TB-Profiler result

Run: ERR11050176
Summary

Run ID: ERR11050176

Sample name:

Date: 02-04-2023 14:54:14

Number of reads: 318547

Percentage reads mapped: 99.45

Strain: lineage4.1.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7689 p.Thr130Ser missense_variant 0.5
gyrA 8206 p.Ile302Thr missense_variant 0.13
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoB 760220 c.414C>T synonymous_variant 0.17
rpoB 761571 p.Pro589Thr missense_variant 0.29
rpoB 762540 p.Asn912Tyr missense_variant 0.33
rpoB 763087 p.Val1094Gly missense_variant 0.25
rpoC 764171 p.Phe268Ile missense_variant 0.33
rpoC 764263 c.894G>A synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 766591 p.Glu1074Asp missense_variant 0.33
rpoC 766703 p.Met1112Val missense_variant 0.29
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777320 c.1161C>G synonymous_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303956 p.Glu342Asp missense_variant 0.33
fbiC 1303966 p.Leu346Val missense_variant 0.29
fbiC 1305477 c.2547C>T synonymous_variant 0.22
embR 1416697 c.651C>T synonymous_variant 0.43
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473412 n.-246T>G upstream_gene_variant 0.21
rrl 1476058 n.2401T>G non_coding_transcript_exon_variant 0.56
fabG1 1673553 p.Asp38Glu missense_variant 0.75
rpsA 1833676 p.Lys45Asn missense_variant 0.29
rpsA 1834371 p.Lys277Thr missense_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170573 p.Leu14Val missense_variant 0.33
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.4
folC 2747409 p.Tyr64Asn missense_variant 0.18
folC 2747416 p.Gln61His missense_variant 0.22
ribD 2987386 p.Ala183Val missense_variant 0.29
ribD 2987498 c.660C>G synonymous_variant 0.4
Rv2752c 3064823 p.Val457Leu missense_variant 0.33
Rv2752c 3065739 c.453G>A synonymous_variant 0.22
Rv2752c 3067053 c.-862C>T upstream_gene_variant 0.17
thyA 3074671 c.-200G>A upstream_gene_variant 0.22
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087361 p.Tyr181Phe missense_variant 0.33
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568759 c.-80A>T upstream_gene_variant 0.33
Rv3236c 3611974 c.1143A>C synonymous_variant 1.0
fbiA 3640414 c.-129G>C upstream_gene_variant 0.13
fbiB 3642149 c.615C>G synonymous_variant 0.29
fbiB 3642233 c.699G>A synonymous_variant 0.5
alr 3840549 p.Glu291Ala missense_variant 0.29
rpoA 3877885 p.Leu208Gln missense_variant 0.29
rpoA 3878306 p.Gly68Arg missense_variant 0.22
ddn 3987097 p.Asn85Ile missense_variant 0.17
clpC1 4039738 p.Thr323Pro missense_variant 0.4
clpC1 4039822 p.Ala295Pro missense_variant 0.18
panD 4044268 p.Met5Arg missense_variant 0.33
embC 4241059 c.1197G>A synonymous_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4243585 p.Phe118Ser missense_variant 0.33
embA 4246383 p.Tyr1051Asn missense_variant 0.2
embB 4247445 p.Asp311Ala missense_variant 0.3
aftB 4267400 c.1437G>C synonymous_variant 0.31
ethA 4327409 p.His22Leu missense_variant 0.2
whiB6 4338449 p.Ala25Thr missense_variant 0.22
whiB6 4338491 p.Thr11Ser missense_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407970 p.Pro78Gln missense_variant 0.33
gid 4407995 p.Ser70Cys missense_variant 0.33
gid 4408003 p.Asp67Gly missense_variant 0.29