.483A>G1.000
gyrA7793c.492G>A1.000
gyrA7799c.498A>G1.000
gyrA7832c.531G>T1.000
gyrA7835c.534A>C1.000
gyrA7859c.558A>C1.000
gyrA7865c.564T>C1.000
gyrA7886c.585T>C1.000
gyrA7889c.588G>A1.000
gyrA7892c.591G>C1.000
gyrA8069c.768T>C1.000
gyrA8121c.820T>C1.000
gyrA8156c.855T>C1.000
gyrA8168c.867A>G1.000
gyrA8294c.993T>C1.000
gyrA8306c.1005C>G1.000
gyrA8310c.1009C>T1.000
gyrA8318c.1017C>A1.000
gyrA8324c.1023T>C1.000
gyrA8339c.1038A>G1.000
gyrA8340p.Ala347Ser1.000
gyrA8375c.1074G>C1.000
gyrA8382p.Leu361Met1.000
gyrA8393c.1092T>C1.000
gyrA8399c.1098T>C1.000
gyrA8402p.Asp367Glu1.000
gyrA8420c.1119T>C1.000
gyrA8421p.Val374Ile1.000
gyrA8433p.Thr378Arg1.000
gyrA8447c.1146C>A1.000
gyrA8450c.1149G>A1.000
gyrA8453c.1152A>C1.000
gyrA8462c.1161A>G1.000
gyrA8480c.1179C>G1.000
gyrA8486c.1185T>C1.000
gyrA8510c.1209G>A1.000
gyrA8513c.1212C>G1.000
gyrA8516c.1215T>C1.000
gyrA8519c.1218A>G1.000
gyrA8546c.1245T>C1.000
gyrA8561c.1260A>G1.000
gyrA8562c.1261C>T1.000
gyrA8573c.1272G>T1.000
gyrA8576c.1275C>G1.000
gyrA8603c.1302A>G1.000
gyrA8609c.1308G>C1.000
gyrA8619c.1318T>C1.000
gyrA8627c.1326C>T1.000
gyrA8628c.1327C>T1.000
gyrA8633c.1332C>G1.000
gyrA8645c.1344C>T1.000
gyrA8655p.Ile452Val1.000
gyrA8711c.1410A>C1.000
gyrA8714c.1413A>G1.000
gyrA8723c.1422G>A1.000
gyrA8729c.1428T>C1.000
gyrA8732c.1431G>C1.000
gyrA8752p.Ala484Gly1.000
gyrA8756c.1455A>G1.000
gyrA8762c.1461G>C1.000
gyrA8767p.Arg489Lys1.000
gyrA8783c.1482G>T1.000
gyrA8786c.1485T>C1.000
gyrA8795c.1494C>T1.000
gyrA8796p.Ile499Val1.000
gyrA8801c.1500G>C1.000
gyrA8810c.1509A>C1.000
gyrA8825c.1524G>A1.000
gyrA8828c.1527T>C1.000
gyrA8829c.1528T>C1.000
gyrA8852c.1551T>C1.000
gyrA8858c.1557T>C1.000
gyrA8870c.1569G>C1.000
gyrA8873c.1572A>C1.000
gyrA8876c.1575C>T1.000
gyrA8882c.1581G>A1.000
gyrA8903c.1602T>C1.000
gyrA8912c.1611G>A1.000
gyrA8915c.1614A>G1.000
gyrA8933c.1632G>A1.000
gyrA8939c.1638T>C1.000
gyrA8942c.1641G>C1.000
gyrA8945c.1644G>T1.000
gyrA8946c.1645T>C1.000
gyrA8981c.1680G>C1.000
gyrA8987c.1686C>G1.000
gyrA8996c.1695T>C1.000
gyrA8998p.Leu566Trp1.000
gyrA9002c.1701C>T1.000
gyrA9003c.1702C>T1.000
gyrA9023c.1722A>C1.000
gyrA9029c.1728T>G1.000
gyrA9032c.1731T>C1.000
gyrA9050p.Asp583Glu1.000
gyrA9056c.1755C>G1.000
gyrA9065c.1764C>G1.000
gyrA9068c.1767G>C1.000
gyrA9071c.1770G>C1.000
gyrA9077c.1776C>G1.000
gyrA9080c.1779G>C1.000
gyrA9089c.1788G>C1.000
gyrA9101c.1800A>G1.000
gyrA9119c.1818A>G1.000
gyrA9197c.1896G>C1.000
gyrA9230c.1929T>C1.000
gyrA9236c.1935G>C1.000
gyrA9242c.1941A>C1.000
gyrA9252p.Val651Ile1.000
gyrA9266c.1965C>T1.000
gyrA9267p.Asn656Gly1.000
gyrA9449c.2148C>G1.000
gyrA9452c.2151G>C1.000
gyrA9455c.2154T>C1.000
rpoB759583c.-224T>G1.000
rpoB759587c.-220T>A1.000
rpoB759606c.-201T>C1.000
rpoB759635c.-172C>T1.000
rpoB759644c.-163T>A1.000
rpoB759647c.-160T>C1.000
rpoB759661c.-146G>C1.000
rpoB759670c.-137C>T1.000
rpoB759671c.-136G>T1.000
rpoB759676c.-131A>G1.000
rpoB760106c.300G>T1.000
rpoB760112c.306T>C1.000
rpoB760118c.312T>C1.000
rpoB760121c.315T>C1.000
rpoB760124c.318C>T1.000
rpoB760130p.Asp108Glu1.000
rpoB760136c.330G>A1.000
rpoB760142c.336C>G1.000
rpoB760172c.366G>C1.000
rpoB760178c.372G>C1.000
rpoB760181c.375T>C1.000
rpoB760184c.378A>G1.000
rpoB760193c.387C>G1.000
rpoB760196c.390C>G1.000
rpoB760202c.396G>A1.000
rpoB760211c.405C>T1.000
rpoB760223c.417T>C1.000
rpoB760235c.429T>C1.000
rpoB760304c.498G>A1.000
rpoB760307c.501T>G1.000
rpoB760325c.519G>C1.000
rpoB760328c.522G>C1.000
rpoB760340c.534G>T1.000
rpoB760343c.537G>C1.000
rpoB760361c.555T>C1.000
rpoB760475c.669A>G1.000
rpoB760481c.675G>C1.000
rpoB760484c.678A>G1.000
rpoB760493c.687C>G1.000
rpoB760497c.691C>T1.000
rpoB760508c.702G>C1.000
rpoB760511c.705G>C1.000
rpoB760528p.Gln241Arg1.000
rpoB760532c.726T>C1.000
rpoB760533p.Val243Thr1.000
rpoB760563p.Arg253Met1.000
rpoB760577c.771G>A1.000
rpoB760580c.774G>A1.000
rpoB760591p.Val262Ala1.000
rpoB760604c.798G>A1.000
rpoB760610c.804G>A1.000
rpoB760611c.805T>C1.000
rpoB760646c.840C>G1.000
rpoB760658c.852G>A1.000
rpoB760661c.855A>C1.000
rpoB760670c.864G>C1.000
rpoB760674c.868T>C1.000
rpoB760679c.873A>G1.000
rpoB760683c.877T>C1.000
rpoB760724c.918T>C1.000
rpoB760730c.924T>C1.000
rpoB760868c.1062C>G1.000
rpoB760916c.1110C>T1.000
rpoB760919c.1113C>G1.000
rpoB760925c.1119T>C1.000
rpoB760928c.1122G>C1.000
rpoB760931c.1125C>G1.000
rpoB760946c.1140A>G1.000
rpoB760971c.1165C>A1.000
rpoB760982c.1176G>C1.000
rpoB760985c.1179G>C1.000
rpoB761006c.1200C>T1.000
rpoB761015c.1209G>C1.000
rpoB761027c.1221A>G1.000
rpoB761030c.1224G>A1.000
rpoB761036c.1230G>C1.000
rpoB761037c.1231T>C1.000
rpoB761051c.1245G>C1.000
rpoB761057c.1251G>A1.000
rpoB761066c.1260G>C1.000
rpoB761096c.1290G>C1.000
rpoB761097c.1291A>T1.000
rpoB761102c.1296A>G1.000
rpoB761132c.1326G>C1.000
rpoB761133c.1327T>C1.000
rpoB761150c.1344A>G1.000
rpoB761153c.1347G>T1.000
rpoB761165c.1359G>C1.000
rpoB761175c.1369C>T1.000
rpoB761180c.1374A>C1.000
rpoB761189c.1383T>G1.000
rpoB761195c.1389G>C1.000
rpoB761201c.1395G>A1.000
rpoB761204c.1398C>G1.000
rpoB761207c.1401C>T1.000
rpoB761210c.1404C>T1.000
rpoB761240c.1434C>T1.000
rpoB761255c.1449T>G1.000
rpoB761261c.1455G>T1.000
rpoB761264c.1458C>G1.000
rpoB761273c.1467T>C1.000
rpoB761318c.1512G>C1.000
rpoB761327c.1521A>G1.000
rpoB761492c.1686G>C1.000
rpoB761502p.Pro566Ala1.000
rpoB761510c.1704T>G1.000
rpoB761528c.1722C>T1.000
rpoB761531c.1725C>G1.000
rpoB761537c.1731C>A1.000
rpoB761561c.1755C>G1.000
rpoB761564c.1758G>C1.000
rpoB761573c.1767C>G1.000
rpoB761579c.1773G>C1.000
rpoB761600c.1794T>G1.000
rpoB761606c.1800C>G1.000
rpoB761612c.1806G>C1.000
rpoB761615c.1809A>C1.000
rpoB761636c.1830G>A1.000
rpoB761645c.1839C>G1.000
rpoB761648c.1842T>C1.000
rpoB761651c.1845C>T1.000
rpoB761657c.1851C>G1.000
rpoB761675c.1869G>C1.000
rpoB761682c.1876C>T1.000
rpoB761687c.1881C>T1.000
rpoB761693c.1887G>C1.000
rpoB761765c.1959T>C1.000
rpoB761772p.His656Ala1.000
rpoB761778p.Asn658Asp1.000
rpoB761791p.Arg662His1.000
rpoB761813c.2007T>C1.000
rpoB761819c.2013G>C1.000
rpoB761822c.2016C>T1.000
rpoB761834c.2028T>C1.000
rpoB761848p.Cys681Ser1.000
rpoB761852c.2046C>G1.000
rpoB761864c.2058G>C1.000
rpoB761867c.2061C>A1.000
rpoB761873c.2067A>G1.000
rpoB761885c.2079T>G1.000
rpoB761891c.2085G>C1.000
rpoB761906c.2100C>G1.000
rpoB761912c.2106T>G1.000
rpoB761913p.Asp703Gln1.000
rpoB761916p.Asp704Asn1.000
rpoB761954c.2148C>G1.000
rpoB761972c.2166C>T1.000
rpoB761990c.2184G>C1.000
rpoB762008c.2202C>G1.000
rpoB762011c.2205G>C1.000
rpoB762017c.2211A>G1.000
rpoB762024p.Val740Ile1.000
rpoB762053c.2247T>C1.000
rpoB762062c.2256T>C1.000
rpoB762065c.2259T>C1.000
rpoB762083c.2277T>C1.000
rpoB762086c.2280G>C1.000
rpoB762114p.Ile770Val1.000
rpoB762131c.2325C>G1.000
rpoB762134c.2328C>G1.000
rpoB762143c.2337T>C1.000
rpoB762149c.2343G>T1.000
rpoB762293c.2487T>C1.000
rpoB762317c.2511A>G1.000
rpoB762338c.2532T>C1.000
rpoB762347c.2541T>C1.000
rpoB762362p.Glu852Asp1.000
rpoB762369c.2563T>C1.000
rpoB762374c.2568G>C1.000
rpoB762380c.2574T>C1.000
rpoB762389c.2583G>A1.000
rpoB762395c.2589G>C1.000
rpoB762398c.2592T>C1.000
rpoB762401c.2595G>C1.000
rpoB762404c.2598T>C1.000
rpoB762410c.2604T>C1.000
rpoB762416c.2610A>G1.000
rpoB762434c.2628T>C1.000
rpoB762449c.2643C>G1.000
rpoB762470c.2664G>C1.000
rpoB762776c.2970C>T1.000
rpoB762782c.2976T>C1.000
rpoB762799p.Ala998Gly1.000
rpoB762812c.3006C>G1.000
rpoB762813p.Met1003Val1.000
rpoB762827c.3021G>C1.000
rpoB762830c.3024C>T1.000
rpoB762836c.3030C>A1.000
rpoB762857c.3051C>G1.000
rpoB762860c.3054G>C1.000
rpoB762890c.3084C>T1.000
rpoB762929c.3123G>C1.000
rpoB762995c.3189G>C1.000
rpoB763028c.3222T>C1.000
rpoB763031c.3225T>G1.000
rpoB763034c.3228C>G1.000
rpoB763040c.3234C>G1.000
rpoB763050c.3244C>T1.000
rpoB763053c.3247T>C1.000
rpoB763070c.3264T>C1.000
rpoB763085c.3279C>G1.000
rpoB763094c.3288G>C1.000
rpoB763115c.3309T>C1.000
rpoB763127c.3321G>C1.000
rpoB763166c.3360A>G1.000
rpoB763169c.3363A>G1.000
rpoB763179c.3373C>T1.000
rpoB763193c.3387C>G1.000
rpoB763202c.3396A>G1.000
rpoB763206c.3400A>T1.000
rpoB763214c.3408T>C1.000
rpoB763226c.3420A>G1.000
rpoB763238c.3432T>C1.000
rpoC763351c.-19T>C1.000
rpoC763352c.-18T>A1.000
rpoC763375c.6C>A1.000
rpoC763402c.33C>T1.000
rpoC763408c.39T>C1.000
rpoC763411c.42T>G1.000
rpoC763414c.45T>C1.000
rpoC763430c.61A>C1.000
rpoC763435c.66A>G1.000
rpoC763444c.75T>C1.000
rpoC763456c.87A>G1.000
rpoC763468c.99G>C1.000
rpoC763486c.117T>C1.000
rpoC763501c.132C>T1.000
rpoC763505c.136C>T1.000
rpoC763546c.177A>G1.000
rpoC763600c.231C>T1.000
rpoC763606c.237C>T1.000
rpoC763633c.264T>C1.000
rpoC763636c.267T>G1.000
rpoC763639c.270G>A1.000
rpoC763658c.289C>T1.000
rpoC763666c.297G>A1.000
rpoC763696c.327T>C1.000
rpoC763702c.333C>G1.000
rpoC763708c.339G>C1.000
rpoC763714c.345G>C1.000
rpoC763717c.348T>C1.000
rpoC763732c.363C>G1.000
rpoC763735c.366G>C1.000
rpoC763744c.375G>C1.000
rpoC763765c.396T>C1.000
rpoC763774c.405G>A1.000
rpoC763781p.Ser138Ala1.000
rpoC763789c.420C>T1.000
rpoC763792p.Glu141Asp1.000
rpoC763801c.432C>G1.000
rpoC763807c.438T>C1.000
rpoC763813c.444C>G1.000
rpoC763819c.450G>C1.000
rpoC763835p.Ala156Thr1.000
rpoC763904p.Ala179Thr1.000
rpoC763916p.Glu183Gln1.000
rpoC763945c.576T>C1.000
rpoC763948c.579G>C1.000
rpoC763987c.618C>T1.000
rpoC763991p.Ile208Leu1.000
rpoC763996c.627T>C1.000
rpoC764005c.636G>C1.000
rpoC764011c.642T>C1.000
rpoC764024c.655T>C1.000
rpoC764040p.Ser224Asn1.000
rpoC764044c.675T>C1.000
rpoC764062c.693C>A1.000
rpoC764083c.714A>G1.000
rpoC764101c.732C>G1.000
rpoC764102p.Val245Gln1.000
rpoC764110c.741C>T1.000
rpoC764119c.750G>A1.000
rpoC764131c.762T>C1.000
rpoC764140c.771C>T1.000
rpoC764161c.792G>C1.000
rpoC764203c.834G>T1.000
rpoC764206p.Asp279Glu1.000
rpoC764217p.Asn283Ser1.000
rpoC764230c.861G>A1.000
rpoC764242c.873C>T1.000
rpoC764254c.885G>T1.000
rpoC764266c.897T>G1.000
rpoC764272c.903G>T1.000
rpoC764278c.909A>G1.000
rpoC764284c.915G>C1.000
rpoC764308c.939G>C1.000
rpoC764311c.942C>G1.000
rpoC764344c.975C>T1.000
rpoC764365c.996C>T1.000
rpoC764371c.1002G>C1.000
rpoC764374c.1005C>T1.000
rpoC764380c.1011G>C1.000
rpoC764381c.1012T>A1.000
rpoC764387c.1018T>C1.000
rpoC764398c.1029G>C1.000
rpoC764405c.1036A>C1.000
rpoC764410c.1041G>A1.000
rpoC764431c.1062G>C1.000
rpoC764434c.1065A>G1.000
rpoC764435c.1066A>C1.000
rpoC764449c.1080G>C1.000
rpoC764452c.1083T>C1.000
rpoC764458c.1089G>C1.000
rpoC764461c.1092A>G1.000
rpoC764497c.1128A>G1.000
rpoC764500c.1131C>G1.000
rpoC764521c.1152T>C1.000
rpoC764536c.1167G>T1.000
rpoC764539c.1170C>G1.000
rpoC764566c.1197C>G1.000
rpoC764611c.1242G>T1.000
rpoC764648c.1279C>A1.000
rpoC764653c.1284G>C1.000
rpoC764656c.1287C>G1.000
rpoC764668c.1299C>T1.000
rpoC764681c.1312C>T1.000
rpoC764714c.1345C>T1.000
rpoC764720c.1351C>T1.000
rpoC764746c.1377G>T1.000
rpoC764752c.1383G>C1.000
rpoC764764c.1395T>C1.000
rpoC764791c.1422C>G1.000
rpoC764800c.1431G>A1.000
rpoC764803c.1434C>T1.000
rpoC764809c.1440C>T1.000
rpoC764815c.1446A>G1.000
rpoC764833c.1464A>G1.000
rpoC764869c.1500C>G1.000
rpoC764872c.1503A>G1.000
rpoC764888c.1519T>C1.000
rpoC764893c.1524T>C1.000
rpoC764902c.1533C>G1.000
rpoC764911c.1542A>G1.000
rpoC764918p.Val517Ile1.000
rpoC764923c.1554A>G1.000
rpoC764932c.1563C>G1.000
rpoC764938c.1569G>A1.000
rpoC764948c.1579T>C1.000
rpoC764968c.1599T>C1.000
rpoC765007c.1638T>G1.000
rpoC765011c.1642A>T0.909
rpoC765019c.1650A>G1.000
rpoC765022c.1653G>C1.000
rpoC765034c.1665T>A1.000
rpoC765040c.1671T>C1.000
rpoC765041c.1672T>C1.000
rpoC765047c.1678T>C1.000
rpoC765052c.1683C>A1.000
rpoC765076c.1707A>T1.000
rpoC765079c.1710T>G1.000
rpoC765082c.1713G>T1.000
rpoC765085c.1716T>C1.000
rpoC765122c.1753C>T1.000
rpoC765131c.1762C>T1.000
rpoC765383p.Met672Leu1.000
rpoC765405p.Leu679Pro1.000
rpoC765409c.2040T>C1.000
rpoC765421c.2052C>G1.000
rpoC765445c.2076G>T1.000
rpoC765454c.2085C>G1.000
rpoC765496c.2127C>G1.000
rpoC765499c.2130C>G1.000
rpoC765526c.2157C>A1.000
rpoC765529c.2160C>G1.000
rpoC765535c.2166C>T1.000
rpoC765541c.2172C>A1.000
rpoC765547c.2178C>A1.000
rpoC765553c.2184C>T1.000
rpoC765556c.2187G>C1.000
rpoC765562c.2193G>C1.000
rpoC765583c.2214G>T1.000
rpoC765586c.2217G>A1.000
rpoC765589c.2220G>C1.000
rpoC765612p.His748Arg1.000
rpoC765622p.Glu751Asp1.000
rpoC765628c.2259G>C1.000
rpoC765658c.2289C>T1.000
rpoC765676c.2307G>A1.000
rpoC765688c.2319G>C1.000
rpoC765689c.2320C>T1.000
rpoC765700c.2331T>C1.000
rpoC765724c.2355C>G1.000
rpoC765727c.2358T>C1.000
rpoC765734c.2365T>C1.000
rpoC765748c.2379C>T1.000
rpoC765752p.Asp795Ser1.000
rpoC765760c.2391C>T1.000
rpoC765784c.2415C>G1.000
rpoC765787c.2418C>T1.000
rpoC765793c.2424C>G1.000
rpoC765796c.2427C>T1.000
rpoC765811c.2442T>C1.000
rpoC765814c.2445A>G1.000
rpoC765826c.2457T>G1.000
rpoC765835c.2466C>T1.000
rpoC765850c.2481G>C1.000
rpoC765883c.2514C>G1.000
rpoC765886c.2517C>G1.000
rpoC765934c.2565C>T1.000
rpoC765952c.2583G>C1.000
rpoC765967c.2598C>T1.000
rpoC765979c.2610C>G1.000
rpoC765994c.2625A>T0.969
rpoC766018c.2649C>T1.000
rpoC766021c.2652G>C1.000
rpoC766043p.Gln892Gly1.000
rpoC766063c.2694C>G1.000
rpoC766082p.Ala905Gln0.933
rpoC766084r.2715a>ag1.000
rpoC766093c.2724C>T1.000
rpoC766094p.Thr909Ala1.000
rpoC766114c.2745C>T1.000
rpoC766270c.2901G>C1.000
rpoC766273c.2904T>C1.000
rpoC766274p.Ala969Thr1.000
rpoC766280p.Ser971Gly1.000
rpoC766300c.2931C>G1.000
rpoC766303c.2934C>T1.000
rpoC766306c.2937C>T1.000
rpoC766312c.2943T>C1.000
rpoC766315c.2946C>G1.000
rpoC766351c.2982C>G1.000
rpoC766357c.2988C>T1.000
rpoC766360c.2991C>T1.000
rpoC766375c.3006C>G1.000
rpoC766378c.3009C>T1.000
rpoC766381c.3012C>T1.000
rpoC766384c.3015A>G1.000
rpoC766387c.3018C>G1.000
rpoC766397c.3028C>T1.000
rpoC766408c.3039C>T1.000
rpoC766426c.3057C>T1.000
rpoC766447c.3078T>C1.000
rpoC766456c.3087C>A1.000
rpoC766486c.3117A>G1.000
rpoC766492c.3123T>C1.000
rpoC766528c.3159T>C1.000
rpoC766534c.3165C>G1.000
rpoC766537c.3168G>A1.000
rpoC766543c.3174C>T1.000
rpoC766549c.3180G>T1.000
rpoC766666c.3297C>T1.000
rpoC766672c.3303T>C1.000
rpoC766726c.3357T>C1.000
rpoC766741c.3372G>C1.000
rpoC766747c.3378C>T1.000
rpoC766765c.3396A>C1.000
rpoC766774c.3405T>C1.000
rpoC766792c.3423C>G1.000
rpoC766798c.3429C>G1.000
rpoC766801c.3432C>G1.000
rpoC766804c.3435A>G1.000
rpoC766843c.3474T>G1.000
rpoC766864c.3495G>C1.000
rpoC766894c.3525T>C1.000
rpoC766895c.3526T>C1.000
rpoC766900c.3531T>C1.000
rpoC766907c.3538C>T1.000
rpoC766915c.3546C>T1.000
rpoC766918c.3549C>T1.000
rpoC766921c.3552G>C1.000
rpoC766933c.3564A>G1.000
rpoC766945c.3576A>G1.000
rpoC766963c.3594T>C1.000
rpoC766972c.3603G>C1.000
rpoC766996c.3627C>T1.000
rpoC767032c.3663G>T1.000
rpoC767035c.3666G>T1.000
rpoC767059c.3690T>C1.000
rpoC767062c.3693C>G1.000
rpoC767086c.3717C>T1.000
rpoC767098c.3729T>C1.000
rpoC767119c.3750A>G1.000
rpoC767167c.3798C>G1.000
rpoC767170c.3801C>T1.000
rpoC767203c.3834C>G1.000
rpoC767209c.3840T>C1.000
rpoC767221c.3852C>G1.000
rpoC767233c.3864T>C1.000
rpsL781571c.12C>T1.000
rpsL781608p.Ser17Ala1.000
rpsL781628c.69T>C1.000
rpsL781631c.72G>C1.000
rpsL781649c.90T>C1.000
rpsL781655c.96T>C1.000
rpsL781658c.99A>G1.000
rpsL781667c.108C>G1.000
rpsL781709c.150G>C1.000
rpsL781715c.156T>C1.000
rpsL781718c.159C>G1.000
rpsL781721c.162C>G1.000
rpsL781728c.169T>C1.000
rpsL781742c.183C>T1.000
rpsL781760c.201T>C1.000
rpsL781808c.249C>A1.000
rpsL781832c.273T>C1.000
rpsL781838c.279G>T1.000
rpsL781841c.282C>G1.000
rpsL781847c.288G>A1.000
rpsL781865c.306G>C1.000
rpsL781868c.309T>C1.000
rpsL781871c.312G>C1.000
rpsL781877c.318T>A1.000
rpsL781880c.321C>G1.000
rpsL781892c.333A>G1.000
rpsL781898c.339A>T1.000
rpsL781916c.357T>C1.000
rpsL781929p.Gly124Ser1.000
rplC800796c.-13A>T1.000
rplC800797c.-12T>C1.000
rplC800799c.-10GGA>G1.000
rplC800844c.36T>C1.000
rplC800865c.57A>G1.000
rplC800867p.Ser20Asn1.000
rplC800877c.69A>C1.000
rplC800889c.81C>A1.000
rplC800901c.93C>G1.000
rplC800904c.96G>C1.000
rplC800907c.99C>G1.000
rplC800913c.105G>C1.000
rplC800916c.108A>G1.000
rplC800919c.111C>G1.000
rplC800934c.126C>G1.000
rplC800937c.129A>G1.000
rplC800946c.138T>C1.000
rplC800949c.141T>C1.000
rplC800970c.162T>C1.000
rplC800976c.168G>A1.000
rplC801174c.366T>C1.000
rplC801216c.408C>A1.000
rplC801219c.411C>T1.000
rplC801220p.Ser138Ala1.000
rplC801246c.438C>G1.000
rplC801252c.444G>C1.000
rplC801267c.459A>T1.000
rplC801270c.462T>C1.000
rplC801276c.468G>C1.000
rplC801312c.504G>C1.000
rplC801333c.525G>A1.000
rplC801339c.531T>G1.000
rplC801341p.Leu178Gln1.000
rplC801348c.540T>G1.000
rplC801357c.549T>C1.000
rplC801372c.564G>A1.000
rplC801375c.567C>T1.000
rplC801385c.577C>T1.000
rplC801405c.597T>C1.000
rplC801417c.609T>C1.000
rplC801423c.615G>C1.000
rplC801426c.618C>G1.000
rplC801438c.630T>C1.000
rrs1471922r.77gt>g1.000
rrs1471925r.80t>c1.000
rrs1471931r.86ga>g1.000
rrs1471934r.89a>g1.000
rrs1471969r.124t>c1.000
rrs1471970r.125g>a1.000
rrs1471984r.139t>a1.000
rrs1471985r.140t>c1.000
rrs1472030r.185g>t1.000
rrs1472031r.186g>t1.000
rrs1472033r.188a>g1.000
rrs1472034r.189t>c1.000
rrs1472040r.195t>c1.000
rrs1472053r.208agc>a1.000
rrs1472061r.216a>t1.000
rrs1472075r.230a>g1.000
rrs1472307r.462c>g1.000
rrs1472969r.1124a>g1.000
rrs1472970r.1125c>g1.000
rrs1472977r.1132g>c1.000
rrs1472978r.1133t>c1.000
rrs1473120r.1275c>ct0.949
rrs1473123r.1278a>t1.000
rrl1473399c.-259A>G1.000
rrl1473401c.-257G>A1.000
rrl1473403c.-255C>T1.000
rrl1473417c.-241C>T1.000
rrl1473419c.-239T>C1.000
rrl1473421c.-237G>A1.000
rrl1473437c.-221T>C1.000
rrl1473449c.-209G>A1.000
rrl1473454c.-204A>G1.000
rrl1473493c.-165G>A1.000
rrl1473517c.-141A>G1.000
rrl1473523c.-135T>G1.000
rrl1473528c.-130G>C1.000
rrl1473541c.-117G>A1.000
rrl1473542c.-116C>T1.000
rrl1473571c.-87C>T1.000
rrl1473600c.-58A>G1.000
rrl1473603c.-55C>T1.000
rrl1473609c.-49G>C1.000
rrl1473613c.-45G>C1.000
rrl1473614c.-44C>G1.000
rrl1473626c.-32C>CT1.000
rrl1473635c.-23A>ATTT1.000
rrl1473648c.-10TTTG>T1.000
rrl1473731r.74t>a1.000
rrl1473806r.149c>t1.000
rrl1473832r.175c>t1.000
rrl1473877r.220g>a1.000
rrl1473887r.230t>a1.000
rrl1473888r.231t>a1.000
rrl1473898r.241c>t1.000
rrl1473924r.267a>at1.000
rrl1473980r.323a>at0.912
rrl1473981r.324g>c1.000
rrl1473995r.338g>t1.000
rrl1474002r.345g>a1.000
rrl1474009r.352a>g1.000
rrl1474034r.377g>a1.000
rrl1474083r.426c>t1.000
rrl1474103r.446a>t1.000
rrl1474140r.483c>t1.000
rrl1474151r.494c>t1.000
rrl1474286r.629ct>c1.000
rrl1474292r.635ttcctctccggagga>t1.000
rrl1474308r.651g>t1.000
rrl1474310r.653t>g1.000
rrl1474362r.705a>g1.000
rrl1474374r.717t>a1.000
rrl1474376r.719t>c1.000
rrl1474417r.760a>t1.000
rrl1474428r.771c>t1.000
rrl1474430r.773c>a1.000
rrl1474437r.780gaa>g1.000
rrl1474632r.975g>t1.000
rrl1474639r.982g>a1.000
rrl1474673r.1016t>c1.000
rrl1474717r.1060a>t1.000
rrl1474794r.1137c>a1.000
rrl1474831r.1174a>g1.000
rrl1474950r.1293g>a1.000
rrl1474961r.1304t>g1.000
rrl1474962r.1305t>c1.000
rrl1474964r.1307t>a1.000
rrl1475006r.1349a>g1.000
rrl1475028r.1371g>a1.000
rrl1475061r.1404c>t1.000
rrl1475213r.1556c>t1.000
rrl1475266r.1609t>c1.000
rrl1475273r.1616t>g1.000
rrl1475289r.1632g>a1.000
rrl1475290r.1633a>g1.000
rrl1475291r.1634a>c1.000
rrl1475315r.1658a>t1.000
rrl1475333r.1676t>c1.000
rrl1475355r.1698c>t1.000
rrl1475369r.1712g>a1.000
rrl1475401r.1744ac>a1.000
rrl1475429r.1772g>a1.000
rrl1475483r.1826c>t1.000
rrl1475526r.1869c>a1.000
rrl1475603r.1946g>a1.000
rrl1475608r.1951t>c1.000
rrl1475638r.1981c>t1.000
rrl1475659r.2002g>a1.000
rrl1475758r.2101ac>a1.000
rrl1475765r.2108ag>a1.000
rrl1475988r.2331a>g1.000
rrl1476035r.2378g>a1.000
rrl1476086r.2429g>a1.000
rrl1476089r.2432t>c1.000
rrl1476095r.2438c>g1.000
rrl1476115r.2458t>c1.000
rrl1476117r.2460g>c1.000
rrl1476214r.2557g>a1.000
rrl1476224r.2567a>g1.000
rrl1476251r.2594t>c1.000
rrl1476281r.2624t>c1.000
rrl1476297r.2640c>t1.000
rrl1476299r.2642c>t1.000
rrl1476529r.2872a>g0.958
rrl1476580r.2923g>a1.000
rrl1476597r.2940g>a1.000
rrl1476619r.2962c>t1.000
rrl1476628r.2971t>a1.000
rrl1476679r.3022t>c1.000
rrl1476726r.3069a>g1.000
rrl1476750r.3093t>c1.000
rrl1476759r.3102t>a1.000
rrl1476770r.3113t>c1.000
rrl1476771r.3114g>a1.000
fabG11673871c.432C>T1.000
fabG11673892c.453C>G1.000
fabG11673901c.462A>G1.000
fabG11673916c.477A>T1.000
fabG11673922c.483T>C1.000
fabG11673946c.507C>A1.000
fabG11673955c.516G>C1.000
fabG11673960p.Ala174Val1.000
fabG11673982c.543G>C1.000
fabG11673991c.552C>T1.000
fabG11674015c.576C>A1.000
fabG11674018c.579G>C1.000
fabG11674024c.585T>C1.000
fabG11674033c.594T>C1.000
fabG11674037p.Gln200Glu1.000
fabG11674045c.606G>A1.000
fabG11674054c.615T>C1.000
fabG11674060c.621A>G1.000
fabG11674079p.Pro214Ala1.000
fabG11674096c.657G>C1.000
fabG11674114c.675T>G1.000
inhA1674501c.300G>A1.000
inhA1674503p.Thr101Ser1.000
inhA1674513c.312C>T1.000
inhA1674542p.Ala114Glu1.000
inhA1674546c.345T>C1.000
inhA1674558c.357C>T1.000
inhA1674570c.369G>C1.000
inhA1674576c.375T>C1.000
inhA1674579c.378G>C1.000
inhA1674582c.381T>C1.000
inhA1674594c.393C>A1.000
inhA1674609c.408G>C1.000
inhA1674618c.417C>T1.000
inhA1674620p.Pro140Arg1.000
inhA1674624c.423A>T1.000
inhA1674627c.426T>C1.000
inhA1674702c.501G>A1.000
inhA1674703c.502T>C1.000
rpsA1833512c.-30AC>A1.000
rpsA1833516c.-26A>G1.000
rpsA1833554p.Thr5Ala1.000
rpsA1833589c.48A>T1.000
rpsA1833595c.54T>C1.000
rpsA1833596c.55A>T1.000
rpsA1833613c.72C>A1.000
rpsA1833661c.120A>G1.000
rpsA1833724c.183C>G1.000
rpsA1833727c.186G>C1.000
rpsA1833745c.204G>C1.000
rpsA1833790c.249T>C1.000
rpsA1833794p.Glu85Lys1.000
rpsA1833802c.261A>G1.000
rpsA1833841c.300C>G1.000
rpsA1833847c.306C>G1.000
rpsA1833850c.309C>G1.000
rpsA1833856c.315A>G1.000
rpsA1833862c.321G>C1.000
rpsA1833874c.333T>C1.000
rpsA1833877c.336C>T1.000
rpsA1833928c.387G>C1.000
rpsA1833940c.399C>T1.000
rpsA1833979c.438T>C1.000
rpsA1834000c.459G>C1.000
rpsA1834015c.474G>C1.000
rpsA1834024c.483G>A1.000
rpsA1834030c.489C>G1.000
rpsA1834051c.510G>A1.000
rpsA1834093c.552G>C1.000
rpsA1834099c.558C>G1.000
rpsA1834102c.561T>A1.000
rpsA1834105c.564C>G1.000
rpsA1834144c.603G>A1.000
rpsA1834148c.607C>T1.000
rpsA1834153c.612T>C1.000
rpsA1834154p.Asn205Gln1.000
rpsA1834157c.616T>C1.000
rpsA1834162c.621A>G1.000
rpsA1834165c.624A>G1.000
rpsA1834177c.636A>C1.000
rpsA1834183c.642T>C1.000
rpsA1834186c.645C>G1.000
rpsA1834189c.648G>C1.000
rpsA1834213c.672G>C1.000
rpsA1834249c.708T>C1.000
rpsA1834255c.714C>G1.000
rpsA1834261c.720A>G1.000
rpsA1834264c.723G>C1.000
rpsA1834297c.756C>G1.000
rpsA1834303c.762T>G1.000
rpsA1834306c.765T>C1.000
rpsA1834336c.795C>G1.000
rpsA1834339c.798C>T1.000
rpsA1834345c.804C>T1.000
rpsA1834348c.807T>C1.000
rpsA1834366c.825A>G1.000
rpsA1834369c.828C>G1.000
rpsA1834375c.834G>A1.000
rpsA1834396c.855G>C1.000
rpsA1834411c.870T>C1.000
rpsA1834423c.882G>C1.000
rpsA1834451c.910T>C1.000
rpsA1834456c.915T>G1.000
rpsA1834468c.927A>G1.000
rpsA1834489c.948T>C1.000
rpsA1834495c.954G>A1.000
rpsA1834546c.1005T>C1.000
rpsA1834564c.1023C>T1.000
rpsA1834585c.1044C>T1.000
rpsA1834594c.1053C>T1.000
rpsA1834598c.1057C>T1.000
rpsA1834609c.1068T>C1.000
rpsA1834615c.1074C>T1.000
rpsA1834633c.1092A>G1.000
rpsA1834639c.1098T>C1.000
rpsA1834672c.1131G>A1.000
rpsA1834690c.1149T>C1.000
rpsA1834733p.Ala398Pro1.000
rpsA1834738p.Glu399Asp1.000
rpsA1834747c.1206A>G1.000
rpsA1834751p.Leu404Met1.000
rpsA1834765p.Glu408Asp1.000
rpsA1834766p.Lys409Ala1.000
rpsA1834775p.Ala412Thr1.000
rpsA1834789c.1248T>C1.000
rpsA1834792c.1251G>C1.000
rpsA1834810c.1269C>G1.000
rpsA1834813c.1272G>C1.000
rpsA1834846c.1305C>T0.909
rpsA1834852c.1311C>G1.000
kasA2518132c.18C>T1.000
kasA2518146p.Phe11Tyr0.929
kasA2518162c.48G>A1.000
kasA2518248p.Ala45Val1.000
kasA2518252c.138C>T1.000
kasA2518261c.147G>A1.000
kasA2518279c.165T>C1.000
kasA2518283p.Ala57Pro1.000
kasA2518300c.186T>C1.000
kasA2518513c.399C>G1.000
kasA2518519c.405G>C1.000
kasA2518534c.420G>C1.000
kasA2518537c.423C>G1.000
kasA2518561c.447T>C1.000
kasA2518567c.453G>C1.000
kasA2518573c.459G>C0.923
kasA2518574p.Ile154Val1.000
kasA2518579c.465T>C1.000
kasA2518588c.474T>C1.000
kasA2518591c.477G>C1.000
kasA2518603c.489G>C1.000
kasA2518609p.Met165Ile1.000
kasA2518627c.513T>C1.000
kasA2518633c.519G>A1.000
kasA2518642c.528A>G1.000
kasA2518645c.531G>C1.000
kasA2518648c.534C>T1.000
kasA2518672c.558G>C1.000
kasA2518714c.600A>T1.000
kasA2518990c.876T>A1.000
kasA2518993c.879C>G1.000
kasA2519008c.894C>G0.938
kasA2519011c.897G>C0.933
kasA2519059c.945G>A1.000
kasA2519062c.948T>G1.000
kasA2519071c.957C>T1.000
kasA2519074c.960C>T1.000
kasA2519077c.963G>C1.000
ahpC2726243c.51T>G1.000
ahpC2726244c.52C>T1.000
ahpC2726255c.63T>C1.000
ahpC2726258c.66C>T1.000
ahpC2726264c.72C>G1.000
ahpC2726303c.111T>C1.000
ahpC2726312c.120T>C1.000
ahpC2726315p.Asp41Glu1.000
ahpC2726318p.Glu42Asp1.000
ahpC2726324c.132A>C1.000
ahpC2726336c.144G>C1.000
ahpC2726348c.156T>C1.000
ahpC2726354c.162G>C1.000
ahpC2726357c.165A>G1.000
ahpC2726366c.174G>C1.000
ahpC2726378c.186T>G1.000
folC2747071c.528G>A1.000
folC2747086c.513T>C1.000
folC2747089c.510C>G1.000
folC2747107c.492C>G1.000
folC2747110c.489A>G1.000
folC2747113c.486G>C1.000
folC2747116c.483C>G1.000
folC2747221c.378C>T1.000
folC2747230c.369G>C1.000
folC2747236c.363C>G1.000
folC2747239c.360A>G1.000
folC2747263c.336G>T1.000
folC2747275c.324A>G1.000
folC2747289p.Pro104Val1.000
folC2747290c.309T>C1.000
folC2747302c.297T>C1.000
folC2747314c.285T>G1.000
thyX3067655c.291C>G1.000
thyX3067661c.285G>C1.000
thyX3067673c.273G>A1.000
thyX3067682c.264C>T1.000
thyX3067685c.261T>C1.000
thyX3067691c.255G>A1.000
thyX3067694c.252C>T1.000
thyX3067718c.228G>C1.000
thyX3067721c.225A>G1.000
thyX3067727c.219T>G1.000
thyX3067742c.204T>G1.000
thyX3067762p.Arg62Lys1.000
thyX3067775c.171G>A1.000
thyX3067781c.165G>C1.000
thyX3067793c.153A>G1.000
thyA3074001c.471G>C1.000
thyA3074004c.468A>G1.000
thyA3074040c.432C>T1.000
thyA3074053p.Arg140Gln1.000
thyA3074057p.Glu139Pro1.000
thyA3074061p.Glu137Asp1.000
thyA3074091c.381G>C1.000
thyA3074094c.378C>G1.000
thyA3074118c.354C>T1.000
thyA3074123p.Asp117Asn1.000
thyA3074127c.345C>G1.000
thyA3074130c.342C>G1.000
thyA3074397c.75T>G1.000
thyA3074409c.63G>A1.000
thyA3074423p.Pro17Ala1.000
thyA3074426p.Thr16Ser1.000
thyA3074436c.36G>A1.000
thyA3074444p.Phe10Leu1.000
thyA3074453c.19G>A1.000
fbiA3640269c.-274A>C1.000
fbiA3640282c.-261C>G1.000
fbiA3640298c.-245A>G1.000
fbiA3640300c.-243A>G1.000
fbiA3640318c.-225A>T1.000
fbiA3640365c.-178C>G1.000
fbiA3641286c.744C>G1.000
fbiA3641288p.Glu249Gly1.000
fbiA3641292c.750G>A1.000
fbiA3641314p.Thr258Ala1.000
fbiA3641319c.777C>T1.000
fbiA3641328c.786T>G1.000
fbiA3641329p.Ile263Leu1.000
fbiA3641352c.810C>G1.000
fbiA3641355c.813T>G1.000
alr3840206c.1215A>G1.000
alr3840230c.1191A>C1.000
alr3840233c.1188T>C1.000
alr3840236c.1185T>G1.000
alr3840275c.1146A>C1.000
embC4240726c.864G>C1.000
embC4240741c.879C>T1.000
embC4240777c.915G>A1.000
embC4240780c.918T>C1.000
embC4240783c.921G>C1.000
embC4240789c.927T>C1.000
embC4240795c.933C>G1.000
embC4240801c.939C>T1.000
embC4240828c.966G>A1.000
embC4240831c.969T>C1.000
embC4240858c.996G>A1.000
embC4240859p.Leu333Met1.000
embC4240867c.1005T>G1.000
embC4240870c.1008T>C1.000
embC4241017c.1155T>C1.000
embC4241023c.1161T>G1.000
embC4241026c.1164C>G1.000
embC4241039p.Asp393Asn1.000
embC4241050c.1188T>G1.000
embC4241056c.1194C>G1.000
embC4241086c.1224G>C1.000
embC4241095c.1233C>T1.000
embC4241107c.1245G>C1.000
embC4241140c.1278A>G1.000
embC4241153p.Ile431Leu1.000
embC4241161c.1299C>G1.000
embC4241162c.1300T>C1.000
embC4241167c.1305C>G1.000
embC4241173c.1311C>T1.000
embC4241179c.1317G>A1.000
embC4241182c.1320G>C1.000
embC4241185c.1323G>C1.000
embC4241203c.1341T>C1.000
embC4241218c.1356G>C1.000
embC4241230c.1368A>G1.000
embC4241380c.1518A>C1.000
embC4241383c.1521G>C1.000
embC4241392c.1530G>C1.000
embC4241449c.1587C>G1.000
embC4241617c.1755G>A1.000
embC4241626c.1764T>C1.000
embC4241644c.1782G>C1.000
embC4241648c.1786T>C1.000
embC4241653c.1791C>G1.000
embC4241656c.1794G>C1.000
embC4241659c.1797G>A1.000
embC4241671c.1809T>G1.000
embC4241689c.1827G>C1.000
embC4241692c.1830C>G1.000
embC4241695c.1833T>G1.000
embC4241704c.1842C>G1.000
embC4241707c.1845G>C1.000
embC4241710c.1848G>A1.000
embC4241713c.1851G>C1.000
embC4241719c.1857G>C1.000
embC4241741p.Val627Ile1.000
embC4241750p.Leu630Met1.000
embC4241755c.1893C>G1.000
embC4241761c.1899G>C1.000
embC4242245p.Thr795Ser1.000
embC4242271c.2409A>G1.000
embC4242274c.2412G>C1.000
embC4242277c.2415T>C1.000
embC4242283c.2421T>C1.000
embC4242287p.Leu809Ile1.000
embC4242305p.Ile815Phe1.000
embC4242315p.Ser818Thr1.000
embC4242320p.Pro820Ala1.000
embC4242334c.2472G>C1.000
embC4242343c.2481G>C1.000
embC4242355c.2493A>G1.000
embC4242886c.3024G>A1.000
embC4242919c.3057A>G1.000
embA4243228c.-5G>C1.000
embA4243240p.His3Leu1.000
embA4243271c.39A>C1.000
embA4243279p.Ala16Val1.000
embA4244070p.Val280Ile1.000
embA4244078c.846G>C1.000
embA4244084c.852C>G1.000
embA4244087c.855G>C1.000
embA4244102c.870A>C1.000
embA4244117c.885G>C1.000
embA4244120c.888T>C1.000
embA4244129c.897G>C1.000
embA4244340p.Ser370Ala1.000
embA4244345c.1113C>G1.000
embA4244372c.1140T>C1.000
embA4244387c.1155C>T1.000
embA4244390c.1158G>C1.000
embA4244408c.1176G>C1.000
embA4244415c.1183T>C1.000
embA4244780c.1548C>G1.000
embA4244802p.Leu524Met1.000
embA4245047c.1815G>C1.000
embA4245051p.Val607Ile1.000
embA4245083c.1851A>C1.000
embA4245086c.1854C>T1.000
embA4245098c.1866C>T1.000
embA4245101c.1869G>C1.000
embA4245125c.1893G>C1.000
embA4245137c.1905T>C1.000
embA4245149c.1917C>G1.000
embA4245182c.1950T>C1.000
embA4245185c.1953G>T1.000
embA4245186p.Thr652Ala1.000
embA4245195p.Ile655Val1.000
embA4245200c.1968C>G1.000
embA4245206c.1974A>C1.000
embA4245207c.1975T>C1.000
embA4245215c.1983A>C1.000
embA4245224c.1992T>C1.000
embA4245257c.2025A>G1.000
embA4245263c.2031A>G1.000
embA4245281c.2049C>G1.000
embA4245282p.Ile684Val1.000
embA4245285c.2053T>C1.000
embA4245293c.2061T>G1.000
embA4245296c.2064G>C1.000
embA4245299c.2067A>G1.000
embA4245623c.2391G>C1.000
embA4246064c.2832T>C1.000
embA4246070c.2838G>C1.000
embA4246082c.2850T>C1.000
embA4246097c.2865C>G1.000
embA4246109c.2877C>G1.000
embA4246115c.2883T>C1.000
embA4246244c.3012G>A1.000
embA4246254p.Leu1008Met1.000
embA4246259c.3027G>C1.000
embA4246268c.3036G>A1.000
embA4246274c.3042G>C1.000
embA4246279p.Ala1016Val1.000
embA4246292c.3060A>G1.000
embA4246307c.3075G>C1.000
embA4246316c.3084T>G1.000
embA4246346c.3114C>G1.000
embA4246355c.3123G>C1.000
embA4246359p.Ala1043Ser1.000
embA4246364c.3132G>C1.000
embA4246373c.3141T>C1.000
embA4246376c.3144G>C1.000
embA4246398p.Ser1056Thr1.000
embA4246413p.His1061Tyr1.000
embB4246828c.315A>G1.000
embB4246843c.330T>C1.000
embB4246844c.331T>C1.000
embB4246853p.Leu114Met1.000
embB4246871p.Ala120Ser1.000
embB4246879c.366C>G1.000
embB4246882c.369G>C1.000
embB4247161c.648G>A1.000
embB4247185c.672G>C1.000
embB4247201p.Val230Ile1.000
embB4247209c.696A>G1.000
embB4247210c.697C>T1.000
embB4247219c.706T>C1.000
embB4247386c.873T>C1.000
embB4247398c.885G>C1.000
embB4247401c.888T>C1.000
embB4247404c.891G>C1.000
embB4247407c.894G>C1.000
embB4247437c.924A>C1.000
embB4247470c.957T>C1.000
embB4247497c.984T>C1.000
embB4247500c.987C>G1.000
embB4247512c.999T>C1.000
embB4247646p.Glu378Ala1.000
embB4247671c.1158G>C1.000
embB4247677c.1164C>G1.000
embB4247684c.1171T>C1.000
embB4247725c.1212G>C1.000
embB4247728c.1215G>A1.000
embB4247734c.1221C>T1.000
embB4247743c.1230C>G1.000
embB4247761c.1248T>C1.000
embB4247779c.1266C>G1.000
embB4247800c.1287A>C1.000
embB4247815c.1302C>G0.929
embB4247816p.Val435Ile1.000
embB4247819p.Val436Ile0.929
embB4247830c.1317A>G1.000
embB4247836c.1323A>G1.000
embB4247839c.1326G>C1.000
embB4247887c.1374C>T1.000
embB4247890c.1377C>G1.000
embB4247899p.Met462Ile1.000
embB4247911p.Leu466Phe1.000
embB4247926c.1413C>A1.000
embB4247932c.1419C>G1.000
embB4247948p.Val479Leu1.000
embB4247953c.1440G>A1.000
embB4247975p.Val488Ile1.000
embB4247989c.1476G>C1.000
embB4247992c.1479G>C1.000
embB4248007c.1494C>G1.000
embB4248042p.Ala510Gly1.000
embB4248046c.1533A>G1.000
embB4248052c.1539G>T1.000
embB4248055c.1542G>C1.000
embB4248058c.1545C>T1.000
embB4248064c.1551G>C1.000
embB4248070c.1557T>C1.000
embB4248094c.1581C>T1.000
embB4248130c.1617G>C1.000
embB4248133c.1620C>G1.000
embB4248142c.1629T>C1.000
embB4248143c.1630T>C1.000
embB4248157c.1644A>G1.000
embB4248178c.1665C>T1.000
embB4248185c.1672T>C1.000
embB4248206p.Ser565Gly1.000
embB4248214c.1701C>G1.000
embB4248217c.1704C>G0.955
embB4248220c.1707A>G1.000
embB4248232c.1719G>A1.000
embB4248233c.1720C>T1.000
embB4248252p.Gly580Ala1.000
embB4248266c.1753C>T1.000
embB4248277c.1764G>C1.000
embB4248280c.1767C>G1.000
embB4248316c.1803C>G1.000
embB4248319c.1806A>G1.000
embB4248334c.1821C>G1.000
embB4248358c.1845C>A1.000
embB4248360p.Pro616Arg1.000
embB4248362p.Ser617Glu1.000
embB4248407p.Leu632Val1.000
embB4248410p.Phe633Leu1.000
embB4248416p.Leu635Met1.000
embB4248430c.1917T>C1.000
embB4248460c.1947C>G1.000
embB4248469c.1956C>T1.000
embB4248472c.1959T>C1.000
embB4248487c.1974C>T1.000
embB4248504p.Asp664Ala1.000
embB4248508c.1995G>A1.000
embB4248514c.2001A>G1.000
embB4248535c.2022C>G1.000
embB4248541c.2028T>C1.000
embB4249312c.2799C>G1.000
embB4249321c.2808A>C1.000
embB4249323p.Ala937Asp1.000
embB4249339c.2826T>C1.000
embB4249348c.2835G>C1.000
embB4249369c.2856T>C1.000
embB4249375c.2862G>C1.000
embB4249381c.2868A>C1.000
embB4249384c.2871G>C1.000
embB4249417c.2904A>G1.000
embB4249429c.2916C>G1.000
embB4249432c.2919A>G1.000
embB4249433c.2920C>T1.000
embB4249444c.2931T>C1.000
embB4249447c.2934G>C1.000
embB4249453c.2940G>C1.000
embB4249456c.2943G>C1.000
embB4249459c.2946G>A1.000
embB4249483c.2970C>G1.000
embB4249486c.2973T>G1.000
embB4249487c.2974T>C1.000
embB4249492c.2979C>G1.000
embB4249501c.2988C>T1.000
embB4249521p.Ala1003Val1.000
embB4249529p.Ile1006Val1.000
embB4249532p.Ala1007Thr1.000
embB4249546c.3033G>A1.000
embB4249568p.Ser1019Asn1.000
embB4249573c.3060T>C1.000
embB4249594c.3081G>C1.000
embB4249607p.Thr1032Val1.000
embB4249618c.3105C>G1.000
embB4249624c.3111C>G1.000
embB4249627c.3114G>C1.000
embB4249640c.3127T>C1.000
embB4249648c.3135G>C1.000
embB4249654c.3141C>T1.000
embB4249657c.3144C>G1.000
embB4249669c.3156C>T1.000
embB4249675c.3162C>G1.000
embB4249693c.3180T>C1.000
embB4249699c.3186T>A1.000
embB4249702c.3189C>A1.000
embB4249711c.3198G>A1.000
embB4249732c.3219C>G1.000
embB4249733p.Pro1074Ala1.000
embB4249741c.3228C>A1.000
embB4249744c.3231G>A1.000
embB4249750p.Glu1079Asp1.000
embB4249751c.3238T>C1.000
embB4249774c.3261C>A1.000
embB4249775c.3262C>T1.000
ethA4326271c.1203A>G1.000
ethA4326298c.1176C>G1.000
ethA4326304c.1170G>C1.000
ethA4326322c.1152A>G1.000
ethA4326331c.1143G>C1.000
ethA4326337c.1137G>A1.000
ethA4326343c.1131G>A1.000
ethA4326346c.1128G>C1.000
ethA4326352c.1122A>C1.000
ethA4326535c.939C>G1.000
ethA4326556c.918A>G1.000
ethA4326565c.909C>A1.000
ethA4326583c.891G>T1.000
ethA4326591c.883A>G1.000
ethA4326598c.876T>C1.000
ethA4326610c.864G>C1.000
ethA4326913c.561C>G1.000
ethA4326916c.558C>T1.000
ethA4326919c.555T>G1.000
ethA4326950p.Ala175Gly1.000
ethA4326952p.Asp174Glu1.000
ethA4326982c.492C>T1.000
ethA4327390c.84C>G1.000
ethA4327396c.78A>G1.000
ethA4327408c.66G>A1.000

Analysis pipeline specifications

TBProfiler Version: 2.1.1

AnalysisProgram
Mappingbwa
Variant CallingBCFtools


Log

Drug Details
The estimated accuracy of drug resistance predictions is:

Drug1Sensitivity (%)Specificity (%)
Isoniazid 92.8 (89.9-95.7)100 (100-100)
Rifampicin 96.2 (93.9-98.5)98.1 (96.8-99.4)
Ethambutal 88.7 (83.6-93.8)81.7 (77.6-85.8)
Pyrazinamide70.9 (62.4-79.4)93.9 (90.6-97.2)
Streptomycin87.1 (82.7-91.5)89.7 (86.0-93.4)
Ethionamide 73.6 (66.7-80.5)93.3 (89.6-97.0)
Moxifloxacin60.0 (29.6-90.4)68.7 (52.6-84.8)
Ofloxacin 85.5 (79.1-91.9)94.9 (91.8-98.0)
Amikacin 82.9 (74.4-91.4)98.3 (96.0-100)
Capreomycin 60.7 (50.6-70.8)90.7 (87.2-94.2)
Kanamycin 87.3 (81.3-93.3)93.4 (89.9-96.9)
Para-aminosalisylic acidNot determinedNot determined
Linezolid Not determinedNot determined
Clofazimine Not determinedNot determined
Bedaquiline Not determinedNot determined
Multi drug resistance91.2 (87.8-94.6)98.4 (97.2-99.6)
Extremely drug resistance75.9 (64.5-87.3)98.4 (97.3-99.5)

Lineages
Lineage2LocationStrainRD type
lineage1Indo-OceanicEAIRD239
lineage1.1Indo-OceanicEAI3;EAI4;EAI5;EAI6RD239
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineage1.1.1.1Indo-OceanicEAI4;ZERORD239
lineage1.1.2Indo-OceanicEAI3;EAI5RD239
lineage1.1.3Indo-OceanicEAI6RD239
lineage1.2Indo-OceanicEAI1;EAI2RD239
lineage1.2.1Indo-OceanicEAI2RD239
lineage1.2.2Indo-OceanicEAI1RD239
lineage2East-AsianBeijingRD105
lineage2.1East-Asian (non-Beijing)NoneNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.2East-Asian (Beijing)Beijing-RD105/RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181
lineage2.2.1.2East-Asian (Beijing)Beijing-RD142RD105;RD207;RD181;RD142
lineage2.2.1.1East-Asian (Beijing)Beijing-RD150RD105;RD207;RD181;RD150
lineage3East-African-IndianCASRD750
lineage3.1East-African-IndianNon-CAS1-DelhiRD750
lineage3.1.1East-African-IndianCAS1-KiliRD750
lineage3.1.2East-African-IndianCAS;CAS2RD750
lineage3.1.2.1East-African-IndianCAS2RD750
lineage3.1.2.2East-African-IndianCASRD750
lineage4Euro-AmericanLAM;T;S;X;HNone
lineage4.1Euro-AmericanT;X;HNone
lineage4.1.2Euro-American (X-type)T;HNone
lineage4.1.2.1Euro-American (X-type)T1;H1RD182
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.2Euro-American (X-type)X1None
lineage4.1.1.1Euro-American (X-type)X2RD183
lineage4.1.1.3Euro-American (Haarlem)X1;X3RD193
lineage4.2Euro-AmericanH;T;LAMNone
lineage4.2.2Euro-American (Ural)T;LAM7-TURNone
lineage4.2.2.1Euro-AmericanLAM7-TURNone
lineage4.2.1Euro-American (TUR)H3;H4None
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.3.1Euro-American (LAM)LAM9None
lineage4.3.3Euro-American (LAM)LAM;TRD115
lineage4.3.4Euro-American (LAM)LAMRD174
lineage4.3.4.1Euro-American (LAM)LAM1;LAM2RD174
lineage4.3.4.2Euro-American (LAM)LAM1;LAM4;LAM11RD174
lineage4.3.4.2.1Euro-American (LAM)LAM11RD174
lineage4.3.2Euro-American (LAM)LAM3None
lineage4.3.2.1Euro-American (LAM)LAM3RD761
lineage4.4Euro-AmericanS;TNone
lineage4.4.2Euro-AmericanT1;T2None
lineage4.4.1Euro-American (S-type)S;TNone
lineage4.4.1.2Euro-AmericanT1None
lineage4.4.1.1Euro-AmericanS;OrphansNone
lineage4.5Euro-AmericanH;TRD122
lineage4.6Euro-AmericanT;LAMNone
lineage4.6.1Euro-American (Uganda)T2RD724
lineage4.6.1.1Euro-American T2-UgandaRD724
lineage4.6.1.2Euro-AmericanT2RD724
lineage4.6.2Euro-AmericanT;LAMRD726
lineage4.6.2.1Euro-AmericanT3RD726
lineage4.6.2.2Euro-American (Cameroon)LAM10-CAMRD726
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.8Euro-American (mainly T)T1;T2;T3;T5RD219
lineage4.9Euro-American (H37Rv-like)T1None
lineage5West-Africa 1AFRI_2;AFRI_3RD711
lineage6West-Africa 2AFRI_1RD702
lineage7Lineage 7NoneNone
lineageBOVM. bovisBOV_1;BOV_2None

Citations
1. Coll F, et al. Rapid determination of anti-tuberculosis drug resistance from whole genome sequences. Genome Medicine (in press)
2. Coll F, et al. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications 2014.

Disclaimer
This tool is for Research Use Only and is offered free for use. The London School of Hygiene and Tropical Medicine shall have no liability for any loss or damages of any kind, however sustained relating to the use of this tool.
© 2019 London School of Hygiene and Tropical Medicine;