TB-Profiler result

Run: ERR046909
Summary

Run ID: ERR046909

Sample name:

Date: 31-03-2023 08:56:51

Number of reads: 4804840

Percentage reads mapped: 99.97

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
fgd1 491027 p.Asn82Thr missense_variant 0.25
rpoC 762836 c.-534C>G upstream_gene_variant 0.27
rpoC 767305 p.Tyr1312* stop_gained 0.24
mmpL5 777399 p.Thr361Arg missense_variant 0.21
mmpR5 779371 p.Ala128Pro missense_variant 0.19
atpE 1461019 c.-26C>A upstream_gene_variant 0.2
rrs 1471658 n.-188T>G upstream_gene_variant 0.18
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.2
inhA 1674892 p.Asn231Asp missense_variant 0.18
ndh 2102891 p.Phe51Ser missense_variant 0.25
PPE35 2167871 c.2742G>C synonymous_variant 0.15
PPE35 2169866 c.747G>C synonymous_variant 0.3
kasA 2518891 c.777C>A synonymous_variant 0.16
eis 2714366 p.Val323Leu missense_variant 0.22
eis 2715586 c.-254G>C upstream_gene_variant 0.3
ahpC 2725954 c.-239C>T upstream_gene_variant 0.2
Rv2752c 3064741 p.Gly484Ala missense_variant 0.23
thyX 3067995 c.-50A>C upstream_gene_variant 0.24
thyA 3073806 c.666C>G synonymous_variant 0.15
fprA 3474601 p.Arg199Gly missense_variant 0.22
fbiB 3641955 p.Gly141Arg missense_variant 0.22
fbiB 3642512 p.Leu326Phe missense_variant 0.21
alr 3840268 p.Thr385Pro missense_variant 0.2
clpC1 4038857 c.1848C>A synonymous_variant 0.17
clpC1 4039363 p.Ala448Pro missense_variant 0.19
clpC1 4039932 p.Gly258Val missense_variant 0.32
embC 4241456 p.Ala532Pro missense_variant 0.33
embC 4242822 p.Val987Gly missense_variant 0.26
embA 4243977 p.Ala249Pro missense_variant 0.15
embA 4246423 p.Val1064Gly missense_variant 0.26
embB 4249330 p.Met939Ile missense_variant 0.2
ubiA 4269529 p.Ala102Gly missense_variant 0.23
ethA 4327672 c.-199G>A upstream_gene_variant 0.38