TB-Profiler result

Run: ERR2512443

Summary

Run ID: ERR2512443

Sample name:

Date: 20-10-2023 09:57:03

Number of reads: 2350104

Percentage reads mapped: 98.02

Strain: lineage4.8

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5524 c.285C>A synonymous_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.24
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.21
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.29
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.36
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.3
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.3
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.24
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.41
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.5
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.35
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.45
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.38
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.38
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.3
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.27
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.31
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249354 c.2841G>C synonymous_variant 1.0
whiB6 4338590 c.-69A>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0