TB-Profiler result

Run: ERR10465923
Summary

Run ID: ERR10465923

Sample name:

Date: 2024-10-03T19:43:19.110025

Number of reads: 7194596

Percentage reads mapped: 99.74

Median coverage: 203.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 576108 p.Ala254Gly missense_variant 0.33 isoniazid
ethionamide
mmaA3 737507 p.Glu215Lys missense_variant 1.0 isoniazid
Rv1129c 1254520 c.8_14dupGGAGTAA frameshift_variant&stop_gained 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
eis 2715072 c.261G>A synonymous_variant 1.0 kanamycin
amikacin
Rv3083 3448388 c.-116C>T upstream_gene_variant 1.0 ethionamide
rpoA 3877759 p.Pro250Leu missense_variant 1.0 rifampicin Uncertain significance
panD 4043967 c.315C>T synonymous_variant 1.0 pyrazinamide
ethR 4328122 p.Pro192Ser missense_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R