TB-Profiler result

Run: ERR2229503
Summary

Run ID: ERR2229503

Sample name:

Date: 18-08-2022 10:31:27

Number of reads: 996773

Percentage reads mapped: 99.28

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6114 p.Gln292Arg missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7416 p.Arg39Ser missense_variant 0.15
gyrA 7423 p.Leu41Arg missense_variant 0.14
gyrA 9507 p.Ala736Ser missense_variant 0.14
rpoB 759775 c.-32G>A upstream_gene_variant 0.14
rpoB 760575 p.Glu257* stop_gained 0.16
rpoB 761960 p.Met718Ile missense_variant 0.12
rpoC 763540 c.171C>T synonymous_variant 0.2
rpoC 764343 p.Arg325His missense_variant 0.18
rpoC 764352 p.Val328Ala missense_variant 0.12
rpoC 766028 p.Arg887Cys missense_variant 0.18
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 800636 c.-173C>A upstream_gene_variant 0.12
fbiC 1303618 p.His230Asn missense_variant 0.14
atpE 1461096 p.Ala18Ser missense_variant 0.15
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476150 n.2493G>T non_coding_transcript_exon_variant 0.17
fabG1 1673346 c.-94C>G upstream_gene_variant 0.44
fabG1 1673349 c.-91G>C upstream_gene_variant 0.42
fabG1 1673357 c.-83G>A upstream_gene_variant 0.17
fabG1 1673359 c.-81T>C upstream_gene_variant 0.17
fabG1 1673361 c.-79C>G upstream_gene_variant 0.17
fabG1 1673380 c.-60C>G upstream_gene_variant 0.23
tlyA 1917972 c.33A>G synonymous_variant 1.0
eis 2714753 p.Gln194Lys missense_variant 0.12
folC 2747204 p.Ala132Glu missense_variant 0.15
folC 2747252 p.Ser116Ile missense_variant 0.15
pepQ 2859601 c.817delG frameshift_variant 0.18
pepQ 2859807 p.His204Gln missense_variant 0.12
thyX 3068063 c.-118C>T upstream_gene_variant 0.14
fbiD 3339517 p.His134Asn missense_variant 0.14
fbiA 3641450 p.Val303Glu missense_variant 0.13
alr 3840232 p.Arg397Cys missense_variant 0.12
alr 3840269 c.1152C>T synonymous_variant 0.14
alr 3841546 c.-126C>A upstream_gene_variant 0.17
panD 4044088 p.Gly65Val missense_variant 0.12
panD 4044125 p.Ala53Thr missense_variant 0.15
embC 4241825 p.Pro655Ala missense_variant 0.15
embA 4246381 p.Trp1050* stop_gained 0.18
embB 4247181 p.Ile223Ser missense_variant 0.11
embB 4249151 p.Ala880Ser missense_variant 0.13
ethR 4328118 p.Glu190Asp missense_variant 0.18