TB-Profiler result

Run: ERR4816115
Summary

Run ID: ERR4816115

Sample name:

Date: 01-04-2023 14:14:51

Number of reads: 1053113

Percentage reads mapped: 99.66

Strain: lineage4.6.4

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.4 Euro-American T;LAM None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9121 p.Arg607His missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoB 761499 p.Val565Met missense_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 778176 p.Gly102Asp missense_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471890 n.45G>A non_coding_transcript_exon_variant 0.5
inhA 1673916 c.-286A>C upstream_gene_variant 0.11
rpsA 1833724 c.183C>G synonymous_variant 0.11
rpsA 1833727 c.186G>A synonymous_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102273 p.Ile257Thr missense_variant 0.11
katG 2154301 p.Leu604Ser missense_variant 0.13
katG 2155053 p.Tyr353* stop_gained 0.13
katG 2155065 c.1047C>A synonymous_variant 1.0
katG 2155120 p.Ser331Asn missense_variant 0.15
katG 2155644 c.468C>T synonymous_variant 1.0
PPE35 2170300 p.Val105Leu missense_variant 0.1
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289274 c.-33G>A upstream_gene_variant 1.0
kasA 2517995 c.-120C>T upstream_gene_variant 0.11
eis 2714393 p.Val314Leu missense_variant 1.0
eis 2714822 p.His171Asn missense_variant 0.13
folC 2746660 c.938delT frameshift_variant 0.11
folC 2747293 c.306G>A synonymous_variant 0.1
pepQ 2859622 p.Pro266Gln missense_variant 0.11
Rv2752c 3065588 p.Asp202Asn missense_variant 0.14
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474322 p.Ala106Thr missense_variant 0.14
Rv3236c 3613235 c.-119G>A upstream_gene_variant 0.11
clpC1 4038634 p.Glu691Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244852 c.1620G>A synonymous_variant 0.13
embB 4248624 p.Thr704Lys missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0