TB-Profiler result

Run: ERR2228826
Summary

Run ID: ERR2228826

Sample name:

Date: 31-03-2023 16:22:19

Number of reads: 1397518

Percentage reads mapped: 99.3

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8856 p.Thr519Ala missense_variant 1.0
rpoC 765237 p.Asp623Ala missense_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779052 p.Glu21Asp missense_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
atpE 1460948 c.-97A>T upstream_gene_variant 0.31
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673605 p.Phe56Val missense_variant 0.25
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168110 p.Thr835Ala missense_variant 0.27
PPE35 2168172 p.Ile814Asn missense_variant 0.15
PPE35 2168728 p.Gly629Arg missense_variant 1.0
Rv1979c 2221792 p.Val458Ala missense_variant 0.11
Rv1979c 2222929 p.Tyr79Ser missense_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746987 p.Tyr204* stop_gained 0.2
folC 2747691 c.-93A>C upstream_gene_variant 0.15
pepQ 2860424 c.-6A>G upstream_gene_variant 0.12
Rv3236c 3612780 p.Leu113Val missense_variant 0.33
fbiB 3642769 p.Leu412Arg missense_variant 0.27
rpoA 3878490 c.18C>G synonymous_variant 0.38
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267681 p.Ser386Ala missense_variant 0.14
aftB 4267878 p.Val320Gly missense_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0