TB-Profiler result

Run: ERR11050803
Summary

Run ID: ERR11050803

Sample name:

Date: 03-04-2023 21:46:27

Number of reads: 2395114

Percentage reads mapped: 99.77

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5078 c.-162C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.15
mshA 576468 p.Val374Gly missense_variant 0.22
mshA 576613 c.1266A>C synonymous_variant 0.31
rpoB 762019 p.Glu738Ala missense_variant 1.0
rpoC 762854 c.-516G>T upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169424 p.Ser397Pro missense_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.35
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pepQ 2860159 p.Ala87Gly missense_variant 0.12
ald 3087818 p.Cys333Trp missense_variant 0.16
fbiD 3339734 p.Ala206Gly missense_variant 0.6
fbiD 3339751 p.Ala212Pro missense_variant 0.21
whiB7 3568428 c.252A>G synonymous_variant 0.3
Rv3236c 3612179 p.Ala313Val missense_variant 1.0
alr 3841424 c.-4C>A upstream_gene_variant 0.17
rpoA 3878618 c.-111A>C upstream_gene_variant 0.43
rpoA 3878637 c.-130G>C upstream_gene_variant 0.67
rpoA 3878641 c.-134C>G upstream_gene_variant 0.54
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.27
aftB 4268356 p.Pro161Ser missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407596 p.Val203Leu missense_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0