TB-Profiler result

Run: ERR4407464
Summary

Run ID: ERR4407464

Sample name:

Date: 01-04-2023 05:45:12

Number of reads: 263077

Percentage reads mapped: 99.45

Strain: lineage4.1.2

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7323 p.Pro8Ala missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9730 p.Asp810Val missense_variant 0.15
fgd1 490671 c.-112A>G upstream_gene_variant 0.11
fgd1 491591 p.Lys270Met missense_variant 1.0
rpoB 759620 c.-187A>C upstream_gene_variant 0.33
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765097 p.Met576Ile missense_variant 0.14
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776316 p.His722Arg missense_variant 0.1
mmpL5 776659 p.Asp608Asn missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1460895 c.-150G>A upstream_gene_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472968 n.1123C>T non_coding_transcript_exon_variant 0.12
fabG1 1673360 c.-80C>T upstream_gene_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102315 c.727delA frameshift_variant 0.12
PPE35 2168501 p.Phe704Leu missense_variant 1.0
PPE35 2169603 p.Gly337Val missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2518767 p.Thr218Asn missense_variant 0.17
folC 2746361 p.Asp413Gly missense_variant 0.18
Rv2752c 3065508 c.684T>C synonymous_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087412 c.596_598delTCA disruptive_inframe_deletion 0.13
fbiD 3339257 p.Leu47Ser missense_variant 0.15
fprA 3473841 c.-166T>C upstream_gene_variant 0.18
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474322 p.Ala106Thr missense_variant 0.18
fprA 3474838 p.Ile278Val missense_variant 0.2
alr 3841612 c.-193_-192insC upstream_gene_variant 1.0
clpC1 4040382 p.Ile108Thr missense_variant 0.14
embC 4242381 p.Pro840Arg missense_variant 0.22
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embC 4243033 p.Trp1057Cys missense_variant 0.17
embB 4247121 p.Ser203Leu missense_variant 1.0
embB 4248429 p.Cys639Tyr missense_variant 0.14
aftB 4267458 p.Trp460* stop_gained 0.13
aftB 4268102 c.735C>T synonymous_variant 0.18
aftB 4268807 c.30G>T synonymous_variant 1.0
ubiA 4269334 p.Ala167Val missense_variant 0.18
ubiA 4269803 p.Ala11Thr missense_variant 0.15
whiB6 4338362 p.Arg54Trp missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0