TB-Profiler result

Run: ERR11050795
Summary

Run ID: ERR11050795

Sample name:

Date: 03-04-2023 21:24:48

Number of reads: 2901125

Percentage reads mapped: 99.68

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 490756 c.-27T>G upstream_gene_variant 0.18
mshA 576108 p.Ala254Gly missense_variant 0.12
mshA 576442 p.Cys365Trp missense_variant 0.34
mshA 576626 p.Thr427Pro missense_variant 0.17
rpoC 764367 p.Gly333Ala missense_variant 0.31
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.38
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673162 c.-278T>C upstream_gene_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168863 c.1750C>T synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.15
PPE35 2170686 c.-74G>A upstream_gene_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.32
Rv2752c 3064823 p.Val457Leu missense_variant 0.25
fbiD 3339734 p.Ala206Gly missense_variant 0.57
fbiD 3339751 p.Ala212Pro missense_variant 0.22
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
Rv3236c 3612047 p.Ala357Val missense_variant 1.0
rpoA 3878580 c.-73A>C upstream_gene_variant 0.2
rpoA 3878641 c.-134C>G upstream_gene_variant 0.88
embC 4240409 p.Pro183Ala missense_variant 0.16
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.61
embB 4246820 p.Pro103Thr missense_variant 1.0
embB 4247016 p.Ser168Trp missense_variant 0.33
embB 4247020 c.507C>G synonymous_variant 0.19
embB 4247033 p.Ser174Arg missense_variant 0.26
embB 4248328 c.1815G>C synonymous_variant 0.14
aftB 4267981 p.Arg286Gly missense_variant 0.21
ethA 4326505 c.969C>G synonymous_variant 1.0
ethA 4328415 c.-942A>G upstream_gene_variant 0.19
whiB6 4338200 p.Asp108His missense_variant 0.22
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0