TB-Profiler result

Run: ERR2503568
Summary

Run ID: ERR2503568

Sample name:

Date: 31-03-2023 18:32:10

Number of reads: 411497

Percentage reads mapped: 99.53

Strain: lineage4.5

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7892 c.591G>A synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576751 p.Lys468Asn missense_variant 0.5
ccsA 620029 c.139C>T synonymous_variant 1.0
rpoB 759615 c.-192A>C upstream_gene_variant 0.2
rpoB 760848 p.Thr348Ala missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 800984 c.177delA frameshift_variant 0.1
fbiC 1303016 p.Val29Gly missense_variant 0.45
fbiC 1304159 p.Val410Gly missense_variant 0.33
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476016 n.2359T>G non_coding_transcript_exon_variant 0.22
rpsA 1833569 p.Gln10Lys missense_variant 0.11
rpsA 1834610 p.Arg357Trp missense_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2167659 p.Thr985Ile missense_variant 0.18
PPE35 2170568 p.Ile15Met missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714566 p.Leu256Pro missense_variant 0.3
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
ddn 3987205 c.363_386delATATTGGCCACAGTTGGTCACGAT disruptive_inframe_deletion 1.0
clpC1 4038318 p.Pro796Leu missense_variant 1.0
embC 4240528 c.666C>T synonymous_variant 1.0
embC 4240929 p.Trp356* stop_gained 0.1
embC 4241041 c.1179C>T synonymous_variant 0.15
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244679 p.Ala483Thr missense_variant 1.0
ubiA 4269355 p.Arg160His missense_variant 0.11
ethA 4326163 c.1311T>C synonymous_variant 0.15
ethA 4326262 c.1212C>T synonymous_variant 1.0
ethR 4327970 p.Phe141Ser missense_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0