TB Profiler
This tool processes raw sequence data to infer strain type and identify known drug resistance markers.
A stand alone version of this tool is now available and can now be run on linux or mac. Installation instructions can be found on GitHub and on the bioconda page.



This tool is for Research Use Only. Data and information provided through use of this tool are not intended for medical purpose or objective and should not be used for clinical diagnosis, patient management, or human clinical trials.
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Single nucleotide polymorphisms (SNPs) in coding regions are annotated using the reference amino acid, codon number and alternative amino acid (e.g. Ser315Thr in katG). SNPs in non-coding regions (i.e. RNA genes and intergenic regions) are annotated using the reference nucleotide, gene coordinate and alternative nucleotide (e.g. A1401G in rrs or C-37A in eis promoter). Indels are annotated using the reference VCF allele, gene coordinate and alternative VCF allele (e.g. T902TA insertion in katG).
Name: 5d807f5f0dfae
Sample: 5d807f5f0dfae

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Summary
ID: 5d807f5f0dfae
Date: Tue Sep 17 08:00:40 2019
Strain: lineage4.3;lineage2.2;lineage2.2.1
Drug-resistance: MDR

Drug1ResistanceSupporting Mutations (frequency)
IsoniazidRkatG p.Ile335Thr (0.44), katG p.Ile317Leu (0.50), katG p.Ser315Thr (0.50)
RifampicinRrpoB p.Asp435Gly (0.12)
EthambutolRembB p.His312Arg (0.90), embB p.Leu359Ile (0.86), embB p.Ala388Gly (0.82), embB p.Asn399Asp (0.91), embB p.Ala659Thr (0.80)
Pyrazinamide
StreptomycinRrrs r.462c>t (0.87)
Ethionamide
Fluoroquinolones
AmikacinRrrs r.1401a>g (0.14)
CapreomycinRrrs r.1401a>g (0.14)
KanamycinRrrs r.1401a>g (0.14)

Lineage2FamilyMain SpoligotypeRDS
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181

Mutations in candidate genes:
GeneChromosome PositionMutationEstimated fraction
gyrB5326c.87T>C0.765
gyrB5341c.102T>C0.867
gyrB5344c.105C>G0.867
gyrB5347c.108G>C0.867
gyrB5353c.114T>C0.867
gyrB5359c.120C>T0.867
gyrB5363c.124T>C0.867
gyrB5371c.132T>C0.812
gyrB5377c.138T>C0.765
gyrB5396p.Ala53Ser0.722
gyrB5419c.180T>C0.722
gyrB6082c.843G>A0.600
gyrB6086p.Thr283Pro0.613
gyrB6091c.852G>C0.636
gyrB6100c.861G>C0.657
gyrB6115c.876A>G0.686
gyrB6123p.Ala295Gly0.711
gyrB6127c.888G>C0.750
gyrB6130c.891T>C0.757
gyrB6136c.897G>A0.756
gyrB6139c.900G>C0.767
gyrB6196c.957C>T0.190
gyrB6238c.999G>A0.878
gyrB6242p.Arg335Lys0.878
gyrB6250c.1011A>G0.907
gyrB6256c.1017G>A0.911
gyrB6268c.1029C>G0.887
gyrB6280c.1041T>C0.873
gyrB6286c.1047T>C0.865
gyrB6289c.1050C>T0.860
gyrB6292c.1053G>C0.863
gyrB6307c.1068T>G0.897
gyrB6319c.1080G>C0.902
gyrB6362c.1123T>C0.920
gyrB6376c.1137G>A0.891
gyrB6379c.1140C>G0.884
gyrB6382c.1143A>G0.884
gyrB6388c.1149T>C0.864
gyrB6403c.1164T>C0.825
gyrB6415c.1176G>C0.794
gyrB6427c.1188T>C0.767
gyrB6430c.1191A>G0.750
gyrB6440p.Thr401Ala0.562
gyrB6448c.1209G>C0.467
gyrB6451c.1212A>G0.467
gyrB6454c.1215C>G0.467
gyrB6457c.1218T>G0.467
gyrB6460c.1221G>C0.467
gyrB6469c.1230T>G0.467
gyrB6475c.1236C>G0.500
gyrB6484c.1245A>G0.385
gyrB6565c.1326G>C0.286
gyrB6571c.1332T>C0.286
gyrB6577c.1338T>C0.286
gyrB6580c.1341C>G0.286
gyrB6598c.1359C>G0.333
gyrB6610c.1371C>G0.333
gyrB6613c.1374A>G0.333
gyrB6616c.1377A>G0.333
gyrB6622c.1383C>T0.357
gyrB6634c.1395T>C0.412
gyrB6637c.1398T>G0.412
gyrB6640c.1401A>G0.412
gyrB6643c.1404A>G0.412
gyrB6649c.1410T>C0.476
gyrB6655c.1416T>C0.556
gyrB6670c.1431G>C0.455
gyrB6673c.1434A>C0.613
gyrB6676c.1437T>G0.594
gyrB6680c.1441C>T0.273
gyrB6700c.1461T>C0.706
gyrB6703c.1464G>C0.714
gyrB6709c.1470A>G0.735
gyrB6712c.1473G>C0.771
gyrB6728c.1489C>T0.730
gyrB6742c.1503A>G0.829
gyrB6745c.1506T>G0.844
gyrB6751c.1512G>C0.776
gyrB6760c.1521G>C0.827
gyrB6763c.1524G>C0.769
gyrB6775c.1536G>C0.769
gyrB6787c.1548G>A0.259
gyrB6793c.1554T>C0.812
gyrB6797p.Gly520Thr0.796
gyrB6811c.1572C>T0.750
gyrB6841c.1602T>C0.833
gyrB6844c.1605T>C0.814
gyrB6853c.1614A>G0.778
gyrB6856c.1617T>C0.794
gyrB6859c.1620T>C0.794
gyrB6862c.1623C>G0.800
gyrB6878c.1639T>C0.838
gyrB6881c.1642T>C0.838
gyrB6889c.1650G>T0.793
gyrB6901c.1662G>C0.807
gyrB6904c.1665C>G0.842
gyrB6910c.1671G>A0.857
gyrB6916c.1677G>C0.842
gyrB6919c.1680T>C0.845
gyrB6925c.1686T>C0.857
gyrB6931c.1692A>G0.846
gyrB6949c.1710A>G0.839
gyrB6952c.1713C>G0.846
gyrB6967c.1728T>C0.841
gyrB6973c.1734G>C0.808
gyrB6982c.1743A>C0.819
gyrB7006c.1767T>C0.734
gyrB7007c.1768C>T0.734
gyrB7010c.1771C>T0.734
gyrB7015p.Glu592Asp0.673
gyrB7023p.Leu595Gln0.717
gyrB7033c.1794G>C0.698
gyrB7051p.Glu604Asp0.667
gyrB7066c.1827G>C0.588
gyrB7075c.1836T>C0.483
gyrB7078c.1839A>C0.444
gyrB7084c.1845A>G0.500
gyrB7090c.1851C>T0.480
gyrB7093c.1854T>G0.480
gyrB7099c.1860G>A0.500
gyrB7108c.1869G>A0.531
gyrB7114c.1875C>A0.562
gyrB7124p.Ser629Thr0.583
gyrB7129c.1890T>C0.583
gyrB7132c.1893T>G0.600
gyrB7141c.1902T>C0.789
gyrB7147c.1908G>C0.800
gyrB7165c.1926C>G0.864
gyrB7178c.1939T>C0.882
gyrB7186c.1947C>G0.906
gyrB7216c.1977G>C0.828
gyrB7234c.1995C>T0.840
gyrB7246c.2007T>C0.833
gyrB7252c.2013G>C0.841
gyrB7256c.2017C>T0.850
gyrA7301c.-1G>C0.500
gyrA7307c.6A>T0.571
gyrA7313c.12G>C0.591
gyrA7317c.16T>C0.591
gyrA7334c.33G>C0.700
gyrA7335p.Leu12Val0.719
gyrA7347p.Glu16Gln0.762
gyrA7355c.54T>C0.311
gyrA7361c.60C>T0.844
gyrA7362p.Glu21Gln1.000
gyrA7391c.90C>T0.881
gyrA7394c.93T>C0.883
gyrA7406c.105G>C0.270
gyrA7412c.111C>G0.270
gyrA7424c.123G>A0.596
gyrA7427c.126G>C0.911
gyrA7436c.135C>T0.222
gyrA7439c.138C>T0.241
gyrA7442c.141G>C0.922
gyrA7451c.150C>G0.922
gyrA7457c.156T>C0.902
gyrA7475c.174A>G0.826
gyrA7480p.Phe60Tyr0.804
gyrA7484c.183T>C0.800
gyrA7490c.189C>G0.760
gyrA7505c.204C>T0.745
gyrA7523c.222C>G0.804
gyrA7532c.231T>G0.764
gyrA7541c.240C>G0.769
gyrA7547c.246C>T0.759
gyrA7571c.270G>C0.750
gyrA7585p.Ser95Thr1.000
gyrA7595c.294C>G0.723
gyrA7601c.300C>G0.705
gyrA7607c.306C>G0.714
gyrA7622c.321C>T0.676
gyrA7625c.324G>C0.677
gyrA7626c.325C>T0.677
gyrA7631c.330G>C0.700
gyrA7637c.336C>G0.724
gyrA7652c.351C>T0.680
gyrA7658c.357A>C0.667
gyrA7664c.363T>C0.588
gyrA7670c.369A>G0.588
gyrA7679c.378G>C0.500
gyrA7694c.393A>G0.868
gyrA7697c.396C>G0.886
gyrA7710c.409T>C0.941
gyrA7728c.427A>C0.964
gyrA7763c.462T>C0.988
gyrA7775c.474C>A0.952
gyrA7781c.480G>C0.603
gyrA7784c.483A>G0.932
gyrA7790c.489G>C0.928
gyrA7793c.492G>C0.922
gyrA7796c.495G>C0.919
gyrA7799c.498A>G0.952
gyrA7814c.513C>G0.877
gyrA7823c.522G>C0.838
gyrA7832c.531G>T0.833
gyrA7835c.534A>C0.857
gyrA7853c.552C>G0.776
gyrA7859c.558A>G0.796
gyrA7865c.564T>C0.782
gyrA7886c.585T>C0.769
gyrA7898p.Asp199Glu0.500
gyrA7901c.600G>C0.385
gyrA7904c.603G>C0.200
gyrA7906p.Phe202Tyr0.200
gyrA7911p.Ala204Cys0.182
gyrA7919p.Glu206Asp0.200
gyrA8039c.738T>C0.250
gyrA8051c.750C>G0.267
gyrA8054c.753T>C0.400
gyrA8057c.756A>G0.412
gyrA8069c.768T>C0.735
gyrA8078c.777A>G0.771
gyrA8090c.789C>A0.795
gyrA8096c.795T>A0.761
gyrA8099c.798T>C0.816
gyrA8111c.810G>C0.818
gyrA8121c.820T>C0.786
gyrA8129c.828T>C0.810
gyrA8135c.834C>G0.815
gyrA8156c.855T>C0.861
gyrA8168c.867A>G0.667
gyrA8177c.876A>C0.868
gyrA8198c.897T>C0.875
gyrA8207c.906T>C0.875
gyrA8219c.918T>C0.873
gyrA8225c.924T>C0.875
gyrA8234c.933T>C0.853
gyrA8237c.936A>G0.721
gyrA8247p.Ile316Val0.897
gyrA8264c.963T>C0.854
gyrA8267c.966G>C0.837
gyrA8270c.969G>C0.840
gyrA8276c.975G>A0.833
gyrA8283p.Ile328Leu0.811
gyrA8294c.993T>C0.828
gyrA8324c.1023T>C0.897
gyrA8330c.1029C>G0.889
gyrA8339c.1038A>G0.875
gyrA8340p.Ala347Ser0.875
gyrA8372c.1071G>C0.855
gyrA8375c.1074G>C0.846
gyrA8382p.Leu361Met0.860
gyrA8387c.1086C>T0.857
gyrA8391p.Tyr364His0.854
gyrA8399c.1098T>C0.833
gyrA8401p.Asp367Ala0.889
gyrA8405c.1104C>T0.909
gyrA8420c.1119T>C0.918
gyrA8442c.1141C>T0.929
gyrA8453c.1152A>C0.922
gyrA8462c.1161A>T0.891
gyrA8465c.1164C>G0.891
gyrA8471c.1170T>C0.891
gyrA8472c.1171C>T0.891
gyrA8480c.1179C>T0.902
gyrA8486c.1185T>C0.882
gyrA8504c.1203G>C0.865
gyrA8516c.1215T>C0.759
gyrA8519c.1218A>C0.731
gyrA8520c.1219C>T0.731
gyrA8528c.1227G>C0.750
gyrA8543c.1242C>G0.774
gyrA8546c.1245T>C0.750
gyrA8552c.1251C>A0.742
gyrA8561c.1260A>G0.788
gyrA8576c.1275C>G0.742
gyrA8579c.1278C>T0.742
gyrA8588c.1287G>A0.805
gyrA8597c.1296C>G0.822
gyrA8603c.1302A>G0.804
gyrA8619c.1318T>C0.816
gyrA8624c.1323G>C0.820
gyrA8636c.1335A>C0.855
gyrA8642c.1341A>G0.860
gyrA8651c.1350C>T0.246
gyrA8672c.1371A>G0.906
gyrA8678c.1377G>A0.645
gyrA8693c.1392T>C0.868
gyrA8696c.1395G>C0.882
gyrA8699c.1398A>G0.880
gyrA8711c.1410A>C0.881
gyrA8714c.1413A>G0.881
gyrA8729c.1428T>C0.871
gyrA8730p.Gly477Arg0.871
gyrA8740p.Arg480His0.852
gyrA8747c.1446A>G0.706
gyrA8750c.1449C>G0.750
gyrA8751p.Ala484Ser0.750
gyrA8756c.1455A>G0.833
gyrA8762c.1461G>C0.789
gyrA8767p.Arg489Lys0.800
gyrA8780p.Asp493Glu0.806
gyrA8786c.1485T>C0.806
gyrA8801c.1500G>C0.793
gyrA8807c.1506C>T0.793
gyrA8810c.1509A>G0.793
gyrA8816c.1515C>G0.781
gyrA8818p.Ser506Asn0.806
gyrA8828c.1527T>C0.814
gyrA8837c.1536C>T0.826
gyrA8852c.1551T>C0.875
gyrA8858c.1557T>C0.860
gyrA8867c.1566A>G0.841
gyrA8870c.1569G>C0.841
gyrA8873c.1572A>C0.844
gyrA8891c.1590G>A0.216
gyrA8897c.1596T>C0.877
gyrA8903c.1602T>C0.873
gyrA8918c.1617C>A0.594
gyrA8933c.1632G>C0.864
gyrA8939c.1638T>C0.868
gyrA8942c.1641G>C0.865
gyrA8946c.1645T>C0.857
gyrA8966c.1665C>G0.833
gyrA8967p.Ala556Arg0.811
gyrA8987c.1686C>G0.786
gyrA8990c.1689C>G0.769
gyrA8996c.1695T>C0.731
gyrA8998p.Leu566Trp0.720
gyrA9017c.1716C>G0.647
gyrA9023c.1722A>C0.625
gyrA9029c.1728T>C0.462
gyrA9032c.1731T>C0.417
gyrA9035c.1734G>C0.417
gyrA9050p.Asp583Glu0.400
gyrA9051c.1750T>C0.400
gyrA9056c.1755C>G0.300
gyrA9068c.1767G>C0.333
gyrA9071c.1770G>C0.385
gyrA9080c.1779G>T0.522
gyrA9089c.1788G>C0.480
gyrA9099c.1798T>C0.520
gyrA9104c.1803C>G0.542
gyrA9119c.1818A>G0.600
gyrA9122c.1821C>G0.636
gyrA9143c.1842T>C0.692
gyrA9152c.1851C>T0.658
gyrA9153p.Thr618Glu0.658
gyrA9158c.1857C>T0.641
gyrA9161c.1860C>G0.641
gyrA9182c.1881T>C0.770
gyrA9191c.1890G>C0.778
gyrA9200c.1899A>G0.797
gyrA9204p.Ser635Thr0.797
gyrA9224c.1923C>T0.787
gyrA9230c.1929T>C0.833
gyrA9233c.1932C>G0.823
gyrA9239c.1938C>T0.836
gyrA9252p.Val651Ile0.851
gyrA9284c.1983T>C0.879
gyrA9291c.1990C>T0.839
gyrA9296c.1995T>C0.833
gyrA9299c.1998G>C0.826
gyrA9300p.Ala667Ser0.826
gyrA9304p.Gly668Asp1.000
gyrA9308p.Asp669Glu0.816
gyrA9323c.2022C>G0.284
gyrA9335c.2034G>C0.891
gyrA9365c.2064G>A0.883
gyrA9374c.2073G>C0.878
gyrA9377c.2076A>G0.872
gyrA9383c.2082T>G0.881
gyrA9386c.2085T>C0.884
gyrA9395c.2094G>C0.857
gyrA9398c.2097T>C0.825
gyrA9413c.2112G>C0.778
rpoB759606c.-201T>C0.839
rpoB759629c.-178T>C0.917
rpoB759644c.-163T>A0.860
rpoB759647c.-160T>C0.842
rpoB759656c.-151A>C0.667
rpoB759657c.-150G>C0.556
rpoB759659c.-148T>A0.625
rpoB759660c.-147T>C0.625
rpoB759662c.-145C>T0.625
rpoB759667c.-140C>T0.667
rpoB759670c.-137C>T0.632
rpoB759671c.-136G>T0.632
rpoB759672c.-135G>C0.632
rpoB759683c.-124T>C0.600
rpoB759701c.-106A>T0.571
rpoB759725c.-82A>C0.182
rpoB760040c.234T>C0.667
rpoB760046c.240G>C0.737
rpoB760060p.Tyr85Leu0.800
rpoB760067c.261G>C0.800
rpoB760070c.264T>G0.842
rpoB760091c.285G>C0.857
rpoB760101c.295T>C0.868
rpoB760112c.306T>C0.872
rpoB760118c.312T>G0.875
rpoB760121c.315T>C0.881
rpoB760130p.Asp108Glu0.917
rpoB760139c.333A>G0.917
rpoB760142c.336C>G0.920
rpoB760181c.375T>C0.920
rpoB760184c.378A>G0.909
rpoB760196c.390C>G0.907
rpoB760223c.417T>C0.877
rpoB760235c.429T>C0.895
rpoB760283c.477G>C0.838
rpoB760298c.492G>C0.831
rpoB760307c.501T>C0.836
rpoB760310c.504G>C0.842
rpoB760321p.Gln172Arg0.128
rpoB760328c.522G>C0.842
rpoB760331c.525G>C0.844
rpoB760340c.534G>T0.836
rpoB760361c.555T>C0.817
rpoB760370c.564C>G0.812
rpoB760376p.Asp190Glu0.790
rpoB760380p.Thr192Leu0.800
rpoB760406c.600G>C0.879
rpoB760412c.606C>G0.868
rpoB760424c.618C>G0.899
rpoB760430c.624T>C0.899
rpoB760475c.669A>G0.901
rpoB760481c.675G>C0.209
rpoB760484c.678A>G0.909
rpoB760522p.Ser239Asn0.973
rpoB760532c.726T>C0.951
rpoB760533p.Val243Thr0.950
rpoB760541c.735G>C0.912
rpoB760547c.741G>C0.941
rpoB760563p.Arg253Met0.911
rpoB760591p.Val262Ala0.879
rpoB760611c.805T>C0.830
rpoB760646c.840C>G0.870
rpoB760655c.849A>G0.818
rpoB760661c.855A>C0.793
rpoB760670c.864G>C0.774
rpoB760674c.868T>C0.765
rpoB760679c.873A>G0.792
rpoB760683c.877T>C0.792
rpoB760715c.909C>G0.784
rpoB760718c.912C>T0.769
rpoB760724c.918T>C0.736
rpoB760730c.924T>C0.745
rpoB760751c.945G>C0.792
rpoB760757c.951T>C0.677
rpoB760759p.Val318Ala0.677
rpoB760769c.963C>G0.645
rpoB760775c.969G>C0.625
rpoB760776c.970T>A0.625
rpoB760793c.987A>G0.700
rpoB760805c.999G>C0.769
rpoB760817c.1011A>G0.818
rpoB760820c.1014T>C0.818
rpoB760826c.1020C>G0.781
rpoB760830c.1024T>C0.781
rpoB760841c.1035T>C0.800
rpoB760845p.Thr347Pro0.816
rpoB760859c.1053T>C0.805
rpoB760862c.1056G>C0.829
rpoB760869p.Val355Ile0.864
rpoB760886c.1080A>G0.882
rpoB760925c.1119T>C0.902
rpoB760928c.1122G>C0.902
rpoB760931c.1125C>G0.902
rpoB760934c.1128C>T0.904
rpoB760946c.1140A>G0.915
rpoB760982c.1176G>C0.915
rpoB760985c.1179G>C0.917
rpoB760991c.1185G>C0.925
rpoB761006c.1200C>G0.935
rpoB761015c.1209G>C0.938
rpoB761021c.1215G>C0.923
rpoB761027c.1221A>G0.923
rpoB761036c.1230G>C0.917
rpoB761037c.1231T>C0.918
rpoB761057c.1251G>C0.886
rpoB761102c.1296A>G0.855
rpoB761129c.1323G>C0.805
rpoB761132c.1326G>T0.767
rpoB761133c.1327T>C0.811
rpoB761150c.1344A>C0.884
rpoB761153c.1347G>C0.838
rpoB761165c.1359G>C0.891
rpoB761180c.1374A>C0.917
rpoB761189c.1383T>C0.914
rpoB761195c.1389G>C0.903
rpoB761207c.1401C>T0.887
rpoB761213c.1407G>C0.883
rpoB761219c.1413G>C0.883
rpoB761249c.1443A>G0.938
rpoB761255c.1449T>G0.928
rpoB761261c.1455G>T0.938
rpoB761306c.1500C>G0.903
rpoB761327c.1521A>G0.891
rpoB761330c.1524G>C0.852
rpoB761354c.1548C>T0.836
rpoB761360c.1554T>C0.833
rpoB761362p.Ser519Thr0.833
rpoB761373p.Val523His0.826
rpoB761408c.1602G>C0.795
rpoB761411c.1605G>A0.488
rpoB761414c.1608A>G0.814
rpoB761423c.1617T>C0.850
rpoB761435c.1629T>C0.778
rpoB761438c.1632G>C0.778
rpoB761439p.Asp545Lys0.778
rpoB761444c.1638T>C0.724
rpoB761447c.1641C>G0.677
rpoB761452p.Val549Glu0.700
rpoB761457p.Pro551Ser0.700
rpoB761465c.1659G>C0.464
rpoB761477c.1671C>G0.862
rpoB761492c.1686G>C0.873
rpoB761510c.1704T>C0.886
rpoB761531c.1725C>G0.865
rpoB761534c.1728G>A0.257
rpoB761537c.1731C>G0.842
rpoB761570c.1764T>C0.775
rpoB761573c.1767C>G0.780
rpoB761579c.1773G>C0.807
rpoB761588c.1782C>T0.786
rpoB761606c.1800C>G0.810
rpoB761612c.1806G>C0.812
rpoB761615c.1809A>C0.803
rpoB761636c.1830G>T0.808
rpoB761645c.1839C>G0.811
rpoB761648c.1842T>C0.816
rpoB761657c.1851C>G0.818
rpoB761675c.1869G>C0.831
rpoB761720c.1914C>G0.765
rpoB761725p.Glu640Ala0.783
rpoB761732c.1926C>G0.776
rpoB761735c.1929C>G0.780
rpoB761747c.1941G>C0.871
rpoB761750c.1944G>C0.877
rpoB761765c.1959T>C0.887
rpoB761772p.His656Ala0.887
rpoB761778p.Asn658Asp0.889
rpoB761791p.Arg662His0.889
rpoB761813c.2007T>C0.877
rpoB761815p.Ala670Glu0.875
rpoB761834c.2028T>C0.927
rpoB761848p.Cys681Ser0.867
rpoB761852c.2046C>G0.901
rpoB761858c.2052G>C0.909
rpoB761873c.2067A>C0.895
rpoB761885c.2079T>C0.910
rpoB761906c.2100C>A0.219
rpoB761909c.2103T>C0.905
rpoB761912c.2106T>C0.905
rpoB761915p.Asp703Glu0.905
rpoB761916p.Asp704Asn0.905
rpoB761948c.2142G>C0.859
rpoB761954c.2148C>G0.868
rpoB762008c.2202C>T0.857
rpoB762014c.2208C>T0.871
rpoB762017c.2211A>G0.871
rpoB762053c.2247T>C0.864
rpoB762062c.2256T>C0.873
rpoB762065c.2259T>C0.878
rpoB762083c.2277T>C0.923
rpoB762086c.2280G>C0.923
rpoB762101c.2295C>G0.899
rpoB762114p.Ile770Val0.896
rpoB762131c.2325C>G0.905
rpoB762140c.2334G>C0.900
rpoB762143c.2337T>C0.900
rpoB762149c.2343G>C0.918
rpoB762167c.2361T>C0.896
rpoB762170c.2364C>G0.594
rpoB762176c.2370T>C0.284
rpoB762185c.2379G>C0.932
rpoB762206c.2400C>G0.306
rpoB762233c.2427G>C0.877
rpoB762246c.2440C>T0.900
rpoB762254c.2448T>G0.922
rpoB762257c.2451C>G0.906
rpoB762266c.2460T>C0.282
rpoB762284c.2478G>C0.873
rpoB762293c.2487T>C0.868
rpoB762314c.2508C>T0.217
rpoB762317c.2511A>G0.241
rpoB762329c.2523G>C0.887
rpoB762338c.2532T>C0.877
rpoB762347c.2541T>C0.864
rpoB762359c.2553C>T0.198
rpoB762362p.Glu852Asp0.897
rpoB762369c.2563T>C0.899
rpoB762395c.2589G>C0.574
rpoB762398c.2592T>C0.836
rpoB762401c.2595G>C0.836
rpoB762404c.2598T>C0.836
rpoB762410c.2604T>G0.284
rpoB762413c.2607G>A0.552
rpoB762416c.2610A>G0.848
rpoB762419c.2613C>G0.853
rpoB762434c.2628T>C0.872
rpoB762449c.2643C>A0.875
rpoB762467c.2661C>T0.859
rpoB762488c.2682G>C0.820
rpoB762489p.Val895Gln0.869
rpoB762509c.2703T>G0.875
rpoB762510p.Ala902Pro0.875
rpoB762521c.2715C>T0.850
rpoB762533c.2727T>C0.891
rpoB762536c.2730T>C0.889
rpoB762537c.2731T>C0.889
rpoB762551c.2745C>G0.913
rpoB762581c.2775T>C0.867
rpoB762582c.2776T>C0.867
rpoB762729p.Gln975Lys0.462
rpoB762736p.Ala977Glu0.462
rpoB762743c.2937G>T0.231
rpoB762744p.Gln980Ala0.462
rpoB762750p.Leu982Met0.467
rpoB762753c.2947T>C0.556
rpoB762758c.2952G>C0.588
rpoB762782c.2976T>C0.828
rpoB762785p.Asp993Glu0.828
rpoB762788c.2982G>C0.828
rpoB762789p.Leu995Met0.828
rpoB762794c.2988C>G0.844
rpoB762799p.Ala998Gly0.829
rpoB762810p.Ala1002Ser0.811
rpoB762813p.Met1003Val0.811
rpoB762818c.3012C>G0.800
rpoB762827c.3021G>C0.822
rpoB762857c.3051C>G0.822
rpoB762860c.3054G>C0.822
rpoB762863c.3057T>C0.826
rpoB762929c.3123G>C0.814
rpoB762989c.3183G>C0.855
rpoB762995c.3189G>T0.857
rpoB763013c.3207C>G0.847
rpoB763028c.3222T>C0.844
rpoB763031c.3225T>G0.158
rpoB763034c.3228C>G0.846
rpoB763040c.3234C>G0.871
rpoB763070c.3264T>C0.887
rpoB763085c.3279C>G0.861
rpoB763115c.3309T>C0.882
rpoB763136c.3330C>T0.857
rpoB763148c.3342G>C0.864
rpoB763158c.3352C>T0.877
rpoB763166c.3360A>G0.870
rpoB763190c.3384C>T0.857
rpoB763202c.3396A>G0.825
rpoB763205c.3399G>C0.821
rpoB763206c.3400A>T0.821
rpoB763214c.3408T>C0.833
rpoB763223c.3417C>T0.184
rpoB763226c.3420A>G0.837
rpoB763227c.3421C>T0.837
rpoB763238c.3432T>C0.837
rpoB763253c.3447G>C0.809
rpoB763256c.3450G>A0.800
rpoB763265c.3459G>C0.190
rpoB763268c.3462C>G0.744
rpoB763283c.3477T>C0.794
rpoB763284c.3478C>T0.788
rpoC763351c.-19T>C0.741
rpoC763352c.-18T>A0.724
rpoC763402c.33C>G0.850
rpoC763411c.42T>G0.878
rpoC763414c.45T>C0.878
rpoC763441c.72C>T0.860
rpoC763444c.75T>C0.867
rpoC763456c.87A>G0.854
rpoC763486c.117T>G0.842
rpoC763492c.123G>A0.232
rpoC763528c.159G>A0.892
rpoC763546c.177A>G0.892
rpoC763570c.201G>C0.873
rpoC763573c.204G>C0.862
rpoC763594c.225C>T0.857
rpoC763603c.234C>T0.857
rpoC763636c.267T>C0.899
rpoC763657c.288G>A0.892
rpoC763660c.291T>G0.889
rpoC763675c.306C>G0.859
rpoC763696c.327T>C0.857
rpoC763702c.333C>G0.859
rpoC763717c.348T>C0.881
rpoC763723c.354G>C0.877
rpoC763732c.363C>G0.873
rpoC763738c.369G>A0.525
rpoC763741c.372C>T0.895
rpoC763744c.375G>C0.897
rpoC763765c.396T>C0.901
rpoC763774c.405G>C0.886
rpoC763807c.438T>C0.915
rpoC763816c.447C>G0.877
rpoC763835p.Ala156Met0.880
rpoC763853p.Val162Ile0.862
rpoC763858c.489A>G0.862
rpoC763861c.492C>T0.209
rpoC763872p.Gly168Ala0.864
rpoC763876p.Glu169Asp0.860
rpoC763879c.510A>G0.851
rpoC763888c.519G>C0.827
rpoC763891c.522G>C0.811
rpoC763894c.525A>G0.811
rpoC763900c.531G>C0.817
rpoC763915c.546C>T0.321
rpoC763942c.573C>G0.309
rpoC763945c.576T>C0.829
rpoC763951c.582G>C0.794
rpoC763960c.591T>C0.800
rpoC763987c.618C>T0.780
rpoC763991p.Ile208Leu0.776
rpoC763996c.627T>C0.818
rpoC764002c.633C>G0.836
rpoC764005c.636G>C0.852
rpoC764020c.651C>T0.167
rpoC764024c.655T>C0.868
rpoC764032p.Asp221Glu0.860
rpoC764040p.Ser224Thr0.854
rpoC764044c.675T>C0.851
rpoC764059c.690G>T0.882
rpoC764083c.714A>G0.897
rpoC764098c.729A>G0.914
rpoC764101c.732C>G0.914
rpoC764102p.Val245Ile0.915
rpoC764112p.Tyr248Phe0.933
rpoC764116c.747C>T0.932
rpoC764131c.762T>C0.903
rpoC764188c.819A>G0.896
rpoC764195p.Ser276Ile0.881
rpoC764203c.834G>C0.867
rpoC764206c.837T>C0.855
rpoC764215c.846A>G0.873
rpoC764236c.867G>A0.875
rpoC764248c.879C>G0.873
rpoC764257c.888G>C0.892
rpoC764266c.897T>C0.889
rpoC764269c.900G>C0.887
rpoC764272c.903G>C0.881
rpoC764278c.909A>G0.906
rpoC764338c.969G>A0.851
rpoC764353c.984G>C0.870
rpoC764365c.996C>T0.877
rpoC764380c.1011G>C0.846
rpoC764381c.1012T>A0.846
rpoC764387c.1018T>C0.849
rpoC764392c.1023C>T0.123
rpoC764405c.1036A>C0.887
rpoC764419c.1050C>G0.880
rpoC764428c.1059G>C0.923
rpoC764431c.1062G>C0.903
rpoC764434c.1065A>G0.903
rpoC764446c.1077T>C0.905
rpoC764449c.1080G>C0.895
rpoC764452c.1083T>C0.895
rpoC764458c.1089G>C0.893
rpoC764461c.1092A>G0.915
rpoC764489c.1120C>T0.908
rpoC764497c.1128A>G0.877
rpoC764510c.1141C>T0.887
rpoC764521c.1152T>C0.887
rpoC764527c.1158C>T0.887
rpoC764536c.1167G>C0.815
rpoC764539c.1170C>G0.765
rpoC764548c.1179G>A0.872
rpoC764551c.1182G>C0.833
rpoC764554c.1185C>T0.840
rpoC764560c.1191T>C0.849
rpoC764566c.1197C>G0.855
rpoC764575c.1206T>G0.857
rpoC764593c.1224C>T0.877
rpoC764611c.1242G>T0.855
rpoC764650c.1281G>C0.891
rpoC764651c.1282T>A0.889
rpoC764752c.1383G>C0.943
rpoC764764c.1395T>C0.923
rpoC764809c.1440C>T0.889
rpoC764815c.1446A>G0.875
rpoC764827c.1458G>C0.855
rpoC764858c.1489T>C0.852
rpoC764872c.1503A>G0.873
rpoC764888c.1519T>C0.862
rpoC764911c.1542A>G0.924
rpoC764932c.1563C>A0.909
rpoC764948c.1579T>C0.915
rpoC764968c.1599T>C0.929
rpoC764995c.1626C>G0.940
rpoC765007c.1638T>G0.932
rpoC765008c.1639T>C0.915
rpoC765011c.1642A>T0.915
rpoC765019c.1650A>G0.942
rpoC765034c.1665T>C0.946
rpoC765040c.1671T>C0.931
rpoC765041c.1672T>C0.931
rpoC765047c.1678T>C0.931
rpoC765055c.1686C>G0.932
rpoC765073c.1704G>C0.906
rpoC765076c.1707A>G0.919
rpoC765079c.1710T>G0.918
rpoC765082c.1713G>C0.889
rpoC765089c.1720T>C0.957
rpoC765103c.1734G>T0.930
rpoC765208c.1839T>C0.364
rpoC765220c.1851A>G0.438
rpoC765233p.Ala622Ser0.389
rpoC765241c.1872C>T0.368
rpoC765244c.1875T>C0.412
rpoC765247c.1878C>G0.412
rpoC765248c.1879T>C0.412
rpoC765251c.1882A>T0.389
rpoC765292c.1923G>C0.824
rpoC765298c.1929G>C0.832
rpoC765300p.Val644Ala0.825
rpoC765319c.1950A>G0.846
rpoC765326p.His653Ala0.828
rpoC765330p.Ser654Asn0.827
rpoC765346c.1977C>G0.788
rpoC765349c.1980T>C0.800
rpoC765352c.1983G>C0.796
rpoC765364c.1995G>A0.206
rpoC765383p.Met672Leu0.852
rpoC765404p.Leu679Val0.855
rpoC765409c.2040T>C0.873
rpoC765421c.2052C>G0.862
rpoC765451c.2082C>A0.680
rpoC765478c.2109T>C0.875
rpoC765499c.2130C>G0.906
rpoC765529c.2160C>T0.896
rpoC765541c.2172C>G0.938
rpoC765553c.2184C>T0.909
rpoC765556c.2187G>C0.935
rpoC765559c.2190G>C0.935
rpoC765580c.2211G>C0.922
rpoC765613p.His748Gln0.912
rpoC765625c.2256C>G0.877
rpoC765628c.2259G>C0.140
rpoC765631p.Asp754Glu0.845
rpoC765700c.2331T>C0.850
rpoC765734c.2365T>C0.870
rpoC765739c.2370G>T0.868
rpoC765751c.2382C>G0.871
rpoC765753p.Asp795Ala0.871
rpoC765772c.2403C>G0.892
rpoC765784c.2415C>G0.912
rpoC765787c.2418C>T0.927
rpoC765793c.2424C>G0.917
rpoC765796c.2427C>T0.914
rpoC765811c.2442T>C0.922
rpoC765814c.2445A>G0.924
rpoC765826c.2457T>C0.924
rpoC765835c.2466C>T0.922
rpoC765850c.2481G>C0.917
rpoC765883c.2514C>G0.900
rpoC765886c.2517C>G0.883
rpoC765892c.2523T>C0.895
rpoC765937c.2568T>C0.902
rpoC765947c.2578T>C0.711
rpoC765967c.2598C>T0.868
rpoC765982c.2613C>G0.845
rpoC765994c.2625A>T0.827
rpoC766010c.2641T>A0.841
rpoC766021c.2652G>C0.826
rpoC766027c.2658G>C0.822
rpoC766043p.Gln892Glu0.857
rpoC766054c.2685C>G0.824
rpoC766082p.Ala905Gln0.769
rpoC766096c.2727G>C0.768
rpoC766129c.2760C>G0.780
rpoC766132c.2763C>T0.146
rpoC766135c.2766G>A0.795
rpoC766141c.2772C>T0.806
rpoC766142c.2773C>T0.806
rpoC766174p.Asn935Lys0.750
rpoC766178p.Ile937Val0.741
rpoC766312c.2943T>G0.800
rpoC766327c.2958C>A0.882
rpoC766345c.2976T>C0.889
rpoC766348c.2979A>G0.889
rpoC766357c.2988C>T0.871
rpoC766363c.2994G>C0.906
rpoC766366c.2997C>G0.886
rpoC766381c.3012C>T0.900
rpoC766384c.3015A>G0.881
rpoC766390c.3021C>T0.881
rpoC766393c.3024C>G0.884
rpoC766408c.3039C>G0.902
rpoC766411c.3042C>G0.902
rpoC766426c.3057C>T0.909
rpoC766447c.3078T>C0.938
rpoC766462c.3093G>C0.938
rpoC766483c.3114G>C0.909
rpoC766484p.Val1039Ile0.909
rpoC766492c.3123T>C0.930
rpoC766522c.3153C>G0.881
rpoC766528c.3159T>C0.889
rpoC766531c.3162G>C0.905
rpoC766540p.Asp1057Glu0.924
rpoC766549c.3180G>C0.925
rpoC766573c.3204T>C0.919
rpoC766582c.3213C>G0.881
rpoC766583p.Gly1072Ser0.881
rpoC766591c.3222A>G0.884
rpoC766594c.3225G>C0.884
rpoC766597c.3228C>G0.889
rpoC766607p.Ile1080Leu0.917
rpoC766630c.3261G>C0.924
rpoC766657c.3288A>G0.957
rpoC766672c.3303T>C0.926
rpoC766673p.Gly1102Asn0.906
rpoC766684c.3315C>T0.508
rpoC766726c.3357T>C0.925
rpoC766738c.3369G>C0.925
rpoC766765c.3396A>C0.924
rpoC766774c.3405T>C0.929
rpoC766801c.3432C>G0.924
rpoC766804c.3435A>G0.925
rpoC766861c.3492G>C0.894
rpoC766864c.3495G>C0.881
rpoC766880p.Gly1171Ser0.479
rpoC766900c.3531T>C0.836
rpoC766933c.3564A>G0.828
rpoC766945c.3576A>G0.848
rpoC766963c.3594T>C0.862
rpoC766972c.3603G>C0.833
rpoC766996c.3627C>T0.855
rpoC767009c.3640T>A0.828
rpoC767014c.3645G>C0.844
rpoC767033c.3664T>A0.864
rpoC767059c.3690T>G0.901
rpoC767062c.3693C>A0.890
rpoC767098c.3729T>C0.868
rpoC767119c.3750A>G0.847
rpoC767134c.3765C>A0.850
rpoC767158c.3789T>C0.842
rpoC767180p.Ala1271Gln0.818
rpoC767191c.3822C>G0.831
rpoC767206c.3837C>G0.804
rpoC767209c.3840T>C0.800
rpoC767212c.3843G>C0.816
rpoC767221c.3852C>G0.816
rpoC767230c.3861G>C0.826
rpoC767233c.3864T>C0.826
rpoC767263c.3894T>C0.690
rpoC767264p.Ala1299Gln0.690
rpoC767275c.3906T>C0.731
rpoC767278c.3909T>C0.769
rpoC767281c.3912C>G0.769
rpoC767284c.3915C>T0.769
rpoC767288c.3919C>T0.800
rpsL781571c.12C>T0.930
rpsL781595c.36T>C0.909
rpsL781605p.Ile16Val0.909
rpsL781608p.Ser17Ala0.945
rpsL781628c.69T>C0.222
rpsL781631c.72G>C0.952
rpsL781649c.90T>C0.931
rpsL781655c.96T>C0.934
rpsL781700c.141G>C0.884
rpsL781703c.144G>T0.879
rpsL781715c.156T>C0.886
rpsL781728c.169T>C0.870
rpsL781736c.177T>C0.866
rpsL781742c.183C>T0.855
rpsL781748c.189C>G0.845
rpsL781754c.195G>C0.222
rpsL781760c.201T>C0.819
rpsL781772c.213C>A0.816
rpsL781808c.249C>T0.806
rpsL781811c.252C>T0.797
rpsL781832c.273T>C0.859
rpsL781838c.279G>C0.844
rpsL781841c.282C>G0.844
rpsL781865c.306G>C0.833
rpsL781868c.309T>C0.844
rpsL781871c.312G>C0.844
rpsL781877c.318T>C0.870
rpsL781892c.333A>G0.836
rpsL781898c.339A>T0.849
rpsL781916c.357T>C0.847
rpsL781929p.Gly124Ser0.843
rplC800794c.-15A>G0.885
rplC800796c.-13A>G0.914
rplC800814c.6A>G0.928
rplC800817c.9A>T0.930
rplC800844c.36T>C0.912
rplC800865c.57A>G0.868
rplC800867p.Ser20Asn0.868
rplC800874c.66A>G0.865
rplC800875p.Val23Ile0.865
rplC800880c.72A>G0.865
rplC800889c.81C>G0.882
rplC800892c.84G>C0.882
rplC800907c.99C>G0.854
rplC800916c.108A>G0.881
rplC800934c.126C>G0.778
rplC800937c.129A>G0.778
rplC800939p.Arg44Gln0.778
rplC800946c.138T>C0.778
rplC800949c.141T>C0.778
rplC800967c.159C>G0.667
rplC800970c.162T>C0.636
rplC801127p.Ala107Thr0.760
rplC801132c.324T>C0.826
rplC801147c.339T>C0.833
rplC801150c.342G>C0.833
rplC801153c.345G>C0.833
rplC801156c.348T>A0.833
rplC801168c.360C>G0.917
rplC801171c.363A>G0.917
rplC801174c.366T>C0.917
rplC801180c.372C>G0.927
rplC801195c.387G>C0.896
rplC801201c.393C>T0.560
rplC801207c.399C>T0.855
rplC801246c.438C>T0.857
rplC801249c.441T>C0.857
rplC801255c.447C>T0.857
rplC801264c.456C>T0.854
rplC801267c.459A>T0.829
rplC801270c.462T>C0.806
rplC801276c.468G>C0.829
rplC801279c.471G>C0.829
rplC801282c.474G>C0.853
rplC801285c.477G>C0.853
rplC801300c.492C>G0.902
rplC801309c.501C>G0.837
rplC801312c.504G>C0.837
rplC801321c.513C>T0.812
rplC801324c.516T>C0.816
rplC801339c.531T>C0.788
rplC801341p.Leu178Gln0.788
rplC801348c.540T>G0.817
rplC801357c.549T>C0.873
rplC801367p.Ala187Thr0.860
rplC801402c.594T>C0.857
rplC801405c.597T>C0.839
rplC801423c.615G>C0.788
rplC801426c.618C>G0.769
rplC801427p.Met207Val0.769
rplC801438c.630T>C0.784
rplC801442p.Ile212Val0.776
rrs1471923r.78t>c0.878
rrs1471925r.80t>c0.878
rrs1471932r.87a>g0.875
rrs1471934r.89a>g0.878
rrs1471969r.124t>c0.795
rrs1471970r.125g>a0.763
rrs1472028r.183a>t0.783
rrs1472029r.184c>t0.783
rrs1472030r.185g>t0.783
rrs1472031r.186g>a0.783
rrs1472033r.188a>g0.750
rrs1472034r.189t>c0.750
rrs1472044r.199g>t0.774
rrs1472045r.200t>a0.774
rrs1472061r.216a>t0.861
rrs1472075r.230a>g0.900
rrs1472108r.263c>t0.936
rrs1472969r.1124a>g0.810
rrs1472970r.1125c>g0.805
rrs1472977r.1132g>c0.816
rrs1472978r.1133t>c0.816
rrs1473105r.1260g>a0.907
rrs1473120r.1275c>ct0.816
rrs1473123r.1278a>t0.868
rrs1473145r.1300c>t0.854
rrs1473166r.1321g>a0.829
rrs1473290r.1445c>t0.796
rrl1473401c.-257G>A0.167
rrl1473403c.-255C>T0.154
rrl1473408c.-250C>T0.154
rrl1473417c.-241C>T0.154
rrl1473419c.-239T>C0.182
rrl1473420c.-238A>G0.182
rrl1473421c.-237G>A0.182
rrl1473437c.-221T>C0.200
rrl1473651c.-7GT>G0.758
rrl1473658r.1t>a0.806
rrl1473659r.2t>a0.806
rrl1473668r.11c>t0.833
rrl1473756r.99g>a0.977
rrl1473758r.101g>t0.978
rrl1473806r.149c>t0.921
rrl1473877r.220g>a0.822
rrl1473898r.241c>t0.826
rrl1473943r.286g>t0.864
rrl1473945r.288t>a0.864
rrl1473946r.289a>t0.864
rrl1473986r.329t>c0.848
rrl1473987r.330g>a0.867
rrl1473995r.338g>t0.907
rrl1474001r.344c>t0.884
rrl1474009r.352a>g0.875
rrl1474012r.355c>t0.875
rrl1474093r.436g>t0.873
rrl1474099r.442g>a0.871
rrl1474103r.446a>t0.873
rrl1474140r.483c>t0.836
rrl1474151r.494c>t0.855
rrl1474181r.524c>t0.889
rrl1474249r.592g>t0.891
rrl1474291r.634tttcctctccggagga>t0.943
rrl1474308r.651g>t0.917
rrl1474310r.653t>g0.880
rrl1474356r.699t>c0.842
rrl1474362r.705a>g0.875
rrl1474376r.719t>c0.889
rrl1474427r.770a>c0.714
rrl1474429r.772g>c0.714
rrl1474432r.775c>g0.682
rrl1474639r.982g>a0.877
rrl1474794r.1137c>t0.958
rrl1474812r.1155g>a0.978
rrl1474823r.1166c>t0.979
rrl1474831r.1174a>g0.980
rrl1474904r.1247g>a1.000
rrl1474956r.1299c>t1.000
rrl1474960r.1303c>g0.979
rrl1474963r.1306g>t1.000
rrl1474964r.1307t>a0.977
rrl1474965r.1308g>c0.977
rrl1474970r.1313g>a1.000
rrl1475006r.1349a>t0.944
rrl1475061r.1404c>t0.860
rrl1475088r.1431a>t0.848
rrl1475199r.1542g>a0.930
rrl1475206r.1549c>t0.884
rrl1475209r.1552g>c0.923
rrl1475213r.1556c>t0.902
rrl1475249r.1592t>c0.878
rrl1475252r.1595c>t0.878
rrl1475266r.1609t>c0.880
rrl1475267r.1610g>a0.860
rrl1475275r.1618c>t0.898
rrl1475276r.1619t>c0.917
rrl1475291r.1634a>c0.923
rrl1475313r.1656g>a0.170
rrl1475315r.1658a>t0.913
rrl1475355r.1698c>t0.933
rrl1475369r.1712g>t0.921
rrl1475402r.1745c>t0.971
rrl1475419r.1762c>t1.000
rrl1475429r.1772g>a0.966
rrl1475436r.1779c>t0.963
rrl1475483r.1826c>t1.000
rrl1475505r.1848g>a1.000
rrl1475526r.1869c>a0.957
rrl1475599r.1942a>g0.963
rrl1475608r.1951t>c0.964
rrl1475642r.1985t>c0.912
rrl1475657r.2000a>g0.902
rrl1475659r.2002g>t0.905
rrl1475758r.2101ac>a0.870
rrl1475763r.2106c>t0.870
rrl1475765r.2108ag>a0.870
rrl1475881r.2224t>c0.820
rrl1475988r.2331a>g0.846
rrl1476031r.2374c>t0.882
rrl1476032r.2375c>a0.879
rrl1476033r.2376t>c0.879
rrl1476034r.2377c>a0.879
rrl1476045r.2388g>t0.906
rrl1476047r.2390g>t0.906
rrl1476048r.2391g>a0.906
rrl1476049r.2392c>t0.906
rrl1476086r.2429g>a0.977
rrl1476089r.2432t>c0.975
rrl1476095r.2438c>g0.952
rrl1476106r.2449a>t0.914
rrl1476108r.2451t>c0.657
rrl1476115r.2458t>c0.914
rrl1476117r.2460g>c0.914
rrl1476214r.2557g>a0.884
rrl1476224r.2567a>g0.886
rrl1476281r.2624t>c0.952
rrl1476583r.2926g>a0.885
rrl1476584r.2927c>t0.887
rrl1476594r.2937c>t0.887
rrl1476597r.2940g>a0.887
rrl1476603r.2946g>a0.887
rrl1476608r.2951c>g0.885
rrl1476628r.2971t>a0.880
rrl1476689r.3032a>t0.951
rrl1476690r.3033c>t0.951
rrl1476693r.3036g>a0.951
rrl1476695r.3038t>a0.952
rrl1476716r.3059a>c0.952
rrl1476726r.3069a>g0.950
rrl1476732r.3075t>c0.971
rrl1476733r.3076c>t0.265
rrl1476750r.3093t>c0.966
rrl1476755r.3098g>a0.933
rrl1476759r.3102t>c0.933
rrl1476770r.3113t>c0.929
rrl1476771r.3114g>a0.929
fabG11673473p.Pro12Ala0.571
fabG11673482p.Ser15Ala0.848
fabG11673487c.48T>C0.851
fabG11673490c.51A>G0.886
fabG11673523c.84G>T0.914
fabG11673535c.96A>G0.912
fabG11673547c.108T>C0.900
fabG11673568c.129C>G0.833
fabG11673574c.135C>G0.843
fabG11673580c.141T>G0.810
fabG11673589c.150A>G0.821
fabG11673595c.156A>C0.650
fabG11673596p.Lys53Glu0.632
fabG11673601c.162G>C0.158
fabG11673602c.163C>T0.579
fabG11673607c.168T>C0.667
fabG11673615p.Glu59Val0.632
fabG11673619c.180T>C0.684
fabG11673633p.Ser65Asn0.647
fabG11673637p.Asp66Glu0.600
fabG11673641p.Val68Ile0.625
fabG11673646c.207T>C0.667
fabG11673657p.Thr73Lys0.667
fabG11673660p.Ala74Glu0.692
fabG11673664c.225A>C0.643
fabG11673667c.228A>G0.722
fabG11673679c.240T>C0.769
fabG11673685c.246C>T0.710
fabG11673703c.264C>T0.387
fabG11673710p.Leu91Ile0.781
fabG11673716p.Ala93Lys0.806
fabG11673733p.Met98Ile0.839
fabG11673742c.303C>T0.387
fabG11673748c.309A>G0.815
fabG11673749p.Lys104Arg0.815
fabG11673758p.Lys107Glu0.786
fabG11673853c.414A>C0.200
fabG11673856c.417T>C0.385
fabG11673890p.Ala151Ser0.862
fabG11673901c.462A>G0.862
fabG11673905p.Ser156Ala0.868
fabG11673916c.477A>C0.886
fabG11673917p.Val160Leu0.886
fabG11673922c.483T>C0.889
fabG11673941p.Ala168Ser0.909
fabG11673946c.507C>G0.158
fabG11673955c.516G>C0.930
fabG11673961c.522A>C0.929
fabG11673985c.546C>G0.943
fabG11674006p.Asp189Glu0.929
fabG11674015c.576C>T0.862
fabG11674018c.579G>C0.852
fabG11674021c.582G>C0.852
fabG11674024c.585T>C0.852
fabG11674033c.594T>C0.875
fabG11674037p.Gln200Ala0.840
fabG11674042c.603G>T0.840
fabG11674049p.Gln204Asp0.840
fabG11674054c.615T>C0.840
fabG11674060c.621A>G0.885
fabG11674063c.624G>C0.885
fabG11674079p.Pro214Ala0.923
fabG11674114c.675T>A0.885
fabG11674123c.684T>C0.877
fabG11674126c.687G>C0.845
fabG11674132c.693T>C0.852
fabG11674136p.Ser233Ala0.849
fabG11674141c.702T>C0.843
fabG11674156c.717C>G0.830
fabG11674171c.732T>C0.725
inhA1674185c.-17A>T0.188
inhA1674237c.36T>C0.154
inhA1674471c.270G>C0.804
inhA1674480c.279T>C0.870
inhA1674486c.285T>C0.879
inhA1674504c.303C>G0.879
inhA1674533p.Ala111Val0.258
inhA1674537c.336C>G0.898
inhA1674542p.Ala114Glu0.867
inhA1674546c.345T>C0.877
inhA1674549c.348G>C0.877
inhA1674552c.351C>G0.879
inhA1674555c.354G>A0.883
inhA1674561c.360C>T0.929
inhA1674582c.381T>C0.914
inhA1674585c.384T>C0.912
inhA1674589p.Met130Leu0.900
inhA1674601p.Leu134Thr0.886
inhA1674624c.423A>C0.896
inhA1674630c.429C>G0.889
inhA1674660c.459G>C0.838
inhA1674672c.471C>G0.815
inhA1674703c.502T>C0.870
inhA1674708c.507G>A0.838
inhA1674718c.517A>C0.882
inhA1674723c.522C>T0.851
inhA1674738c.537C>G0.792
inhA1674741c.540C>T0.787
inhA1674746p.Tyr182Phe0.771
inhA1674750c.549T>C0.766
inhA1674753c.552G>C0.766
inhA1674756c.555T>C0.766
inhA1674759c.558G>C0.771
inhA1674774c.573A>G0.873
inhA1674780c.579T>G0.879
inhA1674789c.588G>C0.875
inhA1674801c.600T>C0.864
inhA1674822c.621C>G0.839
inhA1674828c.627G>A0.844
inhA1674846p.Ile215Met0.857
inhA1674855c.654C>G0.792
inhA1674864c.663C>T0.863
inhA1674870c.669T>C0.868
inhA1674879c.678T>C0.857
inhA1674903c.702T>C0.864
inhA1674904p.Ala235Pro0.864
inhA1674909c.708G>A0.884
inhA1674942c.741T>G0.805
inhA1674960c.759C>G0.789
inhA1674966c.765T>G0.758
inhA1674967p.Asp256Thr0.758
inhA1674987c.786C>T0.629
rpsA1833512c.-30AC>A0.838
rpsA1833518c.-24C>A0.854
rpsA1833532c.-10A>C0.884
rpsA1833554p.Thr5Ala0.925
rpsA1833568c.27G>C0.895
rpsA1833589c.48A>T0.918
rpsA1833595c.54T>C0.919
rpsA1833661c.120A>G0.905
rpsA1833667c.126C>G0.891
rpsA1833721c.180A>G0.875
rpsA1833724c.183C>G0.875
rpsA1833727c.186G>C0.881
rpsA1833742c.201A>G0.893
rpsA1833745c.204G>C0.891
rpsA1833748c.207C>G0.870
rpsA1833787c.246C>G0.862
rpsA1833790c.249T>C0.862
rpsA1833802c.261A>G0.883
rpsA1833811c.270G>T0.850
rpsA1833838c.297G>C0.838
rpsA1833841c.300C>G0.838
rpsA1833847c.306C>G0.822
rpsA1833856c.315A>G0.818
rpsA1833874c.333T>C0.829
rpsA1833928c.387G>C0.833
rpsA1833940c.399C>G0.829
rpsA1833971c.430C>T0.863
rpsA1833979c.438T>C0.892
rpsA1834000c.459G>C0.899
rpsA1834021c.480C>T0.880
rpsA1834030c.489C>G0.885
rpsA1834099c.558C>G0.923
rpsA1834102c.561T>C0.938
rpsA1834105c.564C>G0.922
rpsA1834108c.567C>G0.910
rpsA1834123c.582C>G0.885
rpsA1834150c.609G>C0.851
rpsA1834153c.612T>C0.848
rpsA1834154p.Asn205Gln0.848
rpsA1834157c.616T>C0.848
rpsA1834162c.621A>G0.848
rpsA1834165c.624A>G0.848
rpsA1834169p.Thr210Ala0.857
rpsA1834177c.636A>C1.000
rpsA1834189c.648G>C0.897
rpsA1834195c.654G>C0.903
rpsA1834210c.669C>T0.901
rpsA1834222c.681T>C0.918
rpsA1834231c.690T>C0.917
rpsA1834234c.693G>C0.919
rpsA1834249c.708T>C0.914
rpsA1834261c.720A>G0.926
rpsA1834262c.721T>A0.961
rpsA1834303c.762T>C0.949
rpsA1834306c.765T>C0.948
rpsA1834333c.792C>T0.915
rpsA1834348c.807T>C0.933
rpsA1834366c.825A>G0.968
rpsA1834396c.855G>C0.940
rpsA1834411c.870T>C0.941
rpsA1834417c.876G>C0.941
rpsA1834423c.882G>C0.946
rpsA1834435c.894G>C0.939
rpsA1834451c.910T>C0.925
rpsA1834465c.924T>C0.924
rpsA1834468c.927A>G0.935
rpsA1834489c.948T>C0.938
rpsA1834510c.969C>T0.913
rpsA1834513c.972C>G0.899
rpsA1834528c.987T>C0.905
rpsA1834540c.999G>C0.857
rpsA1834546c.1005T>C0.915
rpsA1834609c.1068T>C0.896
rpsA1834633c.1092A>G0.872
rpsA1834639c.1098T>C0.894
rpsA1834654p.Glu371Asp0.875
rpsA1834684c.1143C>T0.906
rpsA1834690c.1149T>C0.927
rpsA1834732c.1191T>C0.887
rpsA1834733p.Ala398Ser0.885
rpsA1834738c.1197A>G0.873
rpsA1834753c.1212T>C0.892
rpsA1834765p.Glu408Asp0.881
rpsA1834775p.Ala412Thr0.871
rpsA1834780c.1239A>G0.897
rpsA1834786c.1245A>G0.875
rpsA1834789c.1248T>C0.877
rpsA1834792c.1251G>C0.880
rpsA1834849c.1308C>G0.731
rpsA1834852c.1311C>G0.780
tlyA1917940p.Val1Met0.625
tlyA1917943p.Ala2Ser0.650
tlyA1917951c.12T>C0.755
tlyA1917972c.33A>G1.000
tlyA1917975c.36C>G0.770
tlyA1917981c.42G>C0.850
tlyA1917990c.51G>C0.850
tlyA1917993c.54A>G0.850
tlyA1917996c.57A>G0.850
tlyA1918002c.63A>G0.859
tlyA1918036p.Arg33Ser0.870
tlyA1918048p.Leu37Met0.848
tlyA1918057p.Val40Arg0.758
tlyA1918065c.126G>C0.750
tlyA1918067p.Ala43Gly0.778
tlyA1918077c.138G>C0.731
tlyA1918078p.Ser47Ala0.731
tlyA1918082p.Asp48Val0.760
tlyA1918087p.Thr50Ala0.792
tlyA1918092c.153G>C0.792
tlyA1918103p.Val55Ala0.688
tlyA1918111p.Ser58Gly0.500
tlyA1918121p.Ala61Gly0.500
tlyA1918128c.189A>C0.467
tlyA1918137c.198A>C0.462
tlyA1918310p.Asn124Ser0.625
tlyA1918315p.Pro126Ala0.625
tlyA1918323c.384G>C0.588
tlyA1918326c.387G>C0.556
tlyA1918330p.Leu131Val0.556
tlyA1918346p.Ala136Val0.526
tlyA1918352p.Gly138Asp0.526
tlyA1918356c.417C>G0.526
tlyA1918359c.420A>G0.500
tlyA1918362c.423G>C0.500
tlyA1918377c.438T>G0.556
tlyA1918379p.Arg147Pro0.526
tlyA1918382p.Val148Ala0.300
tlyA1918389c.450G>C0.550
tlyA1918392c.453A>C0.550
tlyA1918422c.483T>C0.500
tlyA1918425c.486C>A0.471
tlyA1918434c.495C>G0.273
katG2154724p.Arg463Leu1.000
katG2155080c.1032C>G0.462
katG2155092c.1020C>T0.438
katG2155113c.999G>C0.438
katG2155119c.993A>G0.438
katG2155131c.981T>C0.438
katG2155145p.Asn323Pro0.467
katG2155152c.960T>G0.538
katG2155155c.957G>C0.583
katG2155179c.933G>A0.438
katG2155185c.927A>G0.467
katG2155190p.Thr308Ser0.467
katG2155191c.921T>A0.467
katG2155200c.912A>G0.467
katG2155626c.486C>G0.667
katG2155632c.480T>G0.700
katG2155637p.Leu159Ile0.714
katG2155641p.Lys157Asn0.750
katG2155661p.Val151Ile0.875
katG2155677c.435G>C0.868
katG2155680c.432C>G0.868
katG2155691c.421A>G0.894
katG2155695c.417G>C0.857
katG2155704c.408G>C0.840
katG2155716c.396A>C0.827
katG2155722c.390C>G0.815
katG2155728c.384C>G0.741
katG2155742p.Gly124Gln0.731
katG2155743c.369C>G0.725
katG2155782c.330G>C0.595
katG2155785c.327A>G0.581
katG2155796p.Ala106Ser0.345
katG2155806c.306A>G0.345
katG2155836c.276G>C0.125
kasA2518121p.Gln3Lys0.682
kasA2518132c.18C>T0.714
kasA2518138c.24T>C0.793
kasA2518146p.Phe11Tyr0.828
kasA2518162c.48G>A0.882
kasA2518174c.60A>G0.878
kasA2518190p.Ser26Ala0.889
kasA2518199p.Ile29Val0.889
kasA2518220c.106C>T0.796
kasA2518234c.120G>A0.767
kasA2518248p.Ala45Val0.714
kasA2518261p.Glu49Asp0.692
kasA2518263p.Phe50Tyr0.667
kasA2518265p.Val51Ile0.649
kasA2518396c.282A>G0.273
kasA2518403c.289T>A0.400
kasA2518413p.Ser100Asn0.667
kasA2518421p.Val103Leu0.750
kasA2518429c.315A>C0.739
kasA2518439p.Ala109Ser0.783
kasA2518444c.330T>C0.783
kasA2518447c.333T>G0.741
kasA2518459c.345T>C0.784
kasA2518462c.348A>C0.795
kasA2518468c.354A>C0.821
kasA2518474c.360G>A0.837
kasA2518480c.366T>C0.860
kasA2518483c.369C>G0.872
kasA2518504c.390T>C0.897
kasA2518506p.Ala131Glu0.897
kasA2518519c.405G>C0.905
kasA2518528c.414C>G0.910
kasA2518540c.426T>C0.915
kasA2518561c.447T>C0.881
kasA2518567c.453G>C0.857
kasA2518570c.456G>C0.851
kasA2518573c.459G>C0.787
kasA2518574p.Ile154Val0.833
kasA2518579c.465T>C0.833
kasA2518588c.474T>C0.854
kasA2518591c.477G>C0.854
kasA2518609p.Met165Ile0.867
kasA2518624c.510C>G0.811
kasA2518639c.525G>C0.789
kasA2518657c.543G>C0.816
kasA2518672c.558G>C0.806
kasA2518678c.564C>T0.806
kasA2518684c.570C>G0.806
kasA2518693c.579C>G0.600
kasA2518696c.582C>G0.833
kasA2518702c.588C>T0.871
kasA2518705c.591T>C0.875
kasA2518711c.597A>G0.914
kasA2518714c.600A>C0.917
kasA2518732c.618C>G0.904
kasA2518744c.630C>T0.922
kasA2518747c.633C>G0.925
kasA2518768c.654C>T0.932
kasA2518777c.663C>T0.897
kasA2518783c.669T>C0.905
kasA2518789c.675G>C0.887
kasA2518792c.678C>A0.884
kasA2518795c.681C>G0.892
kasA2518825c.711T>C0.919
kasA2518864c.750G>C0.904
kasA2518879c.765A>G0.919
kasA2518885c.771T>C0.915
kasA2518898c.784T>C0.885
kasA2518906c.792A>G0.860
kasA2518910p.Leu266Met0.860
kasA2518921c.807T>C0.925
kasA2518936c.822C>G0.875
kasA2518939c.825T>C0.909
kasA2518942c.828T>C0.909
kasA2518951c.837G>C0.857
kasA2518954c.840C>G0.810
kasA2518963c.849T>C0.765
kasA2518969c.855T>G0.765
kasA2518975c.861C>G0.750
kasA2518979c.865A>C0.714
kasA2519050c.936C>G0.846
kasA2519053c.939G>C0.846
kasA2519056c.942G>C0.829
kasA2519062c.948T>G0.837
kasA2519068c.954C>T0.840
kasA2519072p.Ala320Thr0.840
kasA2519095c.981C>A0.625
kasA2519107c.993T>C0.812
kasA2519108p.Asp332Gln0.800
kasA2519116c.1002C>G0.640
kasA2519122c.1008G>C0.808
kasA2519137c.1023T>G0.833
kasA2519158c.1044C>T0.831
kasA2519167c.1053T>G0.843
kasA2519173c.1059C>G0.836
kasA2519196p.Thr361Ser0.804
kasA2519215c.1101C>T0.786
kasA2519218c.1104G>A0.741
kasA2519221c.1107G>C0.840
kasA2519227c.1113G>C0.800
kasA2519230c.1116C>T0.800
kasA2519236c.1122G>A0.826
kasA2519239c.1125A>C0.826
kasA2519245c.1131T>C0.826
eis2714846p.Val163Ile0.933
eis2715212p.Pro41Thr0.154
ahpC2726198c.6A>T0.722
ahpC2726204c.12A>G0.762
ahpC2726210c.18T>C0.762
ahpC2726216c.24T>C0.762
ahpC2726219c.27A>G0.727
ahpC2726232p.Gln14Glu0.792
ahpC2726243c.51T>G0.800
ahpC2726244c.52C>T0.800
ahpC2726251p.Gly20Ala0.808
ahpC2726255c.63T>C0.815
ahpC2726258c.66C>T0.821
ahpC2726303c.111T>C0.841
ahpC2726311p.Ser40Asn0.733
ahpC2726315p.Asp41Glu0.733
ahpC2726318p.Glu42Asp0.733
ahpC2726322p.Pro44Ala0.710
ahpC2726330c.138G>A0.710
ahpC2726336c.144G>C0.688
ahpC2726348c.156T>C0.667
ahpC2726357c.165A>G0.647
ahpC2726366c.174G>C0.656
ahpC2726378c.186T>G0.633
ahpC2726387c.195C>T0.522
ahpC2726390c.198G>C0.500
ahpC2726393c.201G>C0.500
ahpC2726397p.Ser69Gly0.500
ahpC2726408c.216T>C0.500
ahpC2726414c.222G>A0.333
ahpC2726506p.Thr105Lys0.273
ahpC2726508c.316T>C0.300
ahpC2726528c.336C>G0.500
ahpC2726540c.348C>G0.500
ahpC2726543c.351A>G0.500
ahpC2726546c.354C>G0.500
ahpC2726551p.Gln120Leu0.500
ahpC2726556p.Ala122Thr0.500
ahpC2726561c.369T>C0.538
ahpC2726564c.372C>G0.538
ahpC2726591c.399C>G0.767
ahpC2726593p.Val134Ala0.767
ahpC2726600c.408T>C0.788
ahpC2726601p.Ile137Leu0.794
ahpC2726638p.Ala149Val0.857
ahpC2726645c.453C>G0.860
ahpC2726657c.465A>C0.830
ahpC2726669p.Asp159Glu0.818
ahpC2726672c.480G>A0.812
ahpC2726675c.483A>G0.812
ahpC2726681c.489A>C0.788
ahpC2726687c.495C>G0.758
ahpC2726693c.501C>G0.758
ahpC2726696c.504C>G0.758
ahpC2726709c.517C>T0.545
ahpC2726717c.525A>G0.727
ahpC2726747c.555A>C0.682
folC2746365p.Leu412Val0.727
folC2746375c.1224C>G0.781
folC2746390c.1209C>G0.794
folC2746393c.1206G>C0.794
folC2746401p.Ser400Ala0.794
folC2746402c.1197A>G0.794
folC2746416p.Glu395Gln0.818
folC2746420c.1179T>G0.818
folC2746426c.1173C>G0.844
folC2746438c.1161C>G0.844
folC2746451p.Gly383Ala0.818
folC2746471c.1128G>T0.771
folC2746478p.Phe374Tyr0.714
folC2746480c.1119T>G0.714
folC2746558c.1041C>A0.182
folC2746564c.1035T>C0.182
folC2746576c.1023G>C0.182
folC2746584c.1015A>G0.182
folC2746591c.1008G>C0.182
folC2746594c.1005A>G0.182
folC2746599p.Thr334Ala0.182
folC2746609c.990A>G0.200
folC2746615c.984G>C0.200
folC2746618c.981C>G0.200
folC2746621c.978G>A0.200
folC2746624c.975G>C0.200
folC2746627p.Asp324Glu0.200
folC2746631p.Gly323Val0.182
folC2746651c.948A>G0.182
folC2747021p.Val193Ala0.545
folC2747023c.576G>C0.636
folC2747026c.573G>C0.625
folC2747032c.567T>G0.773
folC2747059c.540A>G0.839
folC2747062c.537T>C0.806
folC2747065c.534G>A0.781
folC2747071c.528G>C0.735
folC2747086c.513T>G0.765
folC2747089c.510C>G0.765
folC2747101c.498C>G0.758
folC2747107c.492C>G0.735
folC2747110c.489A>G0.735
folC2747113c.486G>C0.676
folC2747116c.483C>G0.676
folC2747134c.465G>C0.658
folC2747224c.375C>G0.710
folC2747239c.360A>G0.771
folC2747248c.351C>G0.822
folC2747264p.Gly112Ala0.891
folC2747266c.333G>A0.891
folC2747275c.324A>G0.877
folC2747289p.Pro104Ala0.898
folC2747290c.309T>C0.898
folC2747293c.306C>T0.900
folC2747302c.297T>C0.914
folC2747314c.285T>G0.882
folC2747317c.282G>C0.863
folC2747343p.Val86Ile0.863
folC2747355p.Val82Ile0.855
folC2747359c.240G>C0.853
folC2747362c.237C>G0.846
folC2747394p.Ile69Val0.792
folC2747395c.204A>G0.809
folC2747407c.192A>G0.609
folC2747415p.Arg62Cys0.571
folC2747419c.180G>C0.524
folC2747422c.177C>T0.571
folC2747425c.174G>A0.571
folC2747442c.157A>G0.571
folC2747467p.Asp44Glu0.583
ribD2986959p.Leu41Val0.267
ribD2986978p.Ser47Thr0.438
ribD2986983p.Leu49Val0.438
ribD2986997c.159T>C0.538
ribD2987001p.Val55Ser0.538
ribD2987005p.Asp56Gly0.538
ribD2987011p.Thr58Ser0.571
ribD2987026p.Ala63Gly0.878
ribD2987033c.195C>G0.881
ribD2987042c.204A>G0.902
ribD2987046p.Val70Ile0.902
ribD2987058c.220T>C0.925
ribD2987066c.228A>G0.925
ribD2987069c.231T>C0.925
ribD2987092p.Val85Ala0.902
ribD2987105c.267C>G0.868
ribD2987108c.270T>C0.868
thyX3067223c.723C>G0.818
thyX3067232c.714G>C0.817
thyX3067246p.Thr234Ala0.836
thyX3067249p.Thr233Ser0.836
thyX3067252p.Val232Ile0.836
thyX3067272p.Ala225Glu0.413
thyX3067274c.672G>C0.839
thyX3067277c.669G>C0.833
thyX3067281p.Val222Ala0.820
thyX3067284p.Ala221Gly0.774
thyX3067286c.660G>C0.774
thyX3067289c.657G>C0.774
thyX3067292c.654C>T0.788
thyX3067295c.651G>A0.792
thyX3067313c.633C>A0.273
thyX3067316c.630T>C0.864
thyX3067325c.621T>C0.871
thyX3067349c.597C>G0.862
thyX3067355c.591T>G0.884
thyX3067367c.579C>G0.888
thyX3067373c.573G>C0.871
thyX3067379c.567G>A0.643
thyX3067391c.555C>G0.889
thyX3067394c.552C>G0.900
thyX3067439c.507T>C0.933
thyX3067442c.504G>A0.227
thyX3067445c.501G>C0.921
thyX3067457c.489G>C0.933
thyX3067462c.484G>A0.917
thyX3067465p.Ile161Val0.944
thyX3067466c.480C>G0.931
thyX3067475c.471T>C0.907
thyX3067491p.Ala152Glu0.606
thyX3067493c.453T>C0.917
thyX3067510c.436G>A0.291
thyX3067515p.Ser144Thr0.918
thyX3067531p.Ala139Ser0.911
thyX3067545p.Glu134Ala0.910
thyX3067549p.Thr133Ala0.900
thyX3067556p.His130Gln0.897
thyX3067559c.387G>C0.897
thyX3067565p.Asp127Glu0.901
thyX3067570p.Ala126Pro0.893
thyX3067577c.369C>T0.908
thyX3067602p.Arg115His0.920
thyX3067611p.Lys112Thr0.936
thyX3067619c.327T>G0.948
thyX3067631c.315G>C0.945
thyX3067634c.312G>C0.947
thyX3067652c.294A>G0.961
thyX3067661c.285G>C0.947
thyX3067685c.261T>G0.958
thyX3067693p.Ile85Leu0.915
thyX3067694c.252C>G0.931
thyX3067702p.Ile82Val0.725
thyX3067718c.228G>C0.941
thyX3067721c.225A>G0.939
thyX3067727c.219T>G0.928
thyX3067736c.210G>A0.926
thyX3067762p.Arg62Lys0.922
thyX3067765p.Leu61Ile0.909
thyX3067772c.174G>C0.221
thyX3067775c.171G>A0.227
thyX3067781c.165G>C0.910
thyX3067793c.153A>G0.922
thyX3067799c.147C>T0.933
thyX3067802c.144G>C0.937
thyX3067814c.132A>G0.951
thyX3067850c.96T>G0.850
thyX3067869p.Thr26Ser0.860
thyX3067874c.72G>C0.860
thyX3067877c.69C>G0.855
thyX3067883c.63G>C0.839
thyX3067886c.60T>G0.855
thyX3067889c.57G>C0.860
thyX3067898p.Asp16Glu0.873
thyX3067935p.Thr4Ile0.769
thyX3067951c.-6A>G0.500
thyA3073812c.660G>C0.865
thyA3073815c.657C>T0.842
thyA3073824c.648T>C0.850
thyA3073827c.645T>C0.829
thyA3073839c.633A>G0.837
thyA3073860c.612G>C0.830
thyA3073863c.609A>G0.872
thyA3073866c.606G>C0.830
thyA3073874p.Ile200Val0.872
thyA3073892c.580A>G0.872
thyA3073898p.Ala192Ser0.848
thyA3073917c.555G>C0.786
thyA3073920c.552G>C0.780
thyA3073925c.547A>G0.800
thyA3073929c.543A>G0.795
thyA3073941c.531G>A0.656
thyA3073953c.519A>G0.591
thyA3073956c.516C>G0.429
thyA3073959c.513A>G0.400
thyA3073977c.495T>C0.429
thyA3073983c.489G>A0.353
thyA3073989c.483A>G0.500
thyA3074004c.468A>G0.571
thyA3074010c.462G>C0.571
thyA3074028c.444C>G0.667
thyA3074031c.441A>G0.683
thyA3074037c.435G>C0.705
thyA3074053p.Arg140Gln0.745
thyA3074057p.Glu139Pro0.745
thyA3074061c.411T>C0.750
thyA3074079c.393C>G0.790
thyA3074097c.375G>C0.828
thyA3074102p.Asp124Asn0.841
thyA3074106c.366A>G0.864
thyA3074127c.345C>G0.853
thyA3074130c.342C>G0.857
thyA3074147p.Ile109Val0.868
thyA3074159p.Ser105Thr0.763
thyA3074160c.312T>C0.763
thyA3074165p.Ala103Thr0.750
thyA3074172c.300C>G0.762
thyA3074175c.297T>C0.767
thyA3074181c.291T>C0.800
thyA3074187c.285A>G0.792
thyA3074205p.Glu89Asp0.836
thyA3074214c.258A>G0.849
thyA3074244c.228T>C0.778
thyA3074263p.Gly70Ala0.743
thyA3074267p.Ile69Val0.722
thyA3074268c.204A>G0.722
thyA3074285c.187A>G0.677
thyA3074286c.186A>G0.677
thyA3074297c.175G>A0.308
thyA3074301c.171G>A0.182
thyA3074305p.Ala56Val0.182
thyA3074307c.165T>C0.182
thyA3074313c.159T>C0.182
thyA3074318p.Phe52Leu0.182
thyA3074319c.153A>G0.154
thyA3074322c.150G>C0.154
thyA3074325c.147T>C0.154
thyA3074334c.138A>G0.684
thyA3074360c.112A>G0.707
thyA3074361c.111A>G0.707
thyA3074372p.Met34Leu0.763
thyA3074377p.Gln32Arg0.744
thyA3074391c.81G>T0.750
thyA3074397c.75T>C0.769
thyA3074423p.Pro17Ala0.526
thyA3074427c.45A>T0.357
thyA3074432p.Thr14Glu0.364
thyA3074433p.Glu13Asp0.364
thyA3074444p.Phe10Leu0.333
thyA3074445c.27G>T0.333
thyA3074448c.24C>G0.308
thyA3074463c.9T>G0.308
thyA3074471p.Val1Pro0.333
ald3087641c.822T>C0.400
ald3087647c.828A>G0.421
ald3087649p.Gly277Asp0.444
ald3087653c.834A>G0.444
ald3087656c.837A>G0.500
ald3087665c.846C>G0.500
ald3087666p.Tyr283His0.500
ald3087672p.His285Asp0.688
ald3087680c.861G>C0.737
ald3087704c.885T>C0.763
ald3087716c.897G>C0.744
ald3087726p.Ala303Ser0.763
ald3087729p.Ser304Ala0.763
ald3087737c.918G>C0.763
ald3087749c.930C>G0.724
ald3087750p.Tyr311Val0.724
ald3087761c.942C>G0.778
ald3087770c.951G>C0.808
ald3087787p.Glu323Ala0.750
ald3087791c.972T>C0.778
ald3087797p.Asp326Glu0.765
ald3087799p.His327Arg0.765
ald3087809c.990G>T0.750
fbiA3640291c.-252T>C0.714
fbiA3640307c.-236C>A0.714
fbiA3640347c.-196A>G0.692
fbiA3640349c.-194A>G0.692
fbiA3640350c.-193C>T0.692
fbiA3640365c.-178C>G0.750
alr3840919p.Gly168Arg0.273
alr3840920c.501C>T0.211
alr3840926c.495A>G0.619
alr3840932c.489G>A0.174
alr3840944c.477A>G0.812
alr3840947c.474C>G0.818
alr3840959c.462C>G0.875
alr3840968c.453C>G0.886
alr3840980c.441C>G0.854
alr3840989c.432C>G0.854
alr3840994p.His143Asp0.872
alr3840997c.424C>G0.854
alr3841001c.420T>C0.837
alr3841010c.411T>C0.881
alr3841018p.Leu135Glu0.885
alr3841022c.399G>C0.892
alr3841028c.393C>G0.900
alr3841033p.Val130Ile0.877
alr3841037c.384C>G0.872
alr3841059p.Gly121Ala0.681
alr3841069p.Ile118Phe0.851
alr3841076c.345C>T0.175
alr3841079c.342A>G0.833
alr3841100c.321T>C0.712
alr3841105p.Thr106Arg0.684
alr3841108p.Ile105Val0.696
alr3841112c.309A>G0.709
alr3841115c.306A>G0.714
alr3841127c.294T>C0.702
alr3841133c.288C>T0.123
alr3841148c.273G>C0.280
alr3841151c.270G>C0.208
panD4044057c.225G>T0.800
panD4044072c.210G>C0.811
panD4044075c.207A>G0.816
panD4044081c.201A>G0.805
panD4044084c.198A>G0.810
panD4044105c.177C>G0.833
panD4044117c.165C>G0.804
panD4044120c.162T>G0.804
panD4044123c.159A>G0.804
panD4044126c.156A>G0.804
panD4044138c.144A>G0.818
panD4044150c.132T>C0.833
panD4044165c.117C>G0.774
panD4044174c.108G>C0.756
panD4044177c.105G>C0.738
panD4044188c.94A>G0.703
panD4044189c.93G>A0.694
panD4044195c.87A>G0.686
panD4044213c.69G>C0.593
embC4240105c.243C>T0.615
embC4240123c.261C>G0.667
embC4240126c.264C>T0.667
embC4240141c.279A>G0.615
embC4240145p.Ala95Thr0.615
embC4240154p.Gln98Gly0.615
embC4240160p.Thr100Ala0.615
embC4240178c.316T>C0.600
embC4240183c.321A>G0.600
embC4240204c.342T>C0.692
embC4240444c.582C>G0.294
embC4240459c.597G>C0.312
embC4240462c.600G>C0.312
embC4240471c.609C>T0.312
embC4240474c.612G>C0.312
embC4240475p.Ala205Ser0.312
embC4240484p.Ala208Thr0.294
embC4240489c.627A>G0.278
embC4240492c.630G>C0.294
embC4240495c.633T>G0.294
embC4240505p.Ser215Ala0.308
embC4240512p.Ser217Thr0.385
embC4240516c.654G>C0.385
embC4240519c.657T>C0.357
embC4240543c.681G>C0.400
embC4240558c.696C>G0.286
embC4240561c.699C>G0.333
embC4240600c.738G>C0.300
embC4240610p.Ile250Arg0.200
embC4240615c.753G>C0.333
embC4240630c.768C>A0.556
embC4240632p.Met257Thr0.611
embC4240642c.780G>C0.714
embC4240645c.783G>C0.714
embC4240651c.789G>A0.208
embC4240654c.792C>G0.522
embC4240660c.798C>G0.480
embC4240669c.807G>C0.792
embC4240671p.Thr270Ile0.792
embC4240677p.Gly272Ala0.826
embC4240685p.Thr275Ala0.895
embC4240693c.831T>G0.884
embC4240699c.837C>G0.886
embC4240726c.864G>C0.909
embC4240780c.918T>C0.901
embC4240783c.921G>C0.904
embC4240789c.927T>C0.933
embC4240819c.957A>G0.910
embC4240828c.966G>A0.887
embC4240831c.969T>G0.882
embC4240867c.1005T>C0.771
embC4240870c.1008T>C0.735
embC4240873c.1011C>G0.743
embC4240879c.1017G>C0.706
embC4240880p.Ala340Thr0.706
embC4240885c.1023T>C0.706
embC4240897c.1035C>G0.727
embC4240898c.1036C>T0.727
embC4240903c.1041C>G0.727
embC4240911p.Ala350Val0.667
embC4240921c.1059C>G0.667
embC4240924c.1062C>G0.643
embC4240936c.1074A>G0.591
embC4240945c.1083T>G0.471
embC4240954p.Ile364Met0.462
embC4240960c.1098G>C0.333
embC4240966c.1104G>C0.300
embC4240990c.1128A>G0.200
embC4240996c.1134G>C0.667
embC4241002c.1140G>C0.607
embC4241013p.Met384Thr0.676
embC4241017c.1155T>C0.697
embC4241023c.1161T>G0.722
embC4241032c.1170G>C0.750
embC4241038c.1176G>C0.738
embC4241047c.1185C>G0.733
embC4241050c.1188T>G0.773
embC4241053c.1191G>C0.750
embC4241089c.1227C>G0.845
embC4241095c.1233C>T0.851
embC4241107c.1245G>C0.896
embC4241140c.1278A>G0.897
embC4241146c.1284C>G0.845
embC4241158c.1296T>C0.911
embC4241161c.1299C>G0.905
embC4241162c.1300T>C0.905
embC4241170c.1308G>C0.841
embC4241173c.1311C>T0.841
embC4241179c.1317G>A0.545
embC4241203c.1341T>C0.868
embC4241206c.1344G>C0.848
embC4241218c.1356G>C0.839
embC4241230c.1368A>G0.815
embC4241233c.1371G>C0.808
embC4241351p.Ile497Val0.829
embC4241361p.Asn500Thr0.833
embC4241363p.Leu501Met0.833
embC4241374c.1512T>G0.262
embC4241380c.1518A>C0.870
embC4241383c.1521G>C0.851
embC4241394p.Lys511Ser0.893
embC4241449c.1587C>G0.909
embC4241453p.Ile531Val0.907
embC4241479c.1617C>G0.875
embC4241480c.1618T>C0.875
embC4241488c.1626G>C0.887
embC4241496p.Ala545Gly0.843
embC4241500c.1638A>C0.837
embC4241501p.Ser547Thr0.837
embC4241506c.1644G>C0.837
embC4241518c.1656A>G0.837
embC4241521c.1659T>C0.826
embC4241530c.1668C>G0.829
embC4241536c.1674A>G0.731
embC4241539c.1677T>C0.708
embC4241545c.1683T>C0.696
embC4241548c.1686T>C0.667
embC4241551c.1689A>G0.636
embC4241567p.Ile569Val0.750
embC4241572c.1710C>G0.704
embC4241578c.1716G>C0.708
embC4241584c.1722T>C0.625
embC4241587c.1725C>G0.625
embC4241591p.Leu577Val0.625
embC4241611c.1749G>C0.652
embC4241614c.1752A>C0.652
embC4241626c.1764T>C0.652
embC4241635c.1773G>C0.625
embC4241644c.1782G>C0.625
embC4241648c.1786T>C0.652
embC4241657p.Ser599Pro0.625
embC4241665c.1803G>C0.625
embC4241671c.1809T>C0.652
embC4242689p.Val943Ile0.800
embC4242710p.Gln950Glu0.786
embC4242715c.2853T>C0.786
embC4242742c.2880C>G0.784
embC4242748c.2886A>G0.769
embC4242754c.2892G>C0.769
embC4242764p.Val968Leu0.736
embC4242772c.2910G>C0.724
embC4242779p.Asn973Asp0.764
embC4242791p.Ala977Ser0.711
embC4242796c.2934G>C0.727
embC4242799c.2937T>C0.727
embC4242802c.2940G>C0.733
embC4242820c.2958G>C0.750
embC4242823c.2961G>C0.761
embC4242832c.2970A>C0.750
embC4242838c.2976C>G0.684
embC4242841c.2979C>T0.657
embC4242844c.2982A>G0.694
embC4242847c.2985C>A0.694
embC4242859c.2997C>T0.743
embC4242862c.3000A>G0.735
embC4242863p.Tyr1001Asn0.735
embC4242883c.3021C>G0.788
embC4242892c.3030G>C0.839
embC4242901c.3039G>C0.806
embC4242919c.3057A>G0.846
embC4242928c.3066A>G0.864
embC4242931c.3069G>C0.818
embC4242940c.3078T>C0.833
embC4242941p.His1027Asn0.824
embC4242946c.3084T>C0.750
embC4242952c.3090T>C0.733
embC4242959c.3097C>T0.182
embC4242965p.Ile1035Val0.636
embA4244284p.Pro351Arg0.250
embA4244298p.Ser356Ala0.250
embA4244309c.1077C>G0.250
embA4244312c.1080T>G0.250
embA4244315c.1083G>C0.273
embA4244324c.1092T>G0.231
embA4244327c.1095T>C0.231
embA4244337p.Leu369Val0.200
embA4244340p.Ser370Ala0.200
embA4244366c.1134C>G0.267
embA4244372c.1140T>G0.267
embA4244378c.1146G>A0.286
embA4244396c.1164T>C0.308
embA4244408c.1176G>C0.250
embA4244412p.Val394Met0.231
embA4244415c.1183T>C0.231
embA4244447c.1215G>C0.565
embA4244462c.1230A>G0.690
embA4244478p.Thr416Leu0.765
embA4244483c.1251T>G0.788
embA4244485p.Thr418Ser0.778
embA4244498c.1266A>G0.822
embA4244507c.1275G>T0.812
embA4244508c.1276T>C0.812
embA4244516c.1284G>C0.843
embA4244517p.Leu429Val0.843
embA4244523p.Pro431Ala0.869
embA4244534c.1302T>C0.881
embA4244537c.1305T>G0.881
embA4244543c.1311C>G0.871
embA4244547p.Ile439Val0.884
embA4244557p.Arg442Thr0.859
embA4244582c.1350T>C0.851
embA4244585c.1353A>G0.851
embA4244611p.Ala460Gly0.654
embA4244616p.Ala462Ser0.625
embA4244619c.1387T>C0.636
embA4244625p.Leu465Val0.636
embA4244631p.Thr467Leu0.636
embA4244645c.1413T>C0.700
embA4244648c.1416G>C0.650
embA4244649p.Asp473Ser0.684
embA4245041c.1809C>G0.892
embA4245044c.1812G>C0.875
embA4245053c.1821G>C0.909
embA4245060c.1828T>C0.896
embA4245083c.1851A>C0.900
embA4245089c.1857G>C0.903
embA4245101c.1869G>C0.910
embA4245137c.1905T>C0.873
embA4245146c.1914G>A0.862
embA4245149c.1917C>G0.862
embA4245153p.Ile641Val0.866
embA4245182c.1950T>C0.884
embA4245189c.1957C>T0.891
embA4245198p.Leu656Ile0.887
embA4245207c.1975T>C0.895
embA4245215c.1983A>C0.904
embA4245222p.Tyr664Gln0.894
embA4245248c.2016G>C0.833
embA4245257c.2025A>G0.825
embA4245263c.2031A>G0.842
embA4245282p.Ile684Val0.739
embA4245285c.2053T>C0.700
embA4245290c.2058C>G0.700
embA4245293c.2061T>G0.700
embA4245296c.2064G>C0.667
embA4245299c.2067A>G0.667
embA4245659c.2427C>G0.816
embA4245674c.2442A>C0.810
embA4245677c.2445G>C0.822
embA4245693p.Ile821Val0.882
embA4245701c.2469G>C0.870
embA4245704c.2472G>C0.893
embA4245725c.2493A>G0.922
embA4245726c.2494T>C0.928
embA4245737c.2505A>C0.935
embA4245740c.2508T>C0.927
embA4245764c.2532G>C0.930
embA4245772p.Asn847Thr0.920
embA4245785c.2553G>C0.919
embA4245807c.2575T>C0.881
embA4245812c.2580G>C0.881
embA4245813p.Pro861Ala0.881
embA4245820p.Ser863Thr0.902
embA4245824c.2592G>C0.900
embA4245833c.2601G>C0.902
embA4245842c.2610G>C0.902
embA4245845c.2613T>C0.881
embA4245851c.2619G>C0.881
embA4245860c.2628C>G0.850
embA4246157c.2925A>G0.300
embA4246164c.2932T>C0.500
embA4246184c.2952A>C0.700
embA4246196c.2964C>G0.737
embA4246205c.2973A>G0.727
embA4246211c.2979T>C0.696
embA4246217c.2985G>A0.708
embA4246220c.2988T>C0.708
embA4246223c.2991C>T0.741
embA4246227p.Ile999Val0.767
embA4246235c.3003G>A0.805
embA4246242p.Gln1004Gly0.805
embA4246250c.3018G>C0.826
embA4246256c.3024G>T0.878
embA4246259c.3027G>C0.896
embA4246264p.His1011Arg0.900
embA4246292c.3060A>G0.897
embA4246305p.Ser1025Glu0.880
embA4246308p.Thr1026Ala0.863
embA4246316c.3084T>G0.873
embA4246319c.3087G>C0.857
embA4246329p.Thr1033Ala0.877
embA4246349c.3117C>G0.889
embA4246359p.Ala1043Ser0.864
embA4246367c.3135C>T0.860
embA4246373c.3141T>C0.846
embA4246376c.3144G>C0.833
embA4246379c.3147C>T0.784
embA4246400c.3168G>C0.806
embA4246413p.His1061Phe0.783
embA4246419c.3187C>T0.783
embB4247355p.Ala281Val0.300
embB4247358p.Val282Ala0.364
embB4247365c.852A>C0.667
embB4247371c.858C>G0.750
embB4247375p.Leu288Val0.800
embB4247386c.873T>C0.846
embB4247389c.876C>G0.846
embB4247395c.882C>G0.882
embB4247401c.888T>C0.889
embB4247407c.894G>C0.889
embB4247425c.912G>C0.919
embB4247434c.921C>G0.921
embB4247437c.924A>G0.897
embB4247440c.927C>G0.897
embB4247446c.933C>T0.897
embB4247464c.951C>G0.946
embB4247470c.957T>C0.953
embB4247491c.978G>C0.959
embB4247497c.984T>C0.961
embB4247512c.999T>C0.973
embB4247539c.1026T>C0.910
embB4247554c.1041T>C0.900
embB4247566c.1053C>A0.895
embB4247572c.1059A>G0.879
embB4247579p.Ala356Phe0.851
embB4247587c.1074G>A0.864
embB4247603c.1090C>T0.860
embB4247611c.1098G>T0.833
embB4247614c.1101T>C0.829
embB4247629c.1116C>G0.731
embB4247632c.1119C>G0.739
embB4247638c.1125G>T0.667
embB4247683c.1170C>G0.840
embB4247692c.1179C>G0.897
embB4247716c.1203C>T0.906
embB4247722c.1209G>C0.879
embB4247725c.1212G>C0.879
embB4247729p.Gly406Pro0.906
embB4247746c.1233C>T0.962
embB4247761c.1248T>C0.897
embB4247773c.1260G>A0.886
embB4247776c.1263G>T0.930
embB4247797c.1284C>G0.882
embB4247800c.1287A>T0.917
embB4247803c.1290G>C0.882
embB4247815c.1302C>G0.878
embB4247819p.Val436Ile0.893
embB4247830c.1317A>G0.889
embB4247836c.1323A>G0.892
embB4247839c.1326G>C0.861
embB4247866c.1353G>C0.878
embB4247875c.1362G>C0.825
embB4247876c.1363C>T0.828
embB4247881c.1368G>C0.838
embB4247887c.1374C>T0.845
embB4247893c.1380C>T0.851
embB4247899p.Met462Ile0.857
embB4247905c.1392G>C0.838
embB4247909c.1396T>C0.848
embB4247914c.1401G>C0.841
embB4247932c.1419C>G0.855
embB4247940p.Leu476Trp0.851
embB4247945c.1432T>C0.843
embB4247951p.Ser480Ala0.849
embB4247956c.1443G>C0.849
embB4247974c.1461C>G0.896
embB4248007c.1494C>G0.855
embB4248011p.Ser500Arg0.855
embB4248014p.Thr501Ala0.870
embB4248035p.Val508Ile0.839
embB4248040c.1527C>G0.831
embB4248041p.Ala510Thr0.831
embB4248044p.Lys511Ala0.817
embB4248070c.1557T>C0.886
embB4248085c.1572T>C0.899
embB4248097c.1584C>G0.905
embB4248130c.1617G>C0.864
embB4248142c.1629T>C0.908
embB4248143c.1630T>C0.909
embB4248157c.1644A>G0.908
embB4248172c.1659G>C0.868
embB4248199c.1686A>G0.855
embB4248200p.Ile563Val0.852
embB4248205c.1692C>G0.852
embB4248206p.Ser565Gly0.852
embB4248220c.1707A>C0.871
embB4248304c.1791G>C0.925
embB4248316c.1803C>G0.881
embB4248319c.1806A>G0.881
embB4248343c.1830G>C0.892
embB4248350c.1837T>C0.869
embB4248355c.1842A>G0.862
embB4248358c.1845C>G0.860
embB4248361c.1848A>C0.857
embB4248362p.Ser617Ala0.857
embB4248373c.1860C>G0.889
embB4248382c.1869C>G0.873
embB4248386c.1873C>A0.871
embB4248407p.Leu632Val0.737
embB4248410p.Phe633Leu0.737
embB4248419p.Leu636Met0.737
embB4248425c.1912T>C0.737
embB4248430c.1917T>C0.718
embB4248432p.Trp640Phe0.718
embB4248457c.1944T>C0.810
embB4248472c.1959T>C0.825
embB4248475c.1962G>C0.796
embB4248504p.Asp664Gly0.756
embB4248508c.1995G>A0.690
embB4248512p.Thr667Ser0.659
embB4248535c.2022C>G0.643
embB4249342c.2829C>G0.154
embB4249348c.2835G>C0.267
embB4249351c.2838C>G0.267
embB4249369c.2856T>C0.761
embB4249375c.2862G>C0.717
embB4249381c.2868A>G0.787
embB4249384c.2871G>T0.745
embB4249417c.2904A>G0.812
embB4249423p.Asp970Glu0.812
embB4249424p.Leu971Met0.812
embB4249429c.2916C>T0.790
embB4249432c.2919A>G0.852
embB4249441c.2928A>G0.877
embB4249444c.2931T>C0.865
embB4249469p.Leu986Met0.887
embB4249486c.2973T>G0.875
embB4249498c.2985G>C0.875
embB4249521p.Ala1003Val0.765
embB4249525c.3012T>C0.760
embB4249529p.Ile1006Val0.755
embB4249532p.Ala1007Thr0.750
embB4249537c.3024A>G0.766
embB4249543c.3030G>C0.761
embB4249546c.3033G>A0.761
embB4249558c.3045A>C0.805
embB4249568p.Ser1019Thr0.778
embB4249573c.3060T>C0.778
embB4249580p.Leu1023Met0.727
embB4249594c.3081G>C0.645
embB4249606c.3093C>A0.429
embB4249609c.3096T>C0.333
embB4249615c.3102C>G0.312
embB4249618c.3105C>G0.312
embB4249624c.3111C>G0.286
embB4249627c.3114G>C0.231
embB4249640c.3127T>C0.273
ethA4327396c.78A>G0.889
ethA4327399p.Asp25Glu0.870
ethA4327423c.51G>C0.851
ethA4327435c.39T>G0.844
ethA4327438c.36A>G0.822
ethA4327452p.Val8Leu0.742
ethA4327453c.21A>G0.742
ethA4327459c.15G>A0.733
ethA4327468c.6G>A0.733
gid4407603c.600C>T0.167
gid4407609c.594C>G0.167
gid4407663c.540T>C0.200
gid4407667p.Ile179Thr0.200
gid4407790p.Ala138Glu1.000

Analysis pipeline specifications

TBProfiler Version: 2.1.1

AnalysisProgram
Mappingbwa
Variant CallingBCFtools


Log

Drug Details
The estimated accuracy of drug resistance predictions is:

Drug1Sensitivity (%)Specificity (%)
Isoniazid 92.8 (89.9-95.7)100 (100-100)
Rifampicin 96.2 (93.9-98.5)98.1 (96.8-99.4)
Ethambutal 88.7 (83.6-93.8)81.7 (77.6-85.8)
Pyrazinamide70.9 (62.4-79.4)93.9 (90.6-97.2)
Streptomycin87.1 (82.7-91.5)89.7 (86.0-93.4)
Ethionamide 73.6 (66.7-80.5)93.3 (89.6-97.0)
Moxifloxacin60.0 (29.6-90.4)68.7 (52.6-84.8)
Ofloxacin 85.5 (79.1-91.9)94.9 (91.8-98.0)
Amikacin 82.9 (74.4-91.4)98.3 (96.0-100)
Capreomycin 60.7 (50.6-70.8)90.7 (87.2-94.2)
Kanamycin 87.3 (81.3-93.3)93.4 (89.9-96.9)
Para-aminosalisylic acidNot determinedNot determined
Linezolid Not determinedNot determined
Clofazimine Not determinedNot determined
Bedaquiline Not determinedNot determined
Multi drug resistance91.2 (87.8-94.6)98.4 (97.2-99.6)
Extremely drug resistance75.9 (64.5-87.3)98.4 (97.3-99.5)

Lineages
Lineage2LocationStrainRD type
lineage1Indo-OceanicEAIRD239
lineage1.1Indo-OceanicEAI3;EAI4;EAI5;EAI6RD239
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineage1.1.1.1Indo-OceanicEAI4;ZERORD239
lineage1.1.2Indo-OceanicEAI3;EAI5RD239
lineage1.1.3Indo-OceanicEAI6RD239
lineage1.2Indo-OceanicEAI1;EAI2RD239
lineage1.2.1Indo-OceanicEAI2RD239
lineage1.2.2Indo-OceanicEAI1RD239
lineage2East-AsianBeijingRD105
lineage2.1East-Asian (non-Beijing)NoneNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.2East-Asian (Beijing)Beijing-RD105/RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181
lineage2.2.1.2East-Asian (Beijing)Beijing-RD142RD105;RD207;RD181;RD142
lineage2.2.1.1East-Asian (Beijing)Beijing-RD150RD105;RD207;RD181;RD150
lineage3East-African-IndianCASRD750
lineage3.1East-African-IndianNon-CAS1-DelhiRD750
lineage3.1.1East-African-IndianCAS1-KiliRD750
lineage3.1.2East-African-IndianCAS;CAS2RD750
lineage3.1.2.1East-African-IndianCAS2RD750
lineage3.1.2.2East-African-IndianCASRD750
lineage4Euro-AmericanLAM;T;S;X;HNone
lineage4.1Euro-AmericanT;X;HNone
lineage4.1.2Euro-American (X-type)T;HNone
lineage4.1.2.1Euro-American (X-type)T1;H1RD182
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.2Euro-American (X-type)X1None
lineage4.1.1.1Euro-American (X-type)X2RD183
lineage4.1.1.3Euro-American (Haarlem)X1;X3RD193
lineage4.2Euro-AmericanH;T;LAMNone
lineage4.2.2Euro-American (Ural)T;LAM7-TURNone
lineage4.2.2.1Euro-AmericanLAM7-TURNone
lineage4.2.1Euro-American (TUR)H3;H4None
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.3.1Euro-American (LAM)LAM9None
lineage4.3.3Euro-American (LAM)LAM;TRD115
lineage4.3.4Euro-American (LAM)LAMRD174
lineage4.3.4.1Euro-American (LAM)LAM1;LAM2RD174
lineage4.3.4.2Euro-American (LAM)LAM1;LAM4;LAM11RD174
lineage4.3.4.2.1Euro-American (LAM)LAM11RD174
lineage4.3.2Euro-American (LAM)LAM3None
lineage4.3.2.1Euro-American (LAM)LAM3RD761
lineage4.4Euro-AmericanS;TNone
lineage4.4.2Euro-AmericanT1;T2None
lineage4.4.1Euro-American (S-type)S;TNone
lineage4.4.1.2Euro-AmericanT1None
lineage4.4.1.1Euro-AmericanS;OrphansNone
lineage4.5Euro-AmericanH;TRD122
lineage4.6Euro-AmericanT;LAMNone
lineage4.6.1Euro-American (Uganda)T2RD724
lineage4.6.1.1Euro-American T2-UgandaRD724
lineage4.6.1.2Euro-AmericanT2RD724
lineage4.6.2Euro-AmericanT;LAMRD726
lineage4.6.2.1Euro-AmericanT3RD726
lineage4.6.2.2Euro-American (Cameroon)LAM10-CAMRD726
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.8Euro-American (mainly T)T1;T2;T3;T5RD219
lineage4.9Euro-American (H37Rv-like)T1None
lineage5West-Africa 1AFRI_2;AFRI_3RD711
lineage6West-Africa 2AFRI_1RD702
lineage7Lineage 7NoneNone
lineageBOVM. bovisBOV_1;BOV_2None

Citations
1. Coll F, et al. Rapid determination of anti-tuberculosis drug resistance from whole genome sequences. Genome Medicine (in press)
2. Coll F, et al. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications 2014.

Disclaimer
This tool is for Research Use Only and is offered free for use. The London School of Hygiene and Tropical Medicine shall have no liability for any loss or damages of any kind, however sustained relating to the use of this tool.
© 2019 London School of Hygiene and Tropical Medicine;