TB-Profiler result

Run: ERR4814390
Summary

Run ID: ERR4814390

Sample name:

Date: 01-04-2023 13:16:01

Number of reads: 905847

Percentage reads mapped: 99.95

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6805 c.-497G>T upstream_gene_variant 0.15
gyrA 7445 c.144C>T synonymous_variant 0.11
gyrA 7446 p.Lys49Glu missense_variant 0.11
mshA 576303 p.Leu319Gln missense_variant 0.12
mshA 576751 p.Lys468Asn missense_variant 0.33
rpoB 760513 p.Gly236Asp missense_variant 0.13
mmpL5 779235 c.-755C>G upstream_gene_variant 0.1
atpE 1461087 p.Leu15Met missense_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472509 n.664G>A non_coding_transcript_exon_variant 0.2
rrl 1476588 n.2931A>G non_coding_transcript_exon_variant 0.11
fabG1 1673861 p.Val141Ala missense_variant 0.12
inhA 1674453 c.252G>T synonymous_variant 0.12
PPE35 2167695 p.Ile973Thr missense_variant 0.12
PPE35 2167703 p.Leu970Phe missense_variant 0.12
PPE35 2167706 c.2907T>A synonymous_variant 0.1
PPE35 2169592 p.Ile341Phe missense_variant 0.12
PPE35 2169596 p.Phe339Val missense_variant 0.12
PPE35 2169605 p.Asn336Thr missense_variant 0.11
kasA 2519078 p.Glu322Leu missense_variant 0.15
kasA 2519083 c.970_976delAACGCCA frameshift_variant 0.13
embA 4244917 p.Leu562Pro missense_variant 0.14
embB 4246567 c.54G>T synonymous_variant 0.1
ethA 4326084 p.Asp464Tyr missense_variant 0.11