TB-Profiler result

Run: ERR2229160
Summary

Run ID: ERR2229160

Sample name:

Date: 31-03-2023 16:45:40

Number of reads: 236060

Percentage reads mapped: 99.21

Strain: lineage4.9

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 0.64
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
ccsA 620475 c.585G>T synonymous_variant 0.4
rpoB 760658 p.Glu284Asp missense_variant 0.33
rpoB 763183 p.Cys1126Phe missense_variant 0.4
rpoC 767268 p.Ala1300Asp missense_variant 0.4
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303160 p.Gly77Glu missense_variant 0.5
fbiC 1303747 p.Thr273Ala missense_variant 1.0
fbiC 1305190 p.Ala754Thr missense_variant 0.4
embR 1416622 p.Asp242Glu missense_variant 0.67
embR 1417450 c.-103C>T upstream_gene_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471839 n.-7G>A upstream_gene_variant 0.67
ndh 2102074 p.Met323Lys missense_variant 1.0
ndh 2102561 c.481delT frameshift_variant 0.22
PPE35 2168123 c.2490A>T synonymous_variant 0.67
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2169168 p.Leu482Ser missense_variant 0.29
PPE35 2169394 p.Ala407Thr missense_variant 0.15
PPE35 2169397 p.Gly406Ser missense_variant 0.16
PPE35 2169866 c.747G>A synonymous_variant 0.15
PPE35 2169879 p.Phe245Ser missense_variant 0.17
PPE35 2169882 p.Ser244Asn missense_variant 0.18
PPE35 2169890 c.723C>T synonymous_variant 0.22
PPE35 2169893 c.720C>A synonymous_variant 0.22
PPE35 2169902 p.Leu237Phe missense_variant 0.2
PPE35 2170048 p.Leu189Val missense_variant 0.27
PPE35 2170053 p.Thr187Ser missense_variant 0.3
PPE35 2170147 p.Ser156Ala missense_variant 0.12
PPE35 2170372 p.Thr81Ala missense_variant 0.18
PPE35 2170376 c.237G>A synonymous_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2288765 c.477G>T synonymous_variant 0.13
pncA 2288837 c.405C>T synonymous_variant 0.13
pncA 2289209 c.33C>T synonymous_variant 0.29
eis 2714783 p.Gln184* stop_gained 0.4
thyX 3067911 p.Ile12Thr missense_variant 0.25
thyA 3074640 c.-169G>A upstream_gene_variant 0.5
ald 3086725 c.-95A>G upstream_gene_variant 0.4
Rv3236c 3612357 p.Glu254* stop_gained 0.33
clpC1 4040562 p.Ser48* stop_gained 0.2
clpC1 4040605 p.Leu34Ile missense_variant 0.22
embB 4246544 p.Thr11Pro missense_variant 0.5
embB 4246548 p.Pro12Gln missense_variant 0.75
embB 4246555 c.42G>C synonymous_variant 0.75
embB 4246556 p.Ala15Pro missense_variant 0.75
embB 4248221 p.Pro570Ser missense_variant 0.2
aftB 4267782 p.Val352Gly missense_variant 0.25
ethR 4326757 c.-792C>G upstream_gene_variant 0.29
ethA 4328055 c.-582A>G upstream_gene_variant 0.33
whiB6 4338595 c.-75delG upstream_gene_variant 1.0