TB-Profiler result

Run: ERR1633825
Summary

Run ID: ERR1633825

Sample name:

Date: 18-08-2022 14:49:21

Number of reads: 804193

Percentage reads mapped: 99.6

Strain: lineage4.3.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 0.99
lineage4.3.2 Euro-American (LAM) LAM3 None 0.99
lineage4.3.2.1 Euro-American (LAM) LAM3 RD761 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5520 p.Pro94Leu missense_variant 1.0
gyrA 7222 c.-80C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576548 p.Ala401Thr missense_variant 0.17
rpoC 763640 p.Arg91Gly missense_variant 0.12
rpoC 764995 c.1626C>G synonymous_variant 1.0
rpoC 765340 p.Gln657His missense_variant 0.13
rpoC 765652 c.2283G>A synonymous_variant 0.13
rpoC 765718 p.Asp783Glu missense_variant 0.12
rpoC 765805 c.2436C>A synonymous_variant 0.12
rpsL 781370 c.-190G>A upstream_gene_variant 0.18
rpsL 781386 c.-174G>A upstream_gene_variant 0.15
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416830 c.517delG frameshift_variant 0.17
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 1.0
rrs 1472940 n.1095G>T non_coding_transcript_exon_variant 0.13
inhA 1673691 c.-511G>C upstream_gene_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154238 p.Thr625Met missense_variant 0.11
thyX 3067866 p.Thr27Ile missense_variant 0.14
thyA 3073722 c.750C>T synonymous_variant 0.11
thyA 3073868 p.Thr202Ala missense_variant 1.0
fbiB 3641853 p.Gly107Ser missense_variant 0.12
embC 4240586 p.Gly242Cys missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244570 c.1338C>T synonymous_variant 0.12
embB 4246811 p.Gly100Ser missense_variant 0.22
embB 4248827 p.Gly772Ser missense_variant 0.12
ethR 4327249 c.-300G>A upstream_gene_variant 0.13
gid 4407681 p.His174Gln missense_variant 0.15
gid 4408156 p.Leu16Arg missense_variant 1.0