TB-Profiler result

Run: ERR11049949
Summary

Run ID: ERR11049949

Sample name:

Date: 02-04-2023 04:27:30

Number of reads: 3340842

Percentage reads mapped: 99.62

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576106 c.759C>G synonymous_variant 0.23
mshA 576442 p.Cys365Trp missense_variant 0.33
mshA 576462 p.Ala372Gly missense_variant 0.14
rpoC 764367 p.Gly333Ala missense_variant 0.15
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.26
mmpS5 778969 c.-65_-64insGAA upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302887 c.-44T>C upstream_gene_variant 1.0
embR 1416722 p.Thr209Ile missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476058 n.2401T>G non_coding_transcript_exon_variant 0.17
fabG1 1673553 p.Asp38Glu missense_variant 0.32
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170037 c.576C>G synonymous_variant 0.25
PPE35 2170065 p.Ala183Gly missense_variant 0.33
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.35
pepQ 2860159 p.Ala87Gly missense_variant 0.15
ald 3087816 p.Cys333Gly missense_variant 0.16
fbiD 3339734 p.Ala206Gly missense_variant 0.67
fbiD 3339749 p.Val211Gly missense_variant 0.4
fbiD 3339751 p.Ala212Pro missense_variant 0.33
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
fprA 3475025 p.Thr340Ile missense_variant 1.0
whiB7 3568428 c.252A>G synonymous_variant 0.29
whiB7 3568431 c.249C>G synonymous_variant 0.33
rpoA 3878559 c.-53delC upstream_gene_variant 0.12
rpoA 3878597 c.-90G>C upstream_gene_variant 0.5
rpoA 3878641 c.-134C>G upstream_gene_variant 0.67
clpC1 4040550 p.Leu52Trp missense_variant 0.22
embC 4240409 p.Pro183Ala missense_variant 0.43
embC 4240427 p.Ser189Cys missense_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243585 p.Phe118Ser missense_variant 0.18
embA 4245255 p.Glu675Lys missense_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.53
embB 4247016 p.Ser168Trp missense_variant 0.24
embB 4248328 c.1815G>C synonymous_variant 0.34
aftB 4267400 c.1437G>C synonymous_variant 0.16
ethA 4328415 c.-942A>G upstream_gene_variant 0.18
whiB6 4338200 p.Asp108His missense_variant 0.21
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0