TB Profiler
This tool processes raw sequence data to infer strain type and identify known drug resistance markers.
A stand alone version of this tool is now available and can now be run on linux or mac. Installation instructions can be found on GitHub and on the bioconda page.



This tool is for Research Use Only. Data and information provided through use of this tool are not intended for medical purpose or objective and should not be used for clinical diagnosis, patient management, or human clinical trials.
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Single nucleotide polymorphisms (SNPs) in coding regions are annotated using the reference amino acid, codon number and alternative amino acid (e.g. Ser315Thr in katG). SNPs in non-coding regions (i.e. RNA genes and intergenic regions) are annotated using the reference nucleotide, gene coordinate and alternative nucleotide (e.g. A1401G in rrs or C-37A in eis promoter). Indels are annotated using the reference VCF allele, gene coordinate and alternative VCF allele (e.g. T902TA insertion in katG).
Name: 5d807cdbf3427
Sample: 5d807cdbf3427

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Summary
ID: 5d807cdbf3427
Date: Tue Sep 17 07:32:30 2019
Strain: lineage2.2.1;lineage4.3;lineage4.2;lineage4.6.1;lineage1.2.2
Drug-resistance: Drug-resistant

Drug1ResistanceSupporting Mutations (frequency)
Isoniazid
RifampicinRrpoB p.Ser450Leu (0.76)
EthambutolRembB p.His312Arg (0.14), embB p.Leu359Ile (0.20), embB p.Ala388Gly (0.12), embB p.Asn399Asp (0.19), embB p.Ala659Thr (0.19)
Pyrazinamide
StreptomycinRrrs r.462c>t (0.30)
Ethionamide
Fluoroquinolones
Amikacin
Capreomycin
Kanamycin

Lineage2FamilyMain SpoligotypeRDS
lineage2East-AsianBeijingRD105
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.2Euro-AmericanH;T;LAMNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage4.6.1Euro-American (Uganda)T2RD724
lineage1.2.2Indo-OceanicEAI1RD239
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181

Mutations in candidate genes:
GeneChromosome PositionMutationEstimated fraction
gyrB6100c.861G>C0.116
gyrB6115c.876A>G0.188
gyrB6123p.Ala295Gly0.171
gyrB6127c.888G>C0.179
gyrB6130c.891T>C0.174
gyrB6136c.897G>A0.176
gyrB6139c.900G>C0.188
gyrB6238c.999G>A0.194
gyrB6242p.Arg335Lys0.190
gyrB6248c.1009C>T0.190
gyrB6256c.1017G>A0.208
gyrB6268c.1029C>G0.244
gyrB6280c.1041T>C0.253
gyrB6286c.1047T>C0.227
gyrB6289c.1050C>T0.224
gyrB6292c.1053G>C0.231
gyrB6307c.1068T>G0.275
gyrB6319c.1080G>C0.260
gyrB6346c.1107C>T0.243
gyrB6362c.1123T>C0.200
gyrB6376c.1137G>A0.197
gyrB6379c.1140C>G0.197
gyrB6382c.1143A>G0.194
gyrB6388c.1149T>C0.197
gyrB6403c.1164T>C0.185
gyrB6598c.1359C>G0.110
gyrB6610c.1371C>G0.107
gyrB6634c.1395T>C0.111
gyrB6649c.1410T>C0.146
gyrB6655c.1416T>C0.149
gyrB6670c.1431G>C0.170
gyrB6673c.1434A>C0.170
gyrB6676c.1437T>G0.170
gyrB6700c.1461T>C0.215
gyrB6703c.1464G>C0.217
gyrB6709c.1470A>G0.204
gyrB6712c.1473G>C0.204
gyrB6728c.1489C>T0.231
gyrB6742c.1503A>G0.220
gyrB6745c.1506T>G0.232
gyrB6751c.1512G>C0.255
gyrB6760c.1521G>C0.260
gyrB6763c.1524G>C0.293
gyrB6775c.1536G>C0.290
gyrB6793c.1554T>C0.257
gyrB6797p.Gly520Thr0.260
gyrB6811c.1572C>T0.241
gyrB6841c.1602T>C0.234
gyrB6844c.1605T>C0.221
gyrB6889c.1650G>T0.146
gyrB6901c.1662G>C0.175
gyrB6904c.1665C>G0.183
gyrB6910c.1671G>A0.209
gyrB6919c.1680T>C0.212
gyrB6925c.1686T>C0.216
gyrB6931c.1692A>G0.250
gyrB6949c.1710A>G0.247
gyrB6952c.1713C>G0.242
gyrB6967c.1728T>C0.239
gyrB6973c.1734G>C0.245
gyrB6982c.1743A>C0.263
gyrB7006c.1767T>C0.217
gyrB7007c.1768C>T0.215
gyrB7010c.1771C>T0.215
gyrB7015c.1776G>A0.222
gyrB7018c.1779G>A0.227
gyrB7023p.Leu595Gln0.217
gyrB7033c.1794G>C0.213
gyrB7051p.Glu604Asp0.194
gyrB7066c.1827G>C0.143
gyrB7108c.1869G>A0.127
gyrB7114c.1875C>A0.122
gyrB7141c.1902T>C0.182
gyrB7147c.1908G>C0.187
gyrB7165c.1926C>G0.210
gyrB7178c.1939T>C0.250
gyrB7186c.1947C>G0.284
gyrB7216c.1977G>C0.292
gyrB7234c.1995C>T0.290
gyrB7246c.2007T>C0.284
gyrB7252c.2013G>C0.271
gyrB7256c.2017C>T0.243
gyrA7334c.33G>C0.176
gyrA7335p.Leu12Val0.176
gyrA7347p.Glu16Gln0.190
gyrA7361c.60C>T0.238
gyrA7362p.Glu21Gln1.000
gyrA7391c.90C>T0.292
gyrA7394c.93T>C0.296
gyrA7427c.126G>C0.290
gyrA7442c.141G>C0.327
gyrA7451c.150C>G0.305
gyrA7457c.156T>C0.295
gyrA7475c.174A>G0.237
gyrA7480p.Phe60Tyr0.216
gyrA7484c.183T>C0.224
gyrA7496c.195C>G0.261
gyrA7514c.213C>G0.248
gyrA7523c.222C>G0.239
gyrA7532c.231T>C0.209
gyrA7541c.240C>G0.209
gyrA7547c.246C>T0.202
gyrA7571c.270G>C0.198
gyrA7585p.Ser95Thr1.000
gyrA7595c.294C>G0.144
gyrA7601c.300C>G0.148
gyrA7607c.306C>G0.138
gyrA7694c.393A>G0.113
gyrA7697c.396C>G0.117
gyrA7710c.409T>C0.158
gyrA7728c.427A>C0.194
gyrA7763c.462T>C0.265
gyrA7775c.474C>A0.264
gyrA7781c.480G>C0.255
gyrA7784c.483A>G0.245
gyrA7790c.489G>C0.245
gyrA7793c.492G>C0.264
gyrA7796c.495G>C0.264
gyrA7799c.498A>G0.264
gyrA7814c.513C>G0.316
gyrA7823c.522G>C0.314
gyrA7832c.531G>T0.312
gyrA7835c.534A>C0.316
gyrA7853c.552C>G0.292
gyrA7859c.558A>G0.278
gyrA7865c.564T>C0.265
gyrA7886c.585T>C0.213
gyrA8069c.768T>C0.131
gyrA8078c.777A>G0.161
gyrA8090c.789C>A0.172
gyrA8096c.795T>A0.175
gyrA8099c.798T>C0.190
gyrA8111c.810G>C0.250
gyrA8121c.820T>C0.279
gyrA8129c.828T>C0.309
gyrA8135c.834C>G0.343
gyrA8156c.855T>C0.348
gyrA8168c.867A>G0.314
gyrA8177c.876A>C0.319
gyrA8186c.885G>A0.356
gyrA8189c.888G>C0.360
gyrA8198c.897T>C0.368
gyrA8207c.906T>C0.348
gyrA8219c.918T>C0.324
gyrA8225c.924T>C0.320
gyrA8234c.933T>C0.329
gyrA8237c.936A>G0.342
gyrA8247p.Ile316Val0.342
gyrA8264c.963T>C0.290
gyrA8267c.966G>C0.286
gyrA8270c.969G>C0.290
gyrA8276c.975G>A0.286
gyrA8283p.Ile328Leu0.265
gyrA8288c.987T>C0.273
gyrA8294c.993T>C0.313
gyrA8324c.1023T>C0.359
gyrA8330c.1029C>G0.321
gyrA8339c.1038A>G0.342
gyrA8340p.Ala347Ser0.338
gyrA8372c.1071G>C0.258
gyrA8375c.1074G>C0.242
gyrA8382p.Leu361Met0.226
gyrA8387c.1086C>T0.217
gyrA8391p.Tyr364His0.202
gyrA8399c.1098T>G0.198
gyrA8401p.Asp367Ala0.195
gyrA8405c.1104C>T0.193
gyrA8420c.1119T>C0.297
gyrA8442c.1141C>T0.347
gyrA8453c.1152A>C0.363
gyrA8462c.1161A>T0.354
gyrA8465c.1164C>G0.354
gyrA8471c.1170T>C0.370
gyrA8472c.1171C>T0.370
gyrA8480c.1179C>T0.420
gyrA8486c.1185T>C0.412
gyrA8516c.1215T>C0.385
gyrA8519c.1218A>C0.371
gyrA8520c.1219C>T0.384
gyrA8528c.1227G>C0.396
gyrA8543c.1242C>G0.398
gyrA8546c.1245T>C0.396
gyrA8552c.1251C>A0.388
gyrA8561c.1260A>G0.394
gyrA8576c.1275C>G0.365
gyrA8579c.1278C>T0.368
gyrA8588c.1287G>A0.372
gyrA8597c.1296C>G0.341
gyrA8603c.1302A>G0.326
gyrA8619c.1318T>C0.277
gyrA8624c.1323G>C0.274
gyrA8636c.1335A>C0.276
gyrA8642c.1341A>G0.274
gyrA8672c.1371A>G0.269
gyrA8693c.1392T>C0.238
gyrA8696c.1395G>C0.231
gyrA8699c.1398A>G0.221
gyrA8711c.1410A>C0.215
gyrA8714c.1413A>G0.226
gyrA8729c.1428T>C0.169
gyrA8730p.Gly477Arg0.167
gyrA8740p.Arg480His0.149
gyrA8858c.1557T>C0.145
gyrA8867c.1566A>G0.143
gyrA8870c.1569G>C0.174
gyrA8873c.1572A>C0.188
gyrA8891c.1590G>A0.284
gyrA8897c.1596T>C0.280
gyrA8903c.1602T>C0.289
gyrA8933c.1632G>C0.313
gyrA8939c.1638T>C0.325
gyrA8942c.1641G>C0.329
gyrA8946c.1645T>C0.338
gyrA8966c.1665C>G0.319
gyrA8967p.Ala556Arg0.315
gyrA8987c.1686C>G0.318
gyrA8990c.1689C>G0.323
gyrA8996c.1695T>C0.323
gyrA8998p.Leu566Trp0.333
gyrA9017c.1716C>G0.321
gyrA9023c.1722A>C0.273
gyrA9029c.1728T>C0.191
gyrA9032c.1731T>C0.163
gyrA9035c.1734G>C0.143
gyrA9080c.1779G>T0.146
gyrA9089c.1788G>C0.154
gyrA9099c.1798T>C0.157
gyrA9104c.1803C>G0.151
gyrA9119c.1818A>G0.145
gyrA9122c.1821C>G0.151
gyrA9143c.1842T>C0.169
gyrA9152c.1851C>T0.133
gyrA9153p.Thr618Glu0.136
gyrA9158c.1857C>T0.131
gyrA9161c.1860C>G0.129
gyrA9182c.1881T>C0.253
gyrA9191c.1890G>C0.247
gyrA9200c.1899A>G0.279
gyrA9204p.Ser635Thr0.276
gyrA9224c.1923C>T0.306
gyrA9230c.1929T>C0.296
gyrA9233c.1932C>G0.296
gyrA9239c.1938C>T0.309
gyrA9252p.Val651Ile0.304
gyrA9284c.1983T>C0.296
gyrA9291c.1990C>T0.269
gyrA9296c.1995T>C0.250
gyrA9299c.1998G>C0.247
gyrA9300p.Ala667Ser0.250
gyrA9304p.Gly668Asp1.000
gyrA9308p.Asp669Glu0.264
gyrA9323c.2022C>A0.320
gyrA9335c.2034G>C0.301
gyrA9365c.2064G>A0.256
gyrA9374c.2073G>C0.226
gyrA9377c.2076A>G0.229
gyrA9383c.2082T>G0.229
gyrA9386c.2085T>C0.220
gyrA9395c.2094G>C0.198
gyrA9398c.2097T>C0.200
gyrA9413c.2112G>C0.167
rpoB759606c.-201T>C0.171
rpoB759629c.-178T>C0.164
rpoB759644c.-163T>A0.127
rpoB759647c.-160T>C0.125
rpoB760046c.240G>C0.116
rpoB760060p.Tyr85Leu0.130
rpoB760067c.261G>C0.132
rpoB760070c.264T>G0.157
rpoB760091c.285G>C0.221
rpoB760101c.295T>C0.227
rpoB760112c.306T>C0.265
rpoB760118c.312T>G0.275
rpoB760121c.315T>C0.275
rpoB760130p.Asp108Glu0.294
rpoB760139c.333A>G0.313
rpoB760142c.336C>G0.309
rpoB760181c.375T>C0.358
rpoB760184c.378A>G0.348
rpoB760196c.390C>G0.371
rpoB760223c.417T>C0.393
rpoB760235c.429T>C0.382
rpoB760283c.477G>C0.395
rpoB760298c.492G>C0.380
rpoB760307c.501T>C0.380
rpoB760310c.504G>C0.366
rpoB760328c.522G>C0.370
rpoB760331c.525G>C0.371
rpoB760340c.534G>T0.351
rpoB760361c.555T>C0.329
rpoB760370c.564C>G0.317
rpoB760376p.Asp190Glu0.294
rpoB760380p.Thr192Leu0.282
rpoB760406c.600G>C0.273
rpoB760412c.606C>G0.260
rpoB760424c.618C>G0.264
rpoB760430c.624T>C0.274
rpoB760475c.669A>G0.291
rpoB760481c.675G>T0.283
rpoB760484c.678A>G0.278
rpoB760522p.Ser239Asn0.232
rpoB760532c.726T>C0.207
rpoB760533p.Val243Thr0.203
rpoB760541c.735G>C0.239
rpoB760547c.741G>C0.250
rpoB760563p.Arg253Met0.214
rpoB760591p.Val262Ala0.219
rpoB760611c.805T>C0.186
rpoB760646c.840C>G0.162
rpoB760655c.849A>G0.160
rpoB760661c.855A>C0.172
rpoB760670c.864G>C0.131
rpoB760674c.868T>C0.129
rpoB760679c.873A>G0.140
rpoB760683c.877T>C0.157
rpoB760715c.909C>G0.148
rpoB760718c.912C>T0.138
rpoB760724c.918T>C0.141
rpoB760730c.924T>C0.146
rpoB760751c.945G>C0.128
rpoB760793c.987A>G0.160
rpoB760805c.999G>C0.184
rpoB760817c.1011A>G0.203
rpoB760820c.1014T>C0.205
rpoB760826c.1020C>G0.203
rpoB760830c.1024T>C0.200
rpoB760841c.1035T>C0.173
rpoB760845p.Thr347Pro0.160
rpoB760859c.1053T>C0.202
rpoB760862c.1056G>C0.207
rpoB760869p.Val355Ile0.233
rpoB760886c.1080A>G0.255
rpoB760925c.1119T>C0.262
rpoB760928c.1122G>C0.256
rpoB760931c.1125C>G0.253
rpoB760934c.1128C>T0.270
rpoB760946c.1140A>G0.305
rpoB760982c.1176G>C0.330
rpoB760985c.1179G>C0.344
rpoB760991c.1185G>C0.330
rpoB761006c.1200C>G0.333
rpoB761015c.1209G>C0.301
rpoB761021c.1215G>C0.299
rpoB761027c.1221A>G0.287
rpoB761036c.1230G>C0.286
rpoB761037c.1231T>C0.278
rpoB761057c.1251G>C0.310
rpoB761102c.1296A>G0.275
rpoB761129c.1323G>C0.186
rpoB761132c.1326G>T0.203
rpoB761133c.1327T>C0.212
rpoB761150c.1344A>C0.237
rpoB761153c.1347G>C0.241
rpoB761165c.1359G>C0.247
rpoB761180c.1374A>C0.239
rpoB761189c.1383T>C0.210
rpoB761195c.1389G>C0.203
rpoB761207c.1401C>T0.198
rpoB761213c.1407G>C0.213
rpoB761219c.1413G>C0.211
rpoB761249c.1443A>G0.214
rpoB761255c.1449T>G0.222
rpoB761261c.1455G>T0.217
rpoB761306c.1500C>G0.228
rpoB761327c.1521A>G0.194
rpoB761330c.1524G>C0.194
rpoB761354c.1548C>T0.215
rpoB761360c.1554T>C0.204
rpoB761362p.Ser519Thr0.198
rpoB761373p.Val523His0.165
rpoB761408c.1602G>C0.204
rpoB761414c.1608A>G0.206
rpoB761423c.1617T>C0.211
rpoB761435c.1629T>C0.122
rpoB761438c.1632G>C0.118
rpoB761439p.Asp545Lys0.118
rpoB761444c.1638T>C0.118
rpoB761447c.1641C>G0.119
rpoB761452p.Val549Glu0.118
rpoB761457p.Pro551Ser0.108
rpoB761477c.1671C>G0.275
rpoB761492c.1686G>C0.316
rpoB761510c.1704T>C0.325
rpoB761531c.1725C>G0.363
rpoB761537c.1731C>G0.375
rpoB761570c.1764T>C0.289
rpoB761573c.1767C>G0.299
rpoB761579c.1773G>C0.316
rpoB761588c.1782C>T0.333
rpoB761606c.1800C>G0.333
rpoB761612c.1806G>C0.337
rpoB761615c.1809A>C0.322
rpoB761636c.1830G>T0.309
rpoB761645c.1839C>G0.250
rpoB761648c.1842T>C0.269
rpoB761657c.1851C>G0.280
rpoB761675c.1869G>C0.258
rpoB761720c.1914C>G0.150
rpoB761725p.Glu640Ala0.130
rpoB761732c.1926C>G0.133
rpoB761735c.1929C>G0.131
rpoB761747c.1941G>C0.192
rpoB761750c.1944G>C0.191
rpoB761765c.1959T>C0.229
rpoB761772p.His656Ala0.234
rpoB761778p.Asn658Asp0.250
rpoB761791p.Arg662His0.258
rpoB761813c.2007T>C0.253
rpoB761815p.Ala670Glu0.253
rpoB761834c.2028T>C0.293
rpoB761848p.Cys681Ser0.265
rpoB761852c.2046C>G0.265
rpoB761858c.2052G>C0.274
rpoB761873c.2067A>C0.239
rpoB761885c.2079T>C0.239
rpoB761906c.2100C>G0.263
rpoB761909c.2103T>C0.234
rpoB761912c.2106T>C0.234
rpoB761915p.Asp703Glu0.234
rpoB761916p.Asp704Asn0.234
rpoB761948c.2142G>C0.282
rpoB761954c.2148C>G0.289
rpoB762008c.2202C>T0.253
rpoB762014c.2208C>T0.257
rpoB762017c.2211A>G0.250
rpoB762053c.2247T>C0.222
rpoB762062c.2256T>C0.224
rpoB762065c.2259T>C0.221
rpoB762083c.2277T>C0.226
rpoB762086c.2280G>C0.237
rpoB762101c.2295C>G0.280
rpoB762114p.Ile770Val0.275
rpoB762131c.2325C>G0.310
rpoB762140c.2334G>C0.329
rpoB762143c.2337T>C0.329
rpoB762149c.2343G>C0.341
rpoB762167c.2361T>C0.367
rpoB762176c.2370T>C0.356
rpoB762185c.2379G>C0.393
rpoB762206c.2400C>G0.433
rpoB762233c.2427G>C0.422
rpoB762246c.2440C>T0.443
rpoB762254c.2448T>G0.434
rpoB762257c.2451C>G0.429
rpoB762266c.2460T>C0.435
rpoB762284c.2478G>C0.402
rpoB762293c.2487T>C0.396
rpoB762317c.2511A>G0.381
rpoB762329c.2523G>C0.389
rpoB762338c.2532T>C0.361
rpoB762347c.2541T>C0.364
rpoB762362p.Glu852Asp0.376
rpoB762369c.2563T>C0.356
rpoB762395c.2589G>C0.297
rpoB762398c.2592T>C0.289
rpoB762401c.2595G>C0.295
rpoB762404c.2598T>C0.295
rpoB762410c.2604T>C0.280
rpoB762416c.2610A>G0.277
rpoB762419c.2613C>G0.290
rpoB762434c.2628T>C0.320
rpoB762449c.2643C>A0.317
rpoB762467c.2661C>T0.320
rpoB762488c.2682G>C0.271
rpoB762489p.Val895Gln0.262
rpoB762509c.2703T>G0.250
rpoB762510p.Ala902Pro0.241
rpoB762521c.2715C>T0.253
rpoB762533c.2727T>C0.208
rpoB762536c.2730T>C0.167
rpoB762537c.2731T>C0.167
rpoB762551c.2745C>G0.129
rpoB762827c.3021G>C0.133
rpoB762857c.3051C>G0.162
rpoB762860c.3054G>C0.164
rpoB762863c.3057T>C0.179
rpoB762929c.3123G>C0.257
rpoB762989c.3183G>C0.278
rpoB762995c.3189G>T0.277
rpoB763013c.3207C>G0.307
rpoB763028c.3222T>C0.310
rpoB763031c.3225T>C0.302
rpoB763034c.3228C>G0.310
rpoB763040c.3234C>G0.352
rpoB763067c.3261C>G0.322
rpoB763070c.3264T>C0.318
rpoB763085c.3279C>G0.311
rpoB763115c.3309T>C0.262
rpoB763136c.3330C>T0.250
rpoB763148c.3342G>C0.263
rpoB763158c.3352C>T0.271
rpoB763166c.3360A>G0.257
rpoB763190c.3384C>T0.180
rpoB763202c.3396A>G0.130
rpoB763205c.3399G>C0.107
rpoB763206c.3400A>T0.105
rpoB763214c.3408T>C0.153
rpoB763226c.3420A>G0.164
rpoB763227c.3421C>T0.164
rpoB763238c.3432T>C0.164
rpoB763253c.3447G>C0.173
rpoB763256c.3450G>A0.173
rpoB763268c.3462C>G0.150
rpoB763283c.3477T>C0.136
rpoB763284c.3478C>T0.138
rpoC763351c.-19T>C0.234
rpoC763352c.-18T>A0.237
rpoC763402c.33C>G0.279
rpoC763411c.42T>G0.300
rpoC763414c.45T>C0.295
rpoC763441c.72C>T0.237
rpoC763444c.75T>C0.237
rpoC763456c.87A>G0.250
rpoC763486c.117T>G0.290
rpoC763492c.123G>C0.268
rpoC763528c.159G>A0.303
rpoC763546c.177A>G0.338
rpoC763570c.201G>C0.338
rpoC763573c.204G>C0.338
rpoC763594c.225C>T0.355
rpoC763603c.234C>T0.355
rpoC763606c.237C>T0.333
rpoC763636c.267T>C0.311
rpoC763657c.288G>A0.292
rpoC763660c.291T>G0.328
rpoC763675c.306C>G0.328
rpoC763696c.327T>C0.328
rpoC763702c.333C>G0.349
rpoC763717c.348T>C0.308
rpoC763723c.354G>C0.349
rpoC763732c.363C>G0.339
rpoC763741c.372C>T0.345
rpoC763744c.375G>C0.333
rpoC763765c.396T>C0.304
rpoC763774c.405G>C0.309
rpoC763807c.438T>C0.279
rpoC763816c.447C>G0.282
rpoC763835p.Ala156Met0.244
rpoC763853p.Val162Ile0.264
rpoC763858c.489A>G0.269
rpoC763872p.Gly168Ala0.235
rpoC763876p.Glu169Asp0.232
rpoC763879c.510A>G0.238
rpoC763888c.519G>C0.217
rpoC763891c.522G>C0.213
rpoC763894c.525A>G0.220
rpoC763900c.531G>C0.237
rpoC763915c.546C>T0.269
rpoC763942c.573C>G0.266
rpoC763945c.576T>C0.264
rpoC763951c.582G>C0.271
rpoC763960c.591T>C0.274
rpoC763987c.618C>T0.242
rpoC763991p.Ile208Leu0.233
rpoC763996c.627T>C0.233
rpoC764002c.633C>G0.231
rpoC764005c.636G>C0.247
rpoC764020c.651C>T0.212
rpoC764024c.655T>C0.221
rpoC764032p.Asp221Glu0.221
rpoC764040p.Ser224Thr0.233
rpoC764044c.675T>C0.216
rpoC764059c.690G>T0.267
rpoC764083c.714A>G0.307
rpoC764098c.729A>G0.329
rpoC764101c.732C>G0.301
rpoC764102p.Val245Ile0.293
rpoC764112p.Tyr248Phe0.315
rpoC764116c.747C>T0.301
rpoC764131c.762T>C0.324
rpoC764188c.819A>G0.247
rpoC764195p.Ser276Ile0.209
rpoC764203c.834G>C0.207
rpoC764206c.837T>C0.215
rpoC764215c.846A>G0.283
rpoC764236c.867G>A0.258
rpoC764248c.879C>G0.269
rpoC764257c.888G>C0.263
rpoC764266c.897T>C0.237
rpoC764269c.900G>C0.237
rpoC764272c.903G>C0.247
rpoC764278c.909A>G0.253
rpoC764338c.969G>A0.306
rpoC764353c.984G>C0.276
rpoC764365c.996C>T0.265
rpoC764380c.1011G>C0.175
rpoC764381c.1012T>A0.171
rpoC764387c.1018T>C0.167
rpoC764405c.1036A>C0.227
rpoC764419c.1050C>G0.250
rpoC764428c.1059G>C0.240
rpoC764431c.1062G>C0.240
rpoC764434c.1065A>G0.242
rpoC764446c.1077T>C0.272
rpoC764449c.1080G>C0.256
rpoC764452c.1083T>C0.258
rpoC764458c.1089G>C0.267
rpoC764461c.1092A>G0.273
rpoC764489c.1120C>T0.309
rpoC764497c.1128A>G0.312
rpoC764510c.1141C>T0.322
rpoC764521c.1152T>C0.318
rpoC764527c.1158C>T0.322
rpoC764536c.1167G>C0.282
rpoC764539c.1170C>G0.308
rpoC764548c.1179G>A0.264
rpoC764551c.1182G>C0.264
rpoC764554c.1185C>T0.270
rpoC764560c.1191T>C0.295
rpoC764566c.1197C>G0.308
rpoC764575c.1206T>G0.278
rpoC764593c.1224C>T0.293
rpoC764611c.1242G>T0.264
rpoC764650c.1281G>C0.209
rpoC764651c.1282T>A0.209
rpoC764669p.Pro434Ser0.718
rpoC764752c.1383G>C0.270
rpoC764764c.1395T>C0.267
rpoC764809c.1440C>T0.301
rpoC764815c.1446A>G0.289
rpoC764827c.1458G>C0.296
rpoC764858c.1489T>C0.284
rpoC764872c.1503A>G0.267
rpoC764888c.1519T>C0.286
rpoC764911c.1542A>G0.302
rpoC764932c.1563C>A0.292
rpoC764948c.1579T>C0.309
rpoC764968c.1599T>C0.314
rpoC764995c.1626C>G0.312
rpoC765007c.1638T>G0.237
rpoC765008c.1639T>C0.237
rpoC765011c.1642A>T0.237
rpoC765019c.1650A>G0.247
rpoC765034c.1665T>C0.259
rpoC765040c.1671T>C0.241
rpoC765041c.1672T>C0.231
rpoC765047c.1678T>C0.256
rpoC765055c.1686C>G0.267
rpoC765073c.1704G>C0.263
rpoC765076c.1707A>G0.250
rpoC765079c.1710T>G0.264
rpoC765082c.1713G>C0.260
rpoC765089c.1720T>C0.286
rpoC765103c.1734G>T0.256
rpoC765292c.1923G>C0.309
rpoC765298c.1929G>C0.325
rpoC765300p.Val644Ala0.325
rpoC765319c.1950A>G0.329
rpoC765326p.His653Ala0.310
rpoC765330p.Ser654Asn0.324
rpoC765346c.1977C>G0.303
rpoC765349c.1980T>C0.303
rpoC765352c.1983G>C0.284
rpoC765383p.Met672Leu0.263
rpoC765404p.Leu679Val0.280
rpoC765409c.2040T>C0.291
rpoC765421c.2052C>G0.289
rpoC765451c.2082C>A0.330
rpoC765478c.2109T>C0.326
rpoC765499c.2130C>G0.301
rpoC765529c.2160C>T0.286
rpoC765541c.2172C>G0.299
rpoC765553c.2184C>T0.273
rpoC765556c.2187G>C0.261
rpoC765559c.2190G>C0.256
rpoC765580c.2211G>C0.263
rpoC765613p.His748Gln0.267
rpoC765625c.2256C>G0.273
rpoC765631p.Asp754Glu0.270
rpoC765700c.2331T>C0.301
rpoC765734c.2365T>C0.258
rpoC765739c.2370G>T0.200
rpoC765751c.2382C>G0.174
rpoC765753p.Asp795Ala0.162
rpoC765772c.2403C>G0.183
rpoC765784c.2415C>G0.169
rpoC765787c.2418C>T0.162
rpoC765793c.2424C>G0.164
rpoC765796c.2427C>T0.164
rpoC765811c.2442T>C0.243
rpoC765814c.2445A>G0.239
rpoC765826c.2457T>C0.211
rpoC765835c.2466C>T0.211
rpoC765850c.2481G>C0.250
rpoC765883c.2514C>G0.279
rpoC765886c.2517C>G0.286
rpoC765892c.2523T>C0.310
rpoC765937c.2568T>C0.252
rpoC765947c.2578T>C0.250
rpoC765967c.2598C>T0.237
rpoC765982c.2613C>G0.229
rpoC765994c.2625A>T0.243
rpoC766010c.2641T>A0.265
rpoC766021c.2652G>C0.278
rpoC766027c.2658G>C0.283
rpoC766043p.Gln892Glu0.269
rpoC766054c.2685C>G0.314
rpoC766082p.Ala905Gln0.310
rpoC766096c.2727G>C0.347
rpoC766129c.2760C>G0.319
rpoC766135c.2766G>A0.309
rpoC766141c.2772C>T0.293
rpoC766142c.2773C>T0.290
rpoC766174p.Asn935Lys0.191
rpoC766178p.Ile937Val0.191
rpoC766357c.2988C>T0.137
rpoC766363c.2994G>C0.145
rpoC766366c.2997C>G0.167
rpoC766381c.3012C>T0.192
rpoC766384c.3015A>G0.195
rpoC766390c.3021C>T0.181
rpoC766393c.3024C>G0.195
rpoC766408c.3039C>G0.244
rpoC766411c.3042C>G0.250
rpoC766426c.3057C>T0.273
rpoC766447c.3078T>C0.292
rpoC766462c.3093G>C0.292
rpoC766483c.3114G>C0.250
rpoC766484p.Val1039Ile0.250
rpoC766492c.3123T>C0.296
rpoC766522c.3153C>G0.329
rpoC766528c.3159T>C0.329
rpoC766531c.3162G>C0.316
rpoC766540p.Asp1057Glu0.351
rpoC766549c.3180G>C0.375
rpoC766573c.3204T>C0.377
rpoC766582c.3213C>G0.354
rpoC766583p.Gly1072Ser0.354
rpoC766591c.3222A>G0.343
rpoC766594c.3225G>C0.338
rpoC766597c.3228C>G0.357
rpoC766607p.Ile1080Leu0.458
rpoC766630c.3261G>C0.409
rpoC766657c.3288A>G0.432
rpoC766672c.3303T>C0.400
rpoC766673p.Gly1102Asn0.384
rpoC766726c.3357T>C0.388
rpoC766738c.3369G>C0.346
rpoC766765c.3396A>C0.342
rpoC766774c.3405T>C0.346
rpoC766801c.3432C>G0.342
rpoC766804c.3435A>G0.338
rpoC766861c.3492G>C0.329
rpoC766864c.3495G>C0.333
rpoC766900c.3531T>C0.375
rpoC766933c.3564A>G0.342
rpoC766945c.3576A>G0.364
rpoC766963c.3594T>C0.404
rpoC766972c.3603G>C0.398
rpoC766996c.3627C>T0.386
rpoC767009c.3640T>A0.314
rpoC767014c.3645G>C0.307
rpoC767033c.3664T>A0.313
rpoC767059c.3690T>G0.321
rpoC767062c.3693C>A0.318
rpoC767098c.3729T>C0.297
rpoC767119c.3750A>G0.264
rpoC767134c.3765C>A0.314
rpoC767158c.3789T>C0.367
rpoC767180p.Ala1271Gln0.368
rpoC767191c.3822C>G0.359
rpoC767206c.3837C>G0.347
rpoC767209c.3840T>C0.340
rpoC767212c.3843G>C0.347
rpoC767221c.3852C>G0.333
rpoC767230c.3861G>C0.309
rpoC767233c.3864T>C0.322
rpoC767263c.3894T>C0.173
rpoC767264p.Ala1299Gln0.178
rpoC767275c.3906T>C0.118
rpoC767278c.3909T>C0.116
rpoC767281c.3912C>G0.114
rpoC767284c.3915C>T0.121
rpoC767288c.3919C>T0.118
rpsL781395c.-165T>C1.000
rpsL781571c.12C>T0.267
rpsL781595c.36T>C0.289
rpsL781605p.Ile16Val0.266
rpsL781608p.Ser17Ala0.280
rpsL781628c.69T>C0.326
rpsL781631c.72G>C0.290
rpsL781649c.90T>C0.269
rpsL781655c.96T>C0.286
rpsL781682c.123T>C0.296
rpsL781700c.141G>C0.268
rpsL781703c.144G>T0.266
rpsL781715c.156T>C0.286
rpsL781728c.169T>C0.333
rpsL781736c.177T>C0.325
rpsL781742c.183C>T0.310
rpsL781748c.189C>G0.313
rpsL781754c.195G>C0.325
rpsL781760c.201T>C0.316
rpsL781772c.213C>A0.316
rpsL781808c.249C>T0.324
rpsL781811c.252C>T0.329
rpsL781832c.273T>C0.314
rpsL781838c.279G>C0.280
rpsL781841c.282C>G0.259
rpsL781865c.306G>C0.244
rpsL781868c.309T>C0.242
rpsL781871c.312G>C0.222
rpsL781877c.318T>C0.231
rpsL781892c.333A>G0.236
rpsL781898c.339A>T0.244
rpsL781916c.357T>C0.253
rpsL781929p.Gly124Ser0.284
rplC800794c.-15A>G0.254
rplC800796c.-13A>G0.250
rplC800814c.6A>G0.244
rplC800817c.9A>T0.247
rplC800844c.36T>C0.241
rplC800865c.57A>G0.205
rplC800867p.Ser20Asn0.195
rplC800874c.66A>G0.171
rplC800875p.Val23Ile0.171
rplC800880c.72A>G0.173
rplC800889c.81C>G0.176
rplC800892c.84G>C0.149
rplC800907c.99C>G0.167
rplC800916c.108A>G0.162
rplC801153c.345G>C0.110
rplC801156c.348T>A0.129
rplC801168c.360C>G0.183
rplC801171c.363A>G0.176
rplC801174c.366T>C0.175
rplC801180c.372C>G0.212
rplC801195c.387G>C0.284
rplC801201c.393C>T0.304
rplC801207c.399C>T0.308
rplC801246c.438C>T0.287
rplC801249c.441T>C0.283
rplC801255c.447C>T0.310
rplC801264c.456C>T0.271
rplC801267c.459A>T0.287
rplC801270c.462T>C0.289
rplC801276c.468G>C0.266
rplC801279c.471G>C0.276
rplC801282c.474G>C0.273
rplC801285c.477G>C0.273
rplC801300c.492C>G0.321
rplC801309c.501C>G0.269
rplC801312c.504G>C0.266
rplC801321c.513C>T0.243
rplC801324c.516T>C0.257
rplC801339c.531T>C0.174
rplC801341p.Leu178Gln0.174
rplC801348c.540T>G0.167
rplC801357c.549T>C0.178
rplC801367p.Ala187Thr0.167
rplC801402c.594T>C0.190
rplC801405c.597T>C0.185
rplC801423c.615G>C0.125
rplC801426c.618C>G0.125
rplC801427p.Met207Val0.125
rplC801438c.630T>C0.129
rplC801442p.Ile212Val0.127
rrs1471923r.78t>c0.270
rrs1471925r.80t>c0.270
rrs1471932r.87a>g0.277
rrs1471934r.89a>g0.281
rrs1471969r.124t>c0.328
rrs1471970r.125g>a0.328
rrs1472028r.183a>t0.277
rrs1472029r.184c>t0.283
rrs1472030r.185g>t0.283
rrs1472031r.186g>a0.283
rrs1472033r.188a>g0.283
rrs1472034r.189t>c0.283
rrs1472044r.199g>t0.400
rrs1472045r.200t>a0.400
rrs1472061r.216a>t0.459
rrs1472075r.230a>g0.487
rrs1472108r.263c>t0.478
rrs1472969r.1124a>g0.380
rrs1472970r.1125c>g0.380
rrs1472977r.1132g>c0.373
rrs1472978r.1133t>c0.373
rrs1473105r.1260g>a0.288
rrs1473123r.1278a>t0.232
rrs1473145r.1300c>t0.286
rrs1473166r.1321g>a0.300
rrs1473290r.1445c>t0.258
rrl1473658r.1t>a0.224
rrl1473659r.2t>a0.224
rrl1473668r.11c>t0.279
rrl1473756r.99g>a0.377
rrl1473758r.101g>t0.370
rrl1473806r.149c>t0.473
rrl1473877r.220g>a0.500
rrl1473898r.241c>t0.421
rrl1473943r.286g>t0.379
rrl1473945r.288t>a0.357
rrl1473946r.289a>t0.357
rrl1473986r.329t>c0.314
rrl1473987r.330g>a0.314
rrl1473995r.338g>t0.327
rrl1474001r.344c>t0.314
rrl1474009r.352a>g0.294
rrl1474012r.355c>t0.292
rrl1474093r.436g>t0.333
rrl1474099r.442g>a0.333
rrl1474103r.446a>t0.316
rrl1474140r.483c>t0.370
rrl1474151r.494c>t0.380
rrl1474181r.524c>t0.379
rrl1474249r.592g>t0.344
rrl1474291r.634tttcctctccggagga>t0.273
rrl1474308r.651g>t0.167
rrl1474310r.653t>g0.167
rrl1474356r.699t>c0.293
rrl1474362r.705a>g0.339
rrl1474376r.719t>c0.365
rrl1474427r.770a>c0.291
rrl1474429r.772g>c0.286
rrl1474432r.775c>g0.276
rrl1474639r.982g>a0.320
rrl1474794r.1137c>t0.268
rrl1474812r.1155g>a0.224
rrl1474823r.1166c>t0.211
rrl1474831r.1174a>g0.237
rrl1474904r.1247g>a0.351
rrl1474956r.1299c>t0.296
rrl1474960r.1303c>g0.308
rrl1474963r.1306g>t0.320
rrl1474964r.1307t>a0.314
rrl1474965r.1308g>c0.314
rrl1474970r.1313g>a0.314
rrl1475006r.1349a>t0.352
rrl1475061r.1404c>t0.254
rrl1475088r.1431a>t0.227
rrl1475199r.1542g>a0.377
rrl1475206r.1549c>t0.377
rrl1475209r.1552g>c0.392
rrl1475213r.1556c>t0.396
rrl1475249r.1592t>c0.464
rrl1475252r.1595c>t0.464
rrl1475266r.1609t>c0.447
rrl1475267r.1610g>a0.447
rrl1475275r.1618c>t0.467
rrl1475276r.1619t>c0.488
rrl1475291r.1634a>c0.535
rrl1475313r.1656g>a0.500
rrl1475315r.1658a>t0.476
rrl1475355r.1698c>t0.500
rrl1475369r.1712g>t0.474
rrl1475402r.1745c>t0.484
rrl1475419r.1762c>t0.455
rrl1475429r.1772g>a0.457
rrl1475436r.1779c>t0.424
rrl1475483r.1826c>t0.387
rrl1475505r.1848g>a0.419
rrl1475526r.1869c>a0.412
rrl1475599r.1942a>g0.483
rrl1475608r.1951t>c0.448
rrl1475642r.1985t>c0.448
rrl1475657r.2000a>g0.394
rrl1475659r.2002g>t0.394
rrl1475758r.2101ac>a0.375
rrl1475763r.2106c>t0.351
rrl1475765r.2108ag>a0.339
rrl1475881r.2224t>c0.412
rrl1475988r.2331a>g0.393
rrl1476031r.2374c>t0.209
rrl1476032r.2375c>a0.205
rrl1476033r.2376t>c0.195
rrl1476034r.2377c>a0.214
rrl1476045r.2388g>t0.225
rrl1476047r.2390g>t0.225
rrl1476048r.2391g>a0.220
rrl1476049r.2392c>t0.238
rrl1476086r.2429g>a0.353
rrl1476089r.2432t>c0.353
rrl1476095r.2438c>g0.333
rrl1476106r.2449a>t0.265
rrl1476115r.2458t>c0.243
rrl1476117r.2460g>c0.243
rrl1476214r.2557g>a0.400
rrl1476224r.2567a>g0.380
rrl1476281r.2624t>c0.359
rrl1476583r.2926g>a0.224
rrl1476584r.2927c>t0.235
rrl1476594r.2937c>t0.261
rrl1476597r.2940g>a0.268
rrl1476603r.2946g>a0.257
rrl1476608r.2951c>g0.270
rrl1476628r.2971t>a0.296
rrl1476689r.3032a>t0.279
rrl1476690r.3033c>t0.269
rrl1476693r.3036g>a0.269
rrl1476695r.3038t>a0.265
rrl1476716r.3059a>c0.288
rrl1476726r.3069a>g0.269
rrl1476732r.3075t>c0.260
rrl1476750r.3093t>c0.200
rrl1476755r.3098g>a0.214
rrl1476759r.3102t>c0.205
rrl1476770r.3113t>c0.178
rrl1476771r.3114g>a0.178
fabG11673482p.Ser15Ala0.167
fabG11673487c.48T>C0.181
fabG11673490c.51A>G0.188
fabG11673523c.84G>T0.279
fabG11673535c.96A>G0.286
fabG11673547c.108T>C0.279
fabG11673548p.Ala37Thr0.282
fabG11673568c.129C>G0.268
fabG11673574c.135C>G0.265
fabG11673580c.141T>G0.266
fabG11673589c.150A>G0.270
fabG11673595c.156A>C0.194
fabG11673596p.Lys53Glu0.194
fabG11673602c.163C>T0.206
fabG11673607c.168T>C0.230
fabG11673615p.Glu59Val0.217
fabG11673619c.180T>C0.267
fabG11673633p.Ser65Asn0.241
fabG11673637p.Asp66Glu0.193
fabG11673641p.Val68Ile0.175
fabG11673646c.207T>C0.203
fabG11673657p.Thr73Lys0.167
fabG11673660p.Ala74Glu0.161
fabG11673664c.225A>C0.194
fabG11673667c.228A>G0.200
fabG11673679c.240T>G0.239
fabG11673685c.246C>T0.280
fabG11673710p.Leu91Ile0.333
fabG11673716p.Ala93Lys0.338
fabG11673733p.Met98Ile0.370
fabG11673748c.309A>G0.354
fabG11673749p.Lys104Arg0.354
fabG11673758p.Lys107Glu0.358
fabG11673890p.Ala151Ser0.221
fabG11673901c.462A>G0.244
fabG11673905p.Ser156Ala0.247
fabG11673916c.477A>C0.270
fabG11673917p.Val160Leu0.270
fabG11673922c.483T>C0.286
fabG11673941p.Ala168Ser0.271
fabG11673946c.507C>G0.270
fabG11673955c.516G>C0.286
fabG11673961c.522A>C0.284
fabG11673985c.546C>G0.256
fabG11674006p.Asp189Glu0.260
fabG11674060c.621A>G0.103
fabG11674063c.624G>C0.103
fabG11674079p.Pro214Ala0.364
fabG11674114c.675T>A0.333
fabG11674123c.684T>C0.321
fabG11674126c.687G>C0.312
fabG11674132c.693T>C0.305
fabG11674136p.Ser233Ala0.289
fabG11674141c.702T>C0.286
fabG11674156c.717C>G0.278
fabG11674171c.732T>C0.188
inhA1674471c.270G>C0.180
inhA1674480c.279T>C0.217
inhA1674486c.285T>C0.246
inhA1674504c.303C>G0.236
inhA1674537c.336C>G0.149
inhA1674542p.Ala114Glu0.145
inhA1674546c.345T>C0.145
inhA1674549c.348G>C0.145
inhA1674552c.351C>G0.145
inhA1674555c.354G>A0.165
inhA1674561c.360C>T0.177
inhA1674582c.381T>C0.195
inhA1674585c.384T>C0.192
inhA1674589p.Met130Leu0.195
inhA1674597c.396G>A0.210
inhA1674601p.Leu134Thr0.193
inhA1674624c.423A>C0.229
inhA1674630c.429C>G0.217
inhA1674660c.459G>C0.256
inhA1674672c.471C>G0.275
inhA1674703c.502T>C0.270
inhA1674708c.507G>A0.258
inhA1674718c.517A>C0.261
inhA1674726c.525G>A0.239
inhA1674738c.537C>G0.180
inhA1674741c.540C>T0.136
inhA1674746p.Tyr182Phe0.128
inhA1674750c.549T>C0.134
inhA1674753c.552G>C0.136
inhA1674756c.555T>C0.136
inhA1674759c.558G>C0.138
inhA1674774c.573A>G0.215
inhA1674780c.579T>G0.207
inhA1674789c.588G>C0.227
inhA1674801c.600T>C0.236
inhA1674822c.621C>G0.233
inhA1674828c.627G>A0.236
inhA1674846p.Ile215Met0.227
inhA1674864c.663C>T0.216
inhA1674870c.669T>C0.207
inhA1674879c.678T>C0.230
inhA1674900c.699G>A0.267
inhA1674903c.702T>C0.258
inhA1674904p.Ala235Pro0.250
inhA1674909c.708G>A0.253
inhA1674942c.741T>G0.244
inhA1674960c.759C>G0.227
inhA1674966c.765T>G0.230
inhA1674967p.Asp256Thr0.230
inhA1674987c.786C>T0.214
rpsA1833518c.-24C>A0.140
rpsA1833532c.-10A>C0.188
rpsA1833554p.Thr5Ala0.230
rpsA1833568c.27G>C0.253
rpsA1833589c.48A>T0.298
rpsA1833595c.54T>C0.298
rpsA1833661c.120A>G0.337
rpsA1833667c.126C>G0.333
rpsA1833721c.180A>G0.355
rpsA1833724c.183C>G0.347
rpsA1833727c.186G>C0.360
rpsA1833742c.201A>G0.351
rpsA1833745c.204G>C0.342
rpsA1833748c.207C>G0.338
rpsA1833787c.246C>G0.244
rpsA1833790c.249T>C0.250
rpsA1833802c.261A>G0.244
rpsA1833811c.270G>T0.247
rpsA1833838c.297G>C0.176
rpsA1833841c.300C>G0.185
rpsA1833847c.306C>G0.206
rpsA1833856c.315A>G0.232
rpsA1833874c.333T>C0.211
rpsA1833928c.387G>C0.224
rpsA1833940c.399C>G0.227
rpsA1833971c.430C>T0.269
rpsA1833979c.438T>C0.271
rpsA1834000c.459G>C0.303
rpsA1834021c.480C>T0.294
rpsA1834030c.489C>G0.343
rpsA1834099c.558C>G0.352
rpsA1834102c.561T>C0.310
rpsA1834105c.564C>G0.314
rpsA1834108c.567C>G0.306
rpsA1834123c.582C>G0.384
rpsA1834150c.609G>C0.196
rpsA1834153c.612T>C0.185
rpsA1834154p.Asn205Gln0.185
rpsA1834157c.616T>C0.185
rpsA1834162c.621A>G0.185
rpsA1834165c.624A>G0.189
rpsA1834169p.Thr210Ala0.200
rpsA1834177c.636A>C1.000
rpsA1834189c.648G>C0.302
rpsA1834195c.654G>C0.292
rpsA1834210c.669C>T0.303
rpsA1834222c.681T>C0.268
rpsA1834231c.690T>C0.263
rpsA1834234c.693G>C0.273
rpsA1834249c.708T>C0.241
rpsA1834261c.720A>G0.247
rpsA1834264c.723G>C0.227
rpsA1834303c.762T>C0.164
rpsA1834306c.765T>C0.162
rpsA1834348c.807T>C0.215
rpsA1834366c.825A>G0.267
rpsA1834375c.834G>A0.284
rpsA1834378c.837T>C0.289
rpsA1834396c.855G>C0.298
rpsA1834411c.870T>C0.310
rpsA1834417c.876G>C0.289
rpsA1834423c.882G>C0.283
rpsA1834435c.894G>C0.258
rpsA1834451c.910T>C0.286
rpsA1834465c.924T>C0.299
rpsA1834468c.927A>G0.291
rpsA1834489c.948T>C0.314
rpsA1834501c.960G>C0.312
rpsA1834510c.969C>T0.268
rpsA1834513c.972C>G0.261
rpsA1834528c.987T>C0.312
rpsA1834540c.999G>C0.310
rpsA1834546c.1005T>C0.305
rpsA1834609c.1068T>C0.366
rpsA1834618c.1077G>C0.384
rpsA1834633c.1092A>G0.378
rpsA1834639c.1098T>C0.368
rpsA1834654p.Glu371Asp0.338
rpsA1834684c.1143C>T0.271
rpsA1834690c.1149T>C0.293
rpsA1834732c.1191T>C0.307
rpsA1834733p.Ala398Ser0.303
rpsA1834738c.1197A>G0.303
rpsA1834753c.1212T>C0.342
rpsA1834765p.Glu408Asp0.326
rpsA1834775p.Ala412Thr0.333
rpsA1834780c.1239A>G0.333
rpsA1834786c.1245A>G0.301
rpsA1834789c.1248T>C0.289
rpsA1834792c.1251G>C0.310
rpsA1834849c.1308C>G0.171
rpsA1834852c.1311C>G0.167
tlyA1917940p.Val1Met0.116
tlyA1917943p.Ala2Ser0.114
tlyA1917951c.12T>C0.181
tlyA1917972c.33A>G1.000
tlyA1917975c.36C>G0.237
tlyA1917981c.42G>C0.286
tlyA1917990c.51G>C0.306
tlyA1917993c.54A>G0.306
tlyA1917996c.57A>G0.308
tlyA1918002c.63A>G0.312
tlyA1918036p.Arg33Ser0.314
tlyA1918048p.Leu37Met0.272
tlyA1918057p.Val40Arg0.213
tlyA1918065c.126G>C0.209
tlyA1918067p.Ala43Gly0.213
tlyA1918077c.138G>C0.198
tlyA1918078p.Ser47Ala0.198
tlyA1918082p.Asp48Val0.196
tlyA1918087p.Thr50Ala0.202
tlyA1918092c.153G>C0.206
tlyA1918103p.Val55Ala0.170
tlyA1918111p.Ser58Gly0.144
tlyA1918121p.Ala61Gly0.150
tlyA1918128c.189A>C0.117
katG2154724p.Arg463Leu1.000
katG2155661p.Val151Ile0.145
katG2155677c.435G>C0.145
katG2155680c.432C>G0.151
katG2155691c.421A>G0.167
katG2155695c.417G>C0.169
katG2155704c.408G>C0.157
katG2155716c.396A>C0.157
katG2155722c.390C>G0.153
katG2155728c.384C>G0.155
kasA2518121p.Gln3Lys0.129
kasA2518132c.18C>T0.164
kasA2518138c.24T>C0.167
kasA2518146p.Phe11Tyr0.189
kasA2518162c.48G>A0.255
kasA2518174c.60A>G0.339
kasA2518190p.Ser26Ala0.355
kasA2518199p.Ile29Val0.328
kasA2518220c.106C>T0.312
kasA2518234c.120G>A0.271
kasA2518248p.Ala45Val0.230
kasA2518261p.Glu49Asp0.213
kasA2518263p.Phe50Tyr0.186
kasA2518265p.Val51Ile0.186
kasA2518421p.Val103Leu0.145
kasA2518429c.315A>C0.154
kasA2518439p.Ala109Ser0.152
kasA2518444c.330T>C0.162
kasA2518447c.333T>G0.176
kasA2518459c.345T>C0.275
kasA2518462c.348A>C0.271
kasA2518468c.354A>C0.284
kasA2518474c.360G>A0.289
kasA2518480c.366T>C0.295
kasA2518483c.369C>G0.287
kasA2518504c.390T>C0.337
kasA2518506p.Ala131Glu0.330
kasA2518519c.405G>C0.348
kasA2518528c.414C>G0.363
kasA2518540c.426T>C0.409
kasA2518561c.447T>C0.355
kasA2518567c.453G>C0.274
kasA2518570c.456G>C0.244
kasA2518574p.Ile154Val0.238
kasA2518579c.465T>C0.253
kasA2518588c.474T>C0.234
kasA2518591c.477G>C0.234
kasA2518609p.Met165Ile0.207
kasA2518624c.510C>G0.174
kasA2518639c.525G>C0.200
kasA2518657c.543G>C0.242
kasA2518672c.558G>C0.226
kasA2518678c.564C>T0.219
kasA2518684c.570C>G0.227
kasA2518693c.579C>G0.213
kasA2518696c.582C>G0.211
kasA2518702c.588C>T0.198
kasA2518705c.591T>C0.216
kasA2518711c.597A>G0.238
kasA2518714c.600A>C0.243
kasA2518732c.618C>G0.292
kasA2518744c.630C>T0.339
kasA2518747c.633C>G0.349
kasA2518768c.654C>T0.381
kasA2518777c.663C>T0.381
kasA2518783c.669T>C0.369
kasA2518789c.675G>C0.324
kasA2518792c.678C>A0.304
kasA2518795c.681C>G0.291
kasA2518825c.711T>C0.340
kasA2518864c.750G>C0.312
kasA2518879c.765A>G0.280
kasA2518885c.771T>C0.274
kasA2518898c.784T>C0.193
kasA2518906c.792A>G0.195
kasA2518910p.Leu266Met0.193
kasA2518921c.807T>C0.181
kasA2518927c.813C>G0.179
kasA2518936c.822C>G0.130
kasA2518939c.825T>C0.136
kasA2518942c.828T>C0.138
kasA2518951c.837G>C0.134
kasA2518954c.840C>G0.121
kasA2518963c.849T>C0.113
kasA2518969c.855T>G0.111
kasA2518975c.861C>G0.121
kasA2518979c.865A>C0.123
kasA2518990c.876T>G0.125
kasA2519050c.936C>G0.253
kasA2519053c.939G>C0.250
kasA2519062c.948T>G0.263
kasA2519068c.954C>T0.300
kasA2519072p.Ala320Thr0.286
kasA2519107c.993T>C0.293
kasA2519108p.Asp332Gln0.293
kasA2519116c.1002C>G0.297
kasA2519122c.1008G>C0.322
kasA2519137c.1023T>G0.286
kasA2519158c.1044C>T0.264
kasA2519167c.1053T>G0.280
kasA2519173c.1059C>G0.256
kasA2519196p.Thr361Ser0.211
kasA2519215c.1101C>T0.108
ahpC2726232p.Gln14Glu0.146
ahpC2726243c.51T>G0.182
ahpC2726244c.52C>T0.182
ahpC2726251p.Gly20Ala0.167
ahpC2726255c.63T>C0.174
ahpC2726258c.66C>T0.196
ahpC2726303c.111T>C0.295
ahpC2726311p.Ser40Asn0.233
ahpC2726315p.Asp41Glu0.238
ahpC2726318p.Glu42Asp0.233
ahpC2726322p.Pro44Ala0.238
ahpC2726330c.138G>A0.233
ahpC2726336c.144G>C0.238
ahpC2726348c.156T>C0.250
ahpC2726357c.165A>G0.231
ahpC2726366c.174G>C0.189
ahpC2726378c.186T>G0.171
ahpC2726387c.195C>T0.114
ahpC2726591c.399C>G0.183
ahpC2726593p.Val134Ala0.183
ahpC2726600c.408T>C0.183
ahpC2726601p.Ile137Leu0.183
ahpC2726638p.Ala149Val0.294
ahpC2726645c.453C>G0.303
ahpC2726657c.465A>C0.278
ahpC2726669p.Asp159Glu0.299
ahpC2726672c.480G>A0.284
ahpC2726675c.483A>G0.292
ahpC2726681c.489A>C0.297
ahpC2726687c.495C>G0.279
ahpC2726693c.501C>G0.239
ahpC2726696c.504C>G0.242
ahpC2726717c.525A>G0.215
ahpC2726747c.555A>C0.167
folC2746365p.Leu412Val0.157
folC2746375c.1224C>G0.178
folC2746390c.1209C>G0.203
folC2746393c.1206G>C0.197
folC2746401p.Ser400Ala0.192
folC2746402c.1197A>G0.187
folC2746416p.Glu395Gln0.179
folC2746420c.1179T>G0.182
folC2746426c.1173C>G0.175
folC2746438c.1161C>G0.169
folC2746451p.Gly383Ala0.175
folC2746471c.1128G>T0.153
folC2746478p.Phe374Tyr0.129
folC2746480c.1119T>G0.133
folC2747026c.573G>C0.103
folC2747032c.567T>G0.118
folC2747059c.540A>G0.147
folC2747062c.537T>C0.153
folC2747065c.534G>A0.149
folC2747071c.528G>C0.149
folC2747086c.513T>G0.145
folC2747089c.510C>G0.145
folC2747101c.498C>G0.143
folC2747107c.492C>G0.153
folC2747110c.489A>G0.151
folC2747113c.486G>C0.151
folC2747116c.483C>G0.149
folC2747134c.465G>C0.164
folC2747224c.375C>G0.119
folC2747239c.360A>G0.150
folC2747248c.351C>G0.197
folC2747264p.Gly112Ala0.208
folC2747266c.333G>A0.208
folC2747275c.324A>G0.203
folC2747289p.Pro104Ala0.207
folC2747290c.309T>C0.212
folC2747293c.306C>T0.216
folC2747302c.297T>C0.261
folC2747314c.285T>G0.278
folC2747317c.282G>C0.287
folC2747343p.Val86Ile0.305
folC2747355p.Val82Ile0.264
folC2747359c.240G>C0.253
folC2747362c.237C>G0.247
folC2747394p.Ile69Val0.220
folC2747395c.204A>G0.203
ribD2987018c.180G>C0.114
ribD2987026p.Ala63Gly0.129
ribD2987033c.195C>G0.135
ribD2987042c.204A>G0.147
ribD2987046p.Val70Ile0.149
ribD2987058c.220T>C0.141
ribD2987066c.228A>G0.139
ribD2987069c.231T>C0.141
ribD2987092p.Val85Ala0.135
ribD2987105c.267C>G0.127
ribD2987108c.270T>C0.129
thyX3067223c.723C>G0.202
thyX3067232c.714G>C0.211
thyX3067246p.Thr234Ala0.225
thyX3067249p.Thr233Ser0.225
thyX3067252p.Val232Ile0.221
thyX3067274c.672G>C0.240
thyX3067277c.669G>C0.240
thyX3067281p.Val222Ala0.238
thyX3067284p.Ala221Gly0.235
thyX3067286c.660G>C0.235
thyX3067289c.657G>C0.233
thyX3067292c.654C>T0.231
thyX3067295c.651G>A0.233
thyX3067313c.633C>A0.278
thyX3067316c.630T>C0.285
thyX3067325c.621T>C0.290
thyX3067349c.597C>G0.296
thyX3067355c.591T>G0.303
thyX3067367c.579C>G0.305
thyX3067373c.573G>C0.311
thyX3067391c.555C>G0.273
thyX3067394c.552C>G0.270
thyX3067439c.507T>C0.260
thyX3067442c.504G>A0.254
thyX3067445c.501G>C0.256
thyX3067457c.489G>C0.200
thyX3067462c.484G>A0.196
thyX3067465p.Ile161Val0.196
thyX3067466c.480C>G0.196
thyX3067475c.471T>C0.207
thyX3067490c.456G>C0.196
thyX3067493c.453T>C0.207
thyX3067510c.436G>A0.220
thyX3067515p.Ser144Thr0.217
thyX3067531p.Ala139Ser0.224
thyX3067545p.Glu134Ala0.190
thyX3067549p.Thr133Ala0.177
thyX3067556p.His130Gln0.162
thyX3067559c.387G>C0.171
thyX3067565p.Asp127Glu0.177
thyX3067570p.Ala126Pro0.171
thyX3067577c.369C>T0.165
thyX3067602p.Arg115His0.215
thyX3067611p.Lys112Thr0.244
thyX3067619c.327T>G0.243
thyX3067631c.315G>C0.231
thyX3067634c.312G>C0.240
thyX3067652c.294A>G0.233
thyX3067661c.285G>C0.235
thyX3067685c.261T>G0.267
thyX3067693p.Ile85Leu0.255
thyX3067694c.252C>G0.258
thyX3067718c.228G>C0.314
thyX3067721c.225A>G0.320
thyX3067727c.219T>G0.327
thyX3067736c.210G>A0.320
thyX3067762p.Arg62Lys0.277
thyX3067765p.Leu61Ile0.287
thyX3067772c.174G>C0.287
thyX3067775c.171G>A0.290
thyX3067781c.165G>C0.313
thyX3067793c.153A>G0.327
thyX3067799c.147C>T0.308
thyX3067802c.144G>C0.302
thyX3067814c.132A>G0.333
thyX3067850c.96T>G0.318
thyX3067869p.Thr26Ser0.256
thyX3067874c.72G>C0.253
thyX3067877c.69C>G0.250
thyX3067883c.63G>C0.247
thyX3067886c.60T>G0.244
thyX3067889c.57G>C0.241
thyX3067898p.Asp16Glu0.277
thyX3067935p.Thr4Ile0.239
thyA3073812c.660G>C0.188
thyA3073815c.657C>T0.186
thyA3073824c.648T>C0.178
thyA3073827c.645T>C0.176
thyA3073839c.633A>G0.211
thyA3073860c.612G>C0.272
thyA3073863c.609A>G0.272
thyA3073866c.606G>C0.272
thyA3073874p.Ile200Val0.272
thyA3073892c.580A>G0.278
thyA3073898p.Ala192Ser0.275
thyA3073917c.555G>C0.266
thyA3073920c.552G>C0.259
thyA3073925c.547A>G0.212
thyA3073929c.543A>G0.202
thyA3073941c.531G>A0.179
thyA3073953c.519A>G0.120
thyA3073983c.489G>A0.108
thyA3074079c.393C>G0.141
thyA3074097c.375G>C0.171
thyA3074102p.Asp124Asn0.181
thyA3074106c.366A>G0.193
thyA3074127c.345C>G0.236
thyA3074130c.342C>G0.250
thyA3074147p.Ile109Val0.253
thyA3074159p.Ser105Thr0.233
thyA3074160c.312T>C0.244
thyA3074165p.Ala103Thr0.241
thyA3074172c.300C>G0.250
thyA3074175c.297T>C0.256
thyA3074181c.291T>C0.325
thyA3074187c.285A>G0.310
thyA3074205p.Glu89Asp0.305
thyA3074214c.258A>G0.279
thyA3074244c.228T>C0.279
thyA3074263p.Gly70Ala0.185
thyA3074267p.Ile69Val0.189
thyA3074268c.204A>G0.189
thyA3074285c.187A>G0.123
thyA3074286c.186A>G0.119
thyA3074334c.138A>G0.203
thyA3074360c.112A>G0.213
thyA3074361c.111A>G0.210
thyA3074372p.Met34Leu0.226
thyA3074377p.Gln32Arg0.212
thyA3074391c.81G>T0.235
thyA3074397c.75T>C0.250
ald3086788c.-32T>C1.000
ald3087641c.822T>C0.104
ald3087653c.834A>G0.120
ald3087656c.837A>G0.133
ald3087665c.846C>G0.135
ald3087666p.Tyr283His0.135
ald3087672p.His285Asp0.155
ald3087680c.861G>C0.173
ald3087704c.885T>C0.175
ald3087716c.897G>C0.179
ald3087726p.Ala303Ser0.173
ald3087729p.Ser304Ala0.179
ald3087737c.918G>C0.170
ald3087749c.930C>G0.110
ald3087750p.Tyr311Val0.110
ald3087761c.942C>G0.108
fbiA3640291c.-252T>C0.183
fbiA3640307c.-236C>A0.175
fbiA3640340c.-203G>A0.800
fbiA3640347c.-196A>G0.175
fbiA3640349c.-194A>G0.175
fbiA3640350c.-193C>T0.177
fbiA3640365c.-178C>G0.183
fbiA3640839c.297C>G0.113
fbiA3640850p.Glu103Gly0.115
fbiA3640857c.315G>C0.118
fbiA3640866c.324T>C0.113
fbiA3640871p.Ala110Gly0.113
fbiA3640878c.336T>C0.115
fbiA3640899c.357G>C0.115
fbiA3640900p.Gln120Asn0.111
fbiA3640914c.372C>G0.122
alr3840652p.Val257Met1.000
alr3841069p.Ile118Phe0.144
panD4044057c.225G>T0.157
panD4044072c.210G>C0.175
panD4044075c.207A>G0.172
panD4044081c.201A>G0.197
panD4044084c.198A>G0.197
panD4044105c.177C>G0.222
panD4044117c.165C>G0.231
panD4044120c.162T>G0.206
panD4044123c.159A>G0.203
panD4044126c.156A>G0.203
panD4044138c.144A>G0.194
panD4044150c.132T>C0.173
panD4044165c.117C>G0.141
embC4240178c.316T>C0.115
embC4240183c.321A>G0.111
embC4240677p.Gly272Ala0.104
embC4240685p.Thr275Ala0.153
embC4240693c.831T>G0.167
embC4240699c.837C>G0.185
embC4240726c.864G>C0.317
embC4240780c.918T>C0.349
embC4240783c.921G>C0.352
embC4240789c.927T>C0.349
embC4240819c.957A>G0.359
embC4240828c.966G>A0.330
embC4240831c.969T>G0.337
embC4240867c.1005T>C0.143
embC4240870c.1008T>C0.141
embC4240873c.1011C>G0.139
embC4240879c.1017G>C0.133
embC4240880p.Ala340Thr0.128
embC4240885c.1023T>C0.133
embC4240897c.1035C>G0.130
embC4240898c.1036C>T0.118
embC4240903c.1041C>G0.117
embC4240911p.Ala350Val0.120
embC4240921c.1059C>G0.107
embC4240924c.1062C>G0.104
embC4241023c.1161T>G0.111
embC4241032c.1170G>C0.117
embC4241038c.1176G>C0.121
embC4241047c.1185C>G0.128
embC4241050c.1188T>G0.127
embC4241053c.1191G>C0.127
embC4241089c.1227C>G0.230
embC4241095c.1233C>T0.252
embC4241107c.1245G>C0.257
embC4241140c.1278A>G0.255
embC4241146c.1284C>G0.260
embC4241158c.1296T>C0.217
embC4241161c.1299C>G0.207
embC4241162c.1300T>C0.204
embC4241170c.1308G>C0.207
embC4241173c.1311C>T0.204
embC4241179c.1317G>A0.204
embC4241203c.1341T>C0.175
embC4241206c.1344G>C0.145
embC4241218c.1356G>C0.120
embC4241230c.1368A>G0.100
embC4241351p.Ile497Val0.131
embC4241361p.Asn500Thr0.155
embC4241363p.Leu501Met0.155
embC4241374c.1512T>G0.258
embC4241380c.1518A>C0.254
embC4241383c.1521G>C0.254
embC4241394p.Lys511Ser0.266
embC4241449c.1587C>G0.333
embC4241453p.Ile531Val0.338
embC4241479c.1617C>G0.250
embC4241480c.1618T>C0.250
embC4241488c.1626G>C0.241
embC4241496p.Ala545Gly0.179
embC4241500c.1638A>C0.179
embC4241501p.Ser547Thr0.179
embC4241506c.1644G>C0.181
embC4241518c.1656A>G0.143
embC4241521c.1659T>C0.145
embC4241530c.1668C>G0.145
embC4241551c.1689A>G0.127
embC4241567p.Ile569Val0.167
embC4241572c.1710C>G0.123
embC4241578c.1716G>C0.105
embC4241591p.Leu577Val0.102
embC4241614c.1752A>C0.102
embC4241626c.1764T>C0.105
embC4241635c.1773G>C0.113
embC4241644c.1782G>C0.122
embC4241648c.1786T>C0.130
embC4241657p.Ser599Pro0.128
embC4241665c.1803G>C0.125
embC4241671c.1809T>C0.115
embC4242643c.2781C>T1.000
embC4242689p.Val943Ile0.141
embC4242710p.Gln950Glu0.184
embC4242715c.2853T>C0.190
embC4242742c.2880C>G0.209
embC4242748c.2886A>G0.204
embC4242754c.2892G>C0.194
embC4242764p.Val968Leu0.204
embC4242772c.2910G>C0.198
embC4242779p.Asn973Asp0.194
embC4242791p.Ala977Ser0.152
embC4242796c.2934G>C0.150
embC4242799c.2937T>C0.152
embC4242802c.2940G>C0.162
embC4242820c.2958G>C0.224
embC4242823c.2961G>C0.221
embC4242832c.2970A>C0.217
embC4242838c.2976C>G0.174
embC4242841c.2979C>T0.181
embC4242844c.2982A>G0.183
embC4242847c.2985C>A0.181
embC4242859c.2997C>T0.202
embC4242862c.3000A>G0.202
embC4242863p.Tyr1001Asn0.202
embC4242883c.3021C>G0.200
embC4242892c.3030G>C0.202
embC4242901c.3039G>C0.205
embC4242919c.3057A>G0.205
embC4242928c.3066A>G0.198
embC4242931c.3069G>C0.163
embA4243460c.228C>T1.000
embA4244507c.1275G>T0.124
embA4244508c.1276T>C0.122
embA4244516c.1284G>C0.140
embA4244517p.Leu429Val0.143
embA4244523p.Pro431Ala0.146
embA4244534c.1302T>C0.204
embA4244537c.1305T>G0.204
embA4244543c.1311C>G0.215
embA4244547p.Ile439Val0.231
embA4244557p.Arg442Thr0.240
embA4244582c.1350T>C0.228
embA4244585c.1353A>G0.221
embA4244611p.Ala460Gly0.143
embA4244616p.Ala462Ser0.129
embA4244619c.1387T>C0.138
embA4244625p.Leu465Val0.141
embA4244631p.Thr467Leu0.148
embA4244645c.1413T>C0.138
embA4244648c.1416G>C0.147
embA4244649p.Asp473Ser0.147
embA4245041c.1809C>G0.126
embA4245044c.1812G>C0.128
embA4245053c.1821G>C0.138
embA4245060c.1828T>C0.151
embA4245083c.1851A>C0.193
embA4245089c.1857G>C0.191
embA4245101c.1869G>C0.239
embA4245137c.1905T>C0.301
embA4245146c.1914G>A0.277
embA4245149c.1917C>G0.300
embA4245153p.Ile641Val0.293
embA4245182c.1950T>C0.306
embA4245189c.1957C>T0.316
embA4245198p.Leu656Ile0.333
embA4245207c.1975T>C0.302
embA4245215c.1983A>C0.321
embA4245222p.Tyr664Gln0.279
embA4245248c.2016G>C0.221
embA4245257c.2025A>G0.185
embA4245263c.2031A>G0.172
embA4245282p.Ile684Val0.116
embA4245285c.2053T>C0.115
embA4245290c.2058C>G0.118
embA4245293c.2061T>G0.118
embA4245296c.2064G>C0.119
embA4245299c.2067A>G0.119
embA4245659c.2427C>G0.181
embA4245674c.2442A>C0.202
embA4245677c.2445G>C0.198
embA4245693p.Ile821Val0.230
embA4245701c.2469G>C0.232
embA4245704c.2472G>C0.250
embA4245725c.2493A>G0.330
embA4245726c.2494T>C0.327
embA4245737c.2505A>C0.347
embA4245740c.2508T>C0.347
embA4245764c.2532G>C0.359
embA4245772p.Asn847Thr0.330
embA4245785c.2553G>C0.305
embA4245807c.2575T>C0.139
embA4245812c.2580G>C0.139
embA4245813p.Pro861Ala0.139
embA4245820p.Ser863Thr0.138
embA4245824c.2592G>C0.128
embA4245833c.2601G>C0.129
embA4245842c.2610G>C0.134
embA4245845c.2613T>C0.134
embA4245851c.2619G>C0.129
embA4246220c.2988T>C0.108
embA4246223c.2991C>T0.105
embA4246227p.Ile999Val0.136
embA4246235c.3003G>A0.185
embA4246242p.Gln1004Gly0.188
embA4246250c.3018G>C0.244
embA4246256c.3024G>T0.244
embA4246259c.3027G>C0.250
embA4246264p.His1011Arg0.253
embA4246292c.3060A>G0.315
embA4246305p.Ser1025Glu0.281
embA4246308p.Thr1026Ala0.294
embA4246316c.3084T>G0.321
embA4246319c.3087G>C0.307
embA4246329p.Thr1033Ala0.314
embA4246349c.3117C>G0.313
embA4246359p.Ala1043Ser0.247
embA4246367c.3135C>T0.234
embA4246373c.3141T>C0.234
embA4246376c.3144G>C0.216
embA4246379c.3147C>T0.216
embA4246400c.3168G>C0.143
embA4246413p.His1061Phe0.127
embA4246419c.3187C>T0.136
embB4246548p.Pro12Gln0.123
embB4247407c.894G>C0.118
embB4247425c.912G>C0.136
embB4247434c.921C>G0.141
embB4247437c.924A>G0.138
embB4247440c.927C>G0.140
embB4247446c.933C>T0.143
embB4247464c.951C>G0.182
embB4247470c.957T>C0.211
embB4247491c.978G>C0.247
embB4247497c.984T>C0.280
embB4247512c.999T>C0.250
embB4247539c.1026T>C0.261
embB4247554c.1041T>C0.247
embB4247566c.1053C>A0.229
embB4247572c.1059A>G0.200
embB4247579p.Ala356Phe0.191
embB4247587c.1074G>A0.200
embB4247603c.1090C>T0.193
embB4247611c.1098G>T0.173
embB4247614c.1101T>C0.158
embB4247629c.1116C>G0.110
embB4247683c.1170C>G0.151
embB4247692c.1179C>G0.164
embB4247716c.1203C>T0.200
embB4247722c.1209G>C0.209
embB4247725c.1212G>C0.209
embB4247729p.Gly406Pro0.219
embB4247746c.1233C>T0.316
embB4247761c.1248T>C0.314
embB4247773c.1260G>A0.312
embB4247776c.1263G>T0.305
embB4247797c.1284C>G0.309
embB4247800c.1287A>T0.302
embB4247803c.1290G>C0.299
embB4247815c.1302C>G0.307
embB4247819p.Val436Ile0.284
embB4247830c.1317A>G0.291
embB4247836c.1323A>G0.282
embB4247839c.1326G>C0.279
embB4247866c.1353G>C0.288
embB4247875c.1362G>C0.271
embB4247876c.1363C>T0.269
embB4247881c.1368G>C0.281
embB4247887c.1374C>T0.286
embB4247893c.1380C>T0.293
embB4247899p.Met462Ile0.297
embB4247905c.1392G>C0.311
embB4247909c.1396T>C0.306
embB4247914c.1401G>C0.306
embB4247932c.1419C>G0.328
embB4247940p.Leu476Trp0.333
embB4247945c.1432T>C0.347
embB4247951p.Ser480Ala0.353
embB4247956c.1443G>C0.320
embB4247974c.1461C>G0.342
embB4248007c.1494C>G0.293
embB4248011p.Ser500Arg0.300
embB4248014p.Thr501Ala0.303
embB4248035p.Val508Ile0.310
embB4248040c.1527C>G0.294
embB4248041p.Ala510Thr0.291
embB4248044p.Lys511Ala0.291
embB4248070c.1557T>C0.333
embB4248085c.1572T>C0.341
embB4248097c.1584C>G0.300
embB4248130c.1617G>C0.256
embB4248142c.1629T>C0.205
embB4248143c.1630T>C0.214
embB4248157c.1644A>G0.205
embB4248172c.1659G>C0.214
embB4248199c.1686A>G0.167
embB4248200p.Ile563Val0.167
embB4248205c.1692C>G0.167
embB4248206p.Ser565Gly0.169
embB4248220c.1707A>C0.224
embB4248304c.1791G>C0.253
embB4248316c.1803C>G0.212
embB4248319c.1806A>G0.200
embB4248343c.1830G>C0.208
embB4248350c.1837T>C0.169
embB4248355c.1842A>G0.176
embB4248358c.1845C>G0.169
embB4248361c.1848A>C0.167
embB4248362p.Ser617Ala0.169
embB4248373c.1860C>G0.200
embB4248382c.1869C>G0.195
embB4248386c.1873C>A0.197
embB4248407p.Leu632Val0.143
embB4248410p.Phe633Leu0.133
embB4248419p.Leu636Met0.132
embB4248425c.1912T>C0.137
embB4248430c.1917T>C0.130
embB4248432p.Trp640Phe0.125
embB4248457c.1944T>C0.231
embB4248472c.1959T>C0.202
embB4248475c.1962G>C0.184
embB4248504p.Asp664Gly0.158
embB4248508c.1995G>A0.147
embB4248512p.Thr667Ser0.144
embB4248535c.2022C>G0.125
embB4249369c.2856T>C0.133
embB4249375c.2862G>C0.162
embB4249381c.2868A>G0.197
embB4249384c.2871G>T0.208
embB4249417c.2904A>G0.263
embB4249423p.Asp970Glu0.263
embB4249424p.Leu971Met0.266
embB4249429c.2916C>T0.280
embB4249432c.2919A>G0.280
embB4249441c.2928A>G0.326
embB4249444c.2931T>C0.326
embB4249469p.Leu986Met0.343
embB4249486c.2973T>G0.347
embB4249498c.2985G>C0.343
embB4249521p.Ala1003Val0.255
embB4249525c.3012T>C0.245
embB4249529p.Ile1006Val0.240
embB4249532p.Ala1007Thr0.230
embB4249537c.3024A>G0.227
embB4249543c.3030G>C0.234
embB4249546c.3033G>A0.237
embB4249558c.3045A>C0.220
embB4249568p.Ser1019Thr0.196
embB4249573c.3060T>C0.191
embB4249580p.Leu1023Met0.170
embB4249594c.3081G>C0.108
ethA4327396c.78A>G0.234
ethA4327399p.Asp25Glu0.231
ethA4327423c.51G>C0.231
ethA4327435c.39T>G0.230
ethA4327438c.36A>G0.217
ethA4327452p.Val8Leu0.193
ethA4327453c.21A>G0.164
ethA4327459c.15G>A0.140
ethA4327468c.6G>A0.140
gid4407588c.615T>C1.000
gid4407927p.Glu92Asp1.000

Analysis pipeline specifications

TBProfiler Version: 2.1.1

AnalysisProgram
Mappingbwa
Variant CallingBCFtools


Log

Drug Details
The estimated accuracy of drug resistance predictions is:

Drug1Sensitivity (%)Specificity (%)
Isoniazid 92.8 (89.9-95.7)100 (100-100)
Rifampicin 96.2 (93.9-98.5)98.1 (96.8-99.4)
Ethambutal 88.7 (83.6-93.8)81.7 (77.6-85.8)
Pyrazinamide70.9 (62.4-79.4)93.9 (90.6-97.2)
Streptomycin87.1 (82.7-91.5)89.7 (86.0-93.4)
Ethionamide 73.6 (66.7-80.5)93.3 (89.6-97.0)
Moxifloxacin60.0 (29.6-90.4)68.7 (52.6-84.8)
Ofloxacin 85.5 (79.1-91.9)94.9 (91.8-98.0)
Amikacin 82.9 (74.4-91.4)98.3 (96.0-100)
Capreomycin 60.7 (50.6-70.8)90.7 (87.2-94.2)
Kanamycin 87.3 (81.3-93.3)93.4 (89.9-96.9)
Para-aminosalisylic acidNot determinedNot determined
Linezolid Not determinedNot determined
Clofazimine Not determinedNot determined
Bedaquiline Not determinedNot determined
Multi drug resistance91.2 (87.8-94.6)98.4 (97.2-99.6)
Extremely drug resistance75.9 (64.5-87.3)98.4 (97.3-99.5)

Lineages
Lineage2LocationStrainRD type
lineage1Indo-OceanicEAIRD239
lineage1.1Indo-OceanicEAI3;EAI4;EAI5;EAI6RD239
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineage1.1.1.1Indo-OceanicEAI4;ZERORD239
lineage1.1.2Indo-OceanicEAI3;EAI5RD239
lineage1.1.3Indo-OceanicEAI6RD239
lineage1.2Indo-OceanicEAI1;EAI2RD239
lineage1.2.1Indo-OceanicEAI2RD239
lineage1.2.2Indo-OceanicEAI1RD239
lineage2East-AsianBeijingRD105
lineage2.1East-Asian (non-Beijing)NoneNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.2East-Asian (Beijing)Beijing-RD105/RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181
lineage2.2.1.2East-Asian (Beijing)Beijing-RD142RD105;RD207;RD181;RD142
lineage2.2.1.1East-Asian (Beijing)Beijing-RD150RD105;RD207;RD181;RD150
lineage3East-African-IndianCASRD750
lineage3.1East-African-IndianNon-CAS1-DelhiRD750
lineage3.1.1East-African-IndianCAS1-KiliRD750
lineage3.1.2East-African-IndianCAS;CAS2RD750
lineage3.1.2.1East-African-IndianCAS2RD750
lineage3.1.2.2East-African-IndianCASRD750
lineage4Euro-AmericanLAM;T;S;X;HNone
lineage4.1Euro-AmericanT;X;HNone
lineage4.1.2Euro-American (X-type)T;HNone
lineage4.1.2.1Euro-American (X-type)T1;H1RD182
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.2Euro-American (X-type)X1None
lineage4.1.1.1Euro-American (X-type)X2RD183
lineage4.1.1.3Euro-American (Haarlem)X1;X3RD193
lineage4.2Euro-AmericanH;T;LAMNone
lineage4.2.2Euro-American (Ural)T;LAM7-TURNone
lineage4.2.2.1Euro-AmericanLAM7-TURNone
lineage4.2.1Euro-American (TUR)H3;H4None
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.3.1Euro-American (LAM)LAM9None
lineage4.3.3Euro-American (LAM)LAM;TRD115
lineage4.3.4Euro-American (LAM)LAMRD174
lineage4.3.4.1Euro-American (LAM)LAM1;LAM2RD174
lineage4.3.4.2Euro-American (LAM)LAM1;LAM4;LAM11RD174
lineage4.3.4.2.1Euro-American (LAM)LAM11RD174
lineage4.3.2Euro-American (LAM)LAM3None
lineage4.3.2.1Euro-American (LAM)LAM3RD761
lineage4.4Euro-AmericanS;TNone
lineage4.4.2Euro-AmericanT1;T2None
lineage4.4.1Euro-American (S-type)S;TNone
lineage4.4.1.2Euro-AmericanT1None
lineage4.4.1.1Euro-AmericanS;OrphansNone
lineage4.5Euro-AmericanH;TRD122
lineage4.6Euro-AmericanT;LAMNone
lineage4.6.1Euro-American (Uganda)T2RD724
lineage4.6.1.1Euro-American T2-UgandaRD724
lineage4.6.1.2Euro-AmericanT2RD724
lineage4.6.2Euro-AmericanT;LAMRD726
lineage4.6.2.1Euro-AmericanT3RD726
lineage4.6.2.2Euro-American (Cameroon)LAM10-CAMRD726
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.8Euro-American (mainly T)T1;T2;T3;T5RD219
lineage4.9Euro-American (H37Rv-like)T1None
lineage5West-Africa 1AFRI_2;AFRI_3RD711
lineage6West-Africa 2AFRI_1RD702
lineage7Lineage 7NoneNone
lineageBOVM. bovisBOV_1;BOV_2None

Citations
1. Coll F, et al. Rapid determination of anti-tuberculosis drug resistance from whole genome sequences. Genome Medicine (in press)
2. Coll F, et al. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications 2014.

Disclaimer
This tool is for Research Use Only and is offered free for use. The London School of Hygiene and Tropical Medicine shall have no liability for any loss or damages of any kind, however sustained relating to the use of this tool.
© 2019 London School of Hygiene and Tropical Medicine;