TB-Profiler result

Run: ERR11081325
Summary

Run ID: ERR11081325

Sample name:

Date: 08-04-2023 16:23:17

Number of reads: 620339

Percentage reads mapped: 99.66

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7879 p.Asn193Ile missense_variant 0.11
fgd1 491005 p.Leu75Met missense_variant 0.1
fgd1 491095 p.Val105Met missense_variant 0.13
fgd1 491776 c.995_996delTG frameshift_variant 0.11
mshA 576108 p.Ala254Gly missense_variant 0.36
ccsA 620087 c.199delC frameshift_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775641 p.Pro947His missense_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302963 c.33T>C synonymous_variant 0.1
fbiC 1303850 p.Pro307His missense_variant 0.25
fbiC 1303876 p.Ala316Thr missense_variant 0.14
fbiC 1304884 p.Trp652Arg missense_variant 0.11
Rv1258c 1406500 c.840delG frameshift_variant 0.15
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
inhA 1674721 p.Phe174Leu missense_variant 0.11
rpsA 1834864 c.1323T>G synonymous_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102975 p.Gly23Val missense_variant 0.14
katG 2154369 c.1743G>T synonymous_variant 0.14
katG 2155547 p.Asp189Asn missense_variant 1.0
katG 2155557 c.555C>T synonymous_variant 0.11
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2747582 p.Ser6Tyr missense_variant 0.12
pepQ 2859440 p.Gly327Ser missense_variant 0.15
pepQ 2860143 c.276G>A synonymous_variant 0.13
Rv2752c 3066061 p.Asp44Ala missense_variant 1.0
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
fprA 3474130 p.Leu42Met missense_variant 0.1
Rv3236c 3612781 c.336G>A synonymous_variant 1.0
clpC1 4040842 c.-138G>T upstream_gene_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242656 p.Pro932Thr missense_variant 0.15
embB 4246584 p.Arg24Pro missense_variant 0.3
embB 4248528 p.Phe672Tyr missense_variant 0.12
ethA 4326564 p.Ala304Thr missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0