TB-Profiler

TB-Profiler result

Run: ERR4814914

This average coverage of the target regions is below the recommended 30x. Some mutations may not be detected due to low coverage.

Summary

Run ID: ERR4814914

Sample name:

Date: 2024-04-15T04:35:59.798210

Number of reads: 283905

Percentage reads mapped: 97.11

Median coverage: 5.0

Strain: lineage3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage3	East-African-Indian	RD750	0.57

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
mmpL5	777940	p.Gly181Ser	missense_variant	1.0	clofazimine
mmpL5	777940	p.Gly181Ser	missense_variant	1.0	bedaquiline
panD	4044693	c.-412C>A	upstream_gene_variant	1.0	pyrazinamide
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R