TB-Profiler result

Run: ERR4815546
Summary

Run ID: ERR4815546

Sample name:

Date: 01-04-2023 13:55:26

Number of reads: 216543

Percentage reads mapped: 94.94

Strain:

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.75 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6940 c.-362G>A upstream_gene_variant 0.15
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575465 p.Ala40Ser missense_variant 0.4
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 761636 c.1830G>T synonymous_variant 0.5
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766536 p.Glu1056Gly missense_variant 0.4
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
mmpS5 779650 c.-745A>G upstream_gene_variant 0.4
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 801035 c.230delC frameshift_variant 0.67
fbiC 1302809 c.-122A>G upstream_gene_variant 0.5
fbiC 1303887 c.957G>T synonymous_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.75
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.6
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.6
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.6
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.75
rrl 1476763 n.3106G>A non_coding_transcript_exon_variant 0.4
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155862 p.Met84Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518366 p.Gln84His missense_variant 0.33
eis 2714307 c.1025delC frameshift_variant 0.4
ahpC 2726153 c.-39delC upstream_gene_variant 0.5
Rv2752c 3065234 p.Arg320Ser missense_variant 0.67
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339379 p.Asp88Tyr missense_variant 0.5
fbiD 3339651 c.536_537delCA frameshift_variant 0.25
Rv3083 3449142 c.639C>T synonymous_variant 0.33
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiB 3642644 p.His370Gln missense_variant 0.5
alr 3840697 p.Ala242Ser missense_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4246978 c.465C>A synonymous_variant 0.67
embB 4247354 p.Ala281Thr missense_variant 0.29
embB 4249757 p.Thr1082Ala missense_variant 1.0
aftB 4267240 p.Phe533Ile missense_variant 0.25
aftB 4267308 p.Leu510Arg missense_variant 0.4
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0