TB-Profiler result

Run: ERR10796613

Summary

Run ID: ERR10796613

Sample name:

Date: 31-03-2023 11:12:30

Number of reads: 657524

Percentage reads mapped: 100.0

Strain: lineage4

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9215 c.1914C>A synonymous_variant 0.25
gyrA 9628 p.Ala776Val missense_variant 0.11
fgd1 490896 c.114C>T synonymous_variant 0.33
mshA 576143 p.Arg266Ser missense_variant 0.22
mshA 576358 c.1011C>G synonymous_variant 0.33
mshA 576718 c.1371C>A synonymous_variant 0.25
ccsA 620151 c.262delA frameshift_variant 1.0
rpoB 759845 c.39T>A synonymous_variant 0.13
rpoB 760310 c.504G>A synonymous_variant 0.18
rpoB 761518 p.Asp571Val missense_variant 0.33
rpoB 762044 c.2238C>T synonymous_variant 0.12
rpoC 766144 c.2775G>T synonymous_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303406 p.Arg159His missense_variant 0.14
fbiC 1304519 p.Ala530Val missense_variant 0.29
fbiC 1304800 p.Arg624Gly missense_variant 0.12
Rv1258c 1407459 c.-119T>A upstream_gene_variant 0.33
embR 1416959 p.Arg130Leu missense_variant 0.22
embR 1417133 p.Ile72Asn missense_variant 0.67
atpE 1460921 c.-124C>T upstream_gene_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.17
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.14
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.15
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.14
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.13
rpsA 1833841 c.300C>A synonymous_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2170552 p.Ser21Pro missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714699 p.Arg212Cys missense_variant 0.5
eis 2715077 p.Ala86Thr missense_variant 0.15
eis 2715181 p.Gly51Asp missense_variant 0.2
ribD 2987456 c.618C>T synonymous_variant 0.29
Rv2752c 3065576 p.Ala206Ser missense_variant 0.14
thyX 3067344 p.Ser201Asn missense_variant 1.0
thyA 3074093 p.Arg127Ser missense_variant 0.11
ald 3086942 c.123G>A synonymous_variant 0.12
ald 3087203 c.384C>A synonymous_variant 0.13
fprA 3474717 c.711C>T synonymous_variant 0.25
alr 3841143 p.Thr93Ile missense_variant 0.29
ddn 3986792 c.-52T>A upstream_gene_variant 0.2
ddn 3986796 c.-48G>A upstream_gene_variant 0.18
clpC1 4038963 p.Asp581Val missense_variant 0.12
clpC1 4039729 p.Asp326Asn missense_variant 1.0
embC 4240821 p.Pro320His missense_variant 0.5
embC 4241503 c.1641G>T synonymous_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4242976 c.-257G>A upstream_gene_variant 0.13
embB 4247045 p.Asp178Asn missense_variant 0.25
aftB 4267179 p.Tyr553Cys missense_variant 0.25
aftB 4267391 c.1446G>A synonymous_variant 0.33
ethA 4326201 p.Asp425Asn missense_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0