TB-Profiler result

Run: ERR11050071
Summary

Run ID: ERR11050071

Sample name:

Date: 02-04-2023 10:19:15

Number of reads: 1906869

Percentage reads mapped: 99.66

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576442 p.Cys365Trp missense_variant 0.18
mshA 576453 p.Val369Gly missense_variant 0.27
mshA 576468 p.Val374Gly missense_variant 0.38
mshA 576616 c.1269G>C synonymous_variant 0.3
rpoB 761161 p.Leu452Arg missense_variant 0.21
rpoC 764367 p.Gly333Ala missense_variant 0.22
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.23
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1407062 c.279G>A synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.24
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170059 p.Val185Gly missense_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.19
folC 2747750 c.-152G>A upstream_gene_variant 1.0
pepQ 2860159 p.Ala87Gly missense_variant 0.24
fbiD 3339734 p.Ala206Gly missense_variant 1.0
whiB7 3568428 c.252A>G synonymous_variant 0.6
rpoA 3878641 c.-134C>G upstream_gene_variant 1.0
embC 4239915 p.Ser18Phe missense_variant 1.0
embC 4240409 p.Pro183Ala missense_variant 0.21
embA 4242475 c.-758G>A upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243331 c.99G>T synonymous_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.41
embB 4247016 p.Ser168Trp missense_variant 0.21
embB 4247020 c.507C>G synonymous_variant 0.4
embB 4247033 p.Ser174Cys missense_variant 0.22
embB 4248328 c.1815G>C synonymous_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0