TB-Profiler result

Run: ERR024358
Summary

Run ID: ERR024358

Sample name:

Date: 31-03-2023 08:15:19

Number of reads: 592409

Percentage reads mapped: 72.56

Strain: lineage4.4.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 0.97
lineage4.4.1 Euro-American (S-type) S;T None 0.99
lineage4.4.1.1 Euro-American S;Orphans None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620241 c.351C>T synonymous_variant 1.0
ccsA 620748 c.858T>G synonymous_variant 0.14
rpoC 763912 c.543G>A synonymous_variant 0.15
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775825 p.Leu886Val missense_variant 0.12
mmpL5 777257 c.1224G>T synonymous_variant 0.18
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781837 p.Val93Ala missense_variant 0.2
fbiC 1303016 p.Val29Gly missense_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101706 p.Ala446Asp missense_variant 0.12
ndh 2102990 p.Val18Ala missense_variant 1.0
PPE35 2167859 c.2754T>G synonymous_variant 0.25
PPE35 2169840 p.Gly258Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ahpC 2726178 c.-15A>T upstream_gene_variant 0.12
ribD 2987560 p.Ala241Asp missense_variant 0.94
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448608 c.105G>A synonymous_variant 1.0
Rv3083 3449583 c.1080G>A synonymous_variant 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474880 p.Asn292Asp missense_variant 0.2
Rv3236c 3612665 p.Val151Ala missense_variant 0.91
fbiA 3640808 p.Met89Thr missense_variant 0.15
fbiA 3641187 p.Asn215Lys missense_variant 0.17
fbiB 3642772 p.Asp413Ala missense_variant 0.29
alr 3840420 p.Arg334Gln missense_variant 0.25
ddn 3987005 c.164delA frameshift_variant 0.2
ddn 3987018 p.Pro59Ala missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242869 p.Val1003Ile missense_variant 0.29
embC 4243115 p.Leu1085Met missense_variant 0.17
aftB 4268384 p.Leu151Phe missense_variant 1.0
ubiA 4269360 p.Leu158Phe missense_variant 0.17
ubiA 4269841 c.-8G>A upstream_gene_variant 1.0
ethA 4327368 p.Glu36* stop_gained 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0