TB-Profiler result

Run: ERR2229022
Summary

Run ID: ERR2229022

Sample name:

Date: 31-03-2023 16:30:42

Number of reads: 745658

Percentage reads mapped: 99.63

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6753 p.Ile505Thr missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 761655 c.1853delC frameshift_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776988 p.Pro498Gln missense_variant 0.12
mmpL5 777146 c.1335C>A synonymous_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781603 p.Lys15Arg missense_variant 0.11
fbiC 1303243 p.Cys105Arg missense_variant 0.11
fbiC 1303747 p.Thr273Ala missense_variant 1.0
Rv1258c 1407165 p.Thr59Met missense_variant 0.12
atpE 1461052 p.Pro3His missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673990 p.Gly184Asp missense_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2169053 c.1560T>A synonymous_variant 0.2
PPE35 2169091 p.Val508Leu missense_variant 0.18
PPE35 2170048 p.Leu189Val missense_variant 0.1
PPE35 2170513 c.100C>T synonymous_variant 0.12
PPE35 2170528 p.Ser29Thr missense_variant 0.12
PPE35 2170532 c.81G>C synonymous_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519281 c.1167G>A synonymous_variant 0.11
eis 2714853 c.480C>A synonymous_variant 0.18
pepQ 2859622 p.Pro266Leu missense_variant 0.17
Rv3083 3448447 c.-56delA upstream_gene_variant 0.17
fbiB 3642601 p.Gly356Glu missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244611 p.Ala460Val missense_variant 0.13
embB 4246082 c.-432T>C upstream_gene_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0