TB-Profiler result

Run: ERR2229326
Summary

Run ID: ERR2229326

Sample name:

Date: 31-03-2023 17:00:41

Number of reads: 1527961

Percentage reads mapped: 98.89

Strain: lineage4.8

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
ccsA 620708 p.Val273Ala missense_variant 0.11
rpoB 762193 p.Leu796Gln missense_variant 0.16
rpoB 762494 p.Glu896Asp missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 779043 c.-563T>C upstream_gene_variant 0.14
mmpL5 779061 c.-581G>T upstream_gene_variant 0.17
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
embR 1417221 p.Val43Phe missense_variant 0.19
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673349 c.-91G>C upstream_gene_variant 0.13
fabG1 1673357 c.-83G>A upstream_gene_variant 0.13
fabG1 1673359 c.-81T>C upstream_gene_variant 0.14
fabG1 1673361 c.-79C>G upstream_gene_variant 0.14
fabG1 1673380 c.-60C>G upstream_gene_variant 0.4
fabG1 1674068 p.Arg210Leu missense_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2170048 p.Leu189Val missense_variant 0.68
PPE35 2170053 p.Thr187Ser missense_variant 0.69
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519155 p.Ile347Met missense_variant 0.11
folC 2746346 p.Ala418Glu missense_variant 0.2
ribD 2987326 p.Ile163Ser missense_variant 0.12
thyX 3067340 c.606G>A synonymous_variant 0.19
fprA 3475147 p.Thr381Ala missense_variant 1.0
clpC1 4040048 c.657C>A synonymous_variant 0.13
embC 4242404 p.Thr848Ala missense_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244936 c.1704C>T synonymous_variant 0.15
embB 4246544 p.Thr11Pro missense_variant 0.26
embB 4246548 p.Pro12Gln missense_variant 0.36
embB 4246555 c.42G>C synonymous_variant 0.45
embB 4246556 p.Ala15Pro missense_variant 0.45
embB 4246563 p.Leu17Trp missense_variant 0.25
embB 4246567 c.54G>T synonymous_variant 0.4
whiB6 4338595 c.-75delG upstream_gene_variant 1.0