TB-Profiler result

Run: ERR4808951
Summary

Run ID: ERR4808951

Sample name:

Date: 01-04-2023 10:04:27

Number of reads: 23722

Percentage reads mapped: 99.55

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6076 c.837C>T synonymous_variant 0.67
gyrA 8288 c.988_989delAA frameshift_variant 1.0
gyrA 8411 c.1110C>A synonymous_variant 0.67
ccsA 619769 c.-122C>T upstream_gene_variant 0.67
ccsA 620605 p.Val239Phe missense_variant 0.67
rpoB 760072 p.Pro89Gln missense_variant 1.0
rpoB 762495 p.Asp897Tyr missense_variant 0.67
rpoC 763936 c.567C>A synonymous_variant 1.0
rpoC 763942 c.573C>A synonymous_variant 1.0
rpoC 765794 p.Gly809Cys missense_variant 1.0
rpoC 765870 p.Arg834Leu missense_variant 1.0
rpoC 766049 p.Glu894* stop_gained 1.0
mmpL5 776544 p.Lys646Met missense_variant 1.0
mmpL5 777004 p.Glu493Lys missense_variant 1.0
mmpL5 779031 c.-551G>T upstream_gene_variant 1.0
mmpR5 779368 p.Asp127Tyr missense_variant 1.0
mmpR5 779399 p.Arg137Leu missense_variant 1.0
mmpR5 779428 p.Glu147* stop_gained 1.0
fbiC 1304631 p.Phe567Leu missense_variant 1.0
fbiC 1304635 p.Gln569Lys missense_variant 1.0
fbiC 1305378 c.2448C>A synonymous_variant 1.0
rrl 1474257 n.600G>T non_coding_transcript_exon_variant 0.67
tlyA 1918675 p.Gln246Lys missense_variant 0.67
tlyA 1918698 c.759C>A synonymous_variant 0.67
ndh 2102824 c.219G>T synonymous_variant 0.67
PPE35 2169080 p.Leu511Phe missense_variant 1.0
kasA 2519321 p.Gly403Trp missense_variant 1.0
thyA 3074074 p.Trp133Leu missense_variant 1.0
thyA 3074079 c.393G>T synonymous_variant 1.0
thyA 3074130 c.342G>T synonymous_variant 1.0
thyA 3074609 c.-138G>T upstream_gene_variant 1.0
ald 3086982 p.Ala55Ser missense_variant 1.0
ald 3087408 p.Leu197Ile missense_variant 0.67
fbiB 3642629 c.1095C>A synonymous_variant 0.67
fbiB 3642659 c.1125C>A synonymous_variant 1.0
clpC1 4039133 c.1572C>A synonymous_variant 0.67
clpC1 4039367 p.Lys446Asn missense_variant 1.0
clpC1 4039742 c.963C>A synonymous_variant 0.67
clpC1 4040027 c.678C>A synonymous_variant 0.67
embC 4241850 p.Thr663Asn missense_variant 1.0
embA 4243410 p.Ala60Ser missense_variant 0.67
embA 4243472 c.240C>A synonymous_variant 0.4
embA 4244750 c.1518C>A synonymous_variant 1.0
embA 4244910 c.1678C>T synonymous_variant 0.67
embA 4245399 p.Leu723Met missense_variant 0.67
embA 4246306 p.Ser1025* stop_gained 0.67
embA 4246318 p.Pro1029Gln missense_variant 0.67
embB 4246548 p.Pro12Gln missense_variant 1.0
embB 4249333 c.2820C>A synonymous_variant 0.5
aftB 4267085 c.1752G>T synonymous_variant 1.0
aftB 4267094 c.1743G>T synonymous_variant 1.0
aftB 4267102 p.Arg579Cys missense_variant 1.0
aftB 4267876 p.Leu321Met missense_variant 0.67
aftB 4267907 c.930C>A synonymous_variant 0.67
aftB 4267921 p.Gln306Lys missense_variant 0.67
aftB 4269702 c.-866C>A upstream_gene_variant 0.67
ethR 4328014 p.Glu156* stop_gained 0.67