TB Profiler
This tool processes raw sequence data to infer strain type and identify known drug resistance markers.
A stand alone version of this tool is now available and can now be run on linux or mac. Installation instructions can be found on GitHub and on the bioconda page.



This tool is for Research Use Only. Data and information provided through use of this tool are not intended for medical purpose or objective and should not be used for clinical diagnosis, patient management, or human clinical trials.
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Single nucleotide polymorphisms (SNPs) in coding regions are annotated using the reference amino acid, codon number and alternative amino acid (e.g. Ser315Thr in katG). SNPs in non-coding regions (i.e. RNA genes and intergenic regions) are annotated using the reference nucleotide, gene coordinate and alternative nucleotide (e.g. A1401G in rrs or C-37A in eis promoter). Indels are annotated using the reference VCF allele, gene coordinate and alternative VCF allele (e.g. T902TA insertion in katG).
Name: 5d7b8311cf0ea
Sample: 5d7b8311cf0ea

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Summary
ID: 5d7b8311cf0ea
Date: Fri Sep 13 12:55:40 2019
Strain: lineage4.3;lineage4.1.1;lineage1.1.1
Drug-resistance: Drug-resistant

Drug1ResistanceSupporting Mutations (frequency)
IsoniazidRkatG p.Ile335Thr (1.00), katG p.Ile317Leu (1.00)
Rifampicin
EthambutolRembB p.His312Arg (1.00), embB p.Leu359Ile (1.00), embB p.Tyr384Asn (1.00), embB p.Ala388Gly (1.00), embB p.Asn399Asp (1.00), embB p.Ala659Thr (1.00)
PyrazinamideRpanD p.Val138Ala (1.00)
StreptomycinRrrs r.462c>t (0.95)
Ethionamide
Fluoroquinolones
Amikacin
Capreomycin
Kanamycin

Lineage2FamilyMain SpoligotypeRDS
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineageBOV AFRI???

Mutations in candidate genes:
GeneChromosome PositionMutationEstimated fraction
gyrB5371c.132T>C1.000
gyrB5377c.138T>C1.000
gyrB5396p.Ala53Ser1.000
gyrB5419c.180T>C1.000
gyrB5772p.Ala178Asp1.000
gyrB5774p.Val179Ile1.000
gyrB5782c.543A>G1.000
gyrB5788c.549G>C1.000
gyrB5791c.552A>G1.000
gyrB5803c.564A>G0.810
gyrB5806c.567C>G0.810
gyrB5809c.570C>G0.810
gyrB5824c.585A>G1.000
gyrB5827c.588G>A1.000
gyrB5849c.610C>T1.000
gyrB5854c.615C>A1.000
gyrB5863c.624G>C1.000
gyrB5873c.634A>C1.000
gyrB5880p.Thr214Ser1.000
gyrB5882p.Gln215Asn1.000
gyrB5887p.Asp216Glu1.000
gyrB5902c.663A>G1.000
gyrB5905c.666G>C1.000
gyrB6100c.861G>C1.000
gyrB6115c.876A>G1.000
gyrB6123p.Ala295Gly1.000
gyrB6127c.888G>C1.000
gyrB6130c.891T>C1.000
gyrB6136c.897G>A1.000
gyrB6139c.900G>C1.000
gyrB6238c.999G>A1.000
gyrB6242p.Arg335Lys1.000
gyrB6250c.1011A>G1.000
gyrB6256c.1017G>A1.000
gyrB6265c.1026C>T1.000
gyrB6268c.1029C>G1.000
gyrB6280c.1041T>C1.000
gyrB6286c.1047T>C1.000
gyrB6289c.1050C>T1.000
gyrB6292c.1053G>C1.000
gyrB6304c.1065C>G1.000
gyrB6307c.1068T>G1.000
gyrB6319c.1080G>C1.000
gyrB6361c.1122G>A1.000
gyrB6362c.1123T>C1.000
gyrB6376c.1137G>A1.000
gyrB6379c.1140C>G1.000
gyrB6382c.1143A>G1.000
gyrB6388c.1149T>C1.000
gyrB6403c.1164T>C1.000
gyrB6415c.1176G>C1.000
gyrB6418c.1179C>G1.000
gyrB6427c.1188T>C1.000
gyrB6598c.1359C>G1.000
gyrB6610c.1371C>G1.000
gyrB6613c.1374A>G1.000
gyrB6616c.1377A>G1.000
gyrB6622c.1383C>T1.000
gyrB6634c.1395T>C1.000
gyrB6637c.1398T>G1.000
gyrB6640c.1401A>G1.000
gyrB6649c.1410T>C1.000
gyrB6655c.1416T>C1.000
gyrB6670c.1431G>C1.000
gyrB6673c.1434A>C1.000
gyrB6676c.1437T>G1.000
gyrB6700c.1461T>C1.000
gyrB6703c.1464G>C1.000
gyrB6709c.1470A>G0.966
gyrB6712c.1473G>C1.000
gyrB6728c.1489C>T1.000
gyrB6742c.1503A>G1.000
gyrB6745c.1506T>G1.000
gyrB6751c.1512G>C1.000
gyrB6760c.1521G>C1.000
gyrB6763c.1524G>C1.000
gyrB6775c.1536G>C1.000
gyrB6793c.1554T>C1.000
gyrB6797p.Gly520Thr1.000
gyrB6811c.1572C>T1.000
gyrB6841c.1602T>C1.000
gyrB6844c.1605T>C1.000
gyrB6949c.1710A>G1.000
gyrB6952c.1713C>G1.000
gyrB6967c.1728T>C1.000
gyrB6973c.1734G>C1.000
gyrB6982c.1743A>C1.000
gyrB7007c.1768C>T1.000
gyrB7010c.1771C>T1.000
gyrB7023p.Leu595Gln1.000
gyrB7033c.1794G>C1.000
gyrB7051p.Glu604Asp1.000
gyrB7066c.1827G>C1.000
gyrB7078c.1839A>C1.000
gyrB7084c.1845A>G1.000
gyrB7090c.1851C>T1.000
gyrB7093c.1854T>G1.000
gyrB7099c.1860G>A1.000
gyrB7108c.1869G>A1.000
gyrB7114c.1875C>A1.000
gyrB7141c.1902T>C1.000
gyrB7165c.1926C>G0.571
gyrB7178c.1939T>C1.000
gyrB7186c.1947C>G1.000
gyrB7216c.1977G>C1.000
gyrB7228c.1989C>T1.000
gyrB7234c.1995C>T1.000
gyrB7246c.2007T>C1.000
gyrB7252c.2013G>C1.000
gyrB7256c.2017C>T1.000
gyrA7334c.33G>C1.000
gyrA7335p.Leu12Val1.000
gyrA7347p.Glu16Gln1.000
gyrA7355c.54T>C1.000
gyrA7361c.60C>T1.000
gyrA7362p.Glu21Gln1.000
gyrA7391c.90C>T1.000
gyrA7394c.93T>C1.000
gyrA7406c.105G>C1.000
gyrA7427c.126G>C1.000
gyrA7442c.141G>C1.000
gyrA7451c.150C>G1.000
gyrA7457c.156T>C1.000
gyrA7475c.174A>G1.000
gyrA7480p.Phe60Tyr1.000
gyrA7484c.183T>C1.000
gyrA7514c.213C>G1.000
gyrA7523c.222C>A1.000
gyrA7532c.231T>C1.000
gyrA7541c.240C>G1.000
gyrA7547c.246C>T1.000
gyrA7562c.261C>T1.000
gyrA7571c.270G>C1.000
gyrA7585p.Ser95Thr1.000
gyrA7595c.294C>G1.000
gyrA7601c.300C>G1.000
gyrA7607c.306C>G1.000
gyrA7622c.321C>T1.000
gyrA7625c.324G>C1.000
gyrA7631c.330G>C1.000
gyrA7637c.336C>G1.000
gyrA7658c.357A>G1.000
gyrA7664c.363T>C1.000
gyrA7670c.369A>G1.000
gyrA7676c.375G>C1.000
gyrA7683c.382A>C1.000
gyrA7694c.393A>G1.000
gyrA7697c.396C>A1.000
gyrA7710c.409T>C1.000
gyrA7715c.414G>C1.000
gyrA7721c.420G>A1.000
gyrA7725c.424C>T1.000
gyrA7728c.427A>C1.000
gyrA7784c.483A>G1.000
gyrA7793c.492G>C1.000
gyrA7796c.495G>C1.000
gyrA7799c.498A>G1.000
gyrA7814c.513C>G1.000
gyrA7823c.522G>C1.000
gyrA7832c.531G>T1.000
gyrA7835c.534A>G1.000
gyrA7853c.552C>G1.000
gyrA7859c.558A>G1.000
gyrA7865c.564T>C1.000
gyrA7886c.585T>C1.000
gyrA8069c.768T>C1.000
gyrA8078c.777A>G1.000
gyrA8090c.789C>A1.000
gyrA8096c.795T>A1.000
gyrA8099c.798T>C1.000
gyrA8111c.810G>C1.000
gyrA8121c.820T>C1.000
gyrA8129c.828T>C1.000
gyrA8135c.834C>G1.000
gyrA8156c.855T>C1.000
gyrA8168c.867A>G0.840
gyrA8177c.876A>C0.840
gyrA8189c.888G>C1.000
gyrA8198c.897T>C1.000
gyrA8207c.906T>C1.000
gyrA8219c.918T>C1.000
gyrA8225c.924T>C1.000
gyrA8234c.933T>C1.000
gyrA8237c.936A>G1.000
gyrA8247p.Ile316Val1.000
gyrA8264c.963T>C1.000
gyrA8267c.966G>C1.000
gyrA8270c.969G>C1.000
gyrA8276c.975G>A1.000
gyrA8283p.Ile328Leu1.000
gyrA8288c.987T>C1.000
gyrA8294c.993T>C1.000
gyrA8324c.1023T>C1.000
gyrA8330c.1029C>G1.000
gyrA8337c.1036C>T1.000
gyrA8342c.1041G>C1.000
gyrA8366c.1065G>T1.000
gyrA8367c.1066C>T1.000
gyrA8372c.1071G>C1.000
gyrA8375c.1074G>C1.000
gyrA8382p.Leu361Met1.000
gyrA8391p.Tyr364His1.000
gyrA8399c.1098T>C1.000
gyrA8400p.Asp367Asn1.000
gyrA8417c.1116C>G1.000
gyrA8420c.1119T>C1.000
gyrA8423c.1122G>C1.000
gyrA8442c.1141C>T1.000
gyrA8453c.1152A>C1.000
gyrA8459c.1158G>A1.000
gyrA8462c.1161A>C1.000
gyrA8465c.1164C>G1.000
gyrA8471c.1170T>C1.000
gyrA8472c.1171C>T1.000
gyrA8480c.1179C>A1.000
gyrA8486c.1185T>C1.000
gyrA8504c.1203G>C1.000
gyrA8516c.1215T>C1.000
gyrA8519c.1218A>C1.000
gyrA8520c.1219C>T1.000
gyrA8528c.1227G>C1.000
gyrA8531c.1230G>C1.000
gyrA8543c.1242C>G1.000
gyrA8546c.1245T>C1.000
gyrA8553c.1252C>A1.000
gyrA8561c.1260A>C1.000
gyrA8588c.1287G>A1.000
gyrA8603c.1302A>G1.000
gyrA8619c.1318T>C1.000
gyrA8624c.1323G>C0.625
gyrA8636c.1335A>C0.625
gyrA8642c.1341A>G1.000
gyrA8672c.1371A>G1.000
gyrA8678c.1377G>A1.000
gyrA8780p.Asp493Glu1.000
gyrA8786c.1485T>C1.000
gyrA8801c.1500G>C1.000
gyrA8807c.1506C>T1.000
gyrA8810c.1509A>G1.000
gyrA8816c.1515C>G1.000
gyrA8818p.Ser506Asn1.000
gyrA8828c.1527T>C1.000
gyrA8829c.1528T>C1.000
gyrA8852c.1551T>C1.000
gyrA8867c.1566A>G1.000
gyrA8870c.1569G>C1.000
gyrA8873c.1572A>C1.000
gyrA8891c.1590G>A1.000
gyrA8897c.1596T>C1.000
gyrA8903c.1602T>C1.000
gyrA8933c.1632G>C1.000
gyrA8946c.1645T>C1.000
gyrA8966c.1665C>G1.000
gyrA8967p.Ala556Arg0.905
gyrA8987c.1686C>A1.000
gyrA8990c.1689C>G1.000
gyrA8996c.1695T>C1.000
gyrA8998p.Leu566Trp1.000
gyrA9017c.1716C>G1.000
gyrA9023c.1722A>G1.000
gyrA9029c.1728T>C1.000
gyrA9032c.1731T>C1.000
gyrA9050p.Asp583Glu1.000
gyrA9051c.1750T>C1.000
gyrA9056c.1755C>G1.000
gyrA9062c.1761C>G1.000
gyrA9065c.1764C>G1.000
gyrA9068c.1767G>C1.000
gyrA9071c.1770G>C1.000
gyrA9080c.1779G>T1.000
gyrA9089c.1788G>C1.000
gyrA9099c.1798T>C1.000
gyrA9104c.1803C>G1.000
gyrA9119c.1818A>G1.000
gyrA9122c.1821C>A1.000
gyrA9143c.1842T>C1.000
gyrA9153p.Thr618Glu1.000
gyrA9158c.1857C>T1.000
gyrA9161c.1860C>G1.000
gyrA9182c.1881T>C1.000
gyrA9191c.1890G>C1.000
gyrA9200c.1899A>G1.000
gyrA9204p.Ser635Thr1.000
gyrA9218c.1917C>T1.000
gyrA9227c.1926C>G1.000
gyrA9230c.1929T>C1.000
gyrA9233c.1932C>G1.000
gyrA9267p.Asn656Gly1.000
gyrA9293c.1992G>C1.000
gyrA9296c.1995T>C1.000
gyrA9299c.1998G>C1.000
gyrA9304p.Gly668Glu1.000
gyrA9308c.2007C>T1.000
gyrA9312c.2011C>T1.000
gyrA9317c.2016G>T1.000
gyrA9323c.2022C>G1.000
gyrA9335c.2034G>C1.000
gyrA9345c.2044A>C1.000
gyrA9365c.2064G>A1.000
gyrA9374c.2073G>C1.000
gyrA9377c.2076A>G1.000
gyrA9383c.2082T>C1.000
gyrA9386c.2085T>C1.000
gyrA9395c.2094G>C1.000
gyrA9398c.2097T>C1.000
gyrA9413c.2112G>C1.000
gyrA9420p.Ile707Ala1.000
gyrA9428c.2127C>T1.000
gyrA9429p.Arg710Tyr1.000
gyrA9435c.2134C>T1.000
gyrA9443c.2142G>C1.000
gyrA9452c.2151G>T1.000
gyrA9467c.2166T>C1.000
gyrA9471c.2170C>T1.000
gyrA9518c.2217A>G1.000
gyrA9521c.2220C>T1.000
gyrA9527c.2226A>G1.000
rpoB759606c.-201T>C1.000
rpoB759629c.-178T>C1.000
rpoB759644c.-163T>A1.000
rpoB759647c.-160T>C1.000
rpoB759812c.6A>T1.000
rpoB759817p.Ser4Phe1.000
rpoB760040c.234T>C1.000
rpoB760046c.240G>C1.000
rpoB760060p.Tyr85Leu1.000
rpoB760067c.261G>C1.000
rpoB760070c.264T>G1.000
rpoB760091c.285G>C1.000
rpoB760101c.295T>C1.000
rpoB760112c.306T>C1.000
rpoB760118c.312T>G1.000
rpoB760121c.315T>C1.000
rpoB760130p.Asp108Glu1.000
rpoB760139c.333A>G1.000
rpoB760142c.336C>G1.000
rpoB760181c.375T>C1.000
rpoB760184c.378A>G1.000
rpoB760196c.390C>G1.000
rpoB760223c.417T>C1.000
rpoB760235c.429T>C1.000
rpoB760283c.477G>C1.000
rpoB760298c.492G>C1.000
rpoB760307c.501T>C1.000
rpoB760310c.504G>C1.000
rpoB760328c.522G>C1.000
rpoB760331c.525G>C1.000
rpoB760340c.534G>T1.000
rpoB760361c.555T>C1.000
rpoB760370c.564C>G1.000
rpoB760376p.Asp190Glu1.000
rpoB760380p.Thr192Leu1.000
rpoB760406c.600G>C1.000
rpoB760412c.606C>G1.000
rpoB760424c.618C>G1.000
rpoB760430c.624T>C1.000
rpoB760475c.669A>G1.000
rpoB760481c.675G>C1.000
rpoB760484c.678A>G1.000
rpoB760522p.Ser239Asn1.000
rpoB760532c.726T>C1.000
rpoB760533p.Val243Thr1.000
rpoB760541c.735G>C1.000
rpoB760547c.741G>C1.000
rpoB760563p.Arg253Met1.000
rpoB760591p.Val262Ala1.000
rpoB760611c.805T>C1.000
rpoB760634c.828T>C1.000
rpoB760646c.840C>G1.000
rpoB760655c.849A>G1.000
rpoB760661c.855A>C1.000
rpoB760670c.864G>C1.000
rpoB760674c.868T>C1.000
rpoB760679c.873A>G1.000
rpoB760683c.877T>C1.000
rpoB760718c.912C>T1.000
rpoB760724c.918T>C1.000
rpoB760730c.924T>C1.000
rpoB760751c.945G>C1.000
rpoB760757c.951T>C1.000
rpoB760759p.Val318Ala1.000
rpoB760769c.963C>G1.000
rpoB760775c.969G>C0.407
rpoB760776c.970T>A0.407
rpoB760793c.987A>G1.000
rpoB760805c.999G>C1.000
rpoB760869p.Val355Ile1.000
rpoB760886c.1080A>G1.000
rpoB760925c.1119T>C1.000
rpoB760928c.1122G>C1.000
rpoB760931c.1125C>G1.000
rpoB760934c.1128C>T1.000
rpoB760946c.1140A>G1.000
rpoB760982c.1176G>C1.000
rpoB760985c.1179G>C1.000
rpoB760991c.1185G>C1.000
rpoB761006c.1200C>G1.000
rpoB761015c.1209G>C1.000
rpoB761021c.1215G>C1.000
rpoB761027c.1221A>G1.000
rpoB761036c.1230G>C1.000
rpoB761037c.1231T>C1.000
rpoB761057c.1251G>C1.000
rpoB761102c.1296A>G1.000
rpoB761129c.1323G>C1.000
rpoB761132c.1326G>T1.000
rpoB761133c.1327T>C1.000
rpoB761150c.1344A>C1.000
rpoB761153c.1347G>C1.000
rpoB761165c.1359G>C1.000
rpoB761180c.1374A>C1.000
rpoB761189c.1383T>C1.000
rpoB761195c.1389G>C1.000
rpoB761207c.1401C>T1.000
rpoB761213c.1407G>C1.000
rpoB761219c.1413G>C1.000
rpoB761249c.1443A>G1.000
rpoB761255c.1449T>G1.000
rpoB761261c.1455G>T1.000
rpoB761306c.1500C>G1.000
rpoB761312c.1506G>C1.000
rpoB761327c.1521A>G1.000
rpoB761330c.1524G>C1.000
rpoB761354c.1548C>T1.000
rpoB761360c.1554T>C1.000
rpoB761362p.Ser519Thr1.000
rpoB761373p.Val523His1.000
rpoB761387c.1581C>T0.129
rpoB761408c.1602G>C1.000
rpoB761414c.1608A>G1.000
rpoB761423c.1617T>C1.000
rpoB761435c.1629T>C1.000
rpoB761438c.1632G>C1.000
rpoB761439p.Asp545Lys1.000
rpoB761444c.1638T>C1.000
rpoB761447c.1641C>G1.000
rpoB761452p.Val549Glu1.000
rpoB761457p.Pro551Ser1.000
rpoB761477c.1671C>G1.000
rpoB761492c.1686G>C1.000
rpoB761510c.1704T>C1.000
rpoB761537c.1731C>G1.000
rpoB761570c.1764T>C1.000
rpoB761573c.1767C>G1.000
rpoB761579c.1773G>C1.000
rpoB761588c.1782C>T1.000
rpoB761606c.1800C>G1.000
rpoB761612c.1806G>C1.000
rpoB761615c.1809A>C1.000
rpoB761636c.1830G>T1.000
rpoB761645c.1839C>G1.000
rpoB761648c.1842T>C1.000
rpoB761657c.1851C>G1.000
rpoB761675c.1869G>C1.000
rpoB761718c.1913 1913del1.000
rpoC763402c.33C>G1.000
rpoC763411c.42T>G1.000
rpoC763414c.45T>C1.000
rpoC763441c.72C>T1.000
rpoC763444c.75T>C1.000
rpoC763456c.87A>G1.000
rpoC763486c.117T>G1.000
rpoC763660c.291T>G1.000
rpoC763675c.306C>G1.000
rpoC763744c.375G>C0.818
rpoC763774c.405G>C1.000
rpoC763807c.438T>C1.000
rpoC763816c.447C>G1.000
rpoC763835p.Ala156Met1.000
rpoC763900c.531G>C1.000
rpoC763936c.567C>G1.000
rpoC763939c.570G>A1.000
rpoC763942c.573C>G1.000
rpoC763948c.579G>A1.000
rpoC763949c.580C>A1.000
rpoC763954c.585C>G1.000
rpoC763963c.594C>T0.514
rpoC763987c.618C>T1.000
rpoC763991p.Ile208Leu1.000
rpoC763996c.627T>C1.000
rpoC764002c.633C>G1.000
rpoC764005c.636G>C1.000
rpoC764044c.675T>C1.000
rpoC764059c.690G>T1.000
rpoC764083c.714A>G1.000
rpoC764098c.729A>G1.000
rpoC764101c.732C>G1.000
rpoC764102p.Val245Ile1.000
rpoC764112p.Tyr248Phe1.000
rpoC764116c.747C>T1.000
rpoC764131c.762T>C1.000
rpoC764140c.771C>T1.000
rpoC764188c.819A>G0.733
rpoC764195p.Ser276Ile0.714
rpoC764203c.834G>C0.714
rpoC764206c.837T>C1.000
rpoC764215c.846A>G1.000
rpoC764236c.867G>A1.000
rpoC764248c.879C>G1.000
rpoC764257c.888G>C1.000
rpoC764266c.897T>C1.000
rpoC764269c.900G>C1.000
rpoC764272c.903G>C1.000
rpoC764278c.909A>G1.000
rpoC764338c.969G>A1.000
rpoC764353c.984G>C1.000
rpoC764365c.996C>T1.000
rpoC764380c.1011G>C1.000
rpoC764381c.1012T>A1.000
rpoC764387c.1018T>C1.000
rpoC764405c.1036A>C1.000
rpoC764419c.1050C>G1.000
rpoC764428c.1059G>C1.000
rpoC764431c.1062G>C1.000
rpoC764434c.1065A>G1.000
rpoC764446c.1077T>C1.000
rpoC764449c.1080G>C1.000
rpoC764452c.1083T>C1.000
rpoC764458c.1089G>C1.000
rpoC764461c.1092A>G1.000
rpoC764489c.1120C>T1.000
rpoC764497c.1128A>G1.000
rpoC764510c.1141C>T1.000
rpoC764521c.1152T>C1.000
rpoC764527c.1158C>T1.000
rpoC764536c.1167G>C1.000
rpoC764539c.1170C>G1.000
rpoC764554c.1185C>T1.000
rpoC764560c.1191T>C1.000
rpoC764566c.1197C>G1.000
rpoC764575c.1206T>G1.000
rpoC764581c.1212T>C1.000
rpoC764593c.1224C>T1.000
rpoC764611c.1242G>T1.000
rpoC764752c.1383G>C1.000
rpoC764764c.1395T>C1.000
rpoC764809c.1440C>T1.000
rpoC764815c.1446A>G1.000
rpoC764827c.1458G>C1.000
rpoC764858c.1489T>C1.000
rpoC764872c.1503A>G1.000
rpoC764888c.1519T>C1.000
rpoC764911c.1542A>G1.000
rpoC764932c.1563C>A1.000
rpoC764935c.1566T>C1.000
rpoC764948c.1579T>C0.955
rpoC764968c.1599T>C1.000
rpoC764995c.1626C>G1.000
rpoC765019c.1650A>G1.000
rpoC765034c.1665T>C1.000
rpoC765040c.1671T>C1.000
rpoC765041c.1672T>C1.000
rpoC765047c.1678T>C1.000
rpoC765053c.1684T>A1.000
rpoC765073c.1704G>C1.000
rpoC765076c.1707A>G1.000
rpoC765079c.1710T>G1.000
rpoC765082c.1713G>C1.000
rpoC765089c.1720T>C1.000
rpoC765103c.1734G>T1.000
rpoC765319c.1950A>G1.000
rpoC765404p.Leu679Val1.000
rpoC765409c.2040T>C1.000
rpoC765421c.2052C>G1.000
rpoC765478c.2109T>C1.000
rpoC765499c.2130C>G1.000
rpoC765529c.2160C>T1.000
rpoC765541c.2172C>G1.000
rpoC765553c.2184C>T1.000
rpoC765556c.2187G>C1.000
rpoC765559c.2190G>C1.000
rpoC765580c.2211G>C1.000
rpoC765613p.His748Gln1.000
rpoC765625c.2256C>G1.000
rpoC765631p.Asp754Glu1.000
rpoC765700c.2331T>C1.000
rpoC765734c.2365T>C1.000
rpoC765739c.2370G>T1.000
rpoC765751c.2382C>G1.000
rpoC765753p.Asp795Ala1.000
rpoC765772c.2403C>G1.000
rpoC765784c.2415C>G1.000
rpoC765787c.2418C>T1.000
rpoC765793c.2424C>G1.000
rpoC765796c.2427C>T1.000
rpoC765811c.2442T>C1.000
rpoC765814c.2445A>G1.000
rpoC765826c.2457T>C1.000
rpoC765835c.2466C>T1.000
rpoC765850c.2481G>C1.000
rpoC765883c.2514C>G1.000
rpoC765886c.2517C>G1.000
rpoC765892c.2523T>C1.000
rpoC765937c.2568T>C1.000
rpoC765967c.2598C>T1.000
rpoC765982c.2613C>G1.000
rpoC765994c.2625A>T1.000
rpoC766010c.2641T>A1.000
rpoC766021c.2652G>C1.000
rpoC766027c.2658G>C1.000
rpoC766030c.2661C>G1.000
rpoC766043p.Gln892Glu1.000
rpoC766054c.2685C>G1.000
rpoC766082p.Ala905Gln1.000
rpoC766096c.2727G>C1.000
rpoC766129c.2760C>G1.000
rpoC766135c.2766G>A1.000
rpoC766141c.2772C>T1.000
rpoC766142c.2773C>T1.000
rpoC766174p.Asn935Lys1.000
rpoC766178p.Ile937Val1.000
rpoC766185p.Glu939Ala1.000
rpoC766189c.2820T>C1.000
rpoC766192c.2823T>C1.000
rpoC766193p.Gln942Glu1.000
rpoC766204c.2835C>T1.000
rpoC766207c.2838T>C1.000
rpoC766216c.2847T>C1.000
rpoC766219p.Asp950Glu1.000
rpoC766222c.2853T>C1.000
rpoC766226c.2857T>C1.000
rpoC766231c.2862T>G1.000
rpoC766234c.2865T>C1.000
rpoC766237c.2868T>C1.000
rpoC766240c.2871T>C1.000
rpoC766243c.2874C>G1.000
rpoC766258c.2889T>C1.000
rpoC766273c.2904T>C1.000
rpoC766274p.Ala969Thr1.000
rpoC766280p.Ser971Gly1.000
rpoC766288c.2919C>G1.000
rpoC766303c.2934C>T1.000
rpoC766312c.2943T>G1.000
rpoC766327c.2958C>A1.000
rpoC766345c.2976T>C1.000
rpoC766348c.2979A>G1.000
rpoC766357c.2988C>T1.000
rpoC766363c.2994G>C1.000
rpoC766381c.3012C>T1.000
rpoC766384c.3015A>G1.000
rpoC766390c.3021C>T1.000
rpoC766408c.3039C>G1.000
rpoC766411c.3042C>G1.000
rpoC766426c.3057C>T1.000
rpoC766447c.3078T>C1.000
rpoC766462c.3093G>C1.000
rpoC766483c.3114G>C1.000
rpoC766484p.Val1039Ile1.000
rpoC766492c.3123T>C1.000
rpoC766522c.3153C>G1.000
rpoC766528c.3159T>C1.000
rpoC766531c.3162G>C1.000
rpoC766540p.Asp1057Glu1.000
rpoC766549c.3180G>T1.000
rpoC766573c.3204T>C1.000
rpoC766582c.3213C>G1.000
rpoC766583p.Gly1072Ser1.000
rpoC766591c.3222A>G0.833
rpoC766594c.3225G>C1.000
rpoC766597c.3228C>G1.000
rpoC766607p.Ile1080Leu1.000
rpoC766630c.3261G>C1.000
rpoC766657c.3288A>G1.000
rpoC766660c.3291G>C1.000
rpoC766672c.3303T>C1.000
rpoC766673p.Gly1102Asn1.000
rpoC766726c.3357T>C1.000
rpoC766738c.3369G>C1.000
rpoC766765c.3396A>C1.000
rpoC766774c.3405T>C1.000
rpoC766801c.3432C>G1.000
rpoC766804c.3435A>G1.000
rpoC766861c.3492G>C1.000
rpoC766864c.3495G>C1.000
rpoC766876c.3507C>T1.000
rpoC766882c.3513C>T1.000
rpoC766894c.3525T>C1.000
rpoC766895c.3526T>C1.000
rpoC766900c.3531T>C1.000
rpoC766933c.3564A>G1.000
rpoC766945c.3576A>G1.000
rpoC766963c.3594T>C0.727
rpoC766972c.3603G>C1.000
rpoC766996c.3627C>T1.000
rpoC767009c.3640T>A1.000
rpoC767014c.3645G>C1.000
rpoC767033c.3664T>A1.000
rpoC767059c.3690T>G1.000
rpoC767062c.3693C>A1.000
rpoC767098c.3729T>C1.000
rpoC767119c.3750A>G1.000
rpoC767134c.3765C>A0.657
rpoC767158c.3789T>C1.000
rpoC767180p.Ala1271Gln0.622
rpoC767191c.3822C>G1.000
rpoC767206c.3837C>G1.000
rpoC767209c.3840T>C1.000
rpoC767212c.3843G>C1.000
rpoC767221c.3852C>G1.000
rpoC767230c.3861G>C1.000
rpoC767233c.3864T>C1.000
rpoC767263c.3894T>C1.000
rpoC767264p.Ala1299Gln1.000
rpoC767275c.3906T>C1.000
rpoC767278c.3909T>C1.000
rpoC767281c.3912C>G1.000
rpoC767284c.3915C>T1.000
rpsL781373c.-187G>C1.000
rpsL781571c.12C>T1.000
rpsL781595c.36T>C1.000
rpsL781605p.Ile16Val1.000
rpsL781608p.Ser17Ala1.000
rpsL781628c.69T>C1.000
rpsL781631c.72G>C1.000
rpsL781649c.90T>C1.000
rpsL781655c.96T>C1.000
rpsL781700c.141G>C1.000
rpsL781703c.144G>T1.000
rpsL781715c.156T>C1.000
rpsL781728c.169T>C1.000
rpsL781736c.177T>C1.000
rpsL781742c.183C>T1.000
rpsL781748c.189C>G1.000
rpsL781754c.195G>C1.000
rpsL781760c.201T>C1.000
rpsL781772c.213C>A1.000
rpsL781808c.249C>T1.000
rpsL781811c.252C>T1.000
rpsL781832c.273T>C1.000
rpsL781838c.279G>C1.000
rpsL781841c.282C>G1.000
rpsL781865c.306G>C1.000
rpsL781868c.309T>C1.000
rpsL781871c.312G>C1.000
rpsL781877c.318T>C1.000
rpsL781892c.333A>G1.000
rpsL781898c.339A>T1.000
rpsL781916c.357T>C1.000
rplC800794c.-15A>G1.000
rplC800796c.-13A>G1.000
rplC800798c.-11TGG>T1.000
rplC800814c.6A>G1.000
rplC800817c.9A>T1.000
rplC800844c.36T>C1.000
rplC801127p.Ala107Thr1.000
rplC801132c.324T>C1.000
rplC801147c.339T>C1.000
rplC801150c.342G>C1.000
rplC801153c.345G>C1.000
rplC801156c.348T>A1.000
rplC801168c.360C>G1.000
rplC801171c.363A>G1.000
rplC801174c.366T>C1.000
rplC801195c.387G>C1.000
rplC801207c.399C>T1.000
rplC801246c.438C>T1.000
rplC801249c.441T>C1.000
rplC801255c.447C>T1.000
rplC801264c.456C>T1.000
rplC801267c.459A>T1.000
rplC801270c.462T>C1.000
rplC801276c.468G>C1.000
rplC801279c.471G>C1.000
rplC801282c.474G>C1.000
rplC801285c.477G>C1.000
rplC801300c.492C>G1.000
rplC801309c.501C>G1.000
rplC801312c.504G>C1.000
rplC801321c.513C>T1.000
rplC801324c.516T>C1.000
rplC801339c.531T>C1.000
rplC801341p.Leu178Gln1.000
rplC801348c.540T>G1.000
rplC801357c.549T>C1.000
rplC801367p.Ala187Thr1.000
rplC801402c.594T>C1.000
rplC801405c.597T>C1.000
rplC801423c.615G>C1.000
rplC801426c.618C>G1.000
rplC801427p.Met207Val1.000
rplC801438c.630T>C1.000
rplC801442p.Ile212Val1.000
rrs1471934r.89a>g1.000
rrs1471969r.124t>c1.000
rrs1471970r.125g>a1.000
rrs1472075r.230a>g1.000
rrs1472108r.263c>t1.000
rrs1472193r.348a>t0.500
rrs1472197r.352a>t0.296
rrs1472240r.395g>c0.644
rrs1472242r.397c>t0.583
rrs1472251r.406g>t0.703
rrs1472252r.407g>a0.560
rrs1472253r.408g>t0.589
rrs1472256r.411t>a0.568
rrs1472259r.414c>a0.618
rrs1472278r.433c>t0.273
rrs1472279r.434t>c0.360
rrs1472285r.440a>g0.548
rrs1472286r.441c>g0.167
rrs1472287r.442c>t0.344
rrs1472288r.443a>t0.194
rrs1472289r.444t>g0.710
rrs1472290r.445c>g0.600
rrs1472298r.453g>c0.172
rrs1472300r.455c>t0.812
rrs1472313r.468g>a0.143
rrs1472315r.470t>g0.528
rrs1472324r.479g>c0.484
rrs1472325r.480g>c0.484
rrs1472326r.481t>g0.184
rrs1472328r.483g>c0.135
rrs1472344r.499c>t0.810
rrs1472349r.504a>c0.283
rrs1472374r.529t>g0.267
rrs1472378r.533g>t0.236
rrs1472379r.534t>g0.216
rrs1472382r.537g>a0.565
rrs1472389r.544g>a0.557
rrs1472390r.545t>a0.371
rrs1472391r.546c>t0.531
rrs1472400r.555c>t0.242
rrs1472412r.567a>c0.554
rrs1472415r.570t>g0.342
rrs1472418r.573t>c0.202
rrs1472422r.577t>c0.416
rrs1472435r.590t>c0.559
rrs1472438r.593t>c0.364
rrs1472439r.594c>t0.545
rrs1472443r.598a>t0.129
rrs1472447r.602c>t0.192
rrs1472448r.603t>c0.429
rrs1472450r.605a>g0.357
rrs1472451r.606c>g0.250
rrs1472452r.607g>a0.179
rrs1472461r.616g>c0.250
rrs1472462r.617t>c0.440
rrs1472464r.619a>g0.480
rrs1472467r.622g>c0.143
rrs1472471r.626g>a0.500
rrs1472485r.640g>a0.424
rrs1472489r.644a>t0.429
rrs1472494r.649a>g0.297
rrs1472498r.653c>t0.486
rrs1472504r.659a>t0.152
rrs1472505r.660g>a0.152
rrs1472507r.662c>a0.143
rrs1472517r.672t>a0.551
rrs1472530r.685g>a0.640
rrs1472537r.692c>t0.513
rrs1472541r.696t>g0.509
rrs1472544r.699c>a0.194
rrs1472545r.700a>t0.587
rrs1472553r.708c>t0.393
rrs1472557r.712g>a0.284
rrs1472558r.713g>a0.223
rrs1472569r.724g>a0.225
rrs1472571r.726g>c0.650
rrs1472572r.727t>c0.373
rrs1472573r.728c>t0.236
rrs1472574r.729t>c0.422
rrs1472579r.734g>a0.422
rrs1472581r.736a>t0.408
rrs1472582r.737g>a0.324
rrs1472583r.738t>a0.321
rrs1472584r.739a>g0.269
rrs1472594r.749g>c0.323
rrs1472598r.753a>c0.539
rrs1472599r.754g>a0.248
rrs1472607r.762g>a0.212
rrs1472612r.767g>t0.256
rrs1472614r.769g>t0.226
rrs1472616r.771g>a0.466
rrs1472634r.789t>g0.210
rrs1472635r.790g>t0.203
rrs1472969r.1124a>g1.000
rrs1472970r.1125c>g1.000
rrs1472977r.1132g>c1.000
rrs1472978r.1133t>c1.000
rrs1473105r.1260g>a1.000
rrs1473120r.1275c>ct0.917
rrs1473123r.1278a>t1.000
rrs1473145r.1300c>t1.000
rrs1473166r.1321g>a1.000
rrs1473290r.1445c>t1.000
rrl1473401c.-257G>A1.000
rrl1473408c.-250C>T1.000
rrl1473417c.-241C>T0.867
rrl1473419c.-239T>C1.000
rrl1473420c.-238A>G1.000
rrl1473421c.-237G>A1.000
rrl1473437c.-221T>C1.000
rrl1473449c.-209G>A1.000
rrl1473452c.-206A>G1.000
rrl1473756r.99g>a1.000
rrl1473758r.101g>t1.000
rrl1473806r.149c>t1.000
rrl1473877r.220g>a1.000
rrl1473898r.241c>t1.000
rrl1473899r.242a>c1.000
rrl1473943r.286g>t1.000
rrl1474140r.483c>t1.000
rrl1474151r.494c>t1.000
rrl1474249r.592g>t1.000
rrl1474291r.634tttcctctccggagga>t1.000
rrl1474356r.699t>c1.000
rrl1474362r.705a>g1.000
rrl1474376r.719t>c1.000
rrl1474409r.752ggcgacccacac>g1.000
rrl1474639r.982g>a1.000
rrl1474794r.1137c>t1.000
rrl1474812r.1155g>a1.000
rrl1474823r.1166c>t1.000
rrl1474831r.1174a>g1.000
rrl1474904r.1247g>a1.000
rrl1474956r.1299c>t1.000
rrl1474961r.1304t>g1.000
rrl1474963r.1306g>a1.000
rrl1474964r.1307t>c1.000
rrl1474970r.1313g>a1.000
rrl1475013r.1356g>a1.000
rrl1475199r.1542g>a1.000
rrl1475206r.1549c>t1.000
rrl1475209r.1552g>c1.000
rrl1475213r.1556c>t1.000
rrl1475249r.1592t>c1.000
rrl1475252r.1595c>t1.000
rrl1475266r.1609t>c1.000
rrl1475275r.1618c>t1.000
rrl1475276r.1619t>c1.000
rrl1475291r.1634a>c1.000
rrl1475313r.1656g>a1.000
rrl1475315r.1658a>t1.000
rrl1475505r.1848g>a1.000
rrl1475526r.1869c>a1.000
rrl1475599r.1942a>g1.000
rrl1475608r.1951t>c1.000
rrl1475642r.1985t>c1.000
rrl1475657r.2000a>g1.000
rrl1475659r.2002g>t1.000
rrl1475881r.2224t>c1.000
rrl1475988r.2331a>g1.000
rrl1476031r.2374c>t1.000
rrl1476032r.2375c>a1.000
rrl1476033r.2376t>c1.000
rrl1476034r.2377c>a1.000
rrl1476045r.2388g>t1.000
rrl1476047r.2390g>t1.000
rrl1476048r.2391g>a1.000
rrl1476049r.2392c>t1.000
rrl1476086r.2429g>a1.000
rrl1476089r.2432t>c1.000
rrl1476095r.2438c>g1.000
rrl1476104r.2447tg>t1.000
rrl1476106r.2449a>t1.000
rrl1476115r.2458t>c1.000
rrl1476117r.2460g>c1.000
rrl1476214r.2557g>a1.000
rrl1476224r.2567a>g1.000
rrl1476281r.2624t>c1.000
rrl1476597r.2940g>a1.000
rrl1476603r.2946g>a1.000
rrl1476608r.2951c>g1.000
rrl1476612r.2955g>t0.200
rrl1476628r.2971t>a1.000
rrl1476689r.3032a>t1.000
rrl1476690r.3033c>t1.000
rrl1476693r.3036g>a1.000
rrl1476695r.3038t>a1.000
rrl1476716r.3059a>c1.000
rrl1476723r.3066t>a1.000
rrl1476726r.3069a>g1.000
rrl1476732r.3075t>c1.000
rrl1476755r.3098g>a1.000
rrl1476759r.3102t>c1.000
rrl1476770r.3113t>c1.000
rrl1476771r.3114g>a1.000
fabG11673568c.129C>G1.000
fabG11673574c.135C>G1.000
fabG11673580c.141T>G1.000
fabG11673589c.150A>G1.000
fabG11673591p.Ala51Val1.000
fabG11673595c.156A>C1.000
fabG11673596p.Lys53Glu1.000
fabG11673602c.163C>T1.000
fabG11673607c.168T>C1.000
fabG11673615p.Glu59Val1.000
fabG11673619c.180T>C1.000
fabG11673633p.Ser65Asn1.000
fabG11673637p.Asp66Glu1.000
fabG11673641p.Val68Ile1.000
fabG11673657p.Thr73Lys1.000
fabG11673660p.Ala74Glu1.000
fabG11673664c.225A>C1.000
fabG11673667c.228A>G1.000
fabG11673679c.240T>C1.000
fabG11673685c.246C>T1.000
fabG11673710p.Leu91Ile1.000
fabG11673716p.Ala93Lys1.000
fabG11673733p.Met98Ile1.000
fabG11673890p.Ala151Ser1.000
fabG11673901c.462A>G1.000
fabG11673905p.Ser156Ala1.000
fabG11673916c.477A>C1.000
fabG11673917p.Val160Leu1.000
fabG11673922c.483T>C1.000
fabG11673941p.Ala168Ser1.000
fabG11673955c.516G>C1.000
fabG11673961c.522A>C1.000
fabG11673985c.546C>G1.000
fabG11674006p.Asp189Glu1.000
fabG11674079p.Pro214Ala1.000
fabG11674105c.666C>T1.000
fabG11674114c.675T>A1.000
fabG11674123c.684T>C1.000
fabG11674126c.687G>C1.000
fabG11674132c.693T>C1.000
fabG11674136p.Ser233Ala1.000
fabG11674141c.702T>C1.000
fabG11674177c.738C>T1.000
inhA1674321c.120G>T1.000
inhA1674324c.123C>T1.000
inhA1674331c.130C>T1.000
inhA1674336c.135G>C1.000
inhA1674352p.Thr51Ala0.500
inhA1674660c.459G>C1.000
inhA1674672c.471C>G1.000
inhA1674703c.502T>C1.000
inhA1674708c.507G>A1.000
inhA1674718c.517A>C1.000
inhA1674738c.537C>G0.857
inhA1674741c.540C>T0.857
inhA1674746p.Tyr182Phe1.000
inhA1674750c.549T>C1.000
inhA1674753c.552G>C1.000
inhA1674756c.555T>C1.000
inhA1674759c.558G>C1.000
inhA1674774c.573A>G1.000
inhA1674780c.579T>G1.000
inhA1674789c.588G>C1.000
inhA1674801c.600T>C1.000
inhA1674816c.615T>C1.000
inhA1674822c.621C>G1.000
inhA1674828c.627G>A1.000
inhA1674846p.Ile215Met1.000
inhA1674864c.663C>T1.000
inhA1674942c.741T>G1.000
rpsA1833512c.-30AC>A1.000
rpsA1833518c.-24C>A0.944
rpsA1833532c.-10A>C1.000
rpsA1833554p.Thr5Ala1.000
rpsA1833568c.27G>C1.000
rpsA1833589c.48A>T1.000
rpsA1833595c.54T>C1.000
rpsA1833661c.120A>G1.000
rpsA1833667c.126C>G1.000
rpsA1833721c.180A>G1.000
rpsA1833724c.183C>G1.000
rpsA1833727c.186G>C1.000
rpsA1833742c.201A>G1.000
rpsA1833745c.204G>C1.000
rpsA1833748c.207C>G1.000
rpsA1833787c.246C>G1.000
rpsA1833790c.249T>C1.000
rpsA1833802c.261A>G1.000
rpsA1833811c.270G>T1.000
rpsA1833838c.297G>C1.000
rpsA1833841c.300C>G1.000
rpsA1833847c.306C>G1.000
rpsA1833856c.315A>G1.000
rpsA1833874c.333T>C1.000
rpsA1833886c.345C>G1.000
rpsA1833928c.387G>C1.000
rpsA1833940c.399C>G1.000
rpsA1833971c.430C>T1.000
rpsA1833979c.438T>C1.000
rpsA1834000c.459G>C1.000
rpsA1834021c.480C>T1.000
rpsA1834030c.489C>G1.000
rpsA1834081c.540C>T1.000
rpsA1834096c.555G>C1.000
rpsA1834099c.558C>G1.000
rpsA1834102c.561T>C1.000
rpsA1834105c.564C>G1.000
rpsA1834108c.567C>G1.000
rpsA1834123c.582C>G1.000
rpsA1834189c.648G>C1.000
rpsA1834195c.654G>C1.000
rpsA1834210c.669C>T1.000
rpsA1834222c.681T>C1.000
rpsA1834231c.690T>C1.000
rpsA1834234c.693G>C1.000
rpsA1834249c.708T>C1.000
rpsA1834261c.720A>G1.000
rpsA1834262c.721T>A1.000
rpsA1834303c.762T>C1.000
rpsA1834306c.765T>C1.000
rpsA1834348c.807T>C1.000
rpsA1834366c.825A>G1.000
rpsA1834396c.855G>C1.000
rpsA1834411c.870T>C1.000
rpsA1834417c.876G>C1.000
rpsA1834423c.882G>C1.000
rpsA1834435c.894G>C1.000
rpsA1834451c.910T>C1.000
rpsA1834465c.924T>C1.000
rpsA1834468c.927A>G1.000
rpsA1834489c.948T>C1.000
rpsA1834513c.972C>G1.000
rpsA1834528c.987T>C1.000
rpsA1834540c.999G>C1.000
rpsA1834546c.1005T>C1.000
rpsA1834555c.1014T>G1.000
rpsA1834609c.1068T>C1.000
rpsA1834618c.1077G>C1.000
rpsA1834633c.1092A>G1.000
rpsA1834639c.1098T>C1.000
rpsA1834654p.Glu371Asp1.000
rpsA1834690c.1149T>C1.000
rpsA1834732c.1191T>C1.000
rpsA1834733p.Ala398Ser1.000
rpsA1834738c.1197A>G1.000
rpsA1834753c.1212T>C1.000
rpsA1834765p.Glu408Asp1.000
rpsA1834775p.Ala412Thr1.000
rpsA1834780c.1239A>G1.000
rpsA1834786c.1245A>G1.000
rpsA1834789c.1248T>C1.000
rpsA1834792c.1251G>C1.000
rpsA1834849c.1308C>G1.000
rpsA1834852c.1311C>G1.000
tlyA1917951c.12T>C1.000
tlyA1917972c.33A>G1.000
tlyA1917975c.36C>G1.000
tlyA1917981c.42G>C0.846
tlyA1917990c.51G>C1.000
tlyA1917993c.54A>G1.000
tlyA1917996c.57A>G1.000
tlyA1918002c.63A>G1.000
tlyA1918036p.Arg33Ser1.000
tlyA1918167c.228G>C0.400
tlyA1918172p.Ala78Gly0.333
tlyA1918177p.Ala80Ser0.333
tlyA1918182c.243G>C0.333
tlyA1918310p.Asn124Ser1.000
tlyA1918315p.Pro126Ala1.000
tlyA1918323c.384G>C1.000
tlyA1918326c.387G>C1.000
tlyA1918330p.Leu131Val1.000
katG2154135c.1977C>G1.000
katG2155080c.1032C>G1.000
katG2155092c.1020C>T1.000
katG2155106c.1006G>A1.000
katG2155113c.999G>C1.000
katG2155119c.993A>G1.000
katG2155131c.981T>C1.000
katG2155145p.Asn323Pro1.000
katG2155152c.960T>G1.000
katG2155155c.957G>C1.000
katG2155179c.933G>A1.000
katG2155185c.927A>G1.000
katG2155190p.Thr308Ser1.000
katG2155191c.921T>A1.000
katG2155200c.912A>G1.000
katG2155626c.486C>G1.000
katG2155632c.480T>G1.000
katG2155637p.Leu159Ile1.000
katG2155641p.Lys157Asn1.000
katG2155661p.Val151Ile1.000
katG2155680c.432C>G1.000
katG2155691c.421A>G1.000
katG2155695c.417G>C1.000
katG2155704c.408G>C1.000
katG2155716c.396A>C1.000
katG2155722c.390C>G1.000
katG2155728c.384C>G1.000
katG2155742p.Gly124Gln1.000
katG2155743c.369C>G1.000
katG2155782c.330G>C1.000
katG2155785c.327A>G1.000
katG2155796p.Ala106Ser1.000
katG2155806c.306A>G1.000
pncA2289100p.Lys48Gln1.000
pncA2289104c.138T>G1.000
pncA2289110c.132G>C1.000
kasA2518199p.Ile29Val1.000
kasA2518220c.106C>T1.000
kasA2518234c.120G>A1.000
kasA2518248p.Ala45Val1.000
kasA2518413p.Ser100Asn1.000
kasA2518421p.Val103Leu1.000
kasA2518429c.315A>C1.000
kasA2518439p.Ala109Ser1.000
kasA2518444c.330T>C1.000
kasA2518447c.333T>G1.000
kasA2518459c.345T>C1.000
kasA2518462c.348A>C1.000
kasA2518468c.354A>C1.000
kasA2518474c.360G>A1.000
kasA2518480c.366T>C1.000
kasA2518483c.369C>G1.000
kasA2518504c.390T>C1.000
kasA2518506p.Ala131Glu1.000
kasA2518519c.405G>C1.000
kasA2518528c.414C>G1.000
kasA2518540c.426T>C1.000
kasA2518561c.447T>C1.000
kasA2518567c.453G>C1.000
kasA2518570c.456G>C1.000
kasA2518574p.Ile154Val1.000
kasA2518579c.465T>C1.000
kasA2518588c.474T>C1.000
kasA2518591c.477G>C1.000
kasA2518609p.Met165Ile1.000
kasA2518624c.510C>G1.000
kasA2518639c.525G>C1.000
kasA2518657c.543G>C1.000
kasA2518768c.654C>T1.000
kasA2518777c.663C>T1.000
kasA2518783c.669T>C1.000
kasA2518789c.675G>C1.000
kasA2518792c.678C>A1.000
kasA2518795c.681C>G1.000
kasA2518825c.711T>C1.000
kasA2519050c.936C>G1.000
kasA2519053c.939G>C1.000
kasA2519062c.948T>G1.000
kasA2519068c.954C>T1.000
kasA2519072p.Ala320Thr1.000
kasA2519107c.993T>C1.000
kasA2519108p.Asp332Gln1.000
kasA2519116c.1002C>G1.000
kasA2519122c.1008G>C1.000
kasA2519137c.1023T>G1.000
kasA2519158c.1044C>T0.968
kasA2519167c.1053T>G1.000
kasA2519173c.1059C>G1.000
kasA2519196p.Thr361Ser1.000
kasA2519215c.1101C>T1.000
kasA2519218c.1104G>A1.000
kasA2519221c.1107G>C1.000
kasA2519227c.1113G>C1.000
kasA2519230c.1116C>T1.000
kasA2519236c.1122G>A1.000
kasA2519239c.1125A>C1.000
kasA2519245c.1131T>C1.000
ahpC2726198c.6A>T1.000
ahpC2726204c.12A>G1.000
ahpC2726210c.18T>C1.000
ahpC2726216c.24T>C1.000
ahpC2726219c.27A>G1.000
ahpC2726232p.Gln14Glu1.000
ahpC2726243c.51T>G1.000
ahpC2726244c.52C>T1.000
ahpC2726251p.Gly20Ala1.000
ahpC2726255c.63T>C1.000
ahpC2726258c.66C>T1.000
ahpC2726303c.111T>C1.000
ahpC2726311p.Ser40Asn1.000
ahpC2726315p.Asp41Glu1.000
ahpC2726318p.Glu42Asp1.000
ahpC2726322p.Pro44Ala1.000
ahpC2726330c.138G>A1.000
ahpC2726336c.144G>C1.000
ahpC2726348c.156T>C1.000
ahpC2726357c.165A>G1.000
ahpC2726366c.174G>C1.000
ahpC2726378c.186T>G1.000
ahpC2726387c.195C>T1.000
ahpC2726390c.198G>C1.000
ahpC2726393c.201G>C1.000
ahpC2726397p.Ser69Gly1.000
ahpC2726408c.216T>C1.000
ahpC2726414c.222G>A0.875
ahpC2726419p.Glu76Ala0.875
ahpC2726506p.Thr105Lys1.000
ahpC2726508c.316T>C1.000
ahpC2726528c.336C>G1.000
ahpC2726540c.348C>G1.000
ahpC2726543c.351A>G1.000
ahpC2726546c.354C>G1.000
ahpC2726551p.Gln120Leu1.000
ahpC2726556p.Ala122Thr1.000
ahpC2726564c.372C>G1.000
ahpC2726579c.387T>C1.000
ahpC2726591c.399C>G1.000
ahpC2726593p.Val134Ala1.000
ahpC2726600c.408T>C1.000
ahpC2726601p.Ile137Leu1.000
ahpC2726638p.Ala149Val1.000
ahpC2726645c.453C>G1.000
ahpC2726657c.465A>C1.000
ahpC2726669p.Asp159Glu1.000
ahpC2726672c.480G>A1.000
ahpC2726675c.483A>G1.000
ahpC2726681c.489A>C1.000
ahpC2726693c.501C>G1.000
ahpC2726696c.504C>G1.000
ahpC2726717c.525A>G1.000
ahpC2726747c.555A>C1.000
folC2746282c.1317A>G1.000
folC2746285c.1314A>G1.000
folC2746308p.Arg431Ser1.000
folC2746365p.Leu412Val1.000
folC2746375c.1224C>G1.000
folC2746390c.1209C>G1.000
folC2746393c.1206G>C1.000
folC2746564c.1035T>C1.000
folC2747021p.Val193Ala1.000
folC2747023c.576G>C1.000
folC2747026c.573G>C1.000
folC2747032c.567T>G1.000
folC2747071c.528G>C1.000
folC2747086c.513T>G1.000
folC2747089c.510C>G1.000
folC2747101c.498C>G1.000
folC2747107c.492C>G1.000
folC2747110c.489A>G1.000
folC2747113c.486G>C1.000
folC2747116c.483C>G1.000
folC2747134c.465G>C1.000
folC2747302c.297T>G1.000
folC2747314c.285T>G1.000
folC2747317c.282G>C1.000
folC2747355p.Val82Ile1.000
folC2747362c.237C>G1.000
folC2747394p.Ile69Val1.000
folC2747395c.204A>G1.000
ribD2986959p.Leu41Val1.000
ribD2986978p.Ser47Thr1.000
ribD2986983p.Leu49Val1.000
ribD2986997c.159T>C1.000
ribD2987001p.Val55Ser1.000
ribD2987005p.Asp56Gly1.000
ribD2987011p.Thr58Ser1.000
ribD2987018c.180G>C1.000
ribD2987026p.Ala63Gly1.000
ribD2987033c.195C>G1.000
ribD2987042c.204A>G1.000
ribD2987046p.Val70Ile1.000
ribD2987058c.220T>C1.000
ribD2987066c.228A>G1.000
ribD2987069c.231T>C1.000
ribD2987092p.Val85Ala1.000
ribD2987105c.267C>G1.000
ribD2987108c.270T>C1.000
thyX3067223c.723C>G1.000
thyX3067232c.714G>C1.000
thyX3067316c.630T>C1.000
thyX3067325c.621T>C1.000
thyX3067349c.597C>G1.000
thyX3067355c.591T>G1.000
thyX3067367c.579C>G1.000
thyX3067373c.573G>C1.000
thyX3067376c.570C>T1.000
thyX3067391c.555C>G1.000
thyX3067394c.552C>G1.000
thyX3067439c.507T>C1.000
thyX3067445c.501G>C1.000
thyX3067457c.489G>C1.000
thyX3067465p.Ile161Val1.000
thyX3067475c.471T>C1.000
thyX3067490c.456G>C1.000
thyX3067493c.453T>C1.000
thyX3067515p.Ser144Thr1.000
thyX3067531p.Ala139Ser1.000
thyX3067545p.Glu134Ala1.000
thyX3067549p.Thr133Ala1.000
thyX3067556p.His130Gln1.000
thyX3067559c.387G>C1.000
thyX3067565p.Asp127Glu1.000
thyX3067570p.Ala126Pro1.000
thyX3067577c.369C>T1.000
thyX3067583c.363G>C1.000
thyX3067611p.Lys112Thr1.000
thyX3067619c.327T>G1.000
thyX3067631c.315G>C1.000
thyX3067634c.312G>C1.000
thyX3067652c.294A>G1.000
thyX3067661c.285G>C1.000
thyX3067685c.261T>G1.000
thyX3067693p.Ile85Leu1.000
thyX3067694c.252C>G1.000
thyX3067718c.228G>C1.000
thyX3067721c.225A>G1.000
thyX3067727c.219T>G1.000
thyX3067738p.Phe70Leu1.000
thyX3067739c.207A>G1.000
thyX3067762p.Arg62Lys1.000
thyX3067765p.Leu61Ile1.000
thyX3067772c.174G>C1.000
thyX3067781c.165G>T1.000
thyX3067793c.153A>G1.000
thyX3067799c.147C>T1.000
thyX3067802c.144G>C1.000
thyX3067814c.132A>G1.000
thyX3067850c.96T>G1.000
thyX3067869p.Thr26Ser0.909
thyX3067874c.72G>C0.900
thyX3067883c.63G>C1.000
thyX3067886c.60T>G1.000
thyX3067889c.57G>C1.000
thyX3067898p.Asp16Glu1.000
thyA3073812c.660G>C1.000
thyA3073815c.657C>T1.000
thyA3073824c.648T>C1.000
thyA3073827c.645T>C1.000
thyA3073836c.636G>A1.000
thyA3073839c.633A>G1.000
thyA3073860c.612G>C1.000
thyA3073863c.609A>G1.000
thyA3073866c.606G>C1.000
thyA3073874p.Ile200Val1.000
thyA3073892c.580A>G1.000
thyA3073898p.Ala192Ser1.000
thyA3073917c.555G>C1.000
thyA3073920c.552G>C1.000
thyA3073925c.547A>G1.000
thyA3073929c.543A>G1.000
thyA3073953c.519A>G1.000
thyA3073956c.516C>G1.000
thyA3073959c.513A>G1.000
thyA3073977c.495T>C1.000
thyA3073989c.483A>G1.000
thyA3074004c.468A>G1.000
thyA3074010c.462G>C1.000
thyA3074028c.444C>G1.000
thyA3074031c.441A>G1.000
thyA3074034c.438A>G1.000
thyA3074037c.435G>C1.000
thyA3074053p.Arg140Gln1.000
thyA3074057p.Glu139Pro1.000
thyA3074061c.411T>C1.000
thyA3074079c.393C>G1.000
thyA3074097c.375G>C1.000
thyA3074102p.Asp124Asn1.000
thyA3074106c.366A>G1.000
thyA3074127c.345C>G1.000
thyA3074130c.342C>G1.000
thyA3074172c.300C>G1.000
thyA3074175c.297T>C1.000
thyA3074181c.291T>C1.000
thyA3074187c.285A>G1.000
thyA3074205p.Glu89Asp1.000
thyA3074214c.258A>G1.000
thyA3074241c.231G>C1.000
thyA3074244c.228T>C1.000
thyA3074254p.His73Arg1.000
thyA3074262c.210A>G1.000
thyA3074267p.Ile69Val1.000
thyA3074268c.204A>G1.000
thyA3074285c.187A>G1.000
thyA3074286c.186A>G1.000
thyA3074412c.60G>A0.600
ald3087578c.759A>C1.000
ald3087590p.His257Gln1.000
ald3087596c.777A>G1.000
ald3087599c.780A>G1.000
ald3087602c.783T>C1.000
ald3087608c.789A>G1.000
ald3087614c.795G>C1.000
ald3087617c.798T>C1.000
ald3087620c.801A>C1.000
ald3087621p.Ala268Ser1.000
ald3087635c.816C>T1.000
ald3087641c.822T>C1.000
ald3087647c.828A>G1.000
ald3087649p.Gly277Asp1.000
ald3087653c.834A>G1.000
ald3087656c.837A>G1.000
ald3087665c.846C>G1.000
ald3087666p.Tyr283His1.000
ald3087672p.His285Asp1.000
ald3087680c.861G>C1.000
ald3087704c.885T>C1.000
ald3087716c.897G>C1.000
ald3087726p.Ala303Ser0.882
ald3087729p.Ser304Ala0.882
ald3087737c.918G>C0.882
ald3087749c.930C>G1.000
ald3087750p.Tyr311Val1.000
ald3087761c.942C>G1.000
ald3087770c.951G>C1.000
ald3087787p.Glu323Ala1.000
ald3087791c.972T>C0.800
ald3087797p.Asp326Glu1.000
ald3087799p.His327Arg1.000
ald3087809c.990G>A1.000
fbiA3640347c.-196A>G1.000
fbiA3640349c.-194A>G1.000
fbiA3640350c.-193C>T1.000
fbiA3640365c.-178C>G1.000
fbiA3640557c.15T>C1.000
fbiA3640562p.Ala7Val1.000
fbiA3640569c.27A>G1.000
fbiA3640572c.30C>T1.000
fbiA3640850p.Glu103Gly1.000
fbiA3640857c.315G>C1.000
fbiA3640866c.324T>C1.000
fbiA3640871p.Ala110Gly1.000
fbiA3640878c.336T>C1.000
fbiA3640899c.357G>C1.000
fbiA3640900p.Gln120Asn1.000
fbiA3640914c.372C>G1.000
fbiA3640930p.Glu130Thr1.000
fbiA3640935c.393C>G1.000
fbiA3640938c.396A>G1.000
fbiA3640944c.402T>C1.000
fbiA3640962c.420C>G1.000
fbiA3640965c.423C>G1.000
fbiA3640966c.424T>C1.000
fbiA3640974c.432T>C1.000
fbiA3640976p.Ala145Val1.000
alr3840229p.Ile398Val1.000
alr3840230c.1191A>C1.000
alr3840233c.1188T>C1.000
alr3840236c.1185T>G1.000
alr3840239c.1182C>G1.000
alr3840248c.1173G>C1.000
alr3840368c.1053G>T1.000
alr3840382p.Met347Val1.000
alr3840959c.462C>G1.000
alr3840968c.453C>G1.000
alr3840980c.441C>G1.000
alr3840989c.432C>G1.000
alr3840994p.His143Asp1.000
alr3840997c.424C>G1.000
alr3841001c.420T>C1.000
alr3841010c.411T>C1.000
alr3841018p.Leu135Glu1.000
alr3841022c.399G>C1.000
alr3841028c.393C>G1.000
alr3841033p.Val130Ile1.000
alr3841039p.Val128Ile1.000
alr3841059p.Gly121Ala1.000
alr3841069p.Ile118Phe1.000
alr3841079c.342A>G1.000
alr3841127c.294T>C1.000
panD4043867p.Gly139Arg1.000
panD4043872p.Gly137Val1.000
panD4043876p.Leu136Ile1.000
panD4043883c.399G>A1.000
panD4043886c.396T>C1.000
panD4043896p.Gly129Ala1.000
panD4043903p.Asn127Asp1.000
panD4043913c.369A>G1.000
panD4043916c.366T>C1.000
panD4043922c.360A>G1.000
panD4044057c.225G>C1.000
panD4044072c.210G>C1.000
panD4044075c.207A>G1.000
panD4044081c.201A>G1.000
panD4044084c.198A>G1.000
panD4044105c.177C>G1.000
panD4044117c.165C>G1.000
panD4044120c.162T>G1.000
panD4044123c.159A>G1.000
panD4044126c.156A>G1.000
panD4044138c.144A>G1.000
panD4044144c.138G>A1.000
panD4044150c.132T>C1.000
panD4044165c.117C>G1.000
panD4044174c.108G>C1.000
panD4044177c.105G>C1.000
embC4240178c.316T>C1.000
embC4240183c.321A>G1.000
embC4240204c.342T>C1.000
embC4240210c.348C>G1.000
embC4240216c.354T>C1.000
embC4240219c.357C>G1.000
embC4240222c.360G>C1.000
embC4240229p.Leu123Ile1.000
embC4240232p.Gln124Val1.000
embC4240249p.Asp129Glu1.000
embC4240258c.396T>G1.000
embC4240267c.405T>C1.000
embC4240270c.408T>C1.000
embC4240277p.Leu139Val1.000
embC4240348c.486T>C0.455
embC4240354c.492C>G0.455
embC4240355p.Ala165Thr0.455
embC4240444c.582C>G1.000
embC4240459c.597G>C1.000
embC4240462c.600G>C1.000
embC4240512p.Ser217Thr1.000
embC4240516c.654G>C1.000
embC4240519c.657T>C1.000
embC4240543c.681G>C1.000
embC4240558c.696C>G1.000
embC4240561c.699C>G1.000
embC4240570c.708C>G1.000
embC4240574p.Val238Leu1.000
embC4240578p.Ala239Val1.000
embC4240582c.720C>G1.000
embC4240587p.Gly242Ala1.000
embC4240592p.Ala244Ser1.000
embC4240600c.738G>C1.000
embC4240610p.Ile250Arg1.000
embC4240615c.753G>C1.000
embC4240630c.768C>A1.000
embC4240632p.Met257Thr1.000
embC4240642c.780G>C1.000
embC4240645c.783G>C1.000
embC4240780c.918T>C1.000
embC4240783c.921G>C1.000
embC4240789c.927T>C1.000
embC4240819c.957A>G1.000
embC4240828c.966G>C1.000
embC4240831c.969T>G1.000
embC4240867c.1005T>C1.000
embC4240870c.1008T>C1.000
embC4240873c.1011C>G1.000
embC4240879c.1017G>C1.000
embC4240880p.Ala340Thr1.000
embC4240885c.1023T>C1.000
embC4240897c.1035C>G1.000
embC4240898c.1036C>T1.000
embC4240903c.1041C>G1.000
embC4240911p.Ala350Val1.000
embC4240921c.1059C>G1.000
embC4240924c.1062C>G1.000
embC4240936c.1074A>G1.000
embC4240945c.1083T>G1.000
embC4240954p.Ile364Met1.000
embC4240960c.1098G>C1.000
embC4240996c.1134G>C1.000
embC4241002c.1140G>C1.000
embC4241013p.Met384Thr1.000
embC4241017c.1155T>C1.000
embC4241023c.1161T>G1.000
embC4241032c.1170G>C1.000
embC4241038c.1176G>C1.000
embC4241047c.1185C>G1.000
embC4241050c.1188T>G1.000
embC4241053c.1191G>C1.000
embC4241089c.1227C>G1.000
embC4241095c.1233C>T1.000
embC4241107c.1245G>C1.000
embC4241140c.1278A>G1.000
embC4241146c.1284C>G1.000
embC4241158c.1296T>C1.000
embC4241161c.1299C>G1.000
embC4241162c.1300T>C1.000
embC4241170c.1308G>C1.000
embC4241173c.1311C>T1.000
embC4241203c.1341T>C1.000
embC4241206c.1344G>C1.000
embC4241218c.1356G>C1.000
embC4241230c.1368A>G1.000
embC4241233c.1371G>C1.000
embC4241518c.1656A>G1.000
embC4241521c.1659T>C1.000
embC4241530c.1668C>A1.000
embC4241536c.1674A>G1.000
embC4241539c.1677T>C1.000
embC4241545c.1683T>C1.000
embC4241548c.1686T>C1.000
embC4241551c.1689A>G1.000
embC4241567p.Ile569Val1.000
embC4241572c.1710C>G1.000
embC4241578c.1716G>C1.000
embC4241584c.1722T>C1.000
embC4241587c.1725C>G1.000
embC4241591p.Leu577Val1.000
embC4241611c.1749G>C1.000
embC4241614c.1752A>C1.000
embC4241626c.1764T>C1.000
embC4241635c.1773G>C1.000
embC4241644c.1782G>C1.000
embC4241648c.1786T>C1.000
embC4241657p.Ser599Pro1.000
embC4241665c.1803G>C1.000
embC4241671c.1809T>C1.000
embC4241713c.1851G>C1.000
embC4241719c.1857G>C1.000
embC4241727p.Phe622Tyr1.000
embC4241741p.Val627Leu1.000
embC4241747p.Val629Leu1.000
embC4241750p.Leu630Val1.000
embC4241755c.1893C>G1.000
embC4241770c.1908T>C1.000
embC4241995c.2133C>G1.000
embC4242002p.Leu714Val1.000
embC4242011p.Leu717Val1.000
embC4242024p.Val721Ala1.000
embC4242036p.Gln725Leu1.000
embC4242106c.2244C>G1.000
embC4242121c.2259A>G1.000
embC4242245p.Thr795Arg0.304
embC4242710p.Gln950Glu1.000
embC4242715c.2853T>C1.000
embC4242742c.2880C>G1.000
embC4242748c.2886A>G1.000
embC4242754c.2892G>C1.000
embC4242764p.Val968Leu1.000
embC4242779p.Asn973Asp1.000
embC4242791p.Ala977Ser1.000
embC4242796c.2934G>C1.000
embC4242799c.2937T>C1.000
embC4242820c.2958G>C1.000
embC4242823c.2961G>C1.000
embC4242832c.2970A>C1.000
embC4242838c.2976C>G1.000
embC4242841c.2979C>T1.000
embC4242844c.2982A>G1.000
embC4242847c.2985C>A1.000
embC4242859c.2997C>T1.000
embC4242862c.3000A>G1.000
embC4242863p.Tyr1001Asn1.000
embC4242883c.3021C>G1.000
embC4242892c.3030G>C1.000
embC4242901c.3039G>C1.000
embC4242919c.3057A>G1.000
embC4242928c.3066A>G1.000
embC4242940c.3078T>C1.000
embA4243218c.-15C>T1.000
embA4243222c.-11C>G1.000
embA4243245p.Gly5Arg1.000
embA4244366c.1134C>G1.000
embA4244372c.1140T>G1.000
embA4244378c.1146G>A1.000
embA4244390c.1158G>C1.000
embA4244393c.1161G>C1.000
embA4244396c.1164T>C1.000
embA4244408c.1176G>C1.000
embA4244412p.Val394Met1.000
embA4244415c.1183T>C1.000
embA4244420c.1188G>C1.000
embA4244426c.1194G>C1.000
embA4244427p.Ser399Ala1.000
embA4244435c.1203G>C1.000
embA4244438c.1206C>G1.000
embA4244439p.Gly403Arg1.000
embA4244447c.1215G>C1.000
embA4244462c.1230A>G1.000
embA4244478p.Thr416Leu1.000
embA4244483c.1251T>G1.000
embA4244485p.Thr418Ser1.000
embA4244498c.1266A>G1.000
embA4244507c.1275G>T1.000
embA4244508c.1276T>C1.000
embA4244516c.1284G>C1.000
embA4244517p.Leu429Val1.000
embA4244523p.Pro431Ala1.000
embA4244534c.1302T>C1.000
embA4244537c.1305T>G1.000
embA4244543c.1311C>G1.000
embA4244547p.Ile439Val1.000
embA4244552c.1320C>G1.000
embA4244557p.Arg442Thr1.000
embA4244567c.1335C>T1.000
embA4244582c.1350T>C1.000
embA4244611p.Ala460Gly0.789
embA4244616p.Ala462Ser1.000
embA4244619c.1387T>C1.000
embA4244625p.Leu465Val1.000
embA4244631p.Thr467Leu1.000
embA4244645c.1413T>C1.000
embA4244648c.1416G>C1.000
embA4244649p.Asp473Ser1.000
embA4245041c.1809C>G1.000
embA4245044c.1812G>C1.000
embA4245053c.1821G>C0.952
embA4245060c.1828T>C1.000
embA4245083c.1851A>C1.000
embA4245089c.1857G>C1.000
embA4245092c.1860C>G1.000
embA4245101c.1869G>C1.000
embA4245137c.1905T>C1.000
embA4245146c.1914G>A1.000
embA4245149c.1917C>G1.000
embA4245153p.Ile641Val1.000
embA4245182c.1950T>C1.000
embA4245189c.1957C>T1.000
embA4245198p.Leu656Ile1.000
embA4245207c.1975T>C1.000
embA4245215c.1983A>C1.000
embA4245222p.Tyr664Gln1.000
embA4245248c.2016G>C1.000
embA4245257c.2025A>G1.000
embA4245263c.2031A>G1.000
embA4245282p.Ile684Val1.000
embA4245285c.2053T>C1.000
embA4245290c.2058C>G1.000
embA4245293c.2061T>G1.000
embA4245296c.2064G>C1.000
embA4245299c.2067A>G1.000
embA4245315p.Val695Thr1.000
embA4245328p.Ala699Val1.000
embA4245335c.2103A>G1.000
embA4245340p.Gly703Ala1.000
embA4245345p.Met705Leu1.000
embA4245348p.Ala706Thr1.000
embA4245355p.Ala708Gly1.000
embA4245368c.2136T>C1.000
embA4245377c.2145T>C1.000
embA4245388p.Ala719Gly1.000
embA4245659c.2427C>G1.000
embA4245668c.2436C>G1.000
embA4245674c.2442A>C1.000
embA4245677c.2445G>C1.000
embA4245693p.Ile821Val1.000
embA4245701c.2469G>C1.000
embA4245704c.2472G>C1.000
embA4245725c.2493A>G1.000
embA4245726c.2494T>C1.000
embA4245737c.2505A>C1.000
embA4245740c.2508T>C1.000
embA4245764c.2532G>C1.000
embA4245772p.Asn847Thr1.000
embA4245785c.2553G>C1.000
embA4245807c.2575T>C1.000
embA4245812c.2580G>C1.000
embA4245813p.Pro861Ala1.000
embA4245820p.Ser863Thr1.000
embA4245824c.2592G>C1.000
embA4245833c.2601G>C1.000
embA4245842c.2610G>C1.000
embA4245845c.2613T>C1.000
embA4245851c.2619G>C1.000
embA4245860c.2628C>G1.000
embA4245885p.Asp885Thr1.000
embA4245892p.Ile887Thr1.000
embA4245899c.2667C>G1.000
embA4245902c.2670G>A1.000
embA4245905c.2673C>G1.000
embA4245911c.2679A>G1.000
embA4245917c.2685G>A1.000
embA4245930p.Gly900Arg1.000
embA4246040c.2808C>G1.000
embA4246041p.Asp937Asn1.000
embA4246055c.2823T>C1.000
embA4246064c.2832T>C1.000
embA4246080p.Pro950Ser1.000
embA4246088c.2856A>G1.000
embA4246097c.2865C>G1.000
embA4246103c.2871C>G1.000
embA4246109c.2877C>G1.000
embA4246115c.2883T>G1.000
embA4246128p.Ser966Thr1.000
embA4246138p.Arg969Gln1.000
embA4246140c.2908T>C1.000
embA4246143p.Ile971Val1.000
embA4246151c.2919A>G1.000
embA4246152p.Ala974Gln1.000
embA4246157c.2925A>G1.000
embA4246164c.2932T>C1.000
embA4246184c.2952A>C1.000
embA4246196c.2964C>G1.000
embA4246205c.2973A>G1.000
embA4246211c.2979T>C1.000
embA4246217c.2985G>A1.000
embA4246220c.2988T>C1.000
embA4246223c.2991C>T1.000
embA4246227p.Ile999Val1.000
embA4246235c.3003G>A1.000
embA4246242p.Gln1004Gly1.000
embA4246250c.3018G>C1.000
embA4246256c.3024G>T1.000
embA4246264p.His1011Arg1.000
embA4246292c.3060A>G1.000
embA4246305p.Ser1025Glu1.000
embA4246308p.Thr1026Ala1.000
embA4246316c.3084T>G1.000
embA4246319c.3087G>C1.000
embA4246329p.Thr1033Leu1.000
embA4246349c.3117C>G1.000
embA4246359p.Ala1043Ser1.000
embA4246367c.3135C>T1.000
embA4246373c.3141T>C1.000
embA4246376c.3144G>C1.000
embA4246379c.3147C>T1.000
embA4246400c.3168G>C1.000
embB4246548p.Pro12Gln0.400
embB4246594c.81C>T1.000
embB4246603c.90C>G1.000
embB4246615c.102G>C1.000
embB4246621c.108T>C1.000
embB4246624c.111C>G1.000
embB4246627c.114T>C1.000
embB4246631c.118T>C0.556
embB4246636c.123G>C0.556
embB4246639c.126G>C0.556
embB4246642c.129G>C0.556
embB4246645c.132G>C0.556
embB4246669c.156C>G1.000
embB4247365c.852A>C1.000
embB4247371c.858C>G1.000
embB4247375p.Leu288Val1.000
embB4247386c.873T>C1.000
embB4247389c.876C>G1.000
embB4247395c.882C>G1.000
embB4247401c.888T>C1.000
embB4247407c.894G>C1.000
embB4247413c.900C>T1.000
embB4247425c.912G>C1.000
embB4247434c.921C>G1.000
embB4247437c.924A>G1.000
embB4247440c.927C>G1.000
embB4247446c.933C>T1.000
embB4247464c.951C>G1.000
embB4247470c.957T>C1.000
embB4247491c.978G>C1.000
embB4247497c.984T>C1.000
embB4247512c.999T>C1.000
embB4247539c.1026T>C1.000
embB4247554c.1041T>C1.000
embB4247566c.1053C>A1.000
embB4247572c.1059A>G1.000
embB4247579p.Ala356Phe1.000
embB4247587c.1074G>A1.000
embB4247603c.1090C>T0.909
embB4247611c.1098G>T1.000
embB4247614c.1101T>C1.000
embB4247629c.1116C>G1.000
embB4247632c.1119C>G1.000
embB4247638c.1125G>C1.000
embB4247646p.Glu378Ala1.000
embB4247656c.1143A>G1.000
embB4247659c.1146C>G1.000
embB4247662c.1149C>G1.000
embB4247683c.1170C>G1.000
embB4247692c.1179C>G1.000
embB4247716c.1203C>T1.000
embB4247746c.1233C>T1.000
embB4247761c.1248T>C1.000
embB4247773c.1260G>A1.000
embB4247776c.1263G>T1.000
embB4247797c.1284C>G1.000
embB4247800c.1287A>T1.000
embB4247803c.1290G>C1.000
embB4247815c.1302C>G1.000
embB4247819p.Val436Ile1.000
embB4247830c.1317A>G1.000
embB4247836c.1323A>G1.000
embB4247839c.1326G>C1.000
embB4247866c.1353G>C0.739
embB4247875c.1362G>C0.545
embB4247876c.1363C>T0.545
embB4247881c.1368G>C0.750
embB4247887c.1374C>T0.750
embB4247893c.1380C>T1.000
embB4247899p.Met462Ile1.000
embB4247905c.1392G>C1.000
embB4247909c.1396T>C1.000
embB4247932c.1419C>G1.000
embB4247940p.Leu476Trp1.000
embB4247945c.1432T>C1.000
embB4247951p.Ser480Ala1.000
embB4247956c.1443G>C1.000
embB4247974c.1461C>G1.000
embB4248007c.1494C>G1.000
embB4248011p.Ser500Arg1.000
embB4248014p.Thr501Ala1.000
embB4248035p.Val508Ile1.000
embB4248040c.1527C>G1.000
embB4248041p.Ala510Thr1.000
embB4248044p.Lys511Ala1.000
embB4248070c.1557T>C1.000
embB4248085c.1572T>C1.000
embB4248097c.1584C>G1.000
embB4248130c.1617G>C1.000
embB4248133c.1620C>G1.000
embB4248139c.1626C>G1.000
embB4248142c.1629T>C1.000
embB4248143c.1630T>C1.000
embB4248157c.1644A>G1.000
embB4248199c.1686A>G1.000
embB4248200p.Ile563Val1.000
embB4248205c.1692C>G1.000
embB4248206p.Ser565Gly1.000
embB4248220c.1707A>C1.000
embB4248304c.1791G>C1.000
embB4248319c.1806A>G1.000
embB4248343c.1830G>C1.000
embB4248350c.1837T>C1.000
embB4248355c.1842A>G1.000
embB4248358c.1845C>G1.000
embB4248361c.1848A>C1.000
embB4248362p.Ser617Ala1.000
embB4248373c.1860C>G1.000
embB4248386c.1873C>A1.000
embB4248407p.Leu632Val1.000
embB4248410p.Phe633Leu1.000
embB4248419p.Leu636Met1.000
embB4248425c.1912T>C1.000
embB4248430c.1917T>C1.000
embB4248432p.Trp640Phe1.000
embB4248457c.1944T>C1.000
embB4248472c.1959T>C1.000
embB4248475c.1962G>C1.000
embB4248500p.Ile663Val1.000
embB4248504p.Asp664Gly1.000
embB4248508c.1995G>A1.000
embB4248512p.Thr667Ser0.933
embB4248535c.2022C>G1.000
embB4249135c.2622G>C1.000
embB4249138c.2625C>G1.000
embB4249145p.Thr878Ser1.000
embB4249153c.2640G>C1.000
embB4249164p.Ala884Asp1.000
embB4249259p.Met916Leu1.000
embB4249268p.Asp919Tyr1.000
embB4249276c.2763A>G1.000
embB4249277p.Tyr922Asn1.000
embB4249282c.2769A>C1.000
embB4249291c.2778C>A1.000
embB4249297c.2784G>C1.000
embB4249312c.2799C>T1.000
embB4249321c.2808A>C1.000
embB4249322p.Ala937Ser1.000
embB4249325p.Lys938Asp1.000
embB4249333c.2820C>G1.000
embB4249336c.2823C>G1.000
embB4249339c.2826T>C1.000
embB4249342c.2829C>G1.000
embB4249348c.2835G>C1.000
embB4249351c.2838C>G1.000
embB4249369c.2856T>C1.000
embB4249375c.2862G>C1.000
embB4249381c.2868A>G1.000
embB4249384c.2871G>T1.000
embB4249417c.2904A>G1.000
embB4249423p.Asp970Glu1.000
embB4249424p.Leu971Met1.000
embB4249429c.2916C>T1.000
embB4249432c.2919A>G1.000
embB4249441c.2928A>G1.000
embB4249444c.2931T>C1.000
embB4249469p.Leu986Met1.000
embB4249486c.2973T>G1.000
embB4249498c.2985G>C1.000
embB4249521p.Ala1003Val1.000
embB4249525c.3012T>C1.000
embB4249615c.3102C>G0.222
embB4249618c.3105C>G0.222
embB4249624c.3111C>G0.222
embB4249627c.3114G>C0.222
ethA4326307c.1167G>C1.000
ethA4326310c.1164A>G1.000
ethA4326836p.Val213Gly1.000
ethA4326847c.627G>C1.000
ethA4326850c.624T>C1.000
ethR4327746c.198A>G1.000
ethR4327755p.Glu69Asp1.000
gid4407603c.600C>T1.000
gid4407609c.594C>G1.000
gid4407622p.Asn194Thr1.000
gid4407652p.Val184Ala1.000
gid4407654c.549C>G1.000
gid4407668p.Ile179Ala1.000

Analysis pipeline specifications

TBProfiler Version: 2.1.1

AnalysisProgram
Mappingbwa
Variant CallingBCFtools


Log

Drug Details
The estimated accuracy of drug resistance predictions is:

Drug1Sensitivity (%)Specificity (%)
Isoniazid 92.8 (89.9-95.7)100 (100-100)
Rifampicin 96.2 (93.9-98.5)98.1 (96.8-99.4)
Ethambutal 88.7 (83.6-93.8)81.7 (77.6-85.8)
Pyrazinamide70.9 (62.4-79.4)93.9 (90.6-97.2)
Streptomycin87.1 (82.7-91.5)89.7 (86.0-93.4)
Ethionamide 73.6 (66.7-80.5)93.3 (89.6-97.0)
Moxifloxacin60.0 (29.6-90.4)68.7 (52.6-84.8)
Ofloxacin 85.5 (79.1-91.9)94.9 (91.8-98.0)
Amikacin 82.9 (74.4-91.4)98.3 (96.0-100)
Capreomycin 60.7 (50.6-70.8)90.7 (87.2-94.2)
Kanamycin 87.3 (81.3-93.3)93.4 (89.9-96.9)
Para-aminosalisylic acidNot determinedNot determined
Linezolid Not determinedNot determined
Clofazimine Not determinedNot determined
Bedaquiline Not determinedNot determined
Multi drug resistance91.2 (87.8-94.6)98.4 (97.2-99.6)
Extremely drug resistance75.9 (64.5-87.3)98.4 (97.3-99.5)

Lineages
Lineage2LocationStrainRD type
lineage1Indo-OceanicEAIRD239
lineage1.1Indo-OceanicEAI3;EAI4;EAI5;EAI6RD239
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineage1.1.1.1Indo-OceanicEAI4;ZERORD239
lineage1.1.2Indo-OceanicEAI3;EAI5RD239
lineage1.1.3Indo-OceanicEAI6RD239
lineage1.2Indo-OceanicEAI1;EAI2RD239
lineage1.2.1Indo-OceanicEAI2RD239
lineage1.2.2Indo-OceanicEAI1RD239
lineage2East-AsianBeijingRD105
lineage2.1East-Asian (non-Beijing)NoneNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.2East-Asian (Beijing)Beijing-RD105/RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181
lineage2.2.1.2East-Asian (Beijing)Beijing-RD142RD105;RD207;RD181;RD142
lineage2.2.1.1East-Asian (Beijing)Beijing-RD150RD105;RD207;RD181;RD150
lineage3East-African-IndianCASRD750
lineage3.1East-African-IndianNon-CAS1-DelhiRD750
lineage3.1.1East-African-IndianCAS1-KiliRD750
lineage3.1.2East-African-IndianCAS;CAS2RD750
lineage3.1.2.1East-African-IndianCAS2RD750
lineage3.1.2.2East-African-IndianCASRD750
lineage4Euro-AmericanLAM;T;S;X;HNone
lineage4.1Euro-AmericanT;X;HNone
lineage4.1.2Euro-American (X-type)T;HNone
lineage4.1.2.1Euro-American (X-type)T1;H1RD182
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.2Euro-American (X-type)X1None
lineage4.1.1.1Euro-American (X-type)X2RD183
lineage4.1.1.3Euro-American (Haarlem)X1;X3RD193
lineage4.2Euro-AmericanH;T;LAMNone
lineage4.2.2Euro-American (Ural)T;LAM7-TURNone
lineage4.2.2.1Euro-AmericanLAM7-TURNone
lineage4.2.1Euro-American (TUR)H3;H4None
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.3.1Euro-American (LAM)LAM9None
lineage4.3.3Euro-American (LAM)LAM;TRD115
lineage4.3.4Euro-American (LAM)LAMRD174
lineage4.3.4.1Euro-American (LAM)LAM1;LAM2RD174
lineage4.3.4.2Euro-American (LAM)LAM1;LAM4;LAM11RD174
lineage4.3.4.2.1Euro-American (LAM)LAM11RD174
lineage4.3.2Euro-American (LAM)LAM3None
lineage4.3.2.1Euro-American (LAM)LAM3RD761
lineage4.4Euro-AmericanS;TNone
lineage4.4.2Euro-AmericanT1;T2None
lineage4.4.1Euro-American (S-type)S;TNone
lineage4.4.1.2Euro-AmericanT1None
lineage4.4.1.1Euro-AmericanS;OrphansNone
lineage4.5Euro-AmericanH;TRD122
lineage4.6Euro-AmericanT;LAMNone
lineage4.6.1Euro-American (Uganda)T2RD724
lineage4.6.1.1Euro-American T2-UgandaRD724
lineage4.6.1.2Euro-AmericanT2RD724
lineage4.6.2Euro-AmericanT;LAMRD726
lineage4.6.2.1Euro-AmericanT3RD726
lineage4.6.2.2Euro-American (Cameroon)LAM10-CAMRD726
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.8Euro-American (mainly T)T1;T2;T3;T5RD219
lineage4.9Euro-American (H37Rv-like)T1None
lineage5West-Africa 1AFRI_2;AFRI_3RD711
lineage6West-Africa 2AFRI_1RD702
lineage7Lineage 7NoneNone
lineageBOVM. bovisBOV_1;BOV_2None

Citations
1. Coll F, et al. Rapid determination of anti-tuberculosis drug resistance from whole genome sequences. Genome Medicine (in press)
2. Coll F, et al. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications 2014.

Disclaimer
This tool is for Research Use Only and is offered free for use. The London School of Hygiene and Tropical Medicine shall have no liability for any loss or damages of any kind, however sustained relating to the use of this tool.
© 2019 London School of Hygiene and Tropical Medicine;