TB-Profiler result

Run: ERR4028198
Summary

Run ID: ERR4028198

Sample name:

Date: 01-04-2023 04:20:28

Number of reads: 929901

Percentage reads mapped: 99.74

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6293 p.Glu352* stop_gained 0.12
gyrB 6329 p.Glu364Lys missense_variant 0.17
gyrA 7844 c.543C>A synonymous_variant 0.14
mshA 576252 p.Ser302Leu missense_variant 1.0
ccsA 620537 p.Val216Glu missense_variant 0.12
ccsA 620597 p.Ala236Val missense_variant 0.15
rpoB 760288 p.Ile161Asn missense_variant 0.12
rpoC 762443 c.-927G>C upstream_gene_variant 0.1
rpoC 764531 p.Gly388Asn missense_variant 0.18
rpoC 765015 p.Ala549Asp missense_variant 0.11
rpoC 765627 p.Ala753Val missense_variant 0.13
rpoC 767200 p.Glu1277Asp missense_variant 0.11
mmpL5 777088 p.Ile465Val missense_variant 0.17
mmpL5 777449 c.1032C>A synonymous_variant 0.12
rplC 800624 c.-185G>C upstream_gene_variant 0.13
atpE 1461059 c.15C>T synonymous_variant 0.18
atpE 1461147 p.Leu35Ile missense_variant 0.1
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.5
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.5
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.67
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.67
inhA 1674278 p.Ala26Val missense_variant 0.13
inhA 1674658 p.Arg153Trp missense_variant 0.12
tlyA 1917970 p.Leu11Ile missense_variant 0.11
PPE35 2169654 p.Gly320Glu missense_variant 0.15
PPE35 2169902 p.Leu237Phe missense_variant 0.12
PPE35 2169910 p.Asn235Tyr missense_variant 0.12
pncA 2289848 c.-607G>A upstream_gene_variant 0.11
pncA 2289936 c.-695T>C upstream_gene_variant 0.12
pncA 2290005 c.-764G>T upstream_gene_variant 0.1
kasA 2518902 p.Ala263Val missense_variant 0.12
pepQ 2859788 p.Val211Met missense_variant 0.13
Rv2752c 3065536 p.Gly219Asp missense_variant 0.17
Rv2752c 3065572 p.Glu207Gly missense_variant 0.22
ald 3087193 p.Gly125Val missense_variant 0.29
fprA 3474270 c.264C>A synonymous_variant 0.15
fprA 3475170 c.1165dupG frameshift_variant 0.11
fprA 3475315 p.His437Tyr missense_variant 0.29
fbiA 3640927 p.Thr129Ala missense_variant 0.11
alr 3840755 c.666C>T synonymous_variant 0.15
embC 4240516 c.654G>A synonymous_variant 0.11
embA 4244204 p.Met324Ile missense_variant 0.13
embB 4249322 p.Ala937Thr missense_variant 0.11
embB 4249520 p.Ala1003Thr missense_variant 0.14
aftB 4268913 c.-77A>T upstream_gene_variant 0.13
aftB 4269753 c.-917G>T upstream_gene_variant 0.12