TB-Profiler result

Run: ERR4812826
Summary

Run ID: ERR4812826

Sample name:

Date: 01-04-2023 12:21:36

Number of reads: 116460

Percentage reads mapped: 99.07

Strain: lineage4.3.4

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3.4 Euro-American (LAM) LAM RD174 0.06
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
gid 4408022 c.180delA frameshift_variant 1.0 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5349 p.Thr37Ile missense_variant 0.18
gyrB 6479 p.Ala414Ser missense_variant 0.17
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 763617 p.Thr83Asn missense_variant 0.33
rpoC 764995 c.1626C>G synonymous_variant 0.86
rpoC 765590 p.Arg741Ser missense_variant 1.0
rpoC 765798 p.Asn810Ser missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834378 c.837T>C synonymous_variant 1.0
Rv1979c 2223123 c.42G>A synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2715221 p.Thr38Ser missense_variant 0.4
Rv2752c 3064543 p.Met550Lys missense_variant 0.67
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
clpC1 4038287 c.2418C>T synonymous_variant 1.0
panD 4044176 p.Ala36Thr missense_variant 0.33
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408209 c.-7G>T upstream_gene_variant 1.0