TB-Profiler result

Run: ERR2229738
Summary

Run ID: ERR2229738

Sample name:

Date: 31-03-2023 17:32:26

Number of reads: 1262154

Percentage reads mapped: 99.31

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 759753 c.-54C>A upstream_gene_variant 0.11
rpoB 762705 p.Ser967Ala missense_variant 0.25
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474091 n.434C>A non_coding_transcript_exon_variant 0.12
rrl 1474911 n.1254G>A non_coding_transcript_exon_variant 0.15
fabG1 1673346 c.-94C>G upstream_gene_variant 0.14
fabG1 1673349 c.-91G>C upstream_gene_variant 0.14
fabG1 1673380 c.-60C>G upstream_gene_variant 0.25
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918550 p.Arg204Pro missense_variant 0.19
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2170048 p.Leu189Val missense_variant 0.25
PPE35 2170053 p.Thr187Ser missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518606 c.492G>C synonymous_variant 0.12
Rv2752c 3065510 p.Gly228Cys missense_variant 0.12
thyX 3067340 c.606G>A synonymous_variant 0.15
Rv3236c 3612903 p.Ala72Ser missense_variant 0.12
alr 3840437 c.984G>A synonymous_variant 0.12
rpoA 3878382 c.126G>A synonymous_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246544 p.Thr11Pro missense_variant 0.27
embB 4246548 p.Pro12Gln missense_variant 0.24
embB 4246555 c.42G>C synonymous_variant 0.27
embB 4246556 p.Ala15Pro missense_variant 0.27
embB 4246563 p.Leu17Trp missense_variant 0.32
embB 4246567 c.54G>T synonymous_variant 0.29
aftB 4267895 p.Phe314Leu missense_variant 0.27
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408171 p.Ile11Asn missense_variant 0.78
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0