TB-Profiler result

Run: ERR2229662
Summary

Run ID: ERR2229662

Sample name:

Date: 31-03-2023 17:24:11

Number of reads: 1178578

Percentage reads mapped: 99.38

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473227 n.1382C>G non_coding_transcript_exon_variant 0.12
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673380 c.-60C>G upstream_gene_variant 0.13
rpsA 1834619 p.Leu360Met missense_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102874 p.Gln57Lys missense_variant 0.13
katG 2154447 c.1665A>G synonymous_variant 0.12
katG 2155705 p.Pro136Arg missense_variant 0.13
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2169269 c.1344A>G synonymous_variant 0.11
PPE35 2169272 c.1341C>G synonymous_variant 0.11
PPE35 2169278 c.1335T>C synonymous_variant 0.21
PPE35 2169281 c.1332T>G synonymous_variant 0.21
PPE35 2169287 c.1326T>C synonymous_variant 0.19
PPE35 2169293 c.1320T>C synonymous_variant 0.16
PPE35 2170048 p.Leu189Val missense_variant 0.19
PPE35 2170053 p.Thr187Ser missense_variant 0.19
Rv1979c 2222887 p.Tyr93Phe missense_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746660 c.938delT frameshift_variant 0.12
Rv2752c 3065013 c.1179G>T synonymous_variant 0.12
Rv2752c 3065562 c.630T>C synonymous_variant 0.11
thyA 3074593 c.-122C>A upstream_gene_variant 0.12
Rv3083 3448319 c.-185C>T upstream_gene_variant 0.14
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
Rv3236c 3612748 c.369G>T synonymous_variant 0.25
rpoA 3878182 p.Asp109Gly missense_variant 0.11
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246548 p.Pro12Gln missense_variant 0.18
embB 4246555 c.42G>C synonymous_variant 0.24
embB 4246556 p.Ala15Pro missense_variant 0.24
embB 4246563 p.Leu17Trp missense_variant 0.13
embB 4246567 c.54G>T synonymous_variant 0.24
aftB 4267025 c.1812C>A synonymous_variant 0.13
ubiA 4269260 p.Arg192Cys missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0