TB-Profiler result

Run: ERR046833
Summary

Run ID: ERR046833

Sample name:

Date: 31-03-2023 08:53:14

Number of reads: 5881430

Percentage reads mapped: 99.66

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoC 762836 c.-534C>G upstream_gene_variant 0.3
rpoC 764725 p.Phe452Leu missense_variant 0.16
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777399 p.Thr361Arg missense_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406750 c.591C>A synonymous_variant 0.15
atpE 1461019 c.-26C>A upstream_gene_variant 0.24
rrs 1471658 n.-188T>G upstream_gene_variant 0.21
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.27
rrl 1476408 n.2751G>C non_coding_transcript_exon_variant 0.15
inhA 1674892 p.Asn231Asp missense_variant 0.16
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.3
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2169379 p.Phe412Val missense_variant 0.19
PPE35 2169866 c.747G>C synonymous_variant 0.34
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.31
eis 2715586 c.-254G>C upstream_gene_variant 0.26
ahpC 2725954 c.-239C>T upstream_gene_variant 0.26
pepQ 2859381 c.1038C>G synonymous_variant 0.25
Rv2752c 3064741 p.Gly484Ala missense_variant 0.26
fbiD 3339550 p.Gly145Trp missense_variant 0.21
Rv3083 3448497 c.-7T>A upstream_gene_variant 0.8
fbiB 3641955 p.Gly141Arg missense_variant 0.29
rpoA 3878238 p.Asp90Glu missense_variant 0.16
ddn 3987013 p.Gly57Ala missense_variant 0.19
clpC1 4038857 c.1848C>A synonymous_variant 0.17
clpC1 4039932 p.Gly258Val missense_variant 0.33
embC 4239842 c.-21C>A upstream_gene_variant 0.13
embC 4241456 p.Ala532Pro missense_variant 0.24
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.4
embC 4242827 p.Leu989Val missense_variant 0.24
ubiA 4269529 p.Ala102Gly missense_variant 0.31
ethA 4327672 c.-199G>A upstream_gene_variant 0.2
ethR 4327912 p.Arg122Gly missense_variant 0.23
whiB6 4338234 c.288A>G synonymous_variant 0.99
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448499 c.-4_*1408del transcript_ablation 1.0