TB-Profiler result

Run: ERR245828
Summary

Run ID: ERR245828

Sample name:

Date: 31-03-2023 18:23:32

Number of reads: 11259982

Percentage reads mapped: 99.44

Strain: lineage4.1.1.3

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 0.99
ccsA 620407 p.Pro173Ala missense_variant 0.24
rpoB 762249 p.Leu815Val missense_variant 0.23
rpoC 762836 c.-534C>G upstream_gene_variant 0.3
rpoC 765150 p.Gly594Glu missense_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777399 p.Thr361Arg missense_variant 0.22
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417501 c.-154A>C upstream_gene_variant 0.31
atpE 1461019 c.-26C>A upstream_gene_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.2
fabG1 1673449 p.Thr4Pro missense_variant 0.41
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918069 p.Thr44Pro missense_variant 0.38
katG 2156096 p.Pro6Ser missense_variant 1.0
PPE35 2169866 c.747G>C synonymous_variant 0.23
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.39
eis 2715586 c.-254G>C upstream_gene_variant 0.61
ahpC 2725954 c.-239C>T upstream_gene_variant 0.27
ahpC 2726756 c.564C>G synonymous_variant 0.28
pepQ 2859381 c.1038C>G synonymous_variant 0.22
ribD 2987589 c.751C>T synonymous_variant 0.99
Rv2752c 3064741 p.Gly484Ala missense_variant 0.18
Rv2752c 3065265 c.927C>G synonymous_variant 0.29
thyA 3073817 p.Gln219Glu missense_variant 0.28
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3449058 p.Ser185Arg missense_variant 0.33
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
fbiB 3641955 p.Gly141Arg missense_variant 0.23
fbiB 3642734 c.1200G>C synonymous_variant 0.35
ddn 3987013 p.Gly57Ala missense_variant 0.18
clpC1 4038857 c.1848C>A synonymous_variant 0.2
clpC1 4039363 p.Ala448Pro missense_variant 0.28
clpC1 4039932 p.Gly258Val missense_variant 0.21
embC 4241429 p.Phe523Val missense_variant 0.46
embC 4242476 p.Pro872Ala missense_variant 0.21
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.28
embC 4242827 p.Leu989Val missense_variant 0.17
embB 4249408 c.2895G>A synonymous_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.25
ethA 4327672 c.-199G>A upstream_gene_variant 0.25
whiB6 4338493 p.Thr10Lys missense_variant 0.21
whiB6 4338595 c.-75delG upstream_gene_variant 1.0