TB-Profiler result

Run: ERR2503372
Summary

Run ID: ERR2503372

Sample name:

Date: 31-03-2023 18:25:16

Number of reads: 404328

Percentage reads mapped: 99.74

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5500 c.261C>T synonymous_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 759615 c.-192A>C upstream_gene_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 778007 c.473delG frameshift_variant 0.11
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406765 c.576A>G synonymous_variant 0.2
Rv1258c 1406774 c.567C>T synonymous_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673560 p.Lys41Gln missense_variant 0.1
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155706 p.Pro136Ser missense_variant 0.11
PPE35 2170385 c.228G>T synonymous_variant 0.11
PPE35 2170392 p.Gly74Ala missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518608 p.Met165Thr missense_variant 0.15
Rv2752c 3066198 c.-8delG upstream_gene_variant 1.0
fbiB 3641971 p.Val146Ala missense_variant 0.13
clpC1 4038995 c.1710G>A synonymous_variant 0.12
embC 4240646 p.Phe262Val missense_variant 0.3
embC 4241734 c.1872C>G synonymous_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267149 p.Glu563Gly missense_variant 1.0
aftB 4267155 p.Gln561Arg missense_variant 1.0
whiB6 4338573 c.-52C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0