TB-Profiler result

Run: ERR2228959

Summary

Run ID: ERR2228959

Sample name:

Date: 31-03-2023 16:28:16

Number of reads: 279314

Percentage reads mapped: 99.57

Strain: lineage4.8

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5158 c.-82G>A upstream_gene_variant 0.12
ccsA 620408 p.Pro173Leu missense_variant 0.15
rpoB 760000 p.Arg65His missense_variant 0.15
rpoB 760127 c.321C>T synonymous_variant 0.25
rpoC 766828 p.His1153Gln missense_variant 0.33
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776532 p.Ala650Glu missense_variant 0.17
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474311 n.654G>A non_coding_transcript_exon_variant 0.18
rrl 1476273 n.2616A>G non_coding_transcript_exon_variant 0.33
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168728 p.Gly629Arg missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2288788 p.Ala152Thr missense_variant 0.29
Rv2752c 3067157 c.-966G>A upstream_gene_variant 0.2
fbiD 3338974 c.-144G>C upstream_gene_variant 0.14
fbiD 3338983 c.-135C>A upstream_gene_variant 0.14
fbiD 3339719 p.Leu201Arg missense_variant 0.22
fprA 3474914 p.Ala303Glu missense_variant 0.17
Rv3236c 3612134 p.Thr328Ile missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4247916 p.Arg468His missense_variant 0.17
aftB 4267406 c.1431G>A synonymous_variant 0.25
aftB 4267962 p.Pro292His missense_variant 0.33
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0