TB-Profiler result

Run: ERR11050458
Summary

Run ID: ERR11050458

Sample name:

Date: 03-04-2023 05:19:43

Number of reads: 3114354

Percentage reads mapped: 99.68

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.16
mshA 576113 p.Arg256Gly missense_variant 0.27
mshA 576453 p.Val369Gly missense_variant 0.2
mshA 576613 c.1266A>C synonymous_variant 0.18
rpoC 764367 p.Gly333Ala missense_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.16
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1305148 p.Val740Ile missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1476058 n.2401T>G non_coding_transcript_exon_variant 0.18
fabG1 1673553 p.Asp38Glu missense_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169122 c.1491C>G synonymous_variant 1.0
PPE35 2169125 p.Val496Ile missense_variant 1.0
PPE35 2169131 c.1482C>T synonymous_variant 1.0
PPE35 2169134 c.1479G>A synonymous_variant 1.0
PPE35 2169141 p.Thr491Met missense_variant 1.0
PPE35 2169144 p.Val490Ala missense_variant 1.0
PPE35 2169149 c.1464G>A synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.23
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.24
pepQ 2860159 p.Ala87Gly missense_variant 0.19
ald 3087095 c.276C>T synonymous_variant 0.99
fbiD 3339734 p.Ala206Gly missense_variant 0.67
fbiD 3339751 p.Ala212Pro missense_variant 0.31
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
whiB7 3568425 c.255T>G synonymous_variant 0.25
whiB7 3568428 c.252A>G synonymous_variant 0.33
rpoA 3878590 c.-83G>C upstream_gene_variant 0.43
rpoA 3878597 c.-90G>C upstream_gene_variant 0.33
rpoA 3878637 c.-130G>C upstream_gene_variant 0.75
rpoA 3878641 c.-134C>G upstream_gene_variant 0.76
clpC1 4040021 c.684A>C synonymous_variant 1.0
embC 4240409 p.Pro183Ala missense_variant 0.33
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.35
embB 4246584 p.Arg24Pro missense_variant 0.33
embB 4248328 c.1815G>C synonymous_variant 0.23
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
PPE35 2169071 c.1463_1541delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNA frameshift_variant 1.0
Rv3083 3448451 c.-52_*1408del transcript_ablation 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0