TB-Profiler result

Run: ERR2513016
Summary

Run ID: ERR2513016

Sample name:

Date: 31-03-2023 19:24:12

Number of reads: 476574

Percentage reads mapped: 99.45

Strain: lineage4.7

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.7 Euro-American (mainly T) T1;T5 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6358 c.-944C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7379 c.78C>G synonymous_variant 1.0
gyrA 7470 p.Tyr57Asn missense_variant 0.11
mshA 576243 p.Gly299Asp missense_variant 0.25
ccsA 620748 c.858T>G synonymous_variant 0.25
rpoB 759620 c.-187A>C upstream_gene_variant 0.24
rpoB 760515 p.Trp237Gly missense_variant 0.12
rpoB 761392 p.Glu529Val missense_variant 0.13
rpoB 761771 p.Met655Ile missense_variant 0.2
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777125 c.1356C>T synonymous_variant 0.13
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474294 n.637C>G non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154820 p.Val431Ala missense_variant 0.18
PPE35 2168828 c.1785G>A synonymous_variant 1.0
PPE35 2169053 c.1560T>C synonymous_variant 1.0
PPE35 2169059 c.1554G>A synonymous_variant 0.67
PPE35 2169063 p.Met517Thr missense_variant 1.0
PPE35 2169065 p.Ala516Thr missense_variant 0.67
PPE35 2169068 c.1545G>T synonymous_variant 0.67
Rv1979c 2222412 p.Asn251Lys missense_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518151 p.Ser13Arg missense_variant 0.25
kasA 2518405 c.291C>G synonymous_variant 0.18
folC 2746307 p.Arg431His missense_variant 0.14
pepQ 2859916 p.Thr168Ile missense_variant 0.2
Rv2752c 3067132 c.-941T>C upstream_gene_variant 0.13
alr 3840831 p.Met197Arg missense_variant 0.11
clpC1 4039484 c.1221T>G synonymous_variant 0.38
clpC1 4039992 p.Val238Ala missense_variant 0.11
embC 4240648 c.786C>T synonymous_variant 0.38
embC 4241474 c.1612C>T synonymous_variant 0.15
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4243111 c.3252delG frameshift_variant 0.18
embA 4244857 c.1629delG frameshift_variant 0.5
embA 4245885 p.Asp885Tyr missense_variant 0.25
embB 4247281 c.768C>T synonymous_variant 0.11
embB 4249732 c.3219C>G synonymous_variant 1.0
ethA 4326397 p.Gln359His missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0