Run ID: 859168fa-7fac-4a0c-9751-f558fcf6af59
Sample name:
Date: 21-01-2023 06:14:08
Number of reads: 27702
Percentage reads mapped: 91.33
Median coverage: 0
Strain: lineage2.2
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | fabG1 | c.-15C>T | Assoc w R | |
katG | p.Ser315Thr | Assoc w R | ||
ethambutol | ||||
pyrazinamide | ||||
moxifloxacin | gyrA | p.Asp94Gly | Assoc w R | |
levofloxacin | gyrA | p.Asp94Gly | Assoc w R | |
bedaquiline | ||||
delamanid | ||||
pretomanid | ||||
linezolid | ||||
streptomycin | ||||
amikacin | eis | c.-14C>T | Assoc w R | |
kanamycin | eis | c.-14C>T | Assoc w R | |
capreomycin | ||||
clofazimine | ||||
ethionamide | fabG1 | c.-15C>T | Assoc w R | |
para-aminosalicylic_acid | ||||
cycloserine |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gyrA | 7582 | p.Asp94Gly | missense_variant | 0.99 | ofloxacin | Uncertain significance | |
moxifloxacin | Assoc w R | ||||||
levofloxacin | Assoc w R | ||||||
fluoroquinolones | Uncertain significance | ||||||
ciprofloxacin | Uncertain significance | ||||||
fabG1 | 1673425 | c.-15C>T | upstream_gene_variant | 0.97 | isoniazid | Assoc w R | |
ethionamide | Assoc w R | ||||||
katG | 2155168 | p.Ser315Thr | missense_variant | 0.98 | isoniazid | Assoc w R | |
eis | 2715346 | c.-14C>T | upstream_gene_variant | 0.88 | kanamycin | Assoc w R | |
amikacin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 0.99 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 0.99 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 0.94 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 0.93 | linezolid | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
aminoglycosides | ||||||
streptomycin | ||||||
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.76 | pyrazinamide | |
tlyA | 1917972 | c.33A>G | synonymous_variant | 0.98 | capreomycin | |
katG | 2154724 | p.Arg463Leu | missense_variant | 0.88 | isoniazid | Uncertain significance |
ribD | 2987091 | p.Val85Met | missense_variant | 0.94 | para-aminosalicylic_acid | |
ald | 3087246 | p.Gln143* | stop_gained | 0.89 | cycloserine | |
ethA | 4326676 | p.Ser266Arg | missense_variant | 0.88 | ethionamide | Uncertain significance |
ethA | 4326974 | p.Trp167Ser | missense_variant | 1.0 | ethionamide | Uncertain significance |
ethR | 4327941 | p.Ser131Arg | missense_variant | 0.99 | ethionamide | Uncertain significance |
gid | 4407588 | c.615A>G | synonymous_variant | 0.99 | streptomycin | |
gid | 4407927 | p.Glu92Asp | missense_variant | 0.97 | streptomycin | Uncertain significance |