TB-Profiler result

Run: ERR3283058
Summary

Run ID: ERR3283058

Sample name:

Date: 2024-03-26T18:18:10.604810

Number of reads: 77992

Percentage reads mapped: 14.31

Median coverage: 3.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.97
lineage4.9 Euro-American (H37Rv-like) None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
mtrB 3627008 c.-395G>C upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3627011 c.-398T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrA 3627208 c.142C>T synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627236 c.-623T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3627248 c.-635C>T upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3627254 c.-641C>A upstream_gene_variant 0.82 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.82 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.8 bedaquiline
rifampicin