TB-Profiler result

Run: ERR1949959
Summary

Run ID: ERR1949959

Sample name:

Date: 31-03-2023 15:35:43

Number of reads: 1021688

Percentage reads mapped: 99.37

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5607 p.Val123Gly missense_variant 0.25
gyrA 7272 c.-30A>C upstream_gene_variant 0.2
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 763023 p.Tyr1073Asp missense_variant 0.21
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
fbiC 1305033 c.2103T>G synonymous_variant 0.33
Rv1258c 1406523 p.Val273Gly missense_variant 0.29
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473885 n.228A>T non_coding_transcript_exon_variant 0.18
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1475834 n.2177T>A non_coding_transcript_exon_variant 0.15
rrl 1476044 n.2387T>A non_coding_transcript_exon_variant 0.33
rrl 1476235 n.2578A>G non_coding_transcript_exon_variant 0.13
rrl 1476795 n.3138A>C splice_region_variant&non_coding_transcript_exon_variant 0.19
inhA 1674400 p.Asn67Tyr missense_variant 0.33
rpsA 1834485 p.Glu315Val missense_variant 0.14
tlyA 1917803 c.-137T>C upstream_gene_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2167745 c.2868C>A synonymous_variant 0.18
PPE35 2168058 p.Gln852Leu missense_variant 0.22
PPE35 2168230 p.Thr795Ser missense_variant 0.22
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2169947 p.Asn222Lys missense_variant 0.15
Rv1979c 2223066 c.99C>T synonymous_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2290042 c.-801T>C upstream_gene_variant 0.11
folC 2746457 p.Val381Gly missense_variant 0.18
folC 2747040 p.Ile187Phe missense_variant 0.15
ribD 2986655 c.-184A>C upstream_gene_variant 0.12
Rv2752c 3065853 c.339A>C synonymous_variant 0.1
thyA 3073695 c.777T>C synonymous_variant 0.11
fbiA 3640376 c.-167T>A upstream_gene_variant 0.25
rpoA 3878490 c.18C>G synonymous_variant 0.22
clpC1 4040249 p.Glu152Asp missense_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245624 p.Ser798Ala missense_variant 0.18
embB 4247028 p.Leu172Gln missense_variant 0.15
aftB 4267632 p.Val402Gly missense_variant 0.2
aftB 4268040 p.Leu266Pro missense_variant 0.13
aftB 4269705 c.-869T>G upstream_gene_variant 0.14
ubiA 4269781 p.Val18Gly missense_variant 0.22
whiB6 4338261 c.261G>C synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448497 c.-6_*1408del transcript_ablation 1.0