TB-Profiler result

Run: ERR3468622
Summary

Run ID: ERR3468622

Sample name:

Date: 01-04-2023 02:19:28

Number of reads: 32255

Percentage reads mapped: 2.29

Strain: lineage4.9

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.98
lineage4.9 Euro-American (H37Rv-like) T1 None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155739 c.372_373insAG frameshift_variant 0.4 isoniazid
katG 2155744 c.366_367delCG frameshift_variant 0.4 isoniazid
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 8285 c.984C>T synonymous_variant 1.0
gyrA 8741 c.1440C>T synonymous_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
rpsA 1834859 p.Ala440Thr missense_variant 1.0
katG 2155503 c.609C>T synonymous_variant 1.0
katG 2155716 c.396T>C synonymous_variant 0.4
katG 2155728 c.384G>C synonymous_variant 0.4
katG 2155731 c.381G>A synonymous_variant 0.4
katG 2155735 p.Met126Ala missense_variant 0.4
katG 2155749 c.363C>G synonymous_variant 0.4
katG 2155758 c.354C>G synonymous_variant 0.4
katG 2155765 p.His116Gly missense_variant 0.4
katG 2155773 c.339C>T synonymous_variant 0.5
katG 2155785 p.Ala109Gly missense_variant 0.5
katG 2155796 p.Ala106Ser missense_variant 0.67
katG 2155800 c.312G>C synonymous_variant 0.67
katG 2155806 c.306T>C synonymous_variant 0.67
katG 2155815 c.297G>T synonymous_variant 0.5
katG 2155821 c.291C>T synonymous_variant 0.67
katG 2155827 c.285C>T synonymous_variant 0.67
katG 2155830 c.282C>T synonymous_variant 0.67
katG 2155836 c.276C>T synonymous_variant 0.67
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
ald 3086728 c.-92C>T upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242970 c.-263C>T upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0