TB Profiler
This tool processes raw sequence data to infer strain type and identify known drug resistance markers.
A stand alone version of this tool is now available and can now be run on linux or mac. Installation instructions can be found on GitHub and on the bioconda page.



This tool is for Research Use Only. Data and information provided through use of this tool are not intended for medical purpose or objective and should not be used for clinical diagnosis, patient management, or human clinical trials.
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Single nucleotide polymorphisms (SNPs) in coding regions are annotated using the reference amino acid, codon number and alternative amino acid (e.g. Ser315Thr in katG). SNPs in non-coding regions (i.e. RNA genes and intergenic regions) are annotated using the reference nucleotide, gene coordinate and alternative nucleotide (e.g. A1401G in rrs or C-37A in eis promoter). Indels are annotated using the reference VCF allele, gene coordinate and alternative VCF allele (e.g. T902TA insertion in katG).
Name: 5d807aea52fa3
Sample: 5d807aea52fa3

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Summary
ID: 5d807aea52fa3
Date: Tue Sep 17 07:22:12 2019
Strain: lineage2.2.1;lineage4.3;lineage4.2;lineage1.2.2
Drug-resistance: XDR

Drug1ResistanceSupporting Mutations (frequency)
IsoniazidRfabG1 c.-15C>T (1.00), inhA p.Ile21Thr (1.00)
RifampicinRrpoB p.Ser450Leu (0.69)
EthambutolRembB p.Met306Ile (0.79), embB p.His312Arg (0.18), embB p.Asp354Ala (0.79), embB p.Leu359Ile (0.14), embB p.Ala659Thr (0.19)
PyrazinamideRpncA c.279 280insG (1.00)
StreptomycinRrpsL p.Lys43Arg (0.65), rrs r.462c>t (0.37)
EthionamideRfabG1 c.-15C>T (1.00), inhA p.Ile21Thr (1.00)
FluoroquinolonesRgyrA p.Asp94Gly (0.75)
AmikacinRrrs r.1401a>g (0.64)
CapreomycinRrrs r.1401a>g (0.64)
KanamycinRrrs r.1401a>g (0.64)

Lineage2FamilyMain SpoligotypeRDS
lineage2East-AsianBeijingRD105
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.2Euro-AmericanH;T;LAMNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage1.2.2Indo-OceanicEAI1RD239
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181

Mutations in candidate genes:
GeneChromosome PositionMutationEstimated fraction
gyrB6100c.861G>C0.139
gyrB6115c.876A>G0.185
gyrB6123p.Ala295Gly0.190
gyrB6127c.888G>C0.195
gyrB6130c.891T>C0.195
gyrB6136c.897G>A0.205
gyrB6139c.900G>C0.205
gyrB6238c.999G>A0.176
gyrB6242p.Arg335Lys0.175
gyrB6248c.1009C>T0.173
gyrB6256c.1017G>A0.239
gyrB6268c.1029C>G0.261
gyrB6280c.1041T>C0.260
gyrB6286c.1047T>C0.253
gyrB6289c.1050C>T0.248
gyrB6292c.1053G>C0.253
gyrB6307c.1068T>G0.264
gyrB6319c.1080G>C0.301
gyrB6346c.1107C>T0.287
gyrB6362c.1123T>C0.257
gyrB6376c.1137G>A0.267
gyrB6379c.1140C>G0.244
gyrB6382c.1143A>G0.250
gyrB6388c.1149T>C0.256
gyrB6403c.1164T>C0.233
gyrB6415c.1176G>C0.174
gyrB6427c.1188T>C0.119
gyrB6430c.1191A>G0.121
gyrB6610c.1371C>G0.125
gyrB6613c.1374A>G0.122
gyrB6616c.1377A>G0.122
gyrB6622c.1383C>T0.122
gyrB6634c.1395T>C0.124
gyrB6637c.1398T>G0.121
gyrB6643c.1404A>G0.117
gyrB6649c.1410T>C0.159
gyrB6655c.1416T>C0.179
gyrB6670c.1431G>C0.184
gyrB6673c.1434A>C0.184
gyrB6676c.1437T>G0.183
gyrB6700c.1461T>C0.215
gyrB6703c.1464G>C0.213
gyrB6709c.1470A>G0.210
gyrB6712c.1473G>C0.223
gyrB6728c.1489C>T0.238
gyrB6742c.1503A>G0.183
gyrB6745c.1506T>G0.194
gyrB6751c.1512G>C0.187
gyrB6760c.1521G>C0.185
gyrB6763c.1524G>C0.184
gyrB6775c.1536G>C0.222
gyrB6793c.1554T>C0.187
gyrB6797p.Gly520Thr0.178
gyrB6811c.1572C>T0.171
gyrB6841c.1602T>C0.125
gyrB6844c.1605T>C0.121
gyrB6889c.1650G>T0.136
gyrB6901c.1662G>C0.167
gyrB6904c.1665C>G0.172
gyrB6910c.1671G>A0.184
gyrB6919c.1680T>C0.163
gyrB6925c.1686T>C0.167
gyrB6931c.1692A>G0.180
gyrB6949c.1710A>G0.206
gyrB6952c.1713C>G0.208
gyrB6967c.1728T>C0.263
gyrB6973c.1734G>C0.269
gyrB6982c.1743A>C0.281
gyrB7006c.1767T>C0.222
gyrB7007c.1768C>T0.216
gyrB7010c.1771C>T0.211
gyrB7015c.1776G>A0.205
gyrB7018c.1779G>A0.198
gyrB7023p.Leu595Gln0.195
gyrB7033c.1794G>C0.197
gyrB7051p.Glu604Asp0.175
gyrB7066c.1827G>C0.149
gyrB7141c.1902T>C0.121
gyrB7147c.1908G>C0.137
gyrB7165c.1926C>G0.150
gyrB7178c.1939T>C0.165
gyrB7186c.1947C>G0.179
gyrB7216c.1977G>C0.181
gyrB7234c.1995C>T0.160
gyrB7246c.2007T>C0.165
gyrB7252c.2013G>C0.165
gyrB7256c.2017C>T0.161
gyrA7334c.33G>C0.131
gyrA7335p.Leu12Val0.133
gyrA7349c.48A>G0.138
gyrA7361c.60C>T0.161
gyrA7362p.Glu21Gln1.000
gyrA7391c.90C>T0.229
gyrA7394c.93T>C0.231
gyrA7427c.126G>C0.254
gyrA7442c.141G>C0.238
gyrA7451c.150C>G0.252
gyrA7457c.156T>C0.248
gyrA7475c.174A>G0.248
gyrA7480p.Phe60Tyr0.217
gyrA7484c.183T>C0.224
gyrA7490c.189C>G0.267
gyrA7523c.222C>G0.276
gyrA7532c.231T>G0.273
gyrA7541c.240C>G0.277
gyrA7547c.246C>T0.277
gyrA7571c.270G>C0.245
gyrA7585p.Ser95Thr0.992
gyrA7595c.294C>G0.218
gyrA7601c.300C>G0.219
gyrA7607c.306C>G0.220
gyrA7622c.321C>T0.165
gyrA7625c.324G>C0.145
gyrA7626c.325C>T0.145
gyrA7631c.330G>C0.154
gyrA7637c.336C>G0.186
gyrA7652c.351C>T0.165
gyrA7658c.357A>C0.146
gyrA7664c.363T>C0.152
gyrA7670c.369A>G0.124
gyrA7679c.378G>C0.110
gyrA7694c.393A>G0.113
gyrA7697c.396C>G0.113
gyrA7730p.Arg143Ser0.112
gyrA7763c.462T>C0.279
gyrA7775c.474C>A0.269
gyrA7781c.480G>C0.226
gyrA7784c.483A>G0.226
gyrA7790c.489G>C0.218
gyrA7793c.492G>C0.220
gyrA7796c.495G>C0.220
gyrA7799c.498A>G0.224
gyrA7814c.513C>G0.280
gyrA7823c.522G>C0.303
gyrA7832c.531G>T0.295
gyrA7835c.534A>C0.295
gyrA7853c.552C>G0.233
gyrA7859c.558A>G0.212
gyrA7865c.564T>C0.188
gyrA7886c.585T>C0.140
gyrA8090c.789C>A0.149
gyrA8096c.795T>A0.178
gyrA8099c.798T>C0.189
gyrA8111c.810G>C0.278
gyrA8121c.820T>C0.308
gyrA8129c.828T>C0.312
gyrA8135c.834C>G0.338
gyrA8153c.852C>T0.329
gyrA8156c.855T>C0.329
gyrA8168c.867A>G0.341
gyrA8177c.876A>C0.337
gyrA8198c.897T>C0.367
gyrA8207c.906T>C0.347
gyrA8219c.918T>C0.388
gyrA8225c.924T>C0.370
gyrA8234c.933T>C0.345
gyrA8237c.936A>G0.324
gyrA8247p.Ile316Val0.275
gyrA8264c.963T>C0.242
gyrA8267c.966G>C0.242
gyrA8270c.969G>C0.258
gyrA8276c.975G>A0.258
gyrA8283p.Ile328Leu0.260
gyrA8288c.987T>C0.273
gyrA8294c.993T>C0.311
gyrA8324c.1023T>C0.304
gyrA8330c.1029C>G0.311
gyrA8339c.1038A>G0.292
gyrA8340p.Ala347Ser0.292
gyrA8372c.1071G>C0.196
gyrA8375c.1074G>C0.200
gyrA8382p.Leu361Met0.200
gyrA8387c.1086C>T0.204
gyrA8391p.Tyr364His0.204
gyrA8396c.1095C>T0.206
gyrA8399c.1098T>G0.211
gyrA8401p.Asp367Ala0.213
gyrA8405c.1104C>T0.212
gyrA8420c.1119T>C0.320
gyrA8442c.1141C>T0.296
gyrA8453c.1152A>C0.250
gyrA8462c.1161A>T0.226
gyrA8465c.1164C>G0.219
gyrA8471c.1170T>C0.225
gyrA8472c.1171C>T0.225
gyrA8480c.1179C>T0.235
gyrA8486c.1185T>C0.230
gyrA8504c.1203G>C0.213
gyrA8519c.1218A>C0.180
gyrA8520c.1219C>T0.178
gyrA8528c.1227G>C0.181
gyrA8543c.1242C>G0.141
gyrA8546c.1245T>C0.144
gyrA8552c.1251C>A0.140
gyrA8561c.1260A>G0.141
gyrA8576c.1275C>G0.143
gyrA8579c.1278C>T0.156
gyrA8588c.1287G>A0.203
gyrA8597c.1296C>G0.195
gyrA8603c.1302A>G0.222
gyrA8619c.1318T>C0.273
gyrA8624c.1323G>C0.287
gyrA8636c.1335A>C0.292
gyrA8642c.1341A>G0.297
gyrA8672c.1371A>G0.307
gyrA8693c.1392T>C0.273
gyrA8696c.1395G>C0.263
gyrA8699c.1398A>G0.263
gyrA8711c.1410A>C0.228
gyrA8714c.1413A>G0.228
gyrA8729c.1428T>C0.128
gyrA8730p.Gly477Arg0.128
gyrA8740p.Arg480His0.133
gyrA8852c.1551T>C0.140
gyrA8858c.1557T>C0.147
gyrA8867c.1566A>G0.156
gyrA8870c.1569G>C0.156
gyrA8873c.1572A>C0.158
gyrA8891c.1590G>A0.173
gyrA8897c.1596T>C0.184
gyrA8903c.1602T>C0.200
gyrA8933c.1632G>C0.223
gyrA8939c.1638T>C0.210
gyrA8942c.1641G>C0.208
gyrA8946c.1645T>C0.202
gyrA8966c.1665C>G0.222
gyrA8967p.Ala556Arg0.227
gyrA8987c.1686C>G0.219
gyrA8990c.1689C>G0.188
gyrA8996c.1695T>C0.176
gyrA8998p.Leu566Trp0.211
gyrA9017c.1716C>G0.158
gyrA9023c.1722A>C0.164
gyrA9029c.1728T>C0.153
gyrA9032c.1731T>C0.141
gyrA9035c.1734G>C0.143
gyrA9089c.1788G>C0.128
gyrA9099c.1798T>C0.128
gyrA9104c.1803C>G0.125
gyrA9119c.1818A>G0.185
gyrA9122c.1821C>G0.191
gyrA9143c.1842T>C0.214
gyrA9152c.1851C>T0.184
gyrA9153p.Thr618Glu0.184
gyrA9158c.1857C>T0.184
gyrA9161c.1860C>G0.204
gyrA9182c.1881T>C0.300
gyrA9191c.1890G>C0.307
gyrA9200c.1899A>G0.319
gyrA9204p.Ser635Thr0.322
gyrA9224c.1923C>T0.333
gyrA9230c.1929T>C0.333
gyrA9233c.1932C>G0.328
gyrA9239c.1938C>T0.317
gyrA9252p.Val651Ile0.333
gyrA9284c.1983T>C0.300
gyrA9291c.1990C>T0.263
gyrA9296c.1995T>C0.269
gyrA9299c.1998G>C0.276
gyrA9300p.Ala667Ser0.279
gyrA9304p.Gly668Asp1.000
gyrA9308p.Asp669Glu0.311
gyrA9323c.2022C>G0.336
gyrA9335c.2034G>C0.295
gyrA9365c.2064G>A0.252
gyrA9374c.2073G>C0.212
gyrA9377c.2076A>G0.216
gyrA9383c.2082T>G0.226
gyrA9386c.2085T>C0.226
gyrA9395c.2094G>C0.215
gyrA9398c.2097T>C0.217
gyrA9413c.2112G>C0.161
rpoB759606c.-201T>C0.185
rpoB759629c.-178T>C0.187
rpoB759644c.-163T>A0.163
rpoB759647c.-160T>C0.165
rpoB760040c.234T>C0.145
rpoB760046c.240G>C0.165
rpoB760060p.Tyr85Leu0.189
rpoB760067c.261G>C0.208
rpoB760070c.264T>G0.225
rpoB760091c.285G>C0.239
rpoB760101c.295T>C0.253
rpoB760112c.306T>C0.250
rpoB760118c.312T>G0.273
rpoB760121c.315T>C0.273
rpoB760130p.Asp108Glu0.290
rpoB760139c.333A>G0.306
rpoB760142c.336C>G0.320
rpoB760181c.375T>C0.358
rpoB760184c.378A>G0.337
rpoB760196c.390C>G0.300
rpoB760223c.417T>C0.330
rpoB760235c.429T>C0.351
rpoB760283c.477G>C0.376
rpoB760298c.492G>C0.348
rpoB760307c.501T>C0.360
rpoB760310c.504G>C0.364
rpoB760328c.522G>C0.330
rpoB760331c.525G>C0.344
rpoB760340c.534G>T0.376
rpoB760361c.555T>C0.383
rpoB760370c.564C>G0.383
rpoB760376p.Asp190Glu0.368
rpoB760380p.Thr192Leu0.349
rpoB760406c.600G>C0.341
rpoB760412c.606C>G0.333
rpoB760424c.618C>G0.322
rpoB760430c.624T>C0.337
rpoB760475c.669A>G0.302
rpoB760481c.675G>C0.264
rpoB760484c.678A>G0.247
rpoB760520c.714C>T0.304
rpoB760522p.Ser239Asn0.304
rpoB760532c.726T>C0.291
rpoB760533p.Val243Thr0.287
rpoB760541c.735G>C0.333
rpoB760547c.741G>C0.341
rpoB760563p.Arg253Met0.333
rpoB760591p.Val262Ala0.351
rpoB760611c.805T>C0.364
rpoB760637c.831G>C0.349
rpoB760646c.840C>G0.366
rpoB760655c.849A>G0.361
rpoB760661c.855A>C0.329
rpoB760670c.864G>C0.280
rpoB760674c.868T>C0.269
rpoB760679c.873A>G0.250
rpoB760683c.877T>C0.253
rpoB760715c.909C>G0.234
rpoB760718c.912C>T0.237
rpoB760724c.918T>C0.224
rpoB760730c.924T>C0.229
rpoB760751c.945G>C0.213
rpoB760757c.951T>C0.145
rpoB760759p.Val318Ala0.143
rpoB760769c.963C>G0.118
rpoB760775c.969G>C0.115
rpoB760777p.Ser324Cys0.113
rpoB760793c.987A>G0.165
rpoB760805c.999G>C0.178
rpoB760817c.1011A>G0.200
rpoB760820c.1014T>C0.187
rpoB760826c.1020C>G0.193
rpoB760830c.1024T>C0.193
rpoB760841c.1035T>C0.209
rpoB760845p.Thr347Pro0.188
rpoB760859c.1053T>C0.245
rpoB760862c.1056G>C0.252
rpoB760869p.Val355Ile0.276
rpoB760886c.1080A>G0.279
rpoB760925c.1119T>C0.301
rpoB760928c.1122G>C0.312
rpoB760931c.1125C>G0.306
rpoB760934c.1128C>T0.307
rpoB760946c.1140A>G0.316
rpoB760982c.1176G>C0.298
rpoB760985c.1179G>C0.304
rpoB760991c.1185G>C0.324
rpoB761006c.1200C>G0.290
rpoB761015c.1209G>C0.302
rpoB761021c.1215G>C0.299
rpoB761027c.1221A>G0.295
rpoB761036c.1230G>C0.298
rpoB761037c.1231T>C0.298
rpoB761057c.1251G>C0.301
rpoB761102c.1296A>G0.330
rpoB761129c.1323G>C0.298
rpoB761132c.1326G>T0.274
rpoB761133c.1327T>C0.277
rpoB761150c.1344A>C0.305
rpoB761153c.1347G>C0.295
rpoB761165c.1359G>C0.263
rpoB761180c.1374A>C0.258
rpoB761189c.1383T>C0.260
rpoB761195c.1389G>C0.247
rpoB761204c.1398C>T0.233
rpoB761207c.1401C>T0.230
rpoB761213c.1407G>C0.210
rpoB761249c.1443A>G0.208
rpoB761255c.1449T>G0.218
rpoB761261c.1455G>T0.228
rpoB761306c.1500C>G0.315
rpoB761327c.1521A>G0.312
rpoB761330c.1524G>C0.293
rpoB761354c.1548C>T0.236
rpoB761360c.1554T>C0.253
rpoB761362p.Ser519Thr0.242
rpoB761372c.1566C>T0.196
rpoB761373p.Val523His0.207
rpoB761408c.1602G>C0.318
rpoB761414c.1608A>G0.305
rpoB761423c.1617T>C0.269
rpoB761435c.1629T>C0.212
rpoB761438c.1632G>C0.178
rpoB761439p.Asp545Lys0.176
rpoB761444c.1638T>C0.178
rpoB761447c.1641C>G0.178
rpoB761452p.Val549Glu0.184
rpoB761457p.Pro551Ser0.186
rpoB761465c.1659G>C0.322
rpoB761477c.1671C>G0.342
rpoB761492c.1686G>C0.354
rpoB761510c.1704T>C0.362
rpoB761531c.1725C>G0.333
rpoB761537c.1731C>G0.315
rpoB761570c.1764T>C0.224
rpoB761573c.1767C>G0.217
rpoB761579c.1773G>C0.243
rpoB761588c.1782C>T0.315
rpoB761606c.1800C>G0.318
rpoB761612c.1806G>C0.279
rpoB761615c.1809A>C0.275
rpoB761636c.1830G>T0.292
rpoB761645c.1839C>G0.302
rpoB761648c.1842T>C0.311
rpoB761657c.1851C>G0.327
rpoB761675c.1869G>C0.333
rpoB761720c.1914C>G0.160
rpoB761725p.Glu640Ala0.167
rpoB761732c.1926C>G0.163
rpoB761735c.1929C>G0.153
rpoB761747c.1941G>C0.215
rpoB761750c.1944G>C0.206
rpoB761765c.1959T>C0.233
rpoB761772p.His656Ala0.236
rpoB761778p.Asn658Asp0.247
rpoB761791p.Arg662His0.268
rpoB761813c.2007T>C0.299
rpoB761815p.Ala670Glu0.287
rpoB761834c.2028T>C0.325
rpoB761848p.Cys681Ser0.263
rpoB761852c.2046C>G0.263
rpoB761858c.2052G>C0.287
rpoB761873c.2067A>C0.267
rpoB761885c.2079T>C0.311
rpoB761906c.2100C>G0.259
rpoB761909c.2103T>C0.259
rpoB761912c.2106T>C0.256
rpoB761915p.Asp703Glu0.247
rpoB761916p.Asp704Asn0.247
rpoB761948c.2142G>C0.180
rpoB761954c.2148C>G0.170
rpoB762008c.2202C>T0.244
rpoB762014c.2208C>T0.229
rpoB762017c.2211A>G0.229
rpoB762053c.2247T>C0.214
rpoB762062c.2256T>C0.209
rpoB762065c.2259T>C0.214
rpoB762083c.2277T>C0.242
rpoB762086c.2280G>C0.232
rpoB762101c.2295C>G0.265
rpoB762114p.Ile770Val0.267
rpoB762131c.2325C>G0.263
rpoB762140c.2334G>C0.238
rpoB762143c.2337T>C0.228
rpoB762149c.2343G>C0.237
rpoB762167c.2361T>C0.277
rpoB762176c.2370T>C0.290
rpoB762185c.2379G>C0.333
rpoB762206c.2400C>G0.379
rpoB762233c.2427G>C0.344
rpoB762246c.2440C>T0.323
rpoB762254c.2448T>G0.319
rpoB762257c.2451C>G0.333
rpoB762266c.2460T>C0.322
rpoB762284c.2478G>C0.311
rpoB762293c.2487T>C0.315
rpoB762317c.2511A>G0.289
rpoB762329c.2523G>C0.250
rpoB762338c.2532T>C0.196
rpoB762347c.2541T>C0.220
rpoB762362p.Glu852Asp0.227
rpoB762369c.2563T>C0.228
rpoB762398c.2592T>C0.247
rpoB762401c.2595G>C0.253
rpoB762404c.2598T>C0.250
rpoB762410c.2604T>C0.250
rpoB762416c.2610A>G0.253
rpoB762419c.2613C>G0.245
rpoB762434c.2628T>C0.260
rpoB762449c.2643C>A0.239
rpoB762467c.2661C>T0.214
rpoB762488c.2682G>C0.243
rpoB762489p.Val895Gln0.241
rpoB762509c.2703T>G0.212
rpoB762510p.Ala902Pro0.214
rpoB762521c.2715C>G0.228
rpoB762533c.2727T>C0.209
rpoB762536c.2730T>C0.213
rpoB762537c.2731T>C0.213
rpoB762551c.2745C>T0.191
rpoB762581c.2775T>C0.145
rpoB762582c.2776T>C0.145
rpoB762782c.2976T>C0.114
rpoB762785p.Asp993Glu0.111
rpoB762788c.2982G>C0.110
rpoB762789p.Leu995Met0.107
rpoB762794c.2988C>G0.108
rpoB762812c.3006C>G0.105
rpoB762813p.Met1003Val0.106
rpoB762818c.3012C>G0.128
rpoB762827c.3021G>C0.216
rpoB762857c.3051C>G0.266
rpoB762860c.3054G>C0.275
rpoB762863c.3057T>C0.278
rpoB762929c.3123G>C0.312
rpoB762989c.3183G>C0.326
rpoB762995c.3189G>T0.356
rpoB763013c.3207C>G0.333
rpoB763028c.3222T>C0.304
rpoB763031c.3225T>C0.315
rpoB763034c.3228C>G0.315
rpoB763040c.3234C>G0.320
rpoB763070c.3264T>C0.363
rpoB763085c.3279C>G0.364
rpoB763115c.3309T>C0.361
rpoB763136c.3330C>T0.321
rpoB763148c.3342G>C0.286
rpoB763158c.3352C>T0.293
rpoB763166c.3360A>G0.290
rpoB763190c.3384C>T0.269
rpoB763202c.3396A>G0.176
rpoB763205c.3399G>C0.169
rpoB763206c.3400A>T0.169
rpoB763214c.3408T>C0.215
rpoB763226c.3420A>G0.212
rpoB763227c.3421C>T0.212
rpoB763238c.3432T>C0.207
rpoB763253c.3447G>C0.188
rpoB763256c.3450G>A0.188
rpoB763268c.3462C>G0.157
rpoB763283c.3477T>C0.145
rpoB763284c.3478C>T0.143
rpoC763351c.-19T>C0.145
rpoC763352c.-18T>A0.145
rpoC763402c.33C>G0.239
rpoC763411c.42T>G0.217
rpoC763414c.45T>C0.208
rpoC763441c.72C>T0.292
rpoC763444c.75T>C0.307
rpoC763456c.87A>G0.325
rpoC763486c.117T>G0.353
rpoC763492c.123G>C0.330
rpoC763528c.159G>A0.344
rpoC763546c.177A>G0.365
rpoC763570c.201G>C0.402
rpoC763573c.204G>C0.388
rpoC763594c.225C>T0.383
rpoC763603c.234C>T0.406
rpoC763636c.267T>C0.378
rpoC763657c.288G>A0.341
rpoC763660c.291T>G0.344
rpoC763675c.306C>G0.341
rpoC763696c.327T>C0.349
rpoC763702c.333C>G0.368
rpoC763717c.348T>C0.349
rpoC763723c.354G>C0.329
rpoC763732c.363C>G0.326
rpoC763741c.372C>T0.302
rpoC763744c.375G>C0.299
rpoC763765c.396T>C0.308
rpoC763774c.405G>C0.267
rpoC763807c.438T>C0.330
rpoC763816c.447C>G0.302
rpoC763835p.Ala156Met0.293
rpoC763853p.Val162Ile0.264
rpoC763858c.489A>G0.262
rpoC763872p.Gly168Ala0.250
rpoC763876p.Glu169Asp0.250
rpoC763879c.510A>G0.255
rpoC763888c.519G>C0.257
rpoC763891c.522G>C0.257
rpoC763894c.525A>G0.260
rpoC763900c.531G>C0.280
rpoC763945c.576T>C0.288
rpoC763951c.582G>C0.300
rpoC763960c.591T>C0.265
rpoC763987c.618C>T0.211
rpoC763991p.Ile208Leu0.207
rpoC763996c.627T>C0.191
rpoC764002c.633C>G0.187
rpoC764005c.636G>C0.209
rpoC764024c.655T>C0.226
rpoC764032p.Asp221Glu0.239
rpoC764040p.Ser224Thr0.231
rpoC764044c.675T>C0.231
rpoC764059c.690G>T0.289
rpoC764083c.714A>G0.281
rpoC764098c.729A>G0.295
rpoC764101c.732C>G0.292
rpoC764102p.Val245Ile0.298
rpoC764112p.Tyr248Phe0.323
rpoC764116c.747C>T0.302
rpoC764131c.762T>C0.306
rpoC764188c.819A>G0.282
rpoC764195p.Ser276Ile0.221
rpoC764203c.834G>C0.211
rpoC764206c.837T>C0.222
rpoC764215c.846A>G0.300
rpoC764236c.867G>A0.273
rpoC764248c.879C>G0.259
rpoC764257c.888G>C0.253
rpoC764266c.897T>C0.250
rpoC764269c.900G>C0.233
rpoC764272c.903G>C0.238
rpoC764278c.909A>G0.264
rpoC764338c.969G>A0.297
rpoC764353c.984G>C0.312
rpoC764365c.996C>T0.282
rpoC764380c.1011G>C0.247
rpoC764381c.1012T>A0.247
rpoC764387c.1018T>C0.253
rpoC764405c.1036A>C0.349
rpoC764419c.1050C>G0.368
rpoC764428c.1059G>C0.321
rpoC764431c.1062G>C0.317
rpoC764434c.1065A>G0.309
rpoC764446c.1077T>C0.286
rpoC764449c.1080G>C0.282
rpoC764452c.1083T>C0.304
rpoC764458c.1089G>C0.282
rpoC764461c.1092A>G0.291
rpoC764489c.1120C>T0.341
rpoC764497c.1128A>G0.333
rpoC764510c.1141C>T0.355
rpoC764521c.1152T>C0.362
rpoC764527c.1158C>T0.323
rpoC764536c.1167G>C0.327
rpoC764539c.1170C>G0.302
rpoC764548c.1179G>A0.293
rpoC764551c.1182G>C0.290
rpoC764554c.1185C>T0.293
rpoC764560c.1191T>C0.305
rpoC764566c.1197C>G0.304
rpoC764575c.1206T>G0.311
rpoC764593c.1224C>T0.284
rpoC764611c.1242G>T0.299
rpoC764650c.1281G>C0.204
rpoC764651c.1282T>A0.204
rpoC764752c.1383G>C0.213
rpoC764764c.1395T>C0.230
rpoC764809c.1440C>T0.250
rpoC764815c.1446A>G0.222
rpoC764821p.Trp484Cys0.769
rpoC764827c.1458G>C0.237
rpoC764858c.1489T>C0.261
rpoC764872c.1503A>G0.270
rpoC764888c.1519T>C0.275
rpoC764911c.1542A>G0.206
rpoC764932c.1563C>A0.216
rpoC764948c.1579T>C0.242
rpoC764968c.1599T>C0.266
rpoC764995c.1626C>G0.222
rpoC765007c.1638T>G0.163
rpoC765008c.1639T>C0.163
rpoC765011c.1642A>T0.167
rpoC765019c.1650A>G0.220
rpoC765034c.1665T>C0.255
rpoC765040c.1671T>C0.255
rpoC765041c.1672T>C0.257
rpoC765047c.1678T>C0.275
rpoC765055c.1686C>G0.267
rpoC765073c.1704G>C0.267
rpoC765076c.1707A>G0.270
rpoC765079c.1710T>G0.278
rpoC765082c.1713G>C0.276
rpoC765089c.1720T>C0.301
rpoC765103c.1734G>T0.295
rpoC765292c.1923G>C0.188
rpoC765298c.1929G>C0.181
rpoC765300p.Val644Ala0.216
rpoC765319c.1950A>G0.208
rpoC765326p.His653Ala0.188
rpoC765330p.Ser654Asn0.188
rpoC765346c.1977C>G0.184
rpoC765349c.1980T>C0.179
rpoC765352c.1983G>C0.215
rpoC765383p.Met672Leu0.260
rpoC765404p.Leu679Val0.262
rpoC765409c.2040T>C0.259
rpoC765421c.2052C>G0.272
rpoC765451c.2082C>A0.284
rpoC765478c.2109T>C0.323
rpoC765499c.2130C>G0.316
rpoC765529c.2160C>T0.287
rpoC765541c.2172C>G0.302
rpoC765553c.2184C>T0.270
rpoC765556c.2187G>C0.273
rpoC765559c.2190G>C0.264
rpoC765580c.2211G>C0.337
rpoC765613p.His748Gln0.327
rpoC765625c.2256C>G0.323
rpoC765631p.Asp754Glu0.323
rpoC765700c.2331T>C0.367
rpoC765734c.2365T>C0.244
rpoC765739c.2370G>T0.221
rpoC765751c.2382C>G0.224
rpoC765753p.Asp795Ala0.229
rpoC765772c.2403C>G0.263
rpoC765784c.2415C>G0.237
rpoC765787c.2418C>T0.213
rpoC765793c.2424C>G0.231
rpoC765796c.2427C>T0.237
rpoC765811c.2442T>C0.258
rpoC765814c.2445A>G0.260
rpoC765826c.2457T>C0.271
rpoC765835c.2466C>T0.273
rpoC765850c.2481G>C0.260
rpoC765883c.2514C>G0.270
rpoC765886c.2517C>G0.264
rpoC765892c.2523T>C0.295
rpoC765937c.2568T>C0.248
rpoC765947c.2578T>C0.286
rpoC765967c.2598C>T0.279
rpoC765982c.2613C>G0.319
rpoC765994c.2625A>T0.330
rpoC766010c.2641T>A0.333
rpoC766021c.2652G>C0.370
rpoC766027c.2658G>C0.356
rpoC766043p.Gln892Glu0.325
rpoC766054c.2685C>G0.327
rpoC766082p.Ala905Gln0.319
rpoC766096c.2727G>C0.330
rpoC766129c.2760C>G0.239
rpoC766135c.2766G>A0.213
rpoC766141c.2772C>T0.207
rpoC766142c.2773C>T0.205
rpoC766174p.Asn935Lys0.133
rpoC766178p.Ile937Val0.127
rpoC766345c.2976T>C0.127
rpoC766348c.2979A>G0.127
rpoC766357c.2988C>T0.163
rpoC766363c.2994G>C0.159
rpoC766366c.2997C>G0.157
rpoC766381c.3012C>T0.207
rpoC766384c.3015A>G0.220
rpoC766390c.3021C>T0.228
rpoC766393c.3024C>G0.256
rpoC766408c.3039C>G0.289
rpoC766411c.3042C>G0.304
rpoC766426c.3057C>T0.315
rpoC766447c.3078T>C0.315
rpoC766462c.3093G>C0.292
rpoC766483c.3114G>C0.264
rpoC766484p.Val1039Ile0.267
rpoC766492c.3123T>C0.263
rpoC766522c.3153C>G0.302
rpoC766528c.3159T>C0.304
rpoC766531c.3162G>C0.300
rpoC766540p.Asp1057Glu0.278
rpoC766549c.3180G>C0.273
rpoC766573c.3204T>C0.286
rpoC766582c.3213C>G0.240
rpoC766583p.Gly1072Ser0.240
rpoC766591c.3222A>G0.258
rpoC766594c.3225G>C0.255
rpoC766597c.3228C>G0.265
rpoC766607p.Ile1080Leu0.324
rpoC766630c.3261G>C0.321
rpoC766657c.3288A>G0.321
rpoC766672c.3303T>C0.302
rpoC766673p.Gly1102Asn0.292
rpoC766684c.3315C>T0.303
rpoC766726c.3357T>C0.297
rpoC766738c.3369G>C0.295
rpoC766765c.3396A>C0.289
rpoC766774c.3405T>C0.261
rpoC766801c.3432C>G0.275
rpoC766804c.3435A>G0.283
rpoC766861c.3492G>C0.284
rpoC766864c.3495G>C0.296
rpoC766900c.3531T>C0.293
rpoC766933c.3564A>G0.314
rpoC766945c.3576A>G0.314
rpoC766963c.3594T>C0.303
rpoC766972c.3603G>C0.296
rpoC766996c.3627C>T0.260
rpoC767009c.3640T>A0.242
rpoC767014c.3645G>C0.242
rpoC767033c.3664T>A0.272
rpoC767059c.3690T>G0.308
rpoC767062c.3693C>A0.295
rpoC767098c.3729T>C0.273
rpoC767119c.3750A>G0.290
rpoC767134c.3765C>A0.291
rpoC767158c.3789T>C0.264
rpoC767180p.Ala1271Gln0.235
rpoC767191c.3822C>G0.227
rpoC767206c.3837C>G0.202
rpoC767209c.3840T>C0.200
rpoC767212c.3843G>C0.207
rpoC767221c.3852C>G0.209
rpoC767230c.3861G>C0.200
rpoC767233c.3864T>C0.189
rpsL781395c.-165T>C1.000
rpsL781397c.-163G>A0.984
rpsL781571c.12C>T0.175
rpsL781595c.36T>C0.225
rpsL781605p.Ile16Val0.225
rpsL781608p.Ser17Ala0.229
rpsL781628c.69T>C0.295
rpsL781631c.72G>C0.289
rpsL781649c.90T>C0.314
rpsL781655c.96T>C0.330
rpsL781682c.123T>C0.319
rpsL781700c.141G>C0.333
rpsL781703c.144G>T0.348
rpsL781715c.156T>C0.372
rpsL781728c.169T>C0.340
rpsL781736c.177T>C0.337
rpsL781742c.183C>T0.327
rpsL781748c.189C>G0.303
rpsL781754c.195G>C0.294
rpsL781760c.201T>C0.300
rpsL781772c.213C>A0.273
rpsL781808c.249C>T0.226
rpsL781811c.252C>T0.219
rpsL781832c.273T>C0.261
rpsL781838c.279G>C0.236
rpsL781841c.282C>G0.234
rpsL781865c.306G>C0.183
rpsL781868c.309T>C0.175
rpsL781871c.312G>C0.171
rpsL781877c.318T>C0.188
rpsL781892c.333A>G0.205
rpsL781898c.339A>T0.207
rpsL781916c.357T>C0.193
rpsL781929p.Gly124Ser0.216
rplC800794c.-15A>G0.140
rplC800796c.-13A>G0.130
rplC800814c.6A>G0.144
rplC800817c.9A>T0.157
rplC800844c.36T>C0.202
rplC800865c.57A>G0.198
rplC800867p.Ser20Asn0.198
rplC800874c.66A>G0.194
rplC800875p.Val23Ile0.194
rplC800880c.72A>G0.194
rplC800889c.81C>G0.188
rplC800892c.84G>C0.192
rplC800907c.99C>G0.172
rplC800916c.108A>G0.162
rplC800934c.126C>G0.122
rplC800937c.129A>G0.121
rplC800939p.Arg44Gln0.125
rplC800946c.138T>C0.124
rplC800949c.141T>C0.120
rplC801147c.339T>C0.112
rplC801150c.342G>C0.109
rplC801153c.345G>C0.111
rplC801156c.348T>A0.106
rplC801168c.360C>A0.123
rplC801171c.363A>G0.130
rplC801174c.366T>C0.131
rplC801180c.372C>G0.168
rplC801195c.387G>C0.207
rplC801201c.393C>T0.208
rplC801207c.399C>T0.211
rplC801246c.438C>T0.211
rplC801249c.441T>C0.220
rplC801255c.447C>T0.208
rplC801264c.456C>T0.170
rplC801267c.459A>T0.163
rplC801270c.462T>C0.162
rplC801276c.468G>C0.157
rplC801279c.471G>C0.160
rplC801282c.474G>C0.163
rplC801285c.477G>C0.165
rplC801300c.492C>G0.264
rplC801309c.501C>G0.277
rplC801312c.504G>C0.277
rplC801321c.513C>T0.255
rplC801324c.516T>C0.250
rplC801339c.531T>C0.213
rplC801341p.Leu178Gln0.209
rplC801348c.540T>G0.278
rplC801357c.549T>C0.313
rplC801367p.Ala187Thr0.330
rplC801402c.594T>C0.337
rplC801405c.597T>C0.337
rplC801423c.615G>C0.316
rplC801426c.618C>G0.292
rplC801427p.Met207Val0.286
rplC801438c.630T>C0.267
rplC801442p.Ile212Val0.253
rrs1471923r.78t>c0.300
rrs1471925r.80t>c0.304
rrs1471932r.87a>g0.292
rrs1471934r.89a>g0.310
rrs1471969r.124t>c0.217
rrs1471970r.125g>a0.217
rrs1472028r.183a>t0.145
rrs1472029r.184c>t0.145
rrs1472030r.185g>t0.151
rrs1472031r.186g>a0.151
rrs1472033r.188a>g0.151
rrs1472034r.189t>c0.148
rrs1472044r.199g>t0.255
rrs1472045r.200t>a0.255
rrs1472061r.216a>t0.305
rrs1472075r.230a>g0.349
rrs1472108r.263c>t0.404
rrs1472969r.1124a>g0.378
rrs1472970r.1125c>g0.370
rrs1472977r.1132g>c0.365
rrs1472978r.1133t>c0.365
rrs1473105r.1260g>a0.321
rrs1473123r.1278a>t0.288
rrs1473145r.1300c>t0.271
rrs1473166r.1321g>a0.228
rrs1473290r.1445c>t0.381
rrl1473658r.1t>a0.155
rrl1473659r.2t>a0.165
rrl1473668r.11c>t0.176
rrl1473756r.99g>a0.227
rrl1473758r.101g>t0.227
rrl1473806r.149c>t0.194
rrl1473877r.220g>a0.310
rrl1473898r.241c>t0.310
rrl1473943r.286g>t0.291
rrl1473945r.288t>a0.291
rrl1473946r.289a>t0.291
rrl1473986r.329t>c0.269
rrl1473987r.330g>a0.275
rrl1473995r.338g>t0.269
rrl1474001r.344c>t0.260
rrl1474009r.352a>g0.271
rrl1474012r.355c>t0.245
rrl1474093r.436g>t0.322
rrl1474099r.442g>a0.358
rrl1474103r.446a>t0.333
rrl1474140r.483c>t0.356
rrl1474151r.494c>t0.375
rrl1474181r.524c>t0.351
rrl1474249r.592g>t0.421
rrl1474291r.634tttcctctccggagga>t0.339
rrl1474308r.651g>t0.273
rrl1474310r.653t>g0.273
rrl1474356r.699t>c0.406
rrl1474362r.705a>g0.371
rrl1474376r.719t>c0.333
rrl1474427r.770a>c0.179
rrl1474429r.772g>c0.182
rrl1474432r.775c>g0.185
rrl1474639r.982g>a0.265
rrl1474794r.1137c>t0.404
rrl1474812r.1155g>a0.365
rrl1474823r.1166c>t0.323
rrl1474831r.1174a>g0.328
rrl1474904r.1247g>a0.333
rrl1474956r.1299c>t0.261
rrl1474960r.1303c>g0.258
rrl1474963r.1306g>t0.262
rrl1474964r.1307t>a0.266
rrl1474965r.1308g>c0.266
rrl1474970r.1313g>a0.279
rrl1475006r.1349a>t0.267
rrl1475061r.1404c>t0.291
rrl1475088r.1431a>t0.351
rrl1475199r.1542g>a0.414
rrl1475206r.1549c>t0.418
rrl1475209r.1552g>c0.418
rrl1475213r.1556c>t0.414
rrl1475249r.1592t>c0.400
rrl1475252r.1595c>t0.404
rrl1475266r.1609t>c0.370
rrl1475267r.1610g>a0.362
rrl1475275r.1618c>t0.367
rrl1475276r.1619t>c0.367
rrl1475291r.1634a>c0.393
rrl1475315r.1658a>t0.382
rrl1475355r.1698c>t0.404
rrl1475369r.1712g>t0.392
rrl1475402r.1745c>t0.386
rrl1475419r.1762c>t0.395
rrl1475429r.1772g>a0.375
rrl1475436r.1779c>t0.385
rrl1475483r.1826c>t0.250
rrl1475505r.1848g>a0.200
rrl1475526r.1869c>a0.206
rrl1475599r.1942a>g0.310
rrl1475608r.1951t>c0.378
rrl1475642r.1985t>c0.491
rrl1475657r.2000a>g0.475
rrl1475659r.2002g>t0.475
rrl1475758r.2101ac>a0.453
rrl1475763r.2106c>t0.373
rrl1475765r.2108ag>a0.380
rrl1475881r.2224t>c0.393
rrl1475988r.2331a>g0.420
rrl1476031r.2374c>t0.278
rrl1476032r.2375c>a0.278
rrl1476033r.2376t>c0.278
rrl1476034r.2377c>a0.278
rrl1476045r.2388g>t0.270
rrl1476047r.2390g>t0.263
rrl1476048r.2391g>a0.263
rrl1476049r.2392c>t0.263
rrl1476086r.2429g>a0.360
rrl1476089r.2432t>c0.367
rrl1476095r.2438c>g0.373
rrl1476106r.2449a>t0.354
rrl1476115r.2458t>c0.352
rrl1476117r.2460g>c0.352
rrl1476214r.2557g>a0.296
rrl1476224r.2567a>g0.278
rrl1476281r.2624t>c0.305
rrl1476583r.2926g>a0.386
rrl1476584r.2927c>t0.364
rrl1476594r.2937c>t0.372
rrl1476597r.2940g>a0.405
rrl1476603r.2946g>a0.432
rrl1476608r.2951c>g0.426
rrl1476628r.2971t>a0.460
rrl1476689r.3032a>t0.400
rrl1476690r.3033c>t0.400
rrl1476693r.3036g>a0.400
rrl1476695r.3038t>a0.377
rrl1476716r.3059a>c0.344
rrl1476726r.3069a>g0.311
rrl1476732r.3075t>c0.297
rrl1476750r.3093t>c0.234
rrl1476755r.3098g>a0.246
rrl1476759r.3102t>c0.226
rrl1476770r.3113t>c0.164
rrl1476771r.3114g>a0.164
fabG11673482p.Ser15Ala0.137
fabG11673487c.48T>C0.145
fabG11673490c.51A>G0.169
fabG11673523c.84G>T0.250
fabG11673535c.96A>G0.247
fabG11673547c.108T>C0.247
fabG11673568c.129C>G0.203
fabG11673574c.135C>G0.200
fabG11673580c.141T>G0.189
fabG11673589c.150A>G0.192
fabG11673595c.156A>C0.154
fabG11673596p.Lys53Glu0.156
fabG11673602c.163C>T0.153
fabG11673607c.168T>C0.136
fabG11673615p.Glu59Val0.127
fabG11673619c.180T>C0.125
fabG11673679c.240T>C0.119
fabG11673685c.246C>T0.134
fabG11673703c.264C>T0.143
fabG11673710p.Leu91Ile0.179
fabG11673716p.Ala93Lys0.152
fabG11673733p.Met98Ile0.143
fabG11673742c.303C>T0.141
fabG11673748c.309A>G0.132
fabG11673749p.Lys104Arg0.130
fabG11673758p.Lys107Glu0.125
fabG11673890p.Ala151Ser0.205
fabG11673901c.462A>G0.275
fabG11673905p.Ser156Ala0.268
fabG11673916c.477A>C0.260
fabG11673917p.Val160Leu0.260
fabG11673922c.483T>C0.273
fabG11673941p.Ala168Ser0.321
fabG11673955c.516G>C0.364
fabG11673961c.522A>C0.354
fabG11673985c.546C>G0.327
fabG11674006p.Asp189Glu0.343
fabG11674015c.576C>T0.198
fabG11674018c.579G>C0.202
fabG11674021c.582G>C0.205
fabG11674024c.585T>C0.202
fabG11674033c.594T>C0.200
fabG11674037p.Gln200Ala0.198
fabG11674042c.603G>T0.207
fabG11674049p.Gln204Asp0.202
fabG11674054c.615T>C0.202
fabG11674060c.621A>G0.207
fabG11674063c.624G>C0.207
fabG11674079p.Pro214Ala0.312
fabG11674114c.675T>A0.223
fabG11674123c.684T>C0.233
fabG11674126c.687G>C0.227
fabG11674132c.693T>C0.218
fabG11674136p.Ser233Ala0.218
fabG11674141c.702T>C0.200
fabG11674156c.717C>G0.193
fabG11674171c.732T>C0.113
inhA1674471c.270G>C0.250
inhA1674480c.279T>C0.267
inhA1674486c.285T>C0.292
inhA1674504c.303C>G0.290
inhA1674537c.336C>G0.244
inhA1674542p.Ala114Glu0.242
inhA1674546c.345T>C0.228
inhA1674549c.348G>C0.223
inhA1674555c.354G>A0.224
inhA1674561c.360C>T0.230
inhA1674565p.Ile122Val0.240
inhA1674582c.381T>C0.220
inhA1674585c.384T>C0.225
inhA1674589p.Met130Leu0.219
inhA1674601p.Leu134Thr0.175
inhA1674624c.423A>C0.222
inhA1674630c.429C>G0.239
inhA1674660c.459G>C0.292
inhA1674672c.471C>G0.291
inhA1674703c.502T>C0.318
inhA1674708c.507G>A0.305
inhA1674718c.517A>C0.308
inhA1674726c.525G>A0.309
inhA1674738c.537C>G0.261
inhA1674741c.540C>T0.266
inhA1674746p.Tyr182Phe0.271
inhA1674750c.549T>C0.264
inhA1674753c.552G>C0.264
inhA1674756c.555T>C0.264
inhA1674759c.558G>C0.262
inhA1674774c.573A>G0.284
inhA1674780c.579T>G0.275
inhA1674789c.588G>C0.272
inhA1674801c.600T>C0.245
inhA1674822c.621C>G0.231
inhA1674828c.627G>A0.224
inhA1674846p.Ile215Met0.243
inhA1674864c.663C>T0.235
inhA1674870c.669T>C0.248
inhA1674879c.678T>C0.220
inhA1674900c.699G>A0.237
inhA1674903c.702T>C0.226
inhA1674904p.Ala235Pro0.223
inhA1674909c.708G>A0.242
inhA1674942c.741T>G0.260
inhA1674960c.759C>G0.235
inhA1674966c.765T>G0.211
inhA1674967p.Asp256Thr0.211
inhA1674987c.786C>T0.196
rpsA1833518c.-24C>A0.256
rpsA1833532c.-10A>C0.261
rpsA1833554p.Thr5Ala0.320
rpsA1833568c.27G>C0.357
rpsA1833589c.48A>T0.361
rpsA1833595c.54T>C0.359
rpsA1833661c.120A>G0.304
rpsA1833667c.126C>G0.315
rpsA1833721c.180A>G0.240
rpsA1833724c.183C>G0.224
rpsA1833727c.186G>C0.224
rpsA1833742c.201A>G0.280
rpsA1833745c.204G>C0.276
rpsA1833748c.207C>G0.265
rpsA1833787c.246C>G0.277
rpsA1833790c.249T>C0.287
rpsA1833802c.261A>G0.301
rpsA1833811c.270G>T0.301
rpsA1833838c.297G>C0.272
rpsA1833841c.300C>G0.257
rpsA1833847c.306C>G0.253
rpsA1833856c.315A>G0.263
rpsA1833874c.333T>C0.258
rpsA1833928c.387G>C0.264
rpsA1833940c.399C>G0.252
rpsA1833971c.430C>T0.243
rpsA1833979c.438T>C0.265
rpsA1834000c.459G>C0.279
rpsA1834021c.480C>T0.283
rpsA1834030c.489C>G0.258
rpsA1834099c.558C>G0.263
rpsA1834102c.561T>C0.258
rpsA1834105c.564C>G0.272
rpsA1834108c.567C>G0.266
rpsA1834123c.582C>G0.307
rpsA1834150c.609G>C0.198
rpsA1834153c.612T>C0.198
rpsA1834154p.Asn205Gln0.200
rpsA1834157c.616T>C0.200
rpsA1834162c.621A>G0.198
rpsA1834165c.624A>G0.200
rpsA1834169p.Thr210Ala0.209
rpsA1834177c.636A>C0.990
rpsA1834189c.648G>C0.294
rpsA1834195c.654G>C0.306
rpsA1834210c.669C>T0.282
rpsA1834222c.681T>C0.274
rpsA1834231c.690T>C0.275
rpsA1834234c.693G>C0.248
rpsA1834249c.708T>C0.255
rpsA1834261c.720A>G0.212
rpsA1834262c.721T>A0.214
rpsA1834303c.762T>C0.302
rpsA1834306c.765T>C0.287
rpsA1834333c.792C>T0.290
rpsA1834348c.807T>C0.245
rpsA1834366c.825A>G0.297
rpsA1834396c.855G>C0.299
rpsA1834411c.870T>C0.280
rpsA1834417c.876G>C0.280
rpsA1834423c.882G>C0.262
rpsA1834435c.894G>C0.239
rpsA1834451c.910T>C0.254
rpsA1834465c.924T>C0.272
rpsA1834468c.927A>G0.272
rpsA1834489c.948T>C0.297
rpsA1834510c.969C>T0.278
rpsA1834513c.972C>G0.283
rpsA1834528c.987T>C0.283
rpsA1834540c.999G>C0.280
rpsA1834546c.1005T>C0.298
rpsA1834609c.1068T>C0.315
rpsA1834633c.1092A>G0.319
rpsA1834639c.1098T>C0.303
rpsA1834654p.Glu371Asp0.300
rpsA1834684c.1143C>T0.298
rpsA1834690c.1149T>C0.318
rpsA1834732c.1191T>C0.257
rpsA1834733p.Ala398Ser0.250
rpsA1834738c.1197A>G0.252
rpsA1834753c.1212T>C0.245
rpsA1834765p.Glu408Asp0.243
rpsA1834775p.Ala412Thr0.220
rpsA1834780c.1239A>G0.235
rpsA1834786c.1245A>G0.242
rpsA1834789c.1248T>C0.250
rpsA1834792c.1251G>C0.242
rpsA1834849c.1308C>G0.198
rpsA1834852c.1311C>G0.183
tlyA1917951c.12T>C0.178
tlyA1917972c.33A>G1.000
tlyA1917975c.36C>G0.212
tlyA1917981c.42G>C0.207
tlyA1917990c.51G>C0.194
tlyA1917993c.54A>G0.195
tlyA1917996c.57A>G0.198
tlyA1918002c.63A>G0.202
tlyA1918036p.Arg33Ser0.189
tlyA1918048p.Leu37Met0.202
katG2154724p.Arg463Leu1.000
katG2155661p.Val151Ile0.145
katG2155677c.435G>C0.186
katG2155680c.432C>G0.186
katG2155691c.421A>G0.226
katG2155695c.417G>C0.227
katG2155704c.408G>C0.236
katG2155716c.396A>C0.250
katG2155722c.390C>G0.253
katG2155728c.384C>G0.250
katG2155742p.Gly124Gln0.226
katG2155743c.369C>G0.224
katG2155782c.330G>C0.205
katG2155785c.327A>G0.213
katG2155796p.Ala106Ser0.119
kasA2518121p.Gln3Lys0.115
kasA2518132c.18C>T0.156
kasA2518138c.24T>C0.194
kasA2518146p.Phe11Tyr0.211
kasA2518162c.48G>A0.215
kasA2518174c.60A>G0.253
kasA2518190p.Ser26Ala0.267
kasA2518199p.Ile29Val0.264
kasA2518220c.106C>T0.243
kasA2518234c.120G>A0.218
kasA2518248p.Ala45Val0.175
kasA2518261p.Glu49Asp0.141
kasA2518263p.Phe50Tyr0.141
kasA2518265p.Val51Ile0.145
kasA2518459c.345T>C0.160
kasA2518462c.348A>C0.160
kasA2518468c.354A>C0.171
kasA2518474c.360G>A0.189
kasA2518480c.366T>C0.194
kasA2518483c.369C>G0.194
kasA2518504c.390T>C0.250
kasA2518506p.Ala131Glu0.248
kasA2518519c.405G>C0.271
kasA2518528c.414C>G0.286
kasA2518540c.426T>C0.307
kasA2518561c.447T>C0.278
kasA2518567c.453G>C0.250
kasA2518570c.456G>C0.247
kasA2518574p.Ile154Val0.256
kasA2518579c.465T>C0.247
kasA2518588c.474T>C0.237
kasA2518591c.477G>C0.242
kasA2518609p.Met165Ile0.209
kasA2518624c.510C>G0.221
kasA2518639c.525G>C0.237
kasA2518657c.543G>C0.194
kasA2518672c.558G>C0.209
kasA2518678c.564C>T0.202
kasA2518684c.570C>G0.242
kasA2518696c.582C>G0.234
kasA2518702c.588C>T0.234
kasA2518705c.591T>C0.241
kasA2518711c.597A>G0.257
kasA2518714c.600A>C0.261
kasA2518732c.618C>G0.308
kasA2518744c.630C>T0.321
kasA2518747c.633C>G0.321
kasA2518768c.654C>T0.345
kasA2518777c.663C>T0.315
kasA2518783c.669T>C0.304
kasA2518789c.675G>C0.330
kasA2518792c.678C>A0.315
kasA2518795c.681C>G0.315
kasA2518825c.711T>C0.348
kasA2518864c.750G>C0.356
kasA2518879c.765A>G0.327
kasA2518885c.771T>C0.317
kasA2518898c.784T>C0.305
kasA2518906c.792A>G0.287
kasA2518910p.Leu266Met0.282
kasA2518921c.807T>C0.282
kasA2518927c.813C>G0.247
kasA2518936c.822C>G0.208
kasA2518939c.825T>C0.203
kasA2518942c.828T>C0.200
kasA2518951c.837G>C0.189
kasA2518954c.840C>G0.189
kasA2518963c.849T>C0.143
kasA2518969c.855T>G0.127
kasA2518975c.861C>G0.110
kasA2519062c.948T>G0.174
kasA2519068c.954C>T0.149
kasA2519072p.Ala320Thr0.144
kasA2519107c.993T>C0.243
kasA2519108p.Asp332Gln0.236
kasA2519116c.1002C>G0.234
kasA2519122c.1008G>C0.259
kasA2519137c.1023T>G0.333
kasA2519158c.1044C>T0.345
kasA2519167c.1053T>G0.349
kasA2519173c.1059C>G0.346
kasA2519196p.Thr361Ser0.287
kasA2519215c.1101C>T0.146
kasA2519218c.1104G>A0.144
kasA2519221c.1107G>C0.148
kasA2519227c.1113G>C0.133
kasA2519230c.1116C>T0.133
kasA2519236c.1122G>A0.120
kasA2519239c.1125A>C0.122
kasA2519245c.1131T>C0.121
ahpC2726198c.6A>T0.103
ahpC2726204c.12A>G0.143
ahpC2726210c.18T>C0.159
ahpC2726216c.24T>C0.164
ahpC2726219c.27A>G0.167
ahpC2726232p.Gln14Glu0.213
ahpC2726243c.51T>G0.188
ahpC2726244c.52C>T0.185
ahpC2726251p.Gly20Ala0.184
ahpC2726255c.63T>C0.195
ahpC2726258c.66C>T0.195
ahpC2726303c.111T>C0.253
ahpC2726311p.Ser40Asn0.163
ahpC2726315p.Asp41Glu0.163
ahpC2726318p.Glu42Asp0.165
ahpC2726322p.Pro44Ala0.163
ahpC2726330c.138G>A0.160
ahpC2726336c.144G>C0.165
ahpC2726348c.156T>C0.152
ahpC2726357c.165A>G0.141
ahpC2726366c.174G>C0.111
ahpC2726591c.399C>G0.205
ahpC2726593p.Val134Ala0.207
ahpC2726600c.408T>C0.196
ahpC2726601p.Ile137Leu0.194
ahpC2726638p.Ala149Val0.255
ahpC2726645c.453C>G0.260
ahpC2726657c.465A>C0.230
ahpC2726669p.Asp159Glu0.224
ahpC2726672c.480G>A0.216
ahpC2726675c.483A>G0.211
ahpC2726681c.489A>C0.215
ahpC2726687c.495C>G0.188
ahpC2726693c.501C>G0.198
ahpC2726696c.504C>G0.198
ahpC2726709c.517C>T0.180
ahpC2726717c.525A>G0.182
ahpC2726747c.555A>C0.145
folC2746365p.Leu412Val0.125
folC2746375c.1224C>G0.163
folC2746390c.1209C>G0.157
folC2746393c.1206G>C0.157
folC2746401p.Ser400Ala0.153
folC2746402c.1197A>G0.155
folC2746416p.Glu395Gln0.163
folC2746420c.1179T>G0.163
folC2746426c.1173C>G0.149
folC2746438c.1161C>G0.165
folC2746451p.Gly383Ala0.169
folC2746471c.1128G>T0.165
folC2746478p.Phe374Tyr0.143
folC2746480c.1119T>G0.152
folC2747021p.Val193Ala0.121
folC2747023c.576G>C0.121
folC2747026c.573G>C0.119
folC2747032c.567T>G0.265
folC2747059c.540A>G0.280
folC2747062c.537T>C0.274
folC2747065c.534G>A0.264
folC2747071c.528G>C0.253
folC2747086c.513T>G0.245
folC2747089c.510C>G0.242
folC2747101c.498C>G0.235
folC2747107c.492C>G0.232
folC2747110c.489A>G0.237
folC2747113c.486G>C0.235
folC2747116c.483C>G0.230
folC2747134c.465G>C0.223
folC2747248c.351C>G0.139
folC2747264p.Gly112Ala0.153
folC2747266c.333G>A0.163
folC2747275c.324A>G0.239
folC2747289p.Pro104Ala0.235
folC2747290c.309T>C0.235
folC2747293c.306C>T0.237
folC2747302c.297T>C0.260
folC2747314c.285T>G0.263
folC2747317c.282G>C0.269
folC2747343p.Val86Ile0.278
folC2747355p.Val82Ile0.244
folC2747359c.240G>C0.244
folC2747362c.237C>G0.242
folC2747394p.Ile69Val0.210
folC2747395c.204A>G0.208
folC2747407c.192A>G0.144
folC2747415p.Arg62Cys0.135
folC2747419c.180G>C0.136
folC2747422c.177C>T0.133
folC2747425c.174G>A0.133
folC2747442c.157A>G0.148
ribD2987026p.Ala63Gly0.226
ribD2987033c.195C>G0.216
ribD2987042c.204A>G0.223
ribD2987046p.Val70Ile0.228
ribD2987058c.220T>C0.223
ribD2987066c.228A>G0.226
ribD2987069c.231T>C0.223
ribD2987092p.Val85Ala0.247
ribD2987105c.267C>G0.193
ribD2987108c.270T>C0.179
thyX3067223c.723C>G0.304
thyX3067232c.714G>C0.337
thyX3067246p.Thr234Ala0.348
thyX3067249p.Thr233Ser0.344
thyX3067252p.Val232Ile0.341
thyX3067274c.672G>C0.345
thyX3067277c.669G>C0.319
thyX3067281p.Val222Ala0.315
thyX3067284p.Ala221Gly0.309
thyX3067286c.660G>C0.305
thyX3067289c.657G>C0.305
thyX3067292c.654C>T0.309
thyX3067295c.651G>A0.309
thyX3067313c.633C>A0.398
thyX3067316c.630T>C0.393
thyX3067325c.621T>C0.378
thyX3067349c.597C>G0.368
thyX3067355c.591T>G0.342
thyX3067367c.579C>G0.330
thyX3067373c.573G>C0.304
thyX3067391c.555C>G0.286
thyX3067394c.552C>G0.278
thyX3067439c.507T>C0.310
thyX3067445c.501G>C0.298
thyX3067457c.489G>C0.234
thyX3067462c.484G>A0.229
thyX3067465p.Ile161Val0.218
thyX3067466c.480C>G0.225
thyX3067475c.471T>C0.257
thyX3067491p.Ala152Glu0.213
thyX3067493c.453T>C0.209
thyX3067510c.436G>A0.238
thyX3067515p.Ser144Thr0.262
thyX3067531p.Ala139Ser0.248
thyX3067545p.Glu134Ala0.250
thyX3067549p.Thr133Ala0.269
thyX3067556p.His130Gln0.237
thyX3067559c.387G>C0.242
thyX3067565p.Asp127Glu0.274
thyX3067570p.Ala126Pro0.266
thyX3067577c.369C>T0.306
thyX3067598c.348G>A0.327
thyX3067602p.Arg115His0.330
thyX3067611p.Lys112Thr0.347
thyX3067619c.327T>G0.378
thyX3067631c.315G>C0.371
thyX3067634c.312G>C0.371
thyX3067652c.294A>G0.398
thyX3067661c.285G>C0.398
thyX3067685c.261T>G0.387
thyX3067693p.Ile85Leu0.349
thyX3067694c.252C>G0.349
thyX3067718c.228G>C0.323
thyX3067721c.225A>G0.323
thyX3067727c.219T>G0.303
thyX3067736c.210G>A0.264
thyX3067739c.207A>G0.250
thyX3067762p.Arg62Lys0.253
thyX3067765p.Leu61Ile0.253
thyX3067781c.165G>C0.286
thyX3067793c.153A>G0.301
thyX3067799c.147C>T0.250
thyX3067802c.144G>C0.242
thyX3067814c.132A>G0.267
thyX3067850c.96T>G0.282
thyX3067869p.Thr26Ser0.268
thyX3067874c.72G>C0.265
thyX3067877c.69C>G0.265
thyX3067883c.63G>C0.265
thyX3067886c.60T>G0.273
thyX3067889c.57G>C0.273
thyX3067898p.Asp16Glu0.303
thyX3067935p.Thr4Ile0.219
thyX3067951c.-6A>G0.193
thyA3073839c.633A>G0.132
thyA3073860c.612G>C0.139
thyA3073863c.609A>G0.138
thyA3073866c.606G>C0.139
thyA3073874p.Ile200Val0.143
thyA3073892c.580A>G0.155
thyA3073898p.Ala192Ser0.156
thyA3073917c.555G>C0.143
thyA3073920c.552G>C0.136
thyA3073925c.547A>G0.124
thyA3073929c.543A>G0.118
thyA3073989c.483A>G0.116
thyA3074004c.468A>G0.149
thyA3074010c.462G>C0.172
thyA3074028c.444C>G0.194
thyA3074031c.441A>G0.193
thyA3074037c.435G>C0.204
thyA3074053p.Arg140Gln0.219
thyA3074057p.Glu139Pro0.206
thyA3074061c.411T>C0.212
thyA3074079c.393C>G0.278
thyA3074097c.375G>C0.279
thyA3074102p.Asp124Asn0.294
thyA3074106c.366A>G0.291
thyA3074127c.345C>G0.333
thyA3074130c.342C>G0.328
thyA3074147p.Ile109Val0.272
thyA3074159p.Ser105Thr0.188
thyA3074160c.312T>C0.182
thyA3074165p.Ala103Thr0.182
thyA3074172c.300C>G0.180
thyA3074175c.297T>C0.186
thyA3074181c.291T>C0.238
thyA3074187c.285A>G0.243
thyA3074205p.Glu89Asp0.260
thyA3074214c.258A>G0.255
thyA3074244c.228T>C0.204
thyA3074263p.Gly70Ala0.143
thyA3074267p.Ile69Val0.148
thyA3074268c.204A>G0.146
thyA3074285c.187A>G0.128
thyA3074286c.186A>G0.126
thyA3074334c.138A>G0.200
thyA3074360c.112A>G0.218
thyA3074361c.111A>G0.216
thyA3074372p.Met34Leu0.213
thyA3074377p.Gln32Arg0.213
thyA3074391c.81G>T0.235
thyA3074397c.75T>C0.220
ald3086788c.-32T>C1.000
ald3087126c.308 309insGC0.912
fbiA3640365c.-178C>G0.105
alr3840989c.432C>G0.115
alr3840994p.His143Asp0.117
alr3840997c.424C>G0.118
alr3841001c.420T>C0.115
alr3841010c.411T>C0.127
alr3841018p.Leu135Glu0.138
alr3841022c.399G>C0.151
alr3841028c.393C>G0.153
alr3841033p.Val130Ile0.176
alr3841037c.384C>G0.190
alr3841059p.Gly121Ala0.242
alr3841069p.Ile118Phe0.260
alr3841079c.342A>G0.246
alr3841100c.321T>C0.177
alr3841105p.Thr106Arg0.171
alr3841108p.Ile105Val0.178
alr3841112c.309A>G0.181
alr3841115c.306A>G0.178
alr3841127c.294T>C0.173
alr3841652c.-232A>T0.217
alr3841654c.-234A>C0.219
alr3841662c.-242A>G0.252
alr3841663c.-243G>A0.252
panD4044072c.210G>C0.136
panD4044075c.207A>G0.130
panD4044081c.201A>G0.138
panD4044084c.198A>G0.144
panD4044105c.177C>G0.159
panD4044117c.165C>G0.147
panD4044120c.162T>G0.147
panD4044123c.159A>G0.144
panD4044126c.156A>G0.146
panD4044138c.144A>G0.156
panD4044150c.132T>C0.144
panD4044165c.117C>G0.136
panD4044174c.108G>C0.128
panD4044177c.105G>C0.128
embC4240654c.792C>G0.116
embC4240660c.798C>G0.134
embC4240669c.807G>C0.129
embC4240671p.Thr270Ile0.134
embC4240677p.Gly272Ala0.132
embC4240685p.Thr275Ala0.219
embC4240693c.831T>G0.247
embC4240699c.837C>G0.253
embC4240726c.864G>C0.264
embC4240780c.918T>C0.320
embC4240783c.921G>C0.324
embC4240789c.927T>C0.362
embC4240819c.957A>G0.392
embC4240828c.966G>A0.387
embC4240831c.969T>G0.351
embC4240867c.1005T>C0.194
embC4240870c.1008T>C0.197
embC4240873c.1011C>G0.189
embC4240879c.1017G>C0.194
embC4240880p.Ala340Thr0.197
embC4240885c.1023T>C0.187
embC4240897c.1035C>G0.176
embC4240898c.1036C>T0.176
embC4240903c.1041C>G0.178
embC4240911p.Ala350Val0.171
embC4240921c.1059C>G0.176
embC4240924c.1062C>G0.155
embC4240936c.1074A>G0.122
embC4240996c.1134G>C0.110
embC4241002c.1140G>C0.113
embC4241013p.Met384Thr0.135
embC4241017c.1155T>C0.135
embC4241023c.1161T>G0.173
embC4241032c.1170G>C0.203
embC4241038c.1176G>C0.222
embC4241047c.1185C>G0.226
embC4241050c.1188T>G0.224
embC4241053c.1191G>C0.224
embC4241089c.1227C>G0.276
embC4241095c.1233C>T0.279
embC4241107c.1245G>C0.298
embC4241140c.1278A>G0.235
embC4241146c.1284C>G0.229
embC4241158c.1296T>C0.182
embC4241161c.1299C>G0.168
embC4241162c.1300T>C0.167
embC4241170c.1308G>C0.170
embC4241173c.1311C>T0.164
embC4241179c.1317G>A0.160
embC4241203c.1341T>C0.122
embC4241206c.1344G>C0.112
embC4241351p.Ile497Val0.147
embC4241361p.Asn500Thr0.147
embC4241363p.Leu501Met0.145
embC4241374c.1512T>G0.222
embC4241380c.1518A>C0.250
embC4241383c.1521G>C0.250
embC4241394p.Lys511Ser0.269
embC4241449c.1587C>G0.337
embC4241453p.Ile531Val0.333
embC4241479c.1617C>G0.289
embC4241480c.1618T>C0.292
embC4241488c.1626G>C0.286
embC4241496p.Ala545Gly0.244
embC4241500c.1638A>C0.247
embC4241501p.Ser547Thr0.250
embC4241506c.1644G>C0.253
embC4241518c.1656A>G0.229
embC4241521c.1659T>C0.232
embC4241530c.1668C>G0.197
embC4241536c.1674A>G0.138
embC4241539c.1677T>C0.125
embC4241545c.1683T>C0.123
embC4241548c.1686T>C0.107
embC4241551c.1689A>G0.111
embC4241567p.Ile569Val0.130
embC4241572c.1710C>G0.137
embC4241578c.1716G>C0.130
embC4242643c.2781C>T1.000
embC4242689p.Val943Ile0.150
embC4242710p.Gln950Glu0.187
embC4242715c.2853T>C0.190
embC4242742c.2880C>G0.208
embC4242748c.2886A>G0.206
embC4242754c.2892G>C0.198
embC4242764p.Val968Leu0.189
embC4242772c.2910G>C0.198
embC4242779p.Asn973Asp0.194
embC4242791p.Ala977Ser0.130
embC4242796c.2934G>C0.130
embC4242799c.2937T>C0.129
embC4242802c.2940G>C0.144
embC4242820c.2958G>C0.184
embC4242823c.2961G>C0.182
embC4242832c.2970A>C0.186
embC4242838c.2976C>G0.141
embC4242841c.2979C>T0.134
embC4242844c.2982A>G0.143
embC4242847c.2985C>A0.150
embC4242859c.2997C>T0.143
embC4242862c.3000A>G0.138
embC4242863p.Tyr1001Asn0.138
embC4242883c.3021C>G0.138
embC4242892c.3030G>C0.139
embC4242901c.3039G>C0.144
embC4242919c.3057A>G0.140
embC4242928c.3066A>G0.140
embC4242931c.3069G>C0.140
embA4243460c.228C>T0.989
embA4244462c.1230A>G0.105
embA4244478p.Thr416Leu0.111
embA4244483c.1251T>G0.109
embA4244485p.Thr418Ser0.112
embA4244498c.1266A>G0.158
embA4244507c.1275G>T0.167
embA4244508c.1276T>C0.168
embA4244516c.1284G>C0.165
embA4244517p.Leu429Val0.170
embA4244523p.Pro431Ala0.188
embA4244534c.1302T>C0.225
embA4244537c.1305T>G0.229
embA4244543c.1311C>G0.243
embA4244547p.Ile439Val0.248
embA4244557p.Arg442Thr0.267
embA4244582c.1350T>C0.243
embA4244585c.1353A>G0.241
embA4245041c.1809C>G0.239
embA4245044c.1812G>C0.239
embA4245053c.1821G>C0.257
embA4245060c.1828T>C0.277
embA4245083c.1851A>C0.322
embA4245089c.1857G>C0.330
embA4245101c.1869G>C0.345
embA4245137c.1905T>C0.359
embA4245146c.1914G>A0.318
embA4245149c.1917C>G0.320
embA4245153p.Ile641Val0.312
embA4245182c.1950T>C0.268
embA4245189c.1957C>T0.250
embA4245198p.Leu656Ile0.267
embA4245207c.1975T>C0.285
embA4245215c.1983A>C0.285
embA4245222p.Tyr664Gln0.264
embA4245248c.2016G>C0.236
embA4245257c.2025A>G0.215
embA4245263c.2031A>G0.222
embA4245282p.Ile684Val0.137
embA4245285c.2053T>C0.135
embA4245290c.2058C>G0.139
embA4245293c.2061T>G0.141
embA4245296c.2064G>C0.147
embA4245299c.2067A>G0.149
embA4245659c.2427C>G0.178
embA4245674c.2442A>C0.216
embA4245677c.2445G>C0.237
embA4245693p.Ile821Val0.238
embA4245701c.2469G>C0.234
embA4245704c.2472G>C0.244
embA4245725c.2493A>G0.278
embA4245726c.2494T>C0.291
embA4245737c.2505A>C0.325
embA4245740c.2508T>C0.325
embA4245764c.2532G>C0.361
embA4245772p.Asn847Thr0.336
embA4245785c.2553G>C0.297
embA4245807c.2575T>C0.149
embA4245812c.2580G>C0.146
embA4245813p.Pro861Ala0.156
embA4245820p.Ser863Thr0.157
embA4245824c.2592G>C0.156
embA4245833c.2601G>C0.163
embA4245842c.2610G>C0.167
embA4245845c.2613T>C0.159
embA4245851c.2619G>C0.165
embA4245860c.2628C>G0.165
embA4246164c.2932T>C0.115
embA4246184c.2952A>C0.137
embA4246196c.2964C>G0.138
embA4246205c.2973A>G0.148
embA4246211c.2979T>C0.144
embA4246217c.2985G>A0.149
embA4246220c.2988T>C0.159
embA4246223c.2991C>T0.157
embA4246227p.Ile999Val0.165
embA4246235c.3003G>A0.232
embA4246242p.Gln1004Gly0.218
embA4246250c.3018G>C0.253
embA4246256c.3024G>T0.243
embA4246259c.3027G>C0.245
embA4246264p.His1011Arg0.250
embA4246292c.3060A>G0.308
embA4246305p.Ser1025Glu0.261
embA4246308p.Thr1026Ala0.255
embA4246316c.3084T>G0.290
embA4246319c.3087G>C0.282
embA4246329p.Thr1033Ala0.287
embA4246349c.3117C>G0.276
embA4246359p.Ala1043Ser0.229
embA4246367c.3135C>T0.226
embA4246373c.3141T>C0.226
embA4246376c.3144G>C0.217
embA4246379c.3147C>T0.219
embA4246400c.3168G>C0.185
embA4246413p.His1061Phe0.178
embA4246419c.3187C>T0.167
embB4246544p.Thr11Pro0.113
embB4246548p.Pro12Gln0.108
embB4247395c.882C>G0.115
embB4247401c.888T>C0.125
embB4247407c.894G>C0.121
embB4247425c.912G>C0.154
embB4247434c.921C>G0.168
embB4247437c.924A>G0.164
embB4247440c.927C>G0.159
embB4247446c.933C>T0.171
embB4247464c.951C>G0.246
embB4247470c.957T>C0.265
embB4247491c.978G>C0.288
embB4247497c.984T>C0.291
embB4247512c.999T>C0.292
embB4247539c.1026T>C0.239
embB4247554c.1041T>C0.221
embB4247566c.1053C>A0.204
embB4247572c.1059A>G0.198
embB4247579p.Ala356Phe0.140
embB4247587c.1074G>A0.140
embB4247746c.1233C>T0.157
embB4247761c.1248T>C0.198
embB4247773c.1260G>A0.197
embB4247776c.1263G>T0.207
embB4247797c.1284C>G0.220
embB4247800c.1287A>T0.220
embB4247803c.1290G>C0.215
embB4247815c.1302C>G0.210
embB4247819p.Val436Ile0.217
embB4247830c.1317A>G0.235
embB4247836c.1323A>G0.250
embB4247839c.1326G>C0.261
embB4247866c.1353G>C0.282
embB4247875c.1362G>C0.252
embB4247876c.1363C>T0.252
embB4247881c.1368G>C0.282
embB4247887c.1374C>T0.286
embB4247893c.1380C>T0.308
embB4247899p.Met462Ile0.298
embB4247905c.1392G>C0.310
embB4247909c.1396T>C0.316
embB4247914c.1401G>C0.301
embB4247932c.1419C>G0.345
embB4247940p.Leu476Trp0.336
embB4247945c.1432T>C0.333
embB4247951p.Ser480Ala0.333
embB4247956c.1443G>C0.360
embB4247974c.1461C>G0.350
embB4248007c.1494C>G0.265
embB4248011p.Ser500Arg0.265
embB4248014p.Thr501Ala0.270
embB4248035p.Val508Ile0.227
embB4248040c.1527C>G0.211
embB4248041p.Ala510Thr0.207
embB4248044p.Lys511Ala0.205
embB4248070c.1557T>C0.280
embB4248085c.1572T>C0.265
embB4248097c.1584C>G0.266
embB4248130c.1617G>C0.274
embB4248142c.1629T>C0.286
embB4248143c.1630T>C0.286
embB4248157c.1644A>G0.289
embB4248172c.1659G>C0.297
embB4248199c.1686A>G0.255
embB4248200p.Ile563Val0.248
embB4248205c.1692C>G0.241
embB4248206p.Ser565Gly0.239
embB4248220c.1707A>C0.336
embB4248304c.1791G>C0.378
embB4248316c.1803C>G0.360
embB4248319c.1806A>G0.351
embB4248343c.1830G>C0.323
embB4248350c.1837T>C0.252
embB4248355c.1842A>G0.239
embB4248358c.1845C>G0.233
embB4248361c.1848A>C0.226
embB4248362p.Ser617Ala0.230
embB4248373c.1860C>G0.279
embB4248382c.1869C>G0.274
embB4248386c.1873C>A0.256
embB4248407p.Leu632Val0.155
embB4248410p.Phe633Leu0.157
embB4248419p.Leu636Met0.165
embB4248425c.1912T>C0.165
embB4248430c.1917T>C0.167
embB4248432p.Trp640Phe0.164
embB4248457c.1944T>C0.195
embB4248472c.1959T>C0.207
embB4248475c.1962G>C0.192
embB4248504p.Asp664Gly0.158
embB4248508c.1995G>A0.130
embB4248512p.Thr667Ser0.127
embB4249381c.2868A>G0.112
embB4249384c.2871G>T0.111
embB4249417c.2904A>G0.183
embB4249423p.Asp970Glu0.179
embB4249424p.Leu971Met0.181
embB4249429c.2916C>T0.183
embB4249432c.2919A>G0.183
embB4249441c.2928A>G0.228
embB4249444c.2931T>C0.222
embB4249469p.Leu986Met0.240
embB4249486c.2973T>G0.227
embB4249498c.2985G>C0.232
embB4249521p.Ala1003Val0.172
embB4249525c.3012T>C0.170
embB4249529p.Ile1006Val0.158
embB4249532p.Ala1007Thr0.150
embB4249537c.3024A>G0.149
embB4249543c.3030G>C0.147
embB4249546c.3033G>A0.152
embB4249558c.3045A>C0.138
embB4249568p.Ser1019Thr0.128
ethA4327396c.78A>G0.222
ethA4327399p.Asp25Glu0.222
ethA4327423c.51G>C0.222
ethA4327435c.39T>G0.221
ethA4327438c.36A>G0.197
ethA4327452p.Val8Leu0.147
ethA4327453c.21A>G0.135
ethA4327459c.15G>A0.138
ethA4327468c.6G>A0.123
gid4407588c.615T>C1.000
gid4407927p.Glu92Asp1.000

Analysis pipeline specifications

TBProfiler Version: 2.1.1

AnalysisProgram
Mappingbwa
Variant CallingBCFtools


Log

Drug Details
The estimated accuracy of drug resistance predictions is:

Drug1Sensitivity (%)Specificity (%)
Isoniazid 92.8 (89.9-95.7)100 (100-100)
Rifampicin 96.2 (93.9-98.5)98.1 (96.8-99.4)
Ethambutal 88.7 (83.6-93.8)81.7 (77.6-85.8)
Pyrazinamide70.9 (62.4-79.4)93.9 (90.6-97.2)
Streptomycin87.1 (82.7-91.5)89.7 (86.0-93.4)
Ethionamide 73.6 (66.7-80.5)93.3 (89.6-97.0)
Moxifloxacin60.0 (29.6-90.4)68.7 (52.6-84.8)
Ofloxacin 85.5 (79.1-91.9)94.9 (91.8-98.0)
Amikacin 82.9 (74.4-91.4)98.3 (96.0-100)
Capreomycin 60.7 (50.6-70.8)90.7 (87.2-94.2)
Kanamycin 87.3 (81.3-93.3)93.4 (89.9-96.9)
Para-aminosalisylic acidNot determinedNot determined
Linezolid Not determinedNot determined
Clofazimine Not determinedNot determined
Bedaquiline Not determinedNot determined
Multi drug resistance91.2 (87.8-94.6)98.4 (97.2-99.6)
Extremely drug resistance75.9 (64.5-87.3)98.4 (97.3-99.5)

Lineages
Lineage2LocationStrainRD type
lineage1Indo-OceanicEAIRD239
lineage1.1Indo-OceanicEAI3;EAI4;EAI5;EAI6RD239
lineage1.1.1Indo-OceanicEAI4;EAI5RD239
lineage1.1.1.1Indo-OceanicEAI4;ZERORD239
lineage1.1.2Indo-OceanicEAI3;EAI5RD239
lineage1.1.3Indo-OceanicEAI6RD239
lineage1.2Indo-OceanicEAI1;EAI2RD239
lineage1.2.1Indo-OceanicEAI2RD239
lineage1.2.2Indo-OceanicEAI1RD239
lineage2East-AsianBeijingRD105
lineage2.1East-Asian (non-Beijing)NoneNone
lineage2.2East-Asian (Beijing)Beijing-RD207RD105;RD207
lineage2.2.2East-Asian (Beijing)Beijing-RD105/RD207RD105;RD207
lineage2.2.1East-Asian (Beijing)Beijing-RD181RD105;RD207;RD181
lineage2.2.1.2East-Asian (Beijing)Beijing-RD142RD105;RD207;RD181;RD142
lineage2.2.1.1East-Asian (Beijing)Beijing-RD150RD105;RD207;RD181;RD150
lineage3East-African-IndianCASRD750
lineage3.1East-African-IndianNon-CAS1-DelhiRD750
lineage3.1.1East-African-IndianCAS1-KiliRD750
lineage3.1.2East-African-IndianCAS;CAS2RD750
lineage3.1.2.1East-African-IndianCAS2RD750
lineage3.1.2.2East-African-IndianCASRD750
lineage4Euro-AmericanLAM;T;S;X;HNone
lineage4.1Euro-AmericanT;X;HNone
lineage4.1.2Euro-American (X-type)T;HNone
lineage4.1.2.1Euro-American (X-type)T1;H1RD182
lineage4.1.1Euro-American (X-type)X1;X2;X3None
lineage4.1.1.2Euro-American (X-type)X1None
lineage4.1.1.1Euro-American (X-type)X2RD183
lineage4.1.1.3Euro-American (Haarlem)X1;X3RD193
lineage4.2Euro-AmericanH;T;LAMNone
lineage4.2.2Euro-American (Ural)T;LAM7-TURNone
lineage4.2.2.1Euro-AmericanLAM7-TURNone
lineage4.2.1Euro-American (TUR)H3;H4None
lineage4.3Euro-American (LAM)mainly-LAMNone
lineage4.3.1Euro-American (LAM)LAM9None
lineage4.3.3Euro-American (LAM)LAM;TRD115
lineage4.3.4Euro-American (LAM)LAMRD174
lineage4.3.4.1Euro-American (LAM)LAM1;LAM2RD174
lineage4.3.4.2Euro-American (LAM)LAM1;LAM4;LAM11RD174
lineage4.3.4.2.1Euro-American (LAM)LAM11RD174
lineage4.3.2Euro-American (LAM)LAM3None
lineage4.3.2.1Euro-American (LAM)LAM3RD761
lineage4.4Euro-AmericanS;TNone
lineage4.4.2Euro-AmericanT1;T2None
lineage4.4.1Euro-American (S-type)S;TNone
lineage4.4.1.2Euro-AmericanT1None
lineage4.4.1.1Euro-AmericanS;OrphansNone
lineage4.5Euro-AmericanH;TRD122
lineage4.6Euro-AmericanT;LAMNone
lineage4.6.1Euro-American (Uganda)T2RD724
lineage4.6.1.1Euro-American T2-UgandaRD724
lineage4.6.1.2Euro-AmericanT2RD724
lineage4.6.2Euro-AmericanT;LAMRD726
lineage4.6.2.1Euro-AmericanT3RD726
lineage4.6.2.2Euro-American (Cameroon)LAM10-CAMRD726
lineage4.7Euro-American (mainly T)T1;T5None
lineage4.8Euro-American (mainly T)T1;T2;T3;T5RD219
lineage4.9Euro-American (H37Rv-like)T1None
lineage5West-Africa 1AFRI_2;AFRI_3RD711
lineage6West-Africa 2AFRI_1RD702
lineage7Lineage 7NoneNone
lineageBOVM. bovisBOV_1;BOV_2None

Citations
1. Coll F, et al. Rapid determination of anti-tuberculosis drug resistance from whole genome sequences. Genome Medicine (in press)
2. Coll F, et al. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications 2014.

Disclaimer
This tool is for Research Use Only and is offered free for use. The London School of Hygiene and Tropical Medicine shall have no liability for any loss or damages of any kind, however sustained relating to the use of this tool.
© 2019 London School of Hygiene and Tropical Medicine;