TB Profiler
This tool processes raw sequence data to infer strain type and identify known drug resistance markers.
A stand alone version of this tool is now available and can now be run on linux or mac. Installation instructions can be found on GitHub and on the bioconda page.



This tool is for Research Use Only. Data and information provided through use of this tool are not intended for medical purpose or objective and should not be used for clinical diagnosis, patient management, or human clinical trials.
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Single nucleotide polymorphisms (SNPs) in coding regions are annotated using the reference amino acid, codon number and alternative amino acid (e.g. Ser315Thr in katG). SNPs in non-coding regions (i.e. RNA genes and intergenic regions) are annotated using the reference nucleotide, gene coordinate and alternative nucleotide (e.g. A1401G in rrs or C-37A in eis promoter). Indels are annotated using the reference VCF allele, gene coordinate and alternative VCF allele (e.g. T902TA insertion in katG).
Name: 5d7f343ad1a6a
Sample: 5d7f343ad1a6a

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Summary
ID: 5d7f343ad1a6a
Date: Mon Sep 16 08:08:29 2019
Strain: lineage4.3
Drug-resistance: Drug-resistant

Drug1ResistanceSupporting Mutations (frequency)
Isoniazid
Rifampicin
EthambutolRembB p.His312Arg (0.97), embB p.Leu359Ile (0.96), embB p.Ala388Gly (0.79), embB p.Asn399Asp (0.85), embB p.Ala659Thr (0.82)
Pyrazinamide
StreptomycinRrrs r.462c>t (0.96)
Ethionamide
Fluoroquinolones
Amikacin
Capreomycin
Kanamycin

Lineage2FamilyMain SpoligotypeRDS
lineage4.3Euro-American (LAM)mainly-LAMNone

Mutations in candidate genes:
GeneChromosome PositionMutationEstimated fraction
gyrB6082c.843G>A0.926
gyrB6086p.Thr283Pro0.931
gyrB6091c.852G>C0.935
gyrB6100c.861G>C0.971
gyrB6115c.876A>G0.974
gyrB6123p.Ala295Gly0.975
gyrB6127c.888G>C0.975
gyrB6130c.891T>C0.975
gyrB6136c.897G>A0.976
gyrB6139c.900G>C0.977
gyrB6196c.957C>T1.000
gyrB6238c.999G>A0.977
gyrB6242p.Arg335Lys0.977
gyrB6250c.1011A>G0.980
gyrB6256c.1017G>A0.982
gyrB6268c.1029C>G0.983
gyrB6280c.1041T>C0.983
gyrB6286c.1047T>C0.981
gyrB6289c.1050C>T0.981
gyrB6292c.1053G>C0.981
gyrB6307c.1068T>G0.984
gyrB6319c.1080G>C0.983
gyrB6362c.1123T>C0.980
gyrB6376c.1137G>A0.977
gyrB6379c.1140C>G0.975
gyrB6382c.1143A>G0.975
gyrB6388c.1149T>C0.974
gyrB6403c.1164T>C0.971
gyrB6415c.1176G>C0.958
gyrB6427c.1188T>C0.952
gyrB6430c.1191A>G0.950
gyrB6440p.Thr401Ala0.950
gyrB6577c.1338T>C0.909
gyrB6580c.1341C>G0.938
gyrB6598c.1359C>G0.950
gyrB6610c.1371C>G0.950
gyrB6613c.1374A>G0.950
gyrB6616c.1377A>G0.950
gyrB6622c.1383C>T0.950
gyrB6634c.1395T>C0.963
gyrB6637c.1398T>G0.963
gyrB6640c.1401A>G0.964
gyrB6643c.1404A>G1.000
gyrB6649c.1410T>C1.000
gyrB6655c.1416T>C1.000
gyrB6670c.1431G>A1.000
gyrB6673c.1434A>C1.000
gyrB6676c.1437T>G1.000
gyrB6700c.1461T>C1.000
gyrB6703c.1464G>C1.000
gyrB6709c.1470A>G1.000
gyrB6712c.1473G>C1.000
gyrB6728c.1489C>T1.000
gyrB6742c.1503A>G0.972
gyrB6745c.1506T>G0.972
gyrB6751c.1512G>C0.976
gyrB6760c.1521G>C0.977
gyrB6763c.1524G>C0.977
gyrB6775c.1536G>C0.974
gyrB6787c.1548G>A0.966
gyrB6793c.1554T>C0.963
gyrB6797p.Gly520Thr0.929
gyrB6811c.1572C>T0.917
gyrB6841c.1602T>C0.882
gyrB6844c.1605T>C0.875
gyrB6889c.1650G>T0.867
gyrB6901c.1662G>C0.895
gyrB6904c.1665C>G0.895
gyrB6910c.1671G>A0.900
gyrB6916c.1677G>C0.900
gyrB6919c.1680T>C0.900
gyrB6925c.1686T>C0.926
gyrB6931c.1692A>G0.939
gyrB6949c.1710A>G0.974
gyrB6952c.1713C>G0.974
gyrB6967c.1728T>C1.000
gyrB6973c.1734G>C1.000
gyrB6982c.1743A>C1.000
gyrB7006c.1767T>C1.000
gyrB7007c.1768C>T1.000
gyrB7010c.1771C>T1.000
gyrB7015c.1776G>A1.000
gyrB7023p.Leu595Gln1.000
gyrB7033c.1794G>C1.000
gyrB7051p.Glu604Asp1.000
gyrB7066c.1827G>C0.971
gyrB7075c.1836T>C0.958
gyrB7078c.1839A>C0.957
gyrB7084c.1845A>G0.920
gyrB7090c.1851C>T0.926
gyrB7093c.1854T>G0.926
gyrB7099c.1860G>A0.923
gyrB7108c.1869G>A0.931
gyrB7114c.1875C>A0.933
gyrB7124p.Ser629Thr0.875
gyrB7129c.1890T>C0.870
gyrB7132c.1893T>G0.875
gyrB7141c.1902T>C0.875
gyrB7147c.1908G>C0.879
gyrB7165c.1926C>G0.902
gyrB7178c.1939T>C0.918
gyrB7186c.1947C>G0.922
gyrB7216c.1977G>C0.956
gyrB7234c.1995C>T0.976
gyrB7246c.2007T>C0.973
gyrB7252c.2013G>C0.971
gyrB7256c.2017C>T0.964
gyrA7334c.33G>C0.933
gyrA7335p.Leu12Val0.941
gyrA7347p.Glu16Gln0.947
gyrA7355c.54T>C0.947
gyrA7361c.60C>T0.947
gyrA7362p.Glu21Gln1.000
gyrA7391c.90C>T0.968
gyrA7394c.93T>C0.969
gyrA7427c.126G>C0.977
gyrA7442c.141G>C0.979
gyrA7451c.150C>G0.962
gyrA7457c.156T>C0.962
gyrA7475c.174A>G0.953
gyrA7480p.Phe60Tyr0.950
gyrA7484c.183T>C0.952
gyrA7490c.189C>G0.960
gyrA7523c.222C>G0.963
gyrA7532c.231T>G0.963
gyrA7541c.240C>G0.981
gyrA7547c.246C>T0.981
gyrA7571c.270G>C0.977
gyrA7585p.Ser95Thr1.000
gyrA7595c.294C>G0.935
gyrA7601c.300C>G0.929
gyrA7607c.306C>T0.929
gyrA7622c.321C>T0.958
gyrA7625c.324G>C0.957
gyrA7631c.330G>C0.955
gyrA7637c.336C>G0.941
gyrA7652c.351C>T0.933
gyrA7658c.357A>C0.929
gyrA7664c.363T>C0.917
gyrA7670c.369A>G0.900
gyrA7679c.378G>C0.800
gyrA7694c.393A>G0.929
gyrA7697c.396C>G0.929
gyrA7710c.409T>C0.903
gyrA7728c.427A>C0.917
gyrA7763c.462T>C0.957
gyrA7784c.483A>G0.962
gyrA7790c.489G>C0.959
gyrA7793c.492G>C0.959
gyrA7796c.495G>C0.958
gyrA7799c.498A>G0.958
gyrA7814c.513C>G0.942
gyrA7823c.522G>C0.955
gyrA7832c.531G>T0.974
gyrA7835c.534A>C0.974
gyrA7853c.552C>G1.000
gyrA7859c.558A>G1.000
gyrA7865c.564T>C1.000
gyrA7886c.585T>C0.964
gyrA8069c.768T>C0.900
gyrA8078c.777A>G0.917
gyrA8090c.789C>A0.875
gyrA8096c.795T>A0.889
gyrA8099c.798T>C0.895
gyrA8111c.810G>C0.920
gyrA8121c.820T>C0.923
gyrA8129c.828T>C0.926
gyrA8135c.834C>G0.935
gyrA8156c.855T>C0.973
gyrA8168c.867A>G0.975
gyrA8177c.876A>C1.000
gyrA8198c.897T>C0.976
gyrA8207c.906T>C0.976
gyrA8219c.918T>C0.977
gyrA8225c.924T>C0.978
gyrA8234c.933T>C0.979
gyrA8247p.Ile316Val0.979
gyrA8264c.963T>C0.980
gyrA8267c.966G>C0.980
gyrA8270c.969G>C0.980
gyrA8276c.975G>A0.981
gyrA8283p.Ile328Leu0.981
gyrA8294c.993T>C0.982
gyrA8324c.1023T>C1.000
gyrA8330c.1029C>G1.000
gyrA8339c.1038A>G1.000
gyrA8340p.Ala347Ser1.000
gyrA8372c.1071G>C1.000
gyrA8375c.1074G>C1.000
gyrA8382p.Leu361Met1.000
gyrA8387c.1086C>T1.000
gyrA8391p.Tyr364His1.000
gyrA8399c.1098T>C1.000
gyrA8401p.Asp367Ala1.000
gyrA8405c.1104C>T1.000
gyrA8420c.1119T>C0.984
gyrA8442c.1141C>T0.982
gyrA8453c.1152A>C0.980
gyrA8462c.1161A>T0.977
gyrA8465c.1164C>G0.977
gyrA8471c.1170T>C0.975
gyrA8472c.1171C>T0.975
gyrA8480c.1179C>T0.974
gyrA8486c.1185T>C0.974
gyrA8504c.1203G>C0.966
gyrA8516c.1215T>C0.933
gyrA8519c.1218A>C0.929
gyrA8520c.1219C>T0.929
gyrA8528c.1227G>C0.947
gyrA8543c.1242C>G0.944
gyrA8546c.1245T>C0.944
gyrA8552c.1251C>A1.000
gyrA8561c.1260A>G1.000
gyrA8576c.1275C>G1.000
gyrA8579c.1278C>T1.000
gyrA8588c.1287G>A1.000
gyrA8597c.1296C>G1.000
gyrA8603c.1302A>G1.000
gyrA8619c.1318T>C1.000
gyrA8624c.1323G>C1.000
gyrA8636c.1335A>C1.000
gyrA8642c.1341A>G1.000
gyrA8672c.1371A>G1.000
gyrA8678c.1377G>A1.000
gyrA8693c.1392T>C1.000
gyrA8696c.1395G>C1.000
gyrA8699c.1398A>G1.000
gyrA8711c.1410A>C1.000
gyrA8714c.1413A>G1.000
gyrA8729c.1428T>C1.000
gyrA8730p.Gly477Arg1.000
gyrA8740p.Arg480His0.929
gyrA8780p.Asp493Glu0.944
gyrA8786c.1485T>C0.944
gyrA8801c.1500G>C0.944
gyrA8807c.1506C>T0.944
gyrA8810c.1509A>G0.944
gyrA8816c.1515C>G0.950
gyrA8818p.Ser506Asn0.957
gyrA8828c.1527T>C0.929
gyrA8837c.1536C>T0.906
gyrA8852c.1551T>C0.919
gyrA8858c.1557T>C0.921
gyrA8867c.1566A>G0.927
gyrA8870c.1569G>C0.927
gyrA8873c.1572A>C0.929
gyrA8897c.1596T>C0.952
gyrA8903c.1602T>C0.950
gyrA8918c.1617C>A0.941
gyrA8933c.1632G>C0.935
gyrA8939c.1638T>C0.926
gyrA8942c.1641G>C0.923
gyrA8946c.1645T>C0.923
gyrA8966c.1665C>G0.900
gyrA8967p.Ala556Arg0.900
gyrA8987c.1686C>G1.000
gyrA8996c.1695T>C1.000
gyrA8998p.Leu566Trp1.000
gyrA9080c.1779G>T1.000
gyrA9089c.1788G>C1.000
gyrA9099c.1798T>C1.000
gyrA9104c.1803C>G1.000
gyrA9119c.1818A>G1.000
gyrA9122c.1821C>A1.000
gyrA9143c.1842T>C1.000
gyrA9152c.1851C>T1.000
gyrA9153p.Thr618Glu1.000
gyrA9158c.1857C>T1.000
gyrA9161c.1860C>G0.966
gyrA9182c.1881T>C0.980
gyrA9191c.1890G>C0.981
gyrA9200c.1899A>G0.982
gyrA9204p.Ser635Thr0.983
gyrA9224c.1923C>T0.982
gyrA9230c.1929T>C0.982
gyrA9233c.1932C>G0.982
gyrA9239c.1938C>T0.982
gyrA9252p.Val651Ile0.981
gyrA9284c.1983T>C0.964
gyrA9291c.1990C>T0.951
gyrA9296c.1995T>C0.951
gyrA9299c.1998G>C0.950
gyrA9300p.Ala667Ser0.950
gyrA9304p.Gly668Asp1.000
gyrA9308p.Asp669Glu0.957
gyrA9323c.2022C>G0.984
gyrA9335c.2034G>C0.981
gyrA9365c.2064G>A0.977
gyrA9374c.2073G>C0.972
gyrA9377c.2076A>G1.000
gyrA9383c.2082T>G1.000
gyrA9386c.2085T>C1.000
gyrA9395c.2094G>C1.000
gyrA9398c.2097T>C1.000
gyrA9413c.2112G>C0.958
rpoB759606c.-201T>C0.971
rpoB759629c.-178T>C0.967
rpoB759644c.-163T>A0.960
rpoB759647c.-160T>C0.957
rpoB759656c.-151A>C0.833
rpoB759657c.-150G>C0.818
rpoB759659c.-148T>A0.818
rpoB759660c.-147T>C0.818
rpoB759662c.-145C>T0.818
rpoB759667c.-140C>T0.818
rpoB759670c.-137C>T0.900
rpoB759671c.-136G>T0.900
rpoB759672c.-135G>C0.900
rpoB759683c.-124T>C0.900
rpoB760046c.240G>C1.000
rpoB760060p.Tyr85Leu0.947
rpoB760067c.261G>C0.950
rpoB760070c.264T>G0.952
rpoB760091c.285G>C0.971
rpoB760101c.295T>C0.975
rpoB760112c.306T>C0.977
rpoB760118c.312T>G0.978
rpoB760121c.315T>C0.978
rpoB760130p.Asp108Glu0.980
rpoB760139c.333A>G0.959
rpoB760142c.336C>G0.980
rpoB760181c.375T>C0.981
rpoB760184c.378A>G0.981
rpoB760196c.390C>G0.979
rpoB760223c.417T>C1.000
rpoB760235c.429T>C1.000
rpoB760283c.477G>C0.976
rpoB760298c.492G>C0.977
rpoB760307c.501T>C0.976
rpoB760310c.504G>C0.977
rpoB760328c.522G>C0.976
rpoB760331c.525G>C0.976
rpoB760340c.534G>T0.977
rpoB760361c.555T>C0.979
rpoB760370c.564C>G0.979
rpoB760376p.Asp190Glu0.978
rpoB760380p.Thr192Leu0.978
rpoB760406c.600G>C1.000
rpoB760412c.606C>G1.000
rpoB760424c.618C>G1.000
rpoB760430c.624T>C1.000
rpoB760475c.669A>G1.000
rpoB760481c.675G>C1.000
rpoB760484c.678A>G1.000
rpoB760522p.Ser239Asn1.000
rpoB760532c.726T>C1.000
rpoB760533p.Val243Thr1.000
rpoB760541c.735G>C1.000
rpoB760547c.741G>C1.000
rpoB760563p.Arg253Met1.000
rpoB760591p.Val262Ala0.985
rpoB760611c.805T>C0.969
rpoB760646c.840C>G0.967
rpoB760655c.849A>G0.968
rpoB760661c.855A>C0.968
rpoB760670c.864G>C0.963
rpoB760674c.868T>C0.963
rpoB760679c.873A>G0.963
rpoB760683c.877T>C0.964
rpoB760718c.912C>T0.957
rpoB760724c.918T>C0.955
rpoB760730c.924T>C0.952
rpoB760751c.945G>C0.971
rpoB760757c.951T>C0.958
rpoB760759p.Val318Ala0.958
rpoB760769c.963C>G0.957
rpoB760775c.969G>C0.955
rpoB760776c.970T>A0.955
rpoB760793c.987A>G1.000
rpoB760805c.999G>C1.000
rpoB760869p.Val355Ile1.000
rpoB760886c.1080A>G1.000
rpoB760925c.1119T>C0.980
rpoB760928c.1122G>C0.980
rpoB760931c.1125C>G0.980
rpoB760934c.1128C>T0.980
rpoB760946c.1140A>G0.965
rpoB760982c.1176G>C0.982
rpoB760985c.1179G>C0.982
rpoB760991c.1185G>C0.983
rpoB761006c.1200C>G0.984
rpoB761015c.1209G>C0.985
rpoB761021c.1215G>C0.985
rpoB761027c.1221A>G0.985
rpoB761036c.1230G>C0.983
rpoB761037c.1231T>C0.983
rpoB761057c.1251G>C0.985
rpoB761102c.1296A>G1.000
rpoB761129c.1323G>C0.984
rpoB761132c.1326G>T0.966
rpoB761133c.1327T>C0.967
rpoB761150c.1344A>C0.983
rpoB761153c.1347G>C0.983
rpoB761165c.1359G>C0.983
rpoB761180c.1374A>C1.000
rpoB761189c.1383T>C1.000
rpoB761195c.1389G>C1.000
rpoB761207c.1401C>T0.984
rpoB761213c.1407G>C0.983
rpoB761249c.1443A>G0.983
rpoB761255c.1449T>G0.983
rpoB761261c.1455G>T0.983
rpoB761306c.1500C>G0.982
rpoB761327c.1521A>G0.981
rpoB761330c.1524G>C0.981
rpoB761354c.1548C>T1.000
rpoB761360c.1554T>C1.000
rpoB761362p.Ser519Thr1.000
rpoB761373p.Val523His1.000
rpoB761408c.1602G>C1.000
rpoB761414c.1608A>G1.000
rpoB761423c.1617T>C1.000
rpoB761435c.1629T>C1.000
rpoB761438c.1632G>C1.000
rpoB761439p.Asp545Lys1.000
rpoB761444c.1638T>C1.000
rpoB761447c.1641C>G1.000
rpoB761452p.Val549Glu1.000
rpoB761457p.Pro551Ser0.958
rpoB761465c.1659G>C0.981
rpoB761477c.1671C>G0.983
rpoB761492c.1686G>C0.983
rpoB761510c.1704T>C0.985
rpoB761531c.1725C>G0.971
rpoB761537c.1731C>G0.972
rpoB761570c.1764T>C0.955
rpoB761573c.1767C>G0.900
rpoB761579c.1773G>C0.971
rpoB761588c.1782C>T0.985
rpoB761606c.1800C>G0.967
rpoB761612c.1806G>C0.965
rpoB761615c.1809A>C0.966
rpoB761636c.1830G>T0.964
rpoB761645c.1839C>G0.965
rpoB761648c.1842T>C0.966
rpoB761657c.1851C>G0.966
rpoB761675c.1869G>C0.982
rpoB761720c.1914C>G0.963
rpoB761725p.Glu640Ala0.962
rpoB761732c.1926C>G0.926
rpoB761735c.1929C>G0.935
rpoB761747c.1941G>C0.950
rpoB761750c.1944G>C0.950
rpoB761765c.1959T>C0.976
rpoB761772p.His656Ala0.976
rpoB761778p.Asn658Asp0.976
rpoB761791p.Arg662His0.974
rpoB761813c.2007T>C0.975
rpoB761815p.Ala670Glu0.973
rpoB761834c.2028T>C0.979
rpoB761848p.Cys681Ser0.933
rpoB761852c.2046C>G0.977
rpoB761858c.2052G>C0.980
rpoB761873c.2067A>C0.962
rpoB761885c.2079T>C0.981
rpoB761906c.2100C>G0.980
rpoB761909c.2103T>C0.980
rpoB761912c.2106T>C0.980
rpoB761915p.Asp703Glu0.980
rpoB761916p.Asp704Asn0.980
rpoB761948c.2142G>C0.967
rpoB761954c.2148C>G0.968
rpoB762008c.2202C>T0.958
rpoB762014c.2208C>T0.956
rpoB762017c.2211A>G0.956
rpoB762053c.2247T>C0.973
rpoB762062c.2256T>C0.974
rpoB762065c.2259T>C0.975
rpoB762083c.2277T>C0.973
rpoB762086c.2280G>C0.972
rpoB762101c.2295C>G0.974
rpoB762114p.Ile770Val0.971
rpoB762131c.2325C>G0.973
rpoB762140c.2334G>C0.974
rpoB762143c.2337T>C0.975
rpoB762149c.2343G>C0.977
rpoB762167c.2361T>C0.979
rpoB762176c.2370T>C0.981
rpoB762185c.2379G>C0.981
rpoB762206c.2400C>G0.982
rpoB762233c.2427G>C0.980
rpoB762236c.2430G>C0.980
rpoB762246c.2440C>T0.981
rpoB762254c.2448T>G1.000
rpoB762257c.2451C>G1.000
rpoB762266c.2460T>C1.000
rpoB762284c.2478G>C1.000
rpoB762293c.2487T>C1.000
rpoB762314c.2508C>T1.000
rpoB762317c.2511A>G1.000
rpoB762329c.2523G>C1.000
rpoB762338c.2532T>C1.000
rpoB762347c.2541T>C1.000
rpoB762362p.Glu852Asp1.000
rpoB762369c.2563T>C1.000
rpoB762398c.2592T>C1.000
rpoB762401c.2595G>C0.976
rpoB762404c.2598T>C0.976
rpoB762410c.2604T>C1.000
rpoB762416c.2610A>G1.000
rpoB762419c.2613C>G0.978
rpoB762434c.2628T>C0.978
rpoB762449c.2643C>A1.000
rpoB762467c.2661C>T0.980
rpoB762488c.2682G>C1.000
rpoB762489p.Val895Gln0.978
rpoB762509c.2703T>G0.976
rpoB762510p.Ala902Pro0.976
rpoB762521c.2715C>G0.975
rpoB762533c.2727T>C1.000
rpoB762536c.2730T>C1.000
rpoB762537c.2731T>C1.000
rpoB762551c.2745C>T1.000
rpoB762581c.2775T>C1.000
rpoB762582c.2776T>C1.000
rpoB762782c.2976T>C0.900
rpoB762785p.Asp993Glu0.900
rpoB762788c.2982G>C0.900
rpoB762789p.Leu995Met0.900
rpoB762794c.2988C>G0.864
rpoB762799p.Ala998Gly0.864
rpoB762810p.Ala1002Ser0.875
rpoB762813p.Met1003Val0.875
rpoB762818c.3012C>G0.875
rpoB762827c.3021G>C0.912
rpoB762857c.3051C>G0.921
rpoB762860c.3054G>C0.921
rpoB762863c.3057T>C0.923
rpoB762929c.3123G>C0.973
rpoB762989c.3183G>C1.000
rpoB762995c.3189G>T1.000
rpoB763013c.3207C>G1.000
rpoB763028c.3222T>C0.980
rpoB763031c.3225T>G0.981
rpoB763034c.3228C>G0.981
rpoB763040c.3234C>G0.982
rpoB763070c.3264T>C0.985
rpoB763085c.3279C>G0.984
rpoB763115c.3309T>C0.986
rpoB763136c.3330C>T0.986
rpoB763148c.3342G>C0.985
rpoB763158c.3352C>T0.985
rpoB763166c.3360A>G0.985
rpoB763190c.3384C>T1.000
rpoB763202c.3396A>G1.000
rpoB763205c.3399G>C1.000
rpoB763206c.3400A>T1.000
rpoB763214c.3408T>C1.000
rpoB763226c.3420A>G1.000
rpoB763227c.3421C>T1.000
rpoB763238c.3432T>C1.000
rpoB763253c.3447G>C1.000
rpoB763256c.3450G>A1.000
rpoB763268c.3462C>G1.000
rpoB763283c.3477T>C1.000
rpoB763284c.3478C>T1.000
rpoC763351c.-19T>C1.000
rpoC763352c.-18T>A1.000
rpoC763402c.33C>G1.000
rpoC763411c.42T>G1.000
rpoC763414c.45T>C1.000
rpoC763441c.72C>T1.000
rpoC763444c.75T>C1.000
rpoC763456c.87A>G1.000
rpoC763486c.117T>G1.000
rpoC763492c.123G>C1.000
rpoC763528c.159G>A0.958
rpoC763546c.177A>G0.956
rpoC763570c.201G>C0.953
rpoC763573c.204G>C0.955
rpoC763594c.225C>T0.960
rpoC763603c.234C>T0.962
rpoC763636c.267T>C0.963
rpoC763660c.291T>G0.981
rpoC763675c.306C>G1.000
rpoC763696c.327T>C1.000
rpoC763702c.333C>G1.000
rpoC763717c.348T>C1.000
rpoC763723c.354G>C1.000
rpoC763732c.363C>G1.000
rpoC763741c.372C>T1.000
rpoC763744c.375G>C1.000
rpoC763765c.396T>C1.000
rpoC763774c.405G>C1.000
rpoC763807c.438T>C1.000
rpoC763816c.447C>G0.980
rpoC763835p.Ala156Met0.981
rpoC763853p.Val162Ile0.982
rpoC763858c.489A>G0.981
rpoC763872p.Gly168Ala0.980
rpoC763876p.Glu169Asp0.979
rpoC763879c.510A>G0.980
rpoC763888c.519G>C0.977
rpoC763891c.522G>C0.975
rpoC763894c.525A>G0.975
rpoC763900c.531G>C0.980
rpoC763945c.576T>C0.981
rpoC763951c.582G>C0.981
rpoC763960c.591T>C1.000
rpoC763987c.618C>T1.000
rpoC763991p.Ile208Leu1.000
rpoC763996c.627T>C1.000
rpoC764002c.633C>G1.000
rpoC764005c.636G>C1.000
rpoC764024c.655T>C0.976
rpoC764032p.Asp221Glu0.974
rpoC764040p.Ser224Thr0.972
rpoC764044c.675T>C0.972
rpoC764059c.690G>T0.980
rpoC764083c.714A>G1.000
rpoC764098c.729A>G1.000
rpoC764101c.732C>G1.000
rpoC764102p.Val245Ile1.000
rpoC764112p.Tyr248Phe1.000
rpoC764116c.747C>T1.000
rpoC764131c.762T>C1.000
rpoC764188c.819A>G0.977
rpoC764195p.Ser276Ile0.970
rpoC764203c.834G>C0.971
rpoC764206c.837T>C0.972
rpoC764215c.846A>G0.980
rpoC764236c.867G>A0.981
rpoC764248c.879C>G0.981
rpoC764266c.897T>C0.981
rpoC764269c.900G>C0.981
rpoC764272c.903G>C0.981
rpoC764278c.909A>G1.000
rpoC764338c.969G>A1.000
rpoC764353c.984G>C1.000
rpoC764365c.996C>T1.000
rpoC764380c.1011G>C0.976
rpoC764381c.1012T>A0.976
rpoC764387c.1018T>C0.976
rpoC764405c.1036A>C0.961
rpoC764419c.1050C>G0.980
rpoC764428c.1059G>C0.979
rpoC764431c.1062G>C0.979
rpoC764434c.1065A>G0.979
rpoC764446c.1077T>C0.974
rpoC764449c.1080G>C0.974
rpoC764452c.1083T>C0.974
rpoC764458c.1089G>C0.972
rpoC764461c.1092A>G0.974
rpoC764489c.1120C>T0.932
rpoC764497c.1128A>G0.925
rpoC764510c.1141C>T0.917
rpoC764521c.1152T>C0.929
rpoC764527c.1158C>T0.952
rpoC764536c.1167G>C0.955
rpoC764539c.1170C>G0.952
rpoC764548c.1179G>A0.941
rpoC764551c.1182G>C0.941
rpoC764554c.1185C>T0.943
rpoC764560c.1191T>C0.949
rpoC764566c.1197C>G0.930
rpoC764575c.1206T>G0.930
rpoC764593c.1224C>T0.932
rpoC764611c.1242G>T0.935
rpoC764650c.1281G>C0.971
rpoC764651c.1282T>A0.970
rpoC764752c.1383G>C1.000
rpoC764764c.1395T>C1.000
rpoC764809c.1440C>T1.000
rpoC764815c.1446A>G1.000
rpoC764824c.1455T>C1.000
rpoC764827c.1458G>C1.000
rpoC764858c.1489T>C1.000
rpoC764872c.1503A>G1.000
rpoC764888c.1519T>C1.000
rpoC764911c.1542A>G0.964
rpoC764932c.1563C>A0.960
rpoC764948c.1579T>C0.960
rpoC764968c.1599T>C0.960
rpoC764995c.1626C>G0.962
rpoC765007c.1638T>G0.953
rpoC765008c.1639T>C0.953
rpoC765011c.1642A>T0.953
rpoC765019c.1650A>G0.964
rpoC765034c.1665T>C0.966
rpoC765040c.1671T>C0.964
rpoC765041c.1672T>C0.964
rpoC765047c.1678T>C0.982
rpoC765055c.1686C>G0.982
rpoC765073c.1704G>C0.981
rpoC765076c.1707A>G0.980
rpoC765079c.1710T>G0.980
rpoC765082c.1713G>C0.981
rpoC765089c.1720T>C0.983
rpoC765103c.1734G>T0.981
rpoC765292c.1923G>C0.976
rpoC765298c.1929G>C0.977
rpoC765300p.Val644Ala0.977
rpoC765319c.1950A>G1.000
rpoC765326p.His653Ala1.000
rpoC765330p.Ser654Asn1.000
rpoC765346c.1977C>G1.000
rpoC765349c.1980T>C1.000
rpoC765352c.1983G>C1.000
rpoC765364c.1995G>A0.982
rpoC765383p.Met672Leu0.982
rpoC765404p.Leu679Val0.964
rpoC765409c.2040T>C0.962
rpoC765421c.2052C>G0.943
rpoC765451c.2082C>A0.948
rpoC765478c.2109T>C0.945
rpoC765499c.2130C>G0.925
rpoC765529c.2160C>T0.960
rpoC765541c.2172C>G0.939
rpoC765553c.2184C>T0.956
rpoC765556c.2187G>C0.955
rpoC765559c.2190G>C0.956
rpoC765580c.2211G>C0.978
rpoC765613p.His748Gln0.936
rpoC765625c.2256C>G0.936
rpoC765631p.Asp754Glu0.935
rpoC765700c.2331T>C0.889
rpoC765734c.2365T>C0.886
rpoC765739c.2370G>T0.889
rpoC765751c.2382C>G0.909
rpoC765753p.Asp795Ala0.909
rpoC765772c.2403C>G0.925
rpoC765784c.2415C>G0.907
rpoC765787c.2418C>T0.897
rpoC765793c.2424C>G0.902
rpoC765796c.2427C>T0.900
rpoC765811c.2442T>C0.943
rpoC765814c.2445A>G0.943
rpoC765826c.2457T>C0.925
rpoC765835c.2466C>T0.925
rpoC765850c.2481G>C0.944
rpoC765883c.2514C>G0.956
rpoC765886c.2517C>G0.956
rpoC765892c.2523T>C0.958
rpoC765937c.2568T>C0.962
rpoC765947c.2578T>C0.964
rpoC765967c.2598C>T0.966
rpoC765982c.2613C>G0.982
rpoC765994c.2625A>T0.983
rpoC766010c.2641T>A0.962
rpoC766018c.2649C>T0.960
rpoC766021c.2652G>C0.960
rpoC766027c.2658G>C0.964
rpoC766043p.Gln892Glu0.968
rpoC766054c.2685C>G0.984
rpoC766082p.Ala905Gln0.962
rpoC766096c.2727G>C0.966
rpoC766129c.2760C>G0.959
rpoC766135c.2766G>A0.958
rpoC766141c.2772C>T0.952
rpoC766142c.2773C>T0.952
rpoC766174p.Asn935Lys0.971
rpoC766178p.Ile937Val0.967
rpoC766327c.2958C>A0.500
rpoC766345c.2976T>C0.688
rpoC766348c.2979A>G0.688
rpoC766357c.2988C>T0.762
rpoC766363c.2994G>C0.818
rpoC766381c.3012C>T0.857
rpoC766384c.3015A>G0.857
rpoC766390c.3021C>T0.867
rpoC766393c.3024C>G0.867
rpoC766408c.3039C>G0.889
rpoC766411c.3042C>G0.872
rpoC766426c.3057C>T0.889
rpoC766447c.3078T>C0.898
rpoC766462c.3093G>T0.918
rpoC766483c.3114G>C0.955
rpoC766484p.Val1039Ile0.952
rpoC766492c.3123T>C0.962
rpoC766522c.3153C>G0.964
rpoC766528c.3159T>C0.962
rpoC766531c.3162G>C0.962
rpoC766540p.Asp1057Glu0.964
rpoC766549c.3180G>C0.966
rpoC766573c.3204T>C1.000
rpoC766582c.3213C>G1.000
rpoC766583p.Gly1072Ser1.000
rpoC766591c.3222A>G1.000
rpoC766594c.3225G>C1.000
rpoC766597c.3228C>G1.000
rpoC766607p.Ile1080Leu1.000
rpoC766630c.3261G>C1.000
rpoC766645c.3276A>G1.000
rpoC766657c.3288A>G1.000
rpoC766672c.3303T>C1.000
rpoC766673p.Gly1102Asn1.000
rpoC766726c.3357T>C0.977
rpoC766738c.3369G>C0.977
rpoC766747c.3378C>G0.977
rpoC766765c.3396A>C0.978
rpoC766774c.3405T>C0.978
rpoC766801c.3432C>G0.978
rpoC766804c.3435A>G0.979
rpoC766861c.3492G>C0.982
rpoC766864c.3495G>C0.980
rpoC766900c.3531T>C0.981
rpoC766933c.3564A>G0.945
rpoC766945c.3576A>G0.945
rpoC766963c.3594T>C0.942
rpoC766972c.3603G>C0.941
rpoC766996c.3627C>T0.938
rpoC767009c.3640T>A0.917
rpoC767014c.3645G>C0.917
rpoC767033c.3664T>A0.932
rpoC767059c.3690T>G0.942
rpoC767062c.3693C>A0.942
rpoC767098c.3729T>C1.000
rpoC767119c.3750A>G1.000
rpoC767134c.3765C>A1.000
rpoC767158c.3789T>C1.000
rpoC767180p.Ala1271Gln0.980
rpoC767191c.3822C>G0.980
rpoC767206c.3837C>G0.978
rpoC767209c.3840T>C0.977
rpoC767212c.3843G>C0.977
rpoC767221c.3852C>G0.979
rpoC767230c.3861G>C0.976
rpoC767233c.3864T>C0.975
rpoC767263c.3894T>C0.958
rpoC767264p.Ala1299Gln0.958
rpoC767275c.3906T>C0.958
rpoC767278c.3909T>C0.958
rpoC767281c.3912C>G0.958
rpoC767284c.3915C>T0.958
rpsL781571c.12C>T0.929
rpsL781595c.36T>C0.941
rpsL781605p.Ile16Val0.941
rpsL781608p.Ser17Ala0.941
rpsL781628c.69T>C0.976
rpsL781631c.72G>C0.977
rpsL781649c.90T>C0.976
rpsL781655c.96T>C1.000
rpsL781682c.123T>C1.000
rpsL781700c.141G>C1.000
rpsL781703c.144G>T1.000
rpsL781715c.156T>C1.000
rpsL781728c.169T>C1.000
rpsL781736c.177T>C1.000
rpsL781742c.183C>T1.000
rpsL781748c.189C>G1.000
rpsL781754c.195G>C1.000
rpsL781760c.201T>C1.000
rpsL781772c.213C>A1.000
rpsL781808c.249C>T1.000
rpsL781811c.252C>T1.000
rpsL781832c.273T>C1.000
rpsL781838c.279G>C1.000
rpsL781841c.282C>G1.000
rpsL781865c.306G>C1.000
rpsL781868c.309T>C1.000
rpsL781871c.312G>C1.000
rpsL781877c.318T>C1.000
rpsL781892c.333A>G1.000
rpsL781898c.339A>T1.000
rpsL781916c.357T>C1.000
rpsL781929p.Gly124Ser1.000
rplC800794c.-15A>G0.844
rplC800796c.-13A>G0.844
rplC800814c.6A>G0.868
rplC800817c.9A>T0.872
rplC800844c.36T>C0.900
rplC800865c.57A>G0.897
rplC800867p.Ser20Asn0.893
rplC800874c.66A>G0.885
rplC800875p.Val23Ile0.885
rplC800880c.72A>G0.885
rplC800889c.81C>G0.885
rplC800892c.84G>C0.885
rplC800907c.99C>G0.920
rplC800916c.108A>G0.957
rplC800934c.126C>G0.833
rplC800937c.129A>G0.818
rplC800939p.Arg44Gln0.818
rplC800946c.138T>C0.818
rplC800949c.141T>C0.818
rplC800967c.159C>G0.800
rplC801127p.Ala107Thr0.957
rplC801132c.324T>C0.963
rplC801147c.339T>C0.969
rplC801150c.342G>C0.969
rplC801153c.345G>C0.969
rplC801156c.348T>A0.969
rplC801168c.360C>G0.978
rplC801171c.363A>G0.978
rplC801174c.366T>C0.979
rplC801180c.372C>G0.980
rplC801195c.387G>C0.982
rplC801201c.393C>T0.983
rplC801207c.399C>T0.983
rplC801246c.438C>T0.982
rplC801249c.441T>C0.982
rplC801255c.447C>T0.982
rplC801264c.456C>T1.000
rplC801267c.459A>T1.000
rplC801270c.462T>C1.000
rplC801276c.468G>C1.000
rplC801279c.471G>C1.000
rplC801282c.474G>C1.000
rplC801285c.477G>C0.944
rplC801300c.492C>G0.979
rplC801309c.501C>G0.938
rplC801312c.504G>C0.935
rplC801321c.513C>T0.959
rplC801324c.516T>C0.959
rplC801339c.531T>C0.955
rplC801341p.Leu178Gln0.955
rplC801348c.540T>G0.958
rplC801357c.549T>C0.962
rplC801367p.Ala187Thr0.963
rplC801402c.594T>C0.967
rplC801405c.597T>C0.967
rplC801423c.615G>C0.960
rplC801426c.618C>G0.960
rplC801427p.Met207Val0.960
rplC801438c.630T>C0.959
rplC801442p.Ile212Val0.942
rrs1471923r.78t>c0.961
rrs1471925r.80t>c0.962
rrs1471932r.87a>g0.964
rrs1471934r.89a>g0.964
rrs1471969r.124t>c0.943
rrs1471970r.125g>a0.945
rrs1472028r.183a>t0.862
rrs1472029r.184c>t0.862
rrs1472030r.185g>t0.893
rrs1472031r.186g>a0.893
rrs1472033r.188a>g0.893
rrs1472034r.189t>c0.897
rrs1472044r.199g>t0.919
rrs1472045r.200t>a0.919
rrs1472061r.216a>t0.952
rrs1472075r.230a>g0.958
rrs1472108r.263c>t0.961
rrs1472969r.1124a>g1.000
rrs1472970r.1125c>g1.000
rrs1472977r.1132g>c1.000
rrs1472978r.1133t>c1.000
rrs1473105r.1260g>a0.956
rrs1473120r.1275c>ct0.837
rrs1473123r.1278a>t0.949
rrs1473145r.1300c>t0.949
rrs1473166r.1321g>a0.957
rrs1473290r.1445c>t1.000
rrl1473651c.-7GT>G0.929
rrl1473658r.1t>a0.929
rrl1473659r.2t>a0.929
rrl1473668r.11c>t0.912
rrl1473756r.99g>a0.944
rrl1473758r.101g>t0.943
rrl1473806r.149c>t0.978
rrl1473877r.220g>a1.000
rrl1473898r.241c>t0.981
rrl1473943r.286g>t0.952
rrl1473945r.288t>a0.952
rrl1473946r.289a>t0.953
rrl1473986r.329t>c0.947
rrl1473987r.330g>a0.946
rrl1473995r.338g>t0.950
rrl1474001r.344c>t0.952
rrl1474009r.352a>g0.951
rrl1474012r.355c>t0.951
rrl1474093r.436g>t0.975
rrl1474099r.442g>a0.974
rrl1474103r.446a>t0.972
rrl1474140r.483c>t1.000
rrl1474151r.494c>t1.000
rrl1474181r.524c>t1.000
rrl1474249r.592g>t0.971
rrl1474291r.634tttcctctccggagga>t0.973
rrl1474308r.651g>t0.969
rrl1474310r.653t>g0.970
rrl1474356r.699t>c1.000
rrl1474362r.705a>g1.000
rrl1474376r.719t>c1.000
rrl1474409r.752ggcgacccacac>g1.000
rrl1474427r.770a>c0.895
rrl1474429r.772g>c0.895
rrl1474432r.775c>g0.895
rrl1474639r.982g>a0.968
rrl1474794r.1137c>t0.980
rrl1474812r.1155g>a0.982
rrl1474823r.1166c>t0.981
rrl1474831r.1174a>g0.980
rrl1474904r.1247g>a0.979
rrl1474956r.1299c>t0.976
rrl1474960r.1303c>g0.976
rrl1474963r.1306g>t0.976
rrl1474964r.1307t>a0.976
rrl1474965r.1308g>c0.976
rrl1474970r.1313g>a0.977
rrl1475006r.1349a>t1.000
rrl1475061r.1404c>t0.976
rrl1475088r.1431a>t0.978
rrl1475199r.1542g>a1.000
rrl1475206r.1549c>t1.000
rrl1475209r.1552g>c1.000
rrl1475213r.1556c>t1.000
rrl1475249r.1592t>c0.975
rrl1475252r.1595c>t0.974
rrl1475266r.1609t>c0.969
rrl1475267r.1610g>a0.969
rrl1475275r.1618c>t0.968
rrl1475276r.1619t>c0.968
rrl1475291r.1634a>c0.971
rrl1475315r.1658a>t0.964
rrl1475355r.1698c>t0.968
rrl1475369r.1712g>t0.970
rrl1475402r.1745c>t0.968
rrl1475419r.1762c>t0.968
rrl1475429r.1772g>a0.966
rrl1475436r.1779c>t0.968
rrl1475483r.1826c>t1.000
rrl1475505r.1848g>a1.000
rrl1475526r.1869c>a1.000
rrl1475599r.1942a>g1.000
rrl1475608r.1951t>c1.000
rrl1475642r.1985t>c1.000
rrl1475657r.2000a>g1.000
rrl1475659r.2002g>t1.000
rrl1475758r.2101ac>a0.947
rrl1475763r.2106c>t0.941
rrl1475765r.2108ag>a0.941
rrl1475881r.2224t>c1.000
rrl1475988r.2331a>g1.000
rrl1476031r.2374c>t1.000
rrl1476032r.2375c>a1.000
rrl1476033r.2376t>c1.000
rrl1476034r.2377c>a1.000
rrl1476045r.2388g>t1.000
rrl1476047r.2390g>t1.000
rrl1476048r.2391g>a1.000
rrl1476049r.2392c>t1.000
rrl1476086r.2429g>a1.000
rrl1476089r.2432t>c1.000
rrl1476095r.2438c>g1.000
rrl1476104r.2447tg>t1.000
rrl1476106r.2449a>t1.000
rrl1476108r.2451t>c1.000
rrl1476115r.2458t>c1.000
rrl1476117r.2460g>c1.000
rrl1476214r.2557g>a1.000
rrl1476224r.2567a>g1.000
rrl1476281r.2624t>c0.977
rrl1476583r.2926g>a0.949
rrl1476584r.2927c>t0.949
rrl1476594r.2937c>t0.957
rrl1476597r.2940g>a0.957
rrl1476603r.2946g>a0.956
rrl1476608r.2951c>g0.952
rrl1476628r.2971t>a0.933
rrl1476689r.3032a>t0.947
rrl1476690r.3033c>t0.947
rrl1476693r.3036g>a0.947
rrl1476695r.3038t>a0.947
rrl1476716r.3059a>c0.933
rrl1476726r.3069a>g0.905
rrl1476732r.3075t>c0.905
rrl1476750r.3093t>c0.875
rrl1476755r.3098g>a0.875
rrl1476759r.3102t>c0.871
rrl1476770r.3113t>c0.885
rrl1476771r.3114g>a0.880
fabG11673482p.Ser15Ala1.000
fabG11673487c.48T>C1.000
fabG11673490c.51A>G1.000
fabG11673523c.84G>T1.000
fabG11673535c.96A>G0.976
fabG11673547c.108T>C0.976
fabG11673568c.129C>G0.976
fabG11673574c.135C>G0.974
fabG11673580c.141T>G0.971
fabG11673589c.150A>G0.969
fabG11673595c.156A>C0.958
fabG11673596p.Lys53Glu0.955
fabG11673602c.163C>T0.955
fabG11673607c.168T>C0.909
fabG11673615p.Glu59Val0.833
fabG11673619c.180T>C0.882
fabG11673679c.240T>C0.929
fabG11673685c.246C>T1.000
fabG11673703c.264C>T1.000
fabG11673710p.Leu91Ile1.000
fabG11673716p.Ala93Lys1.000
fabG11673733p.Met98Ile1.000
fabG11673748c.309A>G1.000
fabG11673749p.Lys104Arg1.000
fabG11673758p.Lys107Glu1.000
fabG11673890p.Ala151Ser1.000
fabG11673901c.462A>G0.968
fabG11673905p.Ser156Ala0.968
fabG11673916c.477A>C0.970
fabG11673917p.Val160Leu0.970
fabG11673922c.483T>C0.971
fabG11673941p.Ala168Ser0.977
fabG11673946c.507C>G0.977
fabG11673955c.516G>C0.979
fabG11673961c.522A>C0.980
fabG11673985c.546C>G0.982
fabG11674006p.Asp189Glu0.981
fabG11674015c.576C>T0.935
fabG11674018c.579G>C0.933
fabG11674021c.582G>C0.933
fabG11674024c.585T>C0.933
fabG11674033c.594T>C0.933
fabG11674037p.Gln200Ala0.933
fabG11674042c.603G>T0.903
fabG11674049p.Gln204Asp0.903
fabG11674054c.615T>C0.933
fabG11674060c.621A>G0.935
fabG11674063c.624G>C0.935
fabG11674079p.Pro214Ala0.968
fabG11674109c.670C>T0.962
fabG11674114c.675T>A0.961
fabG11674123c.684T>C0.955
fabG11674126c.687G>C0.955
fabG11674132c.693T>C0.955
fabG11674136p.Ser233Ala0.950
fabG11674141c.702T>C0.950
fabG11674156c.717C>G0.972
fabG11674171c.732T>C1.000
inhA1674471c.270G>C1.000
inhA1674480c.279T>C1.000
inhA1674486c.285T>C1.000
inhA1674504c.303C>G1.000
inhA1674537c.336C>G0.980
inhA1674542p.Ala114Glu0.980
inhA1674546c.345T>C0.980
inhA1674549c.348G>C0.957
inhA1674552c.351C>G0.958
inhA1674555c.354G>A0.960
inhA1674561c.360C>T0.966
inhA1674582c.381T>C0.965
inhA1674585c.384T>C0.966
inhA1674589p.Met130Leu0.966
inhA1674601p.Leu134Thr0.965
inhA1674624c.423A>C0.969
inhA1674630c.429C>G0.967
inhA1674660c.459G>C0.964
inhA1674672c.471C>G0.962
inhA1674703c.502T>C0.979
inhA1674708c.507G>A0.977
inhA1674718c.517A>C0.975
inhA1674723c.522C>T0.974
inhA1674738c.537C>G0.957
inhA1674741c.540C>T0.955
inhA1674746p.Tyr182Phe0.955
inhA1674750c.549T>C0.952
inhA1674753c.552G>C0.952
inhA1674756c.555T>C0.952
inhA1674759c.558G>C0.960
inhA1674774c.573A>G0.972
inhA1674780c.579T>G0.972
inhA1674789c.588G>C0.974
inhA1674801c.600T>C0.974
inhA1674822c.621C>G1.000
inhA1674828c.627G>A1.000
inhA1674846p.Ile215Met1.000
inhA1674864c.663C>T1.000
inhA1674870c.669T>C1.000
inhA1674879c.678T>C1.000
inhA1674903c.702T>C0.982
inhA1674904p.Ala235Pro0.982
inhA1674909c.708G>A0.981
inhA1674942c.741T>G0.980
inhA1674960c.759C>G0.976
inhA1674966c.765T>G0.971
inhA1674967p.Asp256Thr0.971
inhA1674987c.786C>T0.967
rpsA1833512c.-30AC>A1.000
rpsA1833518c.-24C>A1.000
rpsA1833532c.-10A>C0.971
rpsA1833554p.Thr5Ala0.977
rpsA1833568c.27G>C0.978
rpsA1833589c.48A>T0.978
rpsA1833595c.54T>C0.979
rpsA1833661c.120A>G0.977
rpsA1833667c.126C>G0.976
rpsA1833721c.180A>G0.974
rpsA1833724c.183C>G1.000
rpsA1833727c.186G>C1.000
rpsA1833742c.201A>G1.000
rpsA1833745c.204G>C1.000
rpsA1833748c.207C>G1.000
rpsA1833787c.246C>G1.000
rpsA1833790c.249T>C1.000
rpsA1833802c.261A>G1.000
rpsA1833811c.270G>T1.000
rpsA1833838c.297G>C0.981
rpsA1833841c.300C>G0.981
rpsA1833847c.306C>G0.966
rpsA1833856c.315A>G0.967
rpsA1833874c.333T>C0.968
rpsA1833928c.387G>C0.964
rpsA1833940c.399C>G0.964
rpsA1833971c.430C>T0.980
rpsA1833979c.438T>C0.980
rpsA1834000c.459G>C0.961
rpsA1834021c.480C>T0.962
rpsA1834030c.489C>G0.963
rpsA1834099c.558C>G0.969
rpsA1834102c.561T>C0.953
rpsA1834105c.564C>G0.953
rpsA1834108c.567C>G0.938
rpsA1834123c.582C>G0.971
rpsA1834150c.609G>C1.000
rpsA1834153c.612T>C1.000
rpsA1834154p.Asn205Gln1.000
rpsA1834157c.616T>C1.000
rpsA1834162c.621A>G0.968
rpsA1834165c.624A>G0.968
rpsA1834169p.Thr210Ala0.971
rpsA1834177c.636A>C1.000
rpsA1834189c.648G>C0.980
rpsA1834195c.654G>C0.982
rpsA1834210c.669C>T0.983
rpsA1834222c.681T>C0.964
rpsA1834231c.690T>C0.962
rpsA1834234c.693G>C0.962
rpsA1834249c.708T>C0.957
rpsA1834261c.720A>G0.947
rpsA1834262c.721T>A0.947
rpsA1834303c.762T>C0.944
rpsA1834306c.765T>C0.945
rpsA1834333c.792C>T0.981
rpsA1834348c.807T>C0.955
rpsA1834366c.825A>G0.956
rpsA1834396c.855G>C0.957
rpsA1834411c.870T>C0.947
rpsA1834417c.876G>C0.947
rpsA1834423c.882G>C0.956
rpsA1834435c.894G>C0.953
rpsA1834451c.910T>C1.000
rpsA1834465c.924T>C1.000
rpsA1834468c.927A>G1.000
rpsA1834489c.948T>C1.000
rpsA1834510c.969C>T1.000
rpsA1834513c.972C>G1.000
rpsA1834528c.987T>C1.000
rpsA1834540c.999G>C1.000
rpsA1834546c.1005T>C0.977
rpsA1834609c.1068T>C0.949
rpsA1834633c.1092A>G0.925
rpsA1834639c.1098T>C0.902
rpsA1834654p.Glu371Asp0.918
rpsA1834684c.1143C>T0.949
rpsA1834690c.1149T>C0.950
rpsA1834732c.1191T>C0.966
rpsA1834733p.Ala398Ser0.966
rpsA1834738c.1197A>G0.967
rpsA1834753c.1212T>C0.969
rpsA1834765p.Glu408Asp0.985
rpsA1834775p.Ala412Thr0.986
rpsA1834780c.1239A>G0.986
rpsA1834786c.1245A>G0.985
rpsA1834789c.1248T>C1.000
rpsA1834792c.1251G>C1.000
rpsA1834849c.1308C>G1.000
rpsA1834852c.1311C>G1.000
tlyA1917940p.Val1Met0.920
tlyA1917943p.Ala2Ser0.920
tlyA1917951c.12T>C0.950
tlyA1917972c.33A>G1.000
tlyA1917975c.36C>G0.977
tlyA1917981c.42G>C0.977
tlyA1917990c.51G>C0.955
tlyA1917993c.54A>G0.955
tlyA1917996c.57A>G0.955
tlyA1918002c.63A>G0.957
tlyA1918036p.Arg33Ser0.949
tlyA1918048p.Leu37Met0.941
tlyA1918053c.114G>C0.938
tlyA1918057p.Val40Arg0.857
tlyA1918065c.126G>C0.857
tlyA1918067p.Ala43Gly0.857
tlyA1918191c.252G>C0.833
tlyA1918197c.258T>C0.833
tlyA1918206c.267G>C0.857
tlyA1918212c.273A>G0.857
tlyA1918221c.282T>C0.800
tlyA1918224c.285G>C0.800
tlyA1918236c.297A>C0.800
tlyA1918248c.309T>C0.800
tlyA1918251c.312T>G0.800
tlyA1918258p.His107Glu0.857
tlyA1918271p.Ala111Val0.857
tlyA1918275c.336T>C0.867
tlyA1918278c.339C>G0.889
tlyA1918310p.Asn124Ser0.800
tlyA1918315p.Pro126Ala0.800
tlyA1918323c.384G>C0.857
tlyA1918326c.387G>C0.857
tlyA1918330p.Leu131Val0.857
tlyA1918346p.Ala136Val0.833
tlyA1918352p.Gly138Asp0.833
tlyA1918356c.417C>G0.833
tlyA1918359c.420A>G0.833
tlyA1918362c.423G>C0.818
tlyA1918377c.438T>G0.833
tlyA1918379p.Arg147Pro0.909
tlyA1918382p.Val148Ala0.909
tlyA1918389c.450G>C0.909
tlyA1918392c.453A>C0.909
katG2155626c.486C>G0.882
katG2155632c.480T>G0.941
katG2155637p.Leu159Ile0.941
katG2155641p.Lys157Asn0.947
katG2155661p.Val151Ile0.962
katG2155677c.435G>C0.906
katG2155680c.432C>G0.966
katG2155691c.421A>G0.971
katG2155695c.417G>C0.971
katG2155704c.408G>C0.971
katG2155716c.396A>C0.971
katG2155722c.390C>G0.971
katG2155728c.384C>G0.944
katG2155742p.Gly124Gln0.889
katG2155743c.369C>G0.889
katG2155782c.330G>C0.789
katG2155785c.327A>G0.789
kasA2518121p.Gln3Lys1.000
kasA2518132c.18C>T1.000
kasA2518138c.24T>C1.000
kasA2518146p.Phe11Tyr1.000
kasA2518162c.48G>A1.000
kasA2518174c.60A>G1.000
kasA2518190p.Ser26Ala1.000
kasA2518199p.Ile29Val1.000
kasA2518220c.106C>T1.000
kasA2518234c.120G>A0.960
kasA2518248p.Ala45Val0.957
kasA2518261p.Glu49Asp0.941
kasA2518263p.Phe50Tyr0.933
kasA2518265p.Val51Ile0.933
kasA2518439p.Ala109Ser0.846
kasA2518444c.330T>C0.846
kasA2518447c.333T>G0.846
kasA2518459c.345T>C0.935
kasA2518462c.348A>C0.938
kasA2518468c.354A>C0.946
kasA2518474c.360G>A0.950
kasA2518480c.366T>C0.951
kasA2518483c.369C>G0.952
kasA2518504c.390T>C0.959
kasA2518506p.Ala131Glu0.959
kasA2518519c.405G>C0.981
kasA2518528c.414C>G0.983
kasA2518540c.426T>C0.984
kasA2518561c.447T>C1.000
kasA2518567c.453G>C1.000
kasA2518570c.456G>C1.000
kasA2518573c.459G>C1.000
kasA2518574p.Ile154Val1.000
kasA2518579c.465T>C1.000
kasA2518588c.474T>C1.000
kasA2518591c.477G>C1.000
kasA2518609p.Met165Ile1.000
kasA2518624c.510C>G1.000
kasA2518639c.525G>C1.000
kasA2518657c.543G>C0.971
kasA2518672c.558G>C0.975
kasA2518678c.564C>T0.972
kasA2518684c.570C>G0.971
kasA2518693c.579C>G0.974
kasA2518696c.582C>G0.974
kasA2518702c.588C>T0.974
kasA2518705c.591T>C0.977
kasA2518711c.597A>G0.978
kasA2518714c.600A>C0.978
kasA2518732c.618C>G0.984
kasA2518744c.630C>T0.985
kasA2518747c.633C>G0.985
kasA2518768c.654C>T0.986
kasA2518777c.663C>T0.986
kasA2518783c.669T>C0.986
kasA2518789c.675G>C0.984
kasA2518792c.678C>A0.984
kasA2518795c.681C>G1.000
kasA2518825c.711T>C1.000
kasA2518864c.750G>C1.000
kasA2518879c.765A>G1.000
kasA2518885c.771T>C0.966
kasA2518898c.784T>C0.963
kasA2518906c.792A>G0.960
kasA2518910p.Leu266Met0.959
kasA2518921c.807T>C0.953
kasA2518936c.822C>G0.926
kasA2518939c.825T>C0.926
kasA2518942c.828T>C0.926
kasA2518951c.837G>C0.900
kasA2518954c.840C>G0.889
kasA2518963c.849T>C0.846
kasA2518969c.855T>G0.846
kasA2518975c.861C>G0.833
kasA2519050c.936C>G1.000
kasA2519053c.939G>C1.000
kasA2519056c.942G>C1.000
kasA2519062c.948T>G1.000
kasA2519068c.954C>T1.000
kasA2519072p.Ala320Thr1.000
kasA2519095c.981C>A1.000
kasA2519107c.993T>C1.000
kasA2519108p.Asp332Gln1.000
kasA2519116c.1002C>G1.000
kasA2519122c.1008G>C1.000
kasA2519137c.1023T>G1.000
kasA2519158c.1044C>T1.000
kasA2519167c.1053T>G1.000
kasA2519173c.1059C>G1.000
kasA2519196p.Thr361Ser1.000
kasA2519215c.1101C>T1.000
kasA2519218c.1104G>A1.000
kasA2519221c.1107G>C1.000
kasA2519227c.1113G>C1.000
kasA2519230c.1116C>T1.000
kasA2519236c.1122G>A1.000
kasA2519239c.1125A>C1.000
kasA2519245c.1131T>C1.000
ahpC2726198c.6A>T0.929
ahpC2726204c.12A>G0.947
ahpC2726210c.18T>C0.955
ahpC2726216c.24T>C1.000
ahpC2726232p.Gln14Glu1.000
ahpC2726243c.51T>G1.000
ahpC2726244c.52C>T1.000
ahpC2726251p.Gly20Ala1.000
ahpC2726255c.63T>C1.000
ahpC2726258c.66C>T1.000
ahpC2726303c.111T>C0.950
ahpC2726311p.Ser40Asn0.870
ahpC2726315p.Asp41Glu0.909
ahpC2726318p.Glu42Asp0.909
ahpC2726322p.Pro44Ala0.909
ahpC2726330c.138G>A0.909
ahpC2726336c.144G>C0.909
ahpC2726348c.156T>C0.905
ahpC2726357c.165A>G0.850
ahpC2726366c.174G>C0.867
ahpC2726378c.186T>G0.867
ahpC2726528c.336C>G0.944
ahpC2726540c.348C>G0.895
ahpC2726543c.351A>G0.895
ahpC2726546c.354C>G0.895
ahpC2726551p.Gln120Leu0.895
ahpC2726556p.Ala122Thr0.895
ahpC2726564c.372C>G0.941
ahpC2726591c.399C>G0.951
ahpC2726593p.Val134Ala0.951
ahpC2726600c.408T>C0.955
ahpC2726601p.Ile137Leu0.956
ahpC2726638p.Ala149Val1.000
ahpC2726645c.453C>G1.000
ahpC2726657c.465A>C1.000
ahpC2726669p.Asp159Glu1.000
ahpC2726672c.480G>A1.000
ahpC2726675c.483A>G1.000
ahpC2726681c.489A>C1.000
ahpC2726687c.495C>G1.000
ahpC2726693c.501C>G1.000
ahpC2726696c.504C>G1.000
ahpC2726717c.525A>G1.000
ahpC2726747c.555A>C1.000
folC2747032c.567T>G0.938
folC2747059c.540A>G0.955
folC2747062c.537T>C0.955
folC2747065c.534G>A0.955
folC2747071c.528G>C0.955
folC2747086c.513T>G0.955
folC2747089c.510C>G0.955
folC2747101c.498C>G0.955
folC2747107c.492C>G0.955
folC2747110c.489A>G0.955
folC2747113c.486G>C0.955
folC2747116c.483C>G0.955
folC2747134c.465G>C1.000
folC2747224c.375C>G0.692
folC2747239c.360A>G0.812
folC2747248c.351C>G0.850
folC2747264p.Gly112Ala0.857
folC2747266c.333G>A0.864
folC2747275c.324A>G0.897
folC2747289p.Pro104Ala0.919
folC2747290c.309T>C0.919
folC2747293c.306C>T0.919
folC2747302c.297T>C0.925
folC2747314c.285T>G0.974
folC2747317c.282G>C0.977
folC2747343p.Val86Ile0.979
folC2747355p.Val82Ile0.977
folC2747359c.240G>C0.976
folC2747362c.237C>G0.976
folC2747394p.Ile69Val1.000
folC2747395c.204A>G1.000
folC2747407c.192A>G1.000
folC274741462RS>62LA1.000
folC2747415p.Arg62Cys1.000
folC2747419c.180G>C1.000
folC2747422c.177C>T1.000
folC2747425c.174G>A1.000
folC2747442c.157A>G0.875
folC2747467p.Asp44Glu0.800
ribD2986978p.Ser47Thr0.846
ribD2986983p.Leu49Val0.846
ribD2986997c.159T>C0.846
ribD2987001p.Val55Ser0.846
ribD2987005p.Asp56Gly0.846
ribD2987011p.Thr58Ser0.923
ribD2987026p.Ala63Gly0.966
ribD2987033c.195C>G1.000
ribD2987042c.204A>G1.000
ribD2987046p.Val70Ile1.000
ribD2987058c.220T>C1.000
ribD2987066c.228A>G1.000
ribD2987069c.231T>C1.000
ribD2987092p.Val85Ala0.966
ribD2987105c.267C>G0.958
ribD2987108c.270T>C0.957
thyX3067223c.723C>G0.980
thyX3067232c.714G>C0.982
thyX3067246p.Thr234Ala0.965
thyX3067249p.Thr233Ser0.965
thyX3067252p.Val232Ile0.966
thyX3067274c.672G>C0.980
thyX3067277c.669G>C0.979
thyX3067281p.Val222Ala0.979
thyX3067284p.Ala221Gly0.979
thyX3067286c.660G>C0.979
thyX3067289c.657G>C0.979
thyX3067292c.654C>T0.980
thyX3067295c.651G>A0.980
thyX3067313c.633C>A0.986
thyX3067316c.630T>C0.987
thyX3067325c.621T>C0.974
thyX3067349c.597C>G0.976
thyX3067355c.591T>G0.976
thyX3067367c.579C>G0.977
thyX3067373c.573G>C0.976
thyX3067391c.555C>G0.987
thyX3067394c.552C>G0.988
thyX3067439c.507T>C0.972
thyX3067445c.501G>C0.972
thyX3067457c.489G>C0.964
thyX3067462c.484G>A0.963
thyX3067465p.Ile161Val0.962
thyX3067466c.480C>G0.962
thyX3067475c.471T>C0.967
thyX3067491p.Ala152Glu0.962
thyX3067493c.453T>C0.962
thyX3067510c.436G>A0.979
thyX3067515p.Ser144Thr0.980
thyX3067531p.Ala139Ser0.951
thyX3067545p.Glu134Ala0.976
thyX3067549p.Thr133Ala0.977
thyX3067556p.His130Gln0.975
thyX3067559c.387G>C0.976
thyX3067565p.Asp127Glu0.977
thyX3067570p.Ala126Pro0.977
thyX3067577c.369C>T1.000
thyX3067598c.348G>A1.000
thyX3067602p.Arg115His1.000
thyX3067611p.Lys112Thr1.000
thyX3067619c.327T>G1.000
thyX3067631c.315G>C1.000
thyX3067634c.312G>C1.000
thyX3067652c.294A>G0.982
thyX3067661c.285G>C0.982
thyX3067665p.Ile94Thr0.982
thyX3067685c.261T>G0.982
thyX3067693p.Ile85Leu0.957
thyX3067694c.252C>G0.957
thyX3067718c.228G>C0.960
thyX3067721c.225A>G0.960
thyX3067727c.219T>G0.963
thyX3067736c.210G>A0.962
thyX3067762p.Arg62Lys0.917
thyX3067765p.Leu61Ile0.917
thyX3067772c.174G>C0.919
thyX3067775c.171G>A0.921
thyX3067781c.165G>C0.932
thyX3067793c.153A>G0.956
thyX3067799c.147C>T0.957
thyX3067802c.144G>C0.957
thyX3067850c.96T>G0.981
thyX3067869p.Thr26Ser0.979
thyX3067874c.72G>C0.978
thyX3067877c.69C>G0.977
thyX3067883c.63G>C0.977
thyX3067886c.60T>G0.977
thyX3067889c.57G>C0.977
thyX3067898p.Asp16Glu0.980
thyX3067935p.Thr4Ile0.951
thyX3067951c.-6A>G0.935
thyA3073812c.660G>C0.879
thyA3073815c.657C>T0.879
thyA3073824c.648T>C0.886
thyA3073827c.645T>C0.889
thyA3073839c.633A>G0.900
thyA3073860c.612G>C0.905
thyA3073863c.609A>G0.905
thyA3073866c.606G>C0.905
thyA3073874p.Ile200Val0.905
thyA3073892c.580A>G0.905
thyA3073898p.Ala192Ser0.905
thyA3073917c.555G>C0.897
thyA3073920c.552G>C0.893
thyA3073925c.547A>G0.889
thyA3073929c.543A>G0.913
thyA3073941c.531G>A0.950
thyA3073953c.519A>G0.929
thyA3073956c.516C>G0.909
thyA3073959c.513A>G0.900
thyA3073989c.483A>G1.000
thyA3074004c.468A>G1.000
thyA3074010c.462G>C1.000
thyA3074028c.444C>G1.000
thyA3074031c.441A>G1.000
thyA3074037c.435G>C1.000
thyA3074053p.Arg140Gln1.000
thyA3074057p.Glu139Pro1.000
thyA3074061c.411T>C1.000
thyA3074079c.393C>G1.000
thyA3074097c.375G>C1.000
thyA3074102p.Asp124Asn1.000
thyA3074106c.366A>G1.000
thyA3074127c.345C>G1.000
thyA3074130c.342C>G1.000
thyA3074147p.Ile109Val1.000
thyA3074159p.Ser105Thr1.000
thyA3074160c.312T>C1.000
thyA3074165p.Ala103Thr1.000
thyA3074172c.300C>G1.000
thyA3074175c.297T>C1.000
thyA3074181c.291T>C1.000
thyA3074187c.285A>G1.000
thyA3074205p.Glu89Asp0.978
thyA3074214c.258A>G0.955
thyA3074244c.228T>C0.933
thyA3074263p.Gly70Ala0.900
thyA3074267p.Ile69Val0.900
thyA3074268c.204A>G0.900
thyA3074285c.187A>G0.889
thyA3074286c.186A>G0.889
thyA3074334c.138A>G0.875
thyA3074360c.112A>G0.913
thyA3074361c.111A>G0.955
thyA3074372p.Met34Leu0.955
thyA3074377p.Gln32Arg0.955
thyA3074391c.81G>T0.955
thyA3074397c.75T>C0.955
ald3087665c.846C>G1.000
ald3087666p.Tyr283His1.000
ald3087672p.His285Asp1.000
ald3087680c.861G>C0.958
ald3087704c.885T>C0.920
ald3087716c.897G>C0.885
ald3087726p.Ala303Ser0.885
ald3087729p.Ser304Ala0.885
ald3087737c.918G>C0.885
ald3087749c.930C>G0.850
ald3087750p.Tyr311Val0.850
ald3087761c.942C>G0.850
ald3087770c.951G>C0.850
ald3087787p.Glu323Ala0.786
ald3087791c.972T>C0.750
ald3087797p.Asp326Glu0.700
ald3087799p.His327Arg0.700
fbiA3640291c.-252T>C0.957
fbiA3640307c.-236C>A1.000
fbiA3640347c.-196A>G1.000
fbiA3640349c.-194A>G1.000
fbiA3640350c.-193C>T1.000
fbiA3640365c.-178C>G1.000
alr3840944c.477A>G0.889
alr3840947c.474C>G0.850
alr3840959c.462C>G0.909
alr3840968c.453C>G0.919
alr3840980c.441C>G0.900
alr3840989c.432C>G0.925
alr3840994p.His143Asp0.925
alr3840997c.424C>G0.925
alr3841001c.420T>C0.929
alr3841010c.411T>C0.946
alr3841018p.Leu135Glu0.946
alr3841022c.399G>C0.949
alr3841028c.393C>G0.952
alr3841033p.Val130Ile0.953
alr3841037c.384C>G0.968
alr3841059p.Gly121Ala0.972
alr3841069p.Ile118Phe0.971
alr3841079c.342A>G0.984
alr3841100c.321T>C1.000
alr3841105p.Thr106Arg1.000
alr3841108p.Ile105Val1.000
alr3841112c.309A>G1.000
alr3841115c.306A>G1.000
alr3841127c.294T>C1.000
panD4044057c.225G>T0.810
panD4044072c.210G>C0.875
panD4044075c.207A>G0.875
panD4044081c.201A>G0.880
panD4044084c.198A>G0.880
panD4044105c.177C>G0.862
panD4044117c.165C>G0.893
panD4044120c.162T>G0.893
panD4044123c.159A>G0.862
panD4044126c.156A>G0.862
panD4044138c.144A>G0.926
panD4044150c.132T>C0.926
panD4044165c.117C>G0.923
panD4044174c.108G>C0.917
panD4044177c.105G>C0.909
panD4044188c.94A>G0.833
panD4044189c.93G>A0.818
panD4044195c.87A>G0.800
embC4240105c.243C>T1.000
embC4240123c.261C>G1.000
embC4240126c.264C>T1.000
embC4240141c.279A>G1.000
embC4240145p.Ala95Thr1.000
embC4240154p.Gln98Gly1.000
embC4240160p.Thr100Ala1.000
embC4240178c.316T>C1.000
embC4240183c.321A>G1.000
embC4240204c.342T>C1.000
embC4240444c.582C>G0.909
embC4240459c.597G>C0.909
embC4240462c.600G>C0.909
embC4240474c.612G>C0.909
embC4240475p.Ala205Ser0.909
embC4240484p.Ala208Thr0.909
embC4240489c.627A>G0.909
embC4240492c.630G>C0.909
embC4240495c.633T>G0.909
embC4240512p.Ser217Thr0.909
embC4240516c.654G>C0.909
embC4240519c.657T>C0.909
embC4240543c.681G>C0.909
embC4240630c.768C>A1.000
embC4240632p.Met257Thr1.000
embC4240642c.780G>C1.000
embC4240645c.783G>C1.000
embC4240654c.792C>G1.000
embC4240660c.798C>G1.000
embC4240669c.807G>C1.000
embC4240671p.Thr270Ile1.000
embC4240677p.Gly272Ala1.000
embC4240685p.Thr275Ala1.000
embC4240693c.831T>G0.975
embC4240699c.837C>G0.976
embC4240726c.864G>C0.980
embC4240780c.918T>C0.976
embC4240783c.921G>C0.975
embC4240789c.927T>C0.976
embC4240819c.957A>G0.975
embC4240828c.966G>A0.970
embC4240831c.969T>G0.968
embC4240867c.1005T>C1.000
embC4240870c.1008T>C1.000
embC4240873c.1011C>G1.000
embC4240879c.1017G>C1.000
embC4240880p.Ala340Thr1.000
embC4240885c.1023T>C1.000
embC4240897c.1035C>G1.000
embC4240898c.1036C>T1.000
embC4240903c.1041C>G1.000
embC4240911p.Ala350Val0.909
embC4240921c.1059C>G0.909
embC4240924c.1062C>G0.900
embC4240996c.1134G>C0.941
embC4241002c.1140G>C0.941
embC4241013p.Met384Thr0.950
embC4241017c.1155T>C0.955
embC4241023c.1161T>G0.960
embC4241032c.1170G>C0.968
embC4241038c.1176G>C0.917
embC4241047c.1185C>G0.919
embC4241050c.1188T>G0.947
embC4241053c.1191G>C0.947
embC4241089c.1227C>G0.965
embC4241095c.1233C>T0.967
embC4241107c.1245G>C0.968
embC4241140c.1278A>G0.968
embC4241146c.1284C>G0.966
embC4241158c.1296T>C0.958
embC4241161c.1299C>G0.957
embC4241162c.1300T>C0.957
embC4241170c.1308G>C0.957
embC4241173c.1311C>T0.957
embC4241179c.1317G>A0.956
embC4241203c.1341T>C0.972
embC4241206c.1344G>C0.971
embC4241218c.1356G>C1.000
embC4241230c.1368A>G1.000
embC4241233c.1371G>C1.000
embC4241351p.Ile497Val0.947
embC4241361p.Asn500Thr0.957
embC4241363p.Leu501Met0.957
embC4241374c.1512T>G0.972
embC4241380c.1518A>C0.975
embC4241383c.1521G>C0.975
embC4241394p.Lys511Ser0.978
embC4241449c.1587C>G1.000
embC4241453p.Ile531Val1.000
embC4241479c.1617C>G1.000
embC4241480c.1618T>C1.000
embC4241488c.1626G>C1.000
embC4241496p.Ala545Gly1.000
embC4241500c.1638A>C1.000
embC4241501p.Ser547Thr1.000
embC4241506c.1644G>C0.974
embC4241518c.1656A>G0.971
embC4241521c.1659T>C0.971
embC4241530c.1668C>G0.969
embC4241536c.1674A>G0.958
embC4241539c.1677T>C0.950
embC4241545c.1683T>C0.950
embC4241548c.1686T>C0.947
embC4241551c.1689A>G0.947
embC4241567p.Ile569Val0.933
embC4241572c.1710C>G0.917
embC4242689p.Val943Ile0.920
embC4242710p.Gln950Glu0.939
embC4242715c.2853T>C0.939
embC4242742c.2880C>G1.000
embC4242748c.2886A>G1.000
embC4242754c.2892G>C1.000
embC4242764p.Val968Leu1.000
embC4242772c.2910G>C1.000
embC4242779p.Asn973Asp1.000
embC4242791p.Ala977Ser1.000
embC4242796c.2934G>C1.000
embC4242799c.2937T>C1.000
embC4242802c.2940G>C1.000
embC4242820c.2958G>C0.950
embC4242823c.2961G>C0.949
embC4242832c.2970A>C0.947
embC4242838c.2976C>G0.931
embC4242841c.2979C>T0.929
embC4242844c.2982A>G0.929
embC4242847c.2985C>A0.929
embC4242859c.2997C>T0.923
embC4242862c.3000A>G0.917
embC4242863p.Tyr1001Asn0.917
embC4242883c.3021C>G0.917
embC4242892c.3030G>C0.957
embC4242901c.3039G>C0.957
embC4242919c.3057A>G0.955
embC4242928c.3066A>G0.950
embC4242931c.3069G>C0.950
embC4242940c.3078T>C0.933
embC4242941p.His1027Asn0.929
embC4242946c.3084T>C0.933
embC4242952c.3090T>C0.929
embA4244447c.1215G>C0.700
embA4244462c.1230A>G0.812
embA4244478p.Thr416Leu0.895
embA4244483c.1251T>G0.895
embA4244485p.Thr418Ser0.909
embA4244498c.1266A>G0.929
embA4244507c.1275G>T0.935
embA4244508c.1276T>C0.935
embA4244516c.1284G>C0.941
embA4244517p.Leu429Val0.941
embA4244523p.Pro431Ala0.974
embA4244534c.1302T>C0.927
embA4244537c.1305T>G0.930
embA4244543c.1311C>G0.933
embA4244547p.Ile439Val0.913
embA4244557p.Arg442Thr0.936
embA4244582c.1350T>C0.913
embA4244585c.1353A>G0.909
embA4244611p.Ala460Gly0.864
embA4244616p.Ala462Ser0.850
embA4244619c.1387T>C0.842
embA4244625p.Leu465Val0.842
embA4244631p.Thr467Leu0.889
embA4244645c.1413T>C0.882
embA4244648c.1416G>C0.867
embA4244649p.Asp473Ser0.867
embA4245041c.1809C>G0.929
embA4245044c.1812G>C0.929
embA4245053c.1821G>C0.935
embA4245060c.1828T>C0.968
embA4245083c.1851A>C0.973
embA4245089c.1857G>C0.974
embA4245101c.1869G>C0.979
embA4245137c.1905T>C0.964
embA4245146c.1914G>A0.960
embA4245149c.1917C>G0.960
embA4245153p.Ile641Val0.962
embA4245182c.1950T>C0.980
embA4245189c.1957C>T0.980
embA4245198p.Leu656Ile0.980
embA4245207c.1975T>C0.978
embA4245215c.1983A>C0.977
embA4245222p.Tyr664Gln0.976
embA4245248c.2016G>C1.000
embA4245257c.2025A>G1.000
embA4245263c.2031A>G0.964
embA4245282p.Ile684Val0.938
embA4245285c.2053T>C0.933
embA4245290c.2058C>G0.933
embA4245293c.2061T>G0.933
embA4245296c.2064G>C0.933
embA4245299c.2067A>G0.933
embA4245659c.2427C>G0.880
embA4245674c.2442A>C0.879
embA4245677c.2445G>C0.886
embA4245693p.Ile821Val0.907
embA4245701c.2469G>C0.920
embA4245704c.2472G>C0.904
embA4245725c.2493A>G0.922
embA4245726c.2494T>C0.923
embA4245737c.2505A>C0.933
embA4245740c.2508T>C0.933
embA4245764c.2532G>C0.949
embA4245772p.Asn847Thr0.944
embA4245785c.2553G>C0.954
embA4245807c.2575T>C0.871
embA4245812c.2580G>C0.857
embA4245813p.Pro861Ala0.857
embA4245820p.Ser863Thr0.857
embA4245824c.2592G>C0.857
embA4245833c.2601G>C0.857
embA4245842c.2610G>C0.889
embA4245845c.2613T>C0.889
embA4245851c.2619G>C0.857
embA4245860c.2628C>G0.875
embA4246164c.2932T>C0.667
embA4246184c.2952A>C0.800
embA4246196c.2964C>G0.857
embA4246205c.2973A>G0.867
embA4246211c.2979T>C0.867
embA4246217c.2985G>A0.867
embA4246220c.2988T>C0.929
embA4246223c.2991C>T0.929
embA4246227p.Ile999Val0.944
embA4246235c.3003G>A0.958
embA4246242p.Gln1004Gly0.960
embA4246250c.3018G>C0.969
embA4246256c.3024G>T0.971
embA4246259c.3027G>C0.973
embA4246264p.His1011Arg0.974
embA4246292c.3060A>G0.977
embA4246305p.Ser1025Glu0.975
embA4246308p.Thr1026Ala0.974
embA4246316c.3084T>G0.978
embA4246319c.3087G>C0.978
embA4246329p.Thr1033Ala0.979
embA4246349c.3117C>G1.000
embA4246359p.Ala1043Ser1.000
embA4246367c.3135C>T1.000
embA4246373c.3141T>C1.000
embA4246376c.3144G>C1.000
embA4246379c.3147C>T1.000
embA4246400c.3168G>C1.000
embA4246413p.His1061Phe1.000
embA4246419c.3187C>T1.000
embB4247386c.873T>C0.933
embB4247389c.876C>G0.933
embB4247395c.882C>G0.955
embB4247401c.888T>C0.958
embB4247407c.894G>C0.964
embB4247425c.912G>C0.971
embB4247434c.921C>G0.972
embB4247437c.924A>G0.972
embB4247440c.927C>G0.972
embB4247446c.933C>T0.973
embB4247464c.951C>G0.980
embB4247470c.957T>C0.981
embB4247491c.978G>C0.985
embB4247497c.984T>C0.985
embB4247512c.999T>C0.985
embB4247539c.1026T>C1.000
embB4247554c.1041T>C1.000
embB4247566c.1053C>A1.000
embB4247572c.1059A>G1.000
embB4247579p.Ala356Phe1.000
embB4247587c.1074G>A0.957
embB4247602c.1089G>C0.905
embB4247603c.1090C>T0.905
embB4247611c.1098G>T0.900
embB4247614c.1101T>C0.900
embB4247629c.1116C>G0.875
embB4247632c.1119C>G0.800
embB4247638c.1125G>C0.700
embB4247674c.1161G>C0.789
embB4247683c.1170C>G0.800
embB4247692c.1179C>G0.840
embB4247716c.1203C>T0.852
embB4247722c.1209G>C0.852
embB4247725c.1212G>C0.852
embB4247729p.Gly406Pro0.852
embB4247746c.1233C>T0.949
embB4247761c.1248T>C0.955
embB4247773c.1260G>A0.956
embB4247776c.1263G>T0.959
embB4247797c.1284C>G0.959
embB4247800c.1287A>T0.959
embB4247803c.1290G>C0.959
embB4247815c.1302C>G0.960
embB4247819p.Val436Ile0.958
embB4247830c.1317A>G0.963
embB4247836c.1323A>G0.962
embB4247839c.1326G>C0.962
embB4247866c.1353G>C0.964
embB4247875c.1362G>C0.963
embB4247876c.1363C>T0.962
embB4247881c.1368G>C0.965
embB4247887c.1374C>T0.967
embB4247893c.1380C>T0.968
embB4247899p.Met462Ile0.969
embB4247905c.1392G>C0.969
embB4247909c.1396T>C0.968
embB4247914c.1401G>C0.967
embB4247932c.1419C>G1.000
embB4247940p.Leu476Trp1.000
embB4247945c.1432T>C1.000
embB4247951p.Ser480Ala1.000
embB4247956c.1443G>C0.983
embB4247974c.1461C>G1.000
embB4248007c.1494C>G1.000
embB4248011p.Ser500Arg1.000
embB4248014p.Thr501Ala1.000
embB4248035p.Val508Ile1.000
embB4248040c.1527C>G1.000
embB4248041p.Ala510Thr1.000
embB4248044p.Lys511Ala1.000
embB4248070c.1557T>C1.000
embB4248085c.1572T>C1.000
embB4248097c.1584C>G1.000
embB4248130c.1617G>C1.000
embB4248133c.1620C>G1.000
embB4248139c.1626C>G1.000
embB4248142c.1629T>C1.000
embB4248143c.1630T>C1.000
embB4248157c.1644A>G1.000
embB4248172c.1659G>C1.000
embB4248199c.1686A>G0.978
embB4248200p.Ile563Val0.978
embB4248205c.1692C>G0.977
embB4248206p.Ser565Gly0.977
embB4248220c.1707A>C0.981
embB4248277c.1764G>A1.000
embB4248304c.1791G>C0.982
embB4248316c.1803C>G0.981
embB4248319c.1806A>G0.981
embB4248343c.1830G>C0.981
embB4248350c.1837T>C0.961
embB4248355c.1842A>G0.961
embB4248358c.1845C>G0.959
embB4248361c.1848A>C0.958
embB4248362p.Ser617Ala0.958
embB4248373c.1860C>G0.948
embB4248382c.1869C>G0.944
embB4248386c.1873C>A0.941
embB4248407p.Leu632Val0.900
embB4248410p.Phe633Leu0.897
embB4248419p.Leu636Met0.893
embB4248425c.1912T>C0.889
embB4248430c.1917T>C0.885
embB4248432p.Trp640Phe0.885
embB4248457c.1944T>C0.900
embB4248463c.1950C>G0.889
embB4248472c.1959T>C0.867
embB4248475c.1962G>C0.846
embB4249369c.2856T>C0.833
embB4249375c.2862G>C0.840
embB4249381c.2868A>G0.840
embB4249384c.2871G>T0.840
embB4249417c.2904A>G0.927
embB4249423p.Asp970Glu0.927
embB4249424p.Leu971Met0.927
embB4249429c.2916C>T0.927
embB4249432c.2919A>G0.951
embB4249441c.2928A>G0.980
embB4249444c.2931T>C1.000
embB4249469p.Leu986Met1.000
embB4249486c.2973T>G0.983
embB4249498c.2985G>C0.964
embB4249521p.Ala1003Val0.946
embB4249525c.3012T>C0.944
embB4249529p.Ile1006Val0.943
embB4249532p.Ala1007Thr0.941
embB4249537c.3024A>G0.941
embB4249543c.3030G>C0.941
embB4249546c.3033G>A0.941
embB4249558c.3045A>C0.926
embB4249568p.Ser1019Thr0.917
embB4249573c.3060T>C0.909
embB4249580p.Leu1023Met0.905
embB4249594c.3081G>C0.889
embB4249606c.3093C>A0.818
ethA4327396c.78A>G0.960
ethA4327399p.Asp25Glu0.923
ethA4327423c.51G>C0.923
ethA4327435c.39T>G0.920
ethA4327438c.36A>G0.920
ethA4327452p.Val8Leu0.905
ethA4327453c.21A>G0.905
ethA4327459c.15G>A0.905
ethA4327468c.6G>A0.895

Analysis pipeline specifications

TBProfiler Version: 2.1.1

AnalysisProgram
Mappingbwa
Variant CallingBCFtools


Log

Drug Details
The estimated accuracy of drug resistance predictions is:

Drug1Sensitivity (%)Specificity (%)
Isoniazid 92.8 (89.9-95.7)100 (100-100)
Rifampicin 96.2 (93.9-98.5)98.1 (96.8-99.4)
Ethambutal 88.7 (83.6-93.8)81.7 (77.6-85.8)
Pyrazinamide70.9 (62.4-79.4)93.9 (90.6-97.2)
Streptomycin87.1 (82.7-91.5)89.7 (86.0-93.4)
Ethionamide 73.6 (66.7-80.5)93.3 (89.6-97.0)
Moxifloxacin60.0 (29.6-90.4)68.7 (52.6-84.8)
Ofloxacin 85.5 (79.1-91.9)94.9 (91.8-98.0)
Amikacin 82.9 (74.4-91.4)98.3 (96.0-100)
Capreomycin 60.7 (50.6-70.8)90.7 (87.2-94.2)
Kanamycin 87.3 (81.3-93.3)93.4 (89.9-96.9)
Para-aminosalisylic acidNot determinedNot determined
Linezolid Not determinedNot determined
Clofazimine Not determinedNot determined
Bedaquiline Not determinedNot determined
Multi drug resistance91.2 (87.8-94.6)98.4 (97.2-99.6)
Extremely drug resistance75.9 (64.5-87.3)98.4 (97.3-99.5)

Lineages
Lineage2LocationStrainRD type
lineage1Indo-OceanicEAIRD239
lineage1.1Indo-OceanicEAI3;EAI4;EAI5;EAI6RD239
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineage1.1.1.1Indo-OceanicEAI4;ZERORD239
lineage1.1.2Indo-OceanicEAI3;EAI5RD239
lineage1.1.3Indo-OceanicEAI6RD239
lineage1.2Indo-OceanicEAI1;EAI2RD239
lineage1.2.1Indo-OceanicEAI2RD239
lineage1.2.2Indo-OceanicEAI1RD239
lineage2East-AsianBeijingRD105
lineage2.1East-Asian (non-Beijing)NoneNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.2East-Asian (Beijing)Beijing-RD105/RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181
lineage2.2.1.2East-Asian (Beijing)Beijing-RD142RD105;RD207;RD181;RD142
lineage2.2.1.1East-Asian (Beijing)Beijing-RD150RD105;RD207;RD181;RD150
lineage3East-African-IndianCASRD750
lineage3.1East-African-IndianNon-CAS1-DelhiRD750
lineage3.1.1East-African-IndianCAS1-KiliRD750
lineage3.1.2East-African-IndianCAS;CAS2RD750
lineage3.1.2.1East-African-IndianCAS2RD750
lineage3.1.2.2East-African-IndianCASRD750
lineage4Euro-AmericanLAM;T;S;X;HNone
lineage4.1Euro-AmericanT;X;HNone
lineage4.1.2Euro-American (X-type)T;HNone
lineage4.1.2.1Euro-American (X-type)T1;H1RD182
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.2Euro-American (X-type)X1None
lineage4.1.1.1Euro-American (X-type)X2RD183
lineage4.1.1.3Euro-American (Haarlem)X1;X3RD193
lineage4.2Euro-AmericanH;T;LAMNone
lineage4.2.2Euro-American (Ural)T;LAM7-TURNone
lineage4.2.2.1Euro-AmericanLAM7-TURNone
lineage4.2.1Euro-American (TUR)H3;H4None
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.3.1Euro-American (LAM)LAM9None
lineage4.3.3Euro-American (LAM)LAM;TRD115
lineage4.3.4Euro-American (LAM)LAMRD174
lineage4.3.4.1Euro-American (LAM)LAM1;LAM2RD174
lineage4.3.4.2Euro-American (LAM)LAM1;LAM4;LAM11RD174
lineage4.3.4.2.1Euro-American (LAM)LAM11RD174
lineage4.3.2Euro-American (LAM)LAM3None
lineage4.3.2.1Euro-American (LAM)LAM3RD761
lineage4.4Euro-AmericanS;TNone
lineage4.4.2Euro-AmericanT1;T2None
lineage4.4.1Euro-American (S-type)S;TNone
lineage4.4.1.2Euro-AmericanT1None
lineage4.4.1.1Euro-AmericanS;OrphansNone
lineage4.5Euro-AmericanH;TRD122
lineage4.6Euro-AmericanT;LAMNone
lineage4.6.1Euro-American (Uganda)T2RD724
lineage4.6.1.1Euro-American T2-UgandaRD724
lineage4.6.1.2Euro-AmericanT2RD724
lineage4.6.2Euro-AmericanT;LAMRD726
lineage4.6.2.1Euro-AmericanT3RD726
lineage4.6.2.2Euro-American (Cameroon)LAM10-CAMRD726
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.8Euro-American (mainly T)T1;T2;T3;T5RD219
lineage4.9Euro-American (H37Rv-like)T1None
lineage5West-Africa 1AFRI_2;AFRI_3RD711
lineage6West-Africa 2AFRI_1RD702
lineage7Lineage 7NoneNone
lineageBOVM. bovisBOV_1;BOV_2None

Citations
1. Coll F, et al. Rapid determination of anti-tuberculosis drug resistance from whole genome sequences. Genome Medicine (in press)
2. Coll F, et al. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications 2014.

Disclaimer
This tool is for Research Use Only and is offered free for use. The London School of Hygiene and Tropical Medicine shall have no liability for any loss or damages of any kind, however sustained relating to the use of this tool.
© 2019 London School of Hygiene and Tropical Medicine;