TB-Profiler result

Run: ERR2228957
Summary

Run ID: ERR2228957

Sample name:

Date: 31-03-2023 16:28:05

Number of reads: 308802

Percentage reads mapped: 99.56

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6428 p.Glu397Lys missense_variant 0.12
gyrA 6481 c.-821G>A upstream_gene_variant 0.17
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576440 c.1094delG frameshift_variant 0.13
rpoC 766274 p.Ala969Ser missense_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776590 p.Met631Val missense_variant 0.22
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303196 p.Lys89Arg missense_variant 0.33
fbiC 1303587 c.657G>T synonymous_variant 0.17
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1475189 n.1532G>C non_coding_transcript_exon_variant 0.17
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2170048 p.Leu189Val missense_variant 0.22
PPE35 2170053 p.Thr187Ser missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2288714 c.528C>T synonymous_variant 0.17
ribD 2987440 p.Thr201Ile missense_variant 0.4
ald 3087090 p.Leu91Met missense_variant 0.13
fbiD 3339684 c.567C>T synonymous_variant 0.14
whiB7 3568492 p.Trp63Leu missense_variant 0.29
alr 3841546 c.-126C>A upstream_gene_variant 0.18
ddn 3986823 c.-21T>C upstream_gene_variant 0.2
panD 4043915 p.Phe123Ile missense_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244859 p.Gly543Trp missense_variant 0.5
embA 4244953 p.Phe574Ser missense_variant 0.25
ethR 4326970 c.-579G>T upstream_gene_variant 0.17
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0