TB-Profiler result

Run: ERR2229219
Summary

Run ID: ERR2229219

Sample name:

Date: 31-03-2023 16:49:22

Number of reads: 326736

Percentage reads mapped: 99.54

Strain: lineage4.8

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5685 p.Val149Ala missense_variant 0.12
gyrB 6705 p.Glu489Val missense_variant 0.2
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 575992 c.645C>G synonymous_variant 0.18
rpoB 759620 c.-187A>C upstream_gene_variant 0.5
rpoC 765394 p.Glu675Asp missense_variant 0.22
mmpL5 775603 p.Thr960Pro missense_variant 0.3
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpS5 778527 p.Thr127Ser missense_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.4
fabG1 1673357 c.-83G>A upstream_gene_variant 0.17
fabG1 1673359 c.-81T>C upstream_gene_variant 0.17
fabG1 1673361 c.-79C>G upstream_gene_variant 0.17
fabG1 1673380 c.-60C>G upstream_gene_variant 0.23
tlyA 1918195 p.Cys86Gly missense_variant 0.29
ndh 2102581 c.462T>G synonymous_variant 0.12
ndh 2102586 p.Ser153Gly missense_variant 0.12
ndh 2102589 c.454T>C synonymous_variant 0.11
ndh 2102590 c.453A>C synonymous_variant 0.11
PPE35 2168728 p.Gly629Arg missense_variant 0.91
PPE35 2169308 c.1305C>T synonymous_variant 0.14
PPE35 2169457 p.His386Asp missense_variant 0.1
PPE35 2169902 c.711G>C synonymous_variant 0.12
PPE35 2170048 p.Leu189Val missense_variant 0.2
PPE35 2170053 p.Thr187Ser missense_variant 0.23
PPE35 2170357 p.Ala86Thr missense_variant 0.12
PPE35 2170392 p.Gly74Ala missense_variant 0.15
PPE35 2170400 c.213G>C synonymous_variant 0.15
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518457 p.Gly115Ser missense_variant 0.5
eis 2714361 c.972C>T synonymous_variant 0.18
ahpC 2726338 p.Val49Gly missense_variant 0.2
ahpC 2726383 p.Glu64Gly missense_variant 0.17
Rv2752c 3065601 p.Asp197Glu missense_variant 0.29
fbiA 3640564 p.Gly8Ser missense_variant 0.22
alr 3841546 c.-126C>A upstream_gene_variant 0.18
embC 4241280 p.Val473Glu missense_variant 0.29
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244504 c.1272G>A synonymous_variant 0.29
embA 4244516 c.1284G>A synonymous_variant 0.29
embB 4246544 p.Thr11Pro missense_variant 0.4
embB 4246548 p.Pro12Gln missense_variant 0.4
embB 4246555 c.42G>C synonymous_variant 0.33
embB 4246556 p.Ala15Pro missense_variant 0.33
embB 4246563 p.Leu17Trp missense_variant 0.33
embB 4246567 c.54G>T synonymous_variant 0.33
embB 4248629 p.Pro706Thr missense_variant 0.17
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448497 c.-6_*1408del transcript_ablation 1.0