TB-Profiler result

Run: ERR10610143
Summary

Run ID: ERR10610143

Sample name:

Date: 22-05-2023 21:48:12

Number of reads: 72066

Percentage reads mapped: 97.6

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.97
lineage4.9 Euro-American (H37Rv-like) T1 None 0.98
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6175 p.Glu312Asp missense_variant 1.0
gyrA 7268 c.-34C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7879 p.Asn193Ser missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoC 763886 c.517C>A synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpS5 779515 c.-610C>T upstream_gene_variant 0.4
mmpS5 779625 c.-720G>A upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
ndh 2102240 p.Arg268His missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714481 c.852G>T synonymous_variant 0.4
folC 2747721 c.-123C>T upstream_gene_variant 0.67
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339545 p.Arg143Gln missense_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 1.0
clpC1 4040517 p.Val63Ala missense_variant 1.0
clpC1 4040719 c.-15A>G upstream_gene_variant 1.0
embA 4245670 p.Ala813Gly missense_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
ethA 4326148 c.1326G>T synonymous_variant 1.0
whiB6 4338203 p.Arg107Cys missense_variant 1.0
whiB6 4338571 c.-50G>A upstream_gene_variant 0.67
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407848 p.Ala119Thr missense_variant 1.0
gid 4407873 c.330G>T synonymous_variant 1.0